{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:53:47Z","timestamp":1780102427194,"version":"3.54.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["17-05409S\/P301"],"award-info":[{"award-number":["17-05409S\/P301"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["SVV 260 414"],"award-info":[{"award-number":["SVV 260 414"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["253115 C"],"award-info":[{"award-number":["253115 C"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.vph.2018.08.008","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T10:11:12Z","timestamp":1534327872000},"page":"36-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo"],"prefix":"10.1016","volume":"111","author":[{"given":"Jana","family":"Pourov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Najmanov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vopr\u0161alov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Migkos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Pila\u0159ov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Applov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Nov\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-6900","authenticated-orcid":false,"given":"P\u0159emysl","family":"Mlad\u011bnka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8878","key":"10.1016\/j.vph.2018.08.008_bb0005","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0140-6736(93)92876-U","article-title":"Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen elderly Study","volume":"342","author":"Hertog","year":"1993","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.vph.2018.08.008_bb0010","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3945\/ajcn.110.006783","article-title":"Habitual intake of flavonoid subclasses and incident hypertension in adults","volume":"93","author":"Cassidy","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.vph.2018.08.008_bb0015","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3945\/ajcn.111.016634","article-title":"Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults","volume":"95","author":"McCullough","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"issue":"11","key":"10.1016\/j.vph.2018.08.008_bb0020","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/jn\/137.11.2405","article-title":"Quercetin reduces blood pressure in hypertensive subjects","volume":"137","author":"Edwards","year":"2007","journal-title":"J. Nutr."},{"issue":"7","key":"10.1016\/j.vph.2018.08.008_bb0025","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1017\/S0007114509359127","article-title":"Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study","volume":"102","author":"Egert","year":"2009","journal-title":"Br. J. Nutr."},{"issue":"4","key":"10.1016\/j.vph.2018.08.008_bb0030","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/ajcn\/88.4.1018","article-title":"Pure dietary flavonoids quercetin and (\u2212)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men","volume":"88","author":"Loke","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.vph.2018.08.008_bb0035","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/sj.bjp.0704064","article-title":"Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats","volume":"133","author":"Duarte","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.vph.2018.08.008_bb0040","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11010-005-4503-0","article-title":"Effects of chronic quercetin treatment in experimental renovascular hypertension","volume":"270","author":"Garcia-Saura","year":"2005","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.vph.2018.08.008_bb0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3945\/an.111.001271","article-title":"Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms","volume":"3","author":"Larson","year":"2012","journal-title":"Adv. Nutr."},{"issue":"1\u20132","key":"10.1016\/j.vph.2018.08.008_bb0050","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijpharm.2018.02.036","article-title":"Aqueous injection of quercetin: an approach for confirmation of its direct in vivo cardiovascular effects","volume":"541","author":"Porcu","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.vph.2018.08.008_bb0055","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1039\/c2fo10268d","article-title":"Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats","volume":"3","author":"Galindo","year":"2012","journal-title":"Food Funct."},{"issue":"5","key":"10.1016\/j.vph.2018.08.008_bb0060","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/mnfr.201500761","article-title":"Flavonoid metabolite 3-(3-hydroxyphenyl)propionic acid formed by human microflora decreases arterial blood pressure in rats","volume":"60","author":"Najmanova","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"issue":"8","key":"10.1016\/j.vph.2018.08.008_bb0065","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/mnfr.200800446","article-title":"Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models","volume":"53","author":"Larrosa","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.vph.2018.08.008_bb0070","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jep.2016.09.017","article-title":"Anti-inflammatory activity of Barleria lupulina: Identification of active compounds that activate the Nrf2 cell defense pathway, organize cortical