{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:20:01Z","timestamp":1769631601872,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council, Taiwan","doi-asserted-by":"publisher","award":["102-2320-B-415-002-MY3"],"award-info":[{"award-number":["102-2320-B-415-002-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012537","name":"Chiayi Christian Hospital","doi-asserted-by":"crossref","award":["R105-22"],"award-info":[{"award-number":["R105-22"]}],"id":[{"id":"10.13039\/501100012537","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.vph.2016.09.010","type":"journal-article","created":{"date-parts":[[2016,10,9]],"date-time":"2016-10-09T18:16:10Z","timestamp":1476036970000},"page":"209-218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and phosphatidylinositol 3-kinase\/Akt mechanism"],"prefix":"10.1016","volume":"87","author":[{"given":"Po-Min","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Wen","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Being-Sun","family":"Wung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2016.09.010_bb0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1089-8603(02)00127-1","article-title":"Physiological mechanisms regulating the expression of endothelial-type NO synthase","volume":"7","author":"Li","year":"2002","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.vph.2016.09.010_bb0010","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.vph.2008.06.008","article-title":"Endothelial nitric oxide (NO) and its pathophysiologic regulation","volume":"49","author":"Chatterjee","year":"2008","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.vph.2016.09.010_bb0015","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1089\/ars.2013.5659","article-title":"The multifunctional role and therapeutic potential of HO-1 in the vascular endothelium","volume":"20","author":"Calay","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.vph.2016.09.010_bb0020","first-page":"52","article-title":"Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light","volume":"28","author":"Furchgott","year":"1991","journal-title":"Blood Vessels"},{"key":"10.1016\/j.vph.2016.09.010_bb0025","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0165-6147(97)90687-8","article-title":"Soluble guanylate cyclase: the forgotten sibling","volume":"18","author":"Hobbs","year":"1997","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.vph.2016.09.010_bb0030","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.niox.2010.08.002","article-title":"Role of heme oxygenase in preserving vascular bioactive NO","volume":"23","author":"Pae","year":"2010","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.vph.2016.09.010_bb0035","first-page":"H107","article-title":"NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium","volume":"270","author":"Motterlini","year":"1996","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.vph.2016.09.010_bb0040","doi-asserted-by":"crossref","first-page":"18411","DOI":"10.1074\/jbc.272.29.18411","article-title":"Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions","volume":"272","author":"Foresti","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2016.09.010_bb0045","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/sj.bjp.0705825","article-title":"Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule","volume":"142","author":"Foresti","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2016.09.010_bb0050","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.bcp.2014.10.011","article-title":"Regulation of vascular tone in rabbit ophthalmic artery: cross talk of endogenous and exogenous gas mediators","volume":"92","author":"Salomone","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vph.2016.09.010_bb0055","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.bjp.0706241","article-title":"Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages","volume":"145","author":"Sawle","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2016.09.010_bb0060","first-page":"882","article-title":"Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS","volume":"277","author":"Thorup","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.vph.2016.09.010_bb0065","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1161\/CIRCRESAHA.107.154781","article-title":"Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress","volume":"101","author":"Kim","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.vph.2016.09.010_bb0070","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1124\/mol.109.059519","article-title":"Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase\/heme oxygenase-1 signaling","volume":"77","author":"Schwer","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.vph.2016.09.010_bb0075","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1182\/blood-2011-07-366690","article-title":"Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways","volume":"119","author":"Shin","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.vph.2016.09.010_bb0080","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1042\/BST0351142","article-title":"Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities","volume":"35","author":"Motterlini","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.vph.2016.09.010_bb0085","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ejphar.2011.11.004","article-title":"Divergent mechanisms involved in CO and CORM-2 induced vasorelaxation","volume":"674","author":"Decaluw\u00e9","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vph.2016.09.010_bb0090","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ejphar.2007.06.005","article-title":"Mechanisms of relaxation by carbon monoxide-releasing molecule-2 in murine gastric fundus and jejunum","volume":"572","author":"De Backer","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vph.2016.09.010_bb0095","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0896-6273(00)80103-8","article-title":"Carbon monoxide: an endogenous modulator of the nitric oxide-cyclic GMP signaling system","volume":"16","author":"Ingi","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.vph.2016.09.010_bb0100","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0022-3565(24)29198-9","article-title":"Post-translational control of endothelial nitric oxide synthase: why isn't calcium\/calmodulin enough?","volume":"299","author":"Fulton","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.vph.2016.09.010_bb0105","first-page":"R1","article-title":"Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase","volume":"284","author":"Fleming","year":"2003","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.vph.2016.09.010_bb0110","doi-asserted-by":"crossref","first-page":"C1039","DOI":"10.1152\/ajpcell.00252.2014","article-title":"Novel role for carbon monoxide as a potent regulator of intracellular Ca2+ and nitric oxide in rat pancreatic acinar