{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:25:36Z","timestamp":1790144736709,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870227"],"award-info":[{"award-number":["81870227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870288"],"award-info":[{"award-number":["81870288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.vph.2018.10.009","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T04:07:39Z","timestamp":1540872459000},"page":"27-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Protection of dilator function of coronary arteries from homocysteine by tetramethylpyrazine: Role of ER stress in modulation of BKCa channels"],"prefix":"10.1016","volume":"113","author":[{"given":"Wen-Tao","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Chong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Novakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2018.10.009_bb0005","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/01.RES.0000100068.43006.36","article-title":"Downregulation of the BK channel beta1 subunit in genetic hypertension","volume":"93","author":"Amberg","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.vph.2018.10.009_bb0010","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.CIR.0000047278.28407.C2","article-title":"Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels","volume":"107","author":"Archer","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2018.10.009_bb0015","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejphar.2006.06.073","article-title":"Modulation by homocysteine of the iberiotoxin-sensitive, Ca2+ \u2212activated K+ channels of porcine coronary artery smooth muscle cells","volume":"546","author":"Au","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vph.2018.10.009_bb0020","doi-asserted-by":"crossref","first-page":"956924","DOI":"10.1155\/2014\/956924","article-title":"Suxiao jiuxin pill induces potent relaxation and inhibition on contraction in human artery and the mechanism","volume":"2014","author":"Bai","year":"2014","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.vph.2018.10.009_bb0025","doi-asserted-by":"crossref","first-page":"C278","DOI":"10.1152\/ajpcell.00391.2013","article-title":"SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner","volume":"307","author":"Bollinger","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.vph.2018.10.009_bb0030","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/368850a0","article-title":"Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle","volume":"368","author":"Bolotina","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.vph.2018.10.009_bb0035","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0008-6363(03)00527-3","article-title":"Role of Ca(2+)-sensitive K(+) channels in the remission phase of pulmonary hypertension in chronic obstructive pulmonary diseases","volume":"60","author":"Bonnet","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vph.2018.10.009_bb0040","doi-asserted-by":"crossref","first-page":"H1629","DOI":"10.1152\/ajpheart.00466.2009","article-title":"Impaired function of coronary BK(Ca) channels in metabolic syndrome","volume":"297","author":"Borbouse","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.vph.2018.10.009_bb0045","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/j.lfs.2007.03.003","article-title":"Large-conductance Ca2+\u2212activated K+ currents blocked and impaired by homocysteine in human and rat mesenteric artery smooth muscle cells","volume":"80","author":"Cai","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.vph.2018.10.009_bb0050","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.cardiores.2004.11.018","article-title":"Urocortin-induced relaxation in the human internal mammary artery","volume":"65","author":"Chen","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vph.2018.10.009_bb0055","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1085\/jgp.116.3.411","article-title":"Role of the beta1 subunit in large-conductance Ca(2+)-activated K(+) channel gating energetics. Mechanisms of enhanced Ca(2+) sensitivity","volume":"116","author":"Cox","year":"2000","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.vph.2018.10.009_bb0060","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.lfs.2011.02.025","article-title":"Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes","volume":"88","author":"Gao","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.vph.2018.10.009_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2430329","article-title":"Cardiovascular actions and therapeutic potential of tetramethylpyrazine (active component isolated from Rhizoma Chuanxiong): roles and mechanisms","volume":"2016","author":"Guo","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.vph.2018.10.009_bb0070","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.healun.2009.06.011","article-title":"Role of large-conductance calcium-activated potassium channels of coronary arteries in heart preservation","volume":"28","author":"Han","year":"2009","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.vph.2018.10.009_bb0075","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1248\/bpb.33.1360","article-title":"Endothelium-independent vasorelaxation by Ligusticum wallichii in isolated rat aorta: comparison of a butanolic fraction and tetramethylpyrazine, the main active component of Ligusticum wallichii","volume":"33","author":"Kim","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.vph.2018.10.009_bb0080","first-page":"69","article-title":"Calcium-activated potassium channels and the regulation of vascular tone","volume":"21","author":"Ledoux","year":"2006","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.vph.2018.10.009_bb0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1742-7843.2009.00470.x","article-title":"The effect of tetramethylpyrazine on hydrogen peroxide-induced oxidative damage in human umbilical vein endothelial cells","volume":"106","author":"Li","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.vph.2018.10.009_bb0090","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1529\/biophysj.108.138339","article-title":"Impaired Ca2+\u2212dependent activation of large-conductance Ca2+\u2212activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats","volume":"95","author":"Lu","year":"2008","journal-title":"Biophys. J."