actin, reduce stress fibers, and improve cell junctions in microvascular endothelial cells","volume":"193","author":"Senger","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.vph.2018.08.008_bb0075","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.fct.2014.01.044","article-title":"Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways","volume":"66","author":"Fernandez-Millan","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.vph.2018.08.008_bb0080","doi-asserted-by":"crossref","first-page":"593902","DOI":"10.1155\/2015\/593902","article-title":"Pharmacological properties of protocatechuic Acid and its potential roles as complementary medicine","volume":"2015","author":"Semaming","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"9","key":"10.1016\/j.vph.2018.08.008_bb0085","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00210-014-0995-z","article-title":"Oral administration of quercetin is unable to protect against isoproterenol cardiotoxicity","volume":"387","author":"Riha","year":"2014","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"5","key":"10.1016\/j.vph.2018.08.008_bb0090","doi-asserted-by":"crossref","first-page":"471","DOI":"10.33549\/physiolres.932637","article-title":"The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats","volume":"62","author":"Bencze","year":"2013","journal-title":"Physiol. Res."},{"issue":"6","key":"10.1016\/j.vph.2018.08.008_bb0095","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.freeradbiomed.2010.06.010","article-title":"Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity","volume":"49","author":"Mladenka","year":"2010","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.vph.2018.08.008_bb0100","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00394-015-0865-6","article-title":"Multiple anti-inflammatory and anti-atherosclerotic properties of red wine polyphenolic extracts: differential role of hydroxycinnamic acids, flavonols and stilbenes on endothelial inflammatory gene expression","volume":"55","author":"Calabriso","year":"2016","journal-title":"Eur. J. Nutr."},{"issue":"8","key":"10.1016\/j.vph.2018.08.008_bb0105","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0753-3322(97)88045-6","article-title":"Absorption, metabolism and health effects of dietary flavonoids in man","volume":"51","author":"Hollman","year":"1997","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"10.1016\/j.vph.2018.08.008_bb0110","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3945\/ajcn.111.029330","article-title":"Epicatechin ingested via cocoa products reduces blood pressure in humans: a nonlinear regression model with a Bayesian approach","volume":"95","author":"Ellinger","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.vph.2018.08.008_bb0115","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/07315724.2004.10719347","article-title":"Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland","volume":"23","author":"Sagara","year":"2004","journal-title":"J. Am. Coll. Nutr."},{"issue":"6","key":"10.1016\/j.vph.2018.08.008_bb0120","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.mam.2010.09.003","article-title":"Dietary isoflavones and vascular protection: activation of cellular antioxidant defenses by SERMs or hormesis?","volume":"31","author":"Siow","year":"2010","journal-title":"Mol. Asp. Med."},{"issue":"14","key":"10.1016\/j.vph.2018.08.008_bb0125","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1089\/ars.2012.4581","article-title":"Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases","volume":"18","author":"Del Rio","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.vph.2018.08.008_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.phrs.2014.07.005","article-title":"The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: correlation with beta-glucuronidase activity","volume":"89","author":"Perez","year":"2014","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.vph.2018.08.008_bb0135","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/jn\/128.3.593","article-title":"Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects","volume":"128","author":"Conquer","year":"1998","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.vph.2018.08.008_bb0140","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.atherosclerosis.2008.08.007","article-title":"Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta","volume":"204","author":"Lodi","year":"2009","journal-title":"Atherosclerosis"},{"issue":"12","key":"10.1016\/j.vph.2018.08.008_bb0145","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1139\/y2012-137","article-title":"Role of quercetin in vascular physiology","volume":"90","author":"Chirumbolo","year":"2012","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.vph.2018.08.008_bb0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/mnfr.201500435","article-title":"Systematic analysis of the polyphenol metabolome using the Phenol-Explorer database","volume":"60","author":"Rothwell","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"issue":"3","key":"10.1016\/j.vph.2018.08.008_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032673","article-title":"Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation","volume":"7","author":"Galindo","year":"2012","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.vph.2018.08.008_bb0160","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/mnfr.201100378","article-title":"Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed?","volume":"55","author":"Menendez","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"issue":"3","key":"10.1016\/j.vph.2018.08.008_bb0165","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5483\/BMBRep.2008.41.3.223","article-title":"The bimodal regulation of vascular function by superoxide anion: role of endothelium","volume":"41","author":"Demirci","year":"2008","journal-title":"BMB Rep."