cells","volume":"307","author":"Moustafa","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.vph.2016.09.010_bb0115","doi-asserted-by":"crossref","first-page":"8714","DOI":"10.1074\/jbc.M408092200","article-title":"Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase\/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury","volume":"280","author":"Zhang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2016.09.010_bb0120","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1242\/jcs.02914","article-title":"Inhibition of cellular respiration by endogenously produced carbon monoxide","volume":"119","author":"D'Amico","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.vph.2016.09.010_bb0125","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1096\/fj.06-6644com","article-title":"Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species","volume":"21","author":"Zuckerbraun","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.vph.2016.09.010_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2014.01.042","article-title":"CO-releasing molecules and increased heme oxygenase-1 induce protein S-glutathionylation to modulate NF-kappaB activity in endothelial cells","volume":"70","author":"Yeh","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.vph.2016.09.010_bb0135","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1161\/hq1001.097028","article-title":"Induction of endothelial NO synthase by hydrogen peroxide via a Ca(2+)\/calmodulin-dependent protein kinase II\/janus kinase 2-dependent pathway","volume":"10","author":"Cai","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2016.09.010_bb0140","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/01.RES.86.3.347","article-title":"Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide","volume":"86","author":"Drummond","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.vph.2016.09.010_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044627","article-title":"Role of Ca2+ in the control of H2O2-modulated phosphorylation pathways leading to eNOS activation in cardiac myocytes","volume":"7","author":"Sartoretto","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2016.09.010_bb0150","doi-asserted-by":"crossref","first-page":"H82","DOI":"10.1152\/ajpheart.00300.2012","article-title":"H2O2-induced endothelial NO production contributes to vascular cell apoptosis and increased permeability in rat venules","volume":"304","author":"Zhou","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.vph.2016.09.010_bb0155","first-page":"L370","article-title":"Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity","volume":"295","author":"Kumar","year":"2008","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.vph.2016.09.010_bb0160","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3181\/00379727-211-43982","article-title":"Potentiation of nitric oxide-mediated vasorelaxation by xanthine oxidase inhibitors","volume":"211","author":"Miyamoto","year":"1996","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.vph.2016.09.010_bb0165","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.lfs.2010.10.014","article-title":"Calcium-and phosphatidylinositol 3-kinase\/Akt-dependent activation of endothelial nitric oxide synthase by apigenin","volume":"87","author":"Chen","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.vph.2016.09.010_bb0170","article-title":"Carbon monoxide induces heme oxygenase-1 to modulate STAT3 activation in endothelial cells via S-glutathionylation","volume":"9","author":"Yang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2016.09.010_bb0175","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1124\/mol.53.4.630","article-title":"Activation of protein kinase C\u03b1 and\/or \u03b5 enhances transcription of the human endothelial nitric oxide synthase gene","volume":"53","author":"Li","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.vph.2016.09.010_bb0180","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0014-5793(98)00440-2","article-title":"Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins","volume":"427","author":"Nakatsubo","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.vph.2016.09.010_bb0185","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-201x.2000.00627.x","article-title":"Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress","volume":"168","author":"Fisslthaler","year":"2000","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.vph.2016.09.010_bb0190","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/mnfr.200700335","article-title":"Tannin 1-alpha-O-galloylpunicalagin induces the calcium-dependent activation of endothelial nitric-oxide synthase via the phosphatidylinositol 3-kinase\/Akt pathway in endothelial cells","volume":"52","author":"Chen","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.vph.2016.09.010_bb0195","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nature09599","article-title":"S-glutathionylation uncouples eNOS and regulates its cellular and vascular function","volume":"468","author":"Chen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.vph.2016.09.010_bb0200","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.vph.2016.09.010_bb0210","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1021\/bi972398q","article-title":"Stopped-flow analysis of CO and NO binding to inducible nitric oxide synthase","volume":"37","author":"Abu-Soud","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.vph.2016.09.010_bb0215","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1073\/pnas.87.2.682","article-title":"Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme","volume":"87","author":"Bredt","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2016.09.010_bb0220","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbrc.2013.10.108","article-title":"AT1 receptor blocker potentiates shear-stress induced nitric oxide production via modulation of eNOS phosphorylation of residues Thr(495) and Ser(1177)","volume":"441","author":"Barauna","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vph.2016.09.010_bb0225","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1089\/ars.2011.3904","article-title":"S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide\/reactive oxygen species-mediated signaling","volume":"14","author":"Zweier","year":"2011","journal-title":"Antioxid. Redox Signal."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189116300830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189116300830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T03:52:38Z","timestamp":1749613958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189116300830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":44,"alternative-id":["S1537189116300830"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2016.09.010","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and phosphatidylinositol 3-kinase\/Akt mechanism","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2016.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}