},{"key":"10.1016\/j.vph.2018.10.009_bb0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.taap.2017.10.016","article-title":"Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism","volume":"336","author":"Mak","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.vph.2018.10.009_bb0100","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/sj.bjp.0701940","article-title":"Nitric oxide (NO)-induced activation of large conductance Ca2+\u2212dependent K+ channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery","volume":"124","author":"Mistry","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2018.10.009_bb0105","doi-asserted-by":"crossref","first-page":"627181","DOI":"10.1155\/2014\/627181","article-title":"Tetramethylpyrazine protects against hydrogen peroxide-provoked endothelial dysfunction in isolated Rat Aortic Rings: implications for antioxidant therapy of vascular diseases","volume":"2014","author":"Ni","year":"2014","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.vph.2018.10.009_bb0110","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCRESAHA.114.302168","article-title":"AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+\u2212activated K+ channel remodeling in hyperglycemia and diabetes mellitus","volume":"114","author":"Nystoriak","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.vph.2018.10.009_bb0115","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1055\/s-2006-957933","article-title":"Tetramethylpyrazine, a calcium antagonist","volume":"62","author":"Pang","year":"1996","journal-title":"Planta Med."},{"key":"10.1016\/j.vph.2018.10.009_bb0120","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1476-5381.1996.tb15778.x","article-title":"Ligustrazine-induced endothelium-dependent relaxation in pulmonary arteries via an NO-mediated and exogenous L-arginine-dependent mechanism","volume":"119","author":"Peng","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2018.10.009_bb0125","doi-asserted-by":"crossref","first-page":"16260","DOI":"10.1073\/pnas.0607795103","article-title":"PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription","volume":"103","author":"Sandri","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2018.10.009_bb0130","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.thromres.2014.05.025","article-title":"Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study","volume":"134","author":"Schaffer","year":"2014","journal-title":"Thromb. Res."},{"key":"10.1016\/j.vph.2018.10.009_bb0135","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.brainres.2010.09.011","article-title":"Effects of tetramethylpyrazine on nitric oxide\/cGMP signaling after cerebral vasospasm in rabbits","volume":"1361","author":"Shao","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.vph.2018.10.009_bb0140","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2014.12.109","article-title":"7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels","volume":"457","author":"Son","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vph.2018.10.009_bb0145","doi-asserted-by":"crossref","first-page":"51462","DOI":"10.18632\/oncotarget.17721","article-title":"Activation of PERK branch of ER stress mediates homocysteine-induced BKCa channel dysfunction in coronary artery via FoxO3a-dependent regulation of atrogin-1","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.vph.2018.10.009_bb0150","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0024-3205(02)01852-0","article-title":"Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro","volume":"71","author":"Tsai","year":"2002","journal-title":"Life Sci."},{"key":"10.1016\/j.vph.2018.10.009_bb0155","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10557-013-6440-6","article-title":"Tetramethylpyrazine attenuates atherosclerosis development and protects endothelial cells from ox-LDL","volume":"27","author":"Wang","year":"2013","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.vph.2018.10.009_bb0160","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.atherosclerosis.2015.07.021","article-title":"ER stress mediates homocysteine-induced endothelial dysfunction: Modulation of IKCa and SKCa channels","volume":"242","author":"Wang","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.vph.2018.10.009_bb0165","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/sj.bjp.0706256","article-title":"Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids","volume":"145","author":"Weston","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2018.10.009_bb0170","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/CIRCRESAHA.109.208801","article-title":"Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease","volume":"106","author":"Willis","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.vph.2018.10.009_bb0175","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1046\/j.1440-1681.2003.03913.x","article-title":"Effect of tetramethylpyrazine on potassium channels to lower calcium concentration in cultured aortic smooth muscle cells","volume":"30","author":"Wong","year":"2003","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.vph.2018.10.009_bb0180","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejphar.2011.10.046","article-title":"Protective effects of ligustrazine on TNF-alpha-induced endothelial dysfunction","volume":"674","author":"Wu","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vph.2018.10.009_bb0185","article-title":"Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2018.10.009_bb0190","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10557-013-6478-5","article-title":"Mechanistic studies of AVE3085 against homocysteine in endothelial protection","volume":"27","author":"Yang","year":"2013","journal-title":"Cardiovasc. Drugs Ther."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153718911830274X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153718911830274X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:18:10Z","timestamp":1761527890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153718911830274X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":38,"alternative-id":["S153718911830274X"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2018.10.009","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection of dilator function of coronary arteries from homocysteine by tetramethylpyrazine: Role of ER stress in modulation of BKCa channels","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2018.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}