},{"issue":"7","key":"10.1016\/j.vph.2018.08.008_bb0170","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/sj.bjp.0703233","article-title":"Compounds that block both intermediate-conductance (IK(ca)) and small-conductance (SK(ca)) calcium-activated potassium channels","volume":"129","author":"Malik-Hall","year":"2000","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.vph.2018.08.008_bb0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s12276-018-0043-z","article-title":"Small-conductance Ca(2+)-activated K(+) channels: insights into their roles in cardiovascular disease","volume":"50","author":"Gu","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.vph.2018.08.008_bb0180","first-page":"5","article-title":"Potassium channels and prostacyclin contribute to vasorelaxant activities of Tridax procumbens crude aqueous leaf extract in rat superior mesenteric arteries","volume":"44","author":"Salahdeen","year":"2015","journal-title":"Afr. J. Med. Med. Sci."},{"issue":"3","key":"10.1016\/j.vph.2018.08.008_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/nu9030268","article-title":"Absorption, metabolism and excretion of cranberry (Poly)phenols in humans: a dose response study and assessment of inter-individual variability","volume":"9","author":"Feliciano","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.vph.2018.08.008_bb0190","first-page":"1","article-title":"Quercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats","author":"Palle","year":"2017","journal-title":"Xenobiotica"},{"issue":"3","key":"10.1016\/j.vph.2018.08.008_bb0195","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1017\/S0007114514003511","article-title":"Phenolic sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit puree","volume":"113","author":"Pimpao","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.vph.2018.08.008_bb0200","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.abb.2016.01.014","article-title":"Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols","volume":"599","author":"Feliciano","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.vph.2018.08.008_bb0205","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3945\/ajcn.113.066639","article-title":"Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity","volume":"98","author":"Rodriguez-Mateos","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.vph.2018.08.008_bb0210","first-page":"729","article-title":"Serum concentrations of rutoside metabolites after oral administration of a rutoside formulation to humans","volume":"37","author":"Sawai","year":"1987","journal-title":"Arzneimittelforschung"},{"issue":"6","key":"10.1016\/j.vph.2018.08.008_bb0215","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1093\/jn\/133.6.1806","article-title":"Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans","volume":"133","author":"Olthof","year":"2003","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.vph.2018.08.008_bb0220","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0891-5849(02)00877-8","article-title":"The metabolic fate of dietary polyphenols in humans","volume":"33","author":"Rechner","year":"2002","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.vph.2018.08.008_bb0225","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/med.21282","article-title":"Emerging sulfated flavonoids and other polyphenols as drugs: nature as an inspiration","volume":"34","author":"Correia-Da-Silva","year":"2014","journal-title":"Med. Res. Rev."},{"issue":"1\u20132","key":"10.1016\/j.vph.2018.08.008_bb0230","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.mrfmmm.2004.01.015","article-title":"Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription","volume":"551","author":"O'Leary","year":"2004","journal-title":"Mutat. Res."},{"issue":"6","key":"10.1016\/j.vph.2018.08.008_bb0235","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1742-7843.2006.pto_565.x","article-title":"Effects of daidzein sulfates on blood pressure and artery of rats","volume":"99","author":"Cao","year":"2006","journal-title":"Basic Clin. Pharmacol. Toxicol."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189118301241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189118301241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:17:32Z","timestamp":1761527852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189118301241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":47,"alternative-id":["S1537189118301241"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2018.08.008","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two flavonoid metabolites, 3,4-dihydroxyphenylacetic acid and 4-methylcatechol, relax arteries ex vivo and decrease blood pressure in vivo","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2018.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}