{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:12:54Z","timestamp":1773303174798,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004381","name":"Western University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.vph.2018.11.004","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T11:46:48Z","timestamp":1542455208000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction"],"prefix":"10.1016","volume":"113","author":[{"given":"Sevtap","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur Banu","family":"Bal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6khan","family":"Sadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan Emel","family":"Usanmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve Matilda","family":"Tuglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mecit Orhan","family":"Uludag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Demirel-Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.vph.2018.11.004_bb0005","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/nm.2541","article-title":"Under pressure: the search for the essential mechanisms of hypertension","volume":"17","author":"Coffman","year":"2011","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.vph.2018.11.004_bb0010","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1248\/bpb.26.1701","article-title":"Effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt hypertensive rats","volume":"26","author":"Nakano","year":"2003","journal-title":"Biol. Pharm. Bull."},{"issue":"1\u20132","key":"10.1016\/j.vph.2018.11.004_bb0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/B:MCBI.0000021360.89867.64","article-title":"Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats","volume":"259","author":"Galisteo","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.vph.2018.11.004_bb0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/CS20060185","article-title":"Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity","volume":"112","author":"Vera","year":"2007","journal-title":"Clin. Sci."},{"issue":"6","key":"10.1016\/j.vph.2018.11.004_bb0025","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s10517-007-0212-x","article-title":"Effect of antioxidants pQ510 and resveratrol on regulatory function of the endothelium in rats with modeled arterial hypertension","volume":"143","author":"Gumanova","year":"2007","journal-title":"Bull. Exp. Biol. Med."},{"issue":"6","key":"10.1016\/j.vph.2018.11.004_bb0030","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00424-010-0808-2","article-title":"Nitric oxide and oxidative stress in vascular disease","volume":"459","author":"F\u00f6rstermann","year":"2010","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.vph.2018.11.004_bb0035","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"5","key":"10.1016\/j.vph.2018.11.004_bb0040","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10495-013-0818-6","article-title":"New directions in ER stress-induced cell death","volume":"18","author":"Logue","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.vph.2018.11.004_bb0045","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1172\/JCI64583","article-title":"ER stress in the brain subfornical organ mediates angiotensin dependent hypertension","volume":"122","author":"Young","year":"2012","journal-title":"J. Clin. Investig."},{"issue":"7","key":"10.1016\/j.vph.2018.11.004_bb0050","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/ATVBAHA.112.249318","article-title":"Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice","volume":"32","author":"Kassan","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.vph.2018.11.004_bb0055","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/ATVBAHA.112.300606","article-title":"Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-\u03b12 in vivo","volume":"33","author":"Liang","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.vph.2018.11.004_bb0060","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11033-014-3737-x","article-title":"Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension","volume":"42","author":"Han","year":"2015","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"10.1016\/j.vph.2018.11.004_bb0065","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0952-3278(91)90156-Y","article-title":"Inhibition of iloprost of the contractile effect of noradrenaline in mesenteric artery rings: evidence for a possible calcium-dependent mechanism","author":"Demirel","year":"1991","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"3","key":"10.1016\/j.vph.2018.11.004_bb0070","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/clinchem\/44.3.679","article-title":"Semiautomated measurement of nitrate in biological fluids","volume":"44","author":"Navarro-Gonzalvez","year":"1998","journal-title":"Clin. Chem."},{"issue":"Suppl. 2","key":"10.1016\/j.vph.2018.11.004_bb0075","first-page":"67","article-title":"A microplate based spectrophotometric method for the determination of the total antioxidant capacity of human plasma: modified cupric reducing ability assay","volume":"22","author":"Usanmaz","year":"2008","journal-title":"Fundamental & Clin. Pharmacol."},{"issue":"10","key":"10.1016\/j.vph.2018.11.004_bb0080","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1101\/gad.13.10.1211","article-title":"Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls","volume":"13","author":"Kaufman","year":"1999","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.vph.2018.11.004_bb0085","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1152\/ajpheart.00952.2012","article-title":"Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat","volume":"305","author":"Spitler","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.vph.2018.11.004_bb0090","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/HYPERTENSIONAHA.113.02558","article-title":"Endoplasmic reticulum stress contributes to aortic stiffening via proapoptotic and fibrotic signaling mechanisms","volume":"63","author":"Spitler","year":"2014","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.vph.2018.11.004_bb0095","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/iub.1292","article-title":"Endoplasmic reticulum stress and endothelial dysfunction","volume":"66","author":"Lenna","year":"2014","journal-title":"IUBMB Life"},{"issue":"6","key":"10.1016\/j.vph.2018.11.004_bb0100","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1161\/HYPERTENSIONAHA.115.05344","article-title":"Role of epidermal growth factor receptor and endoplasmic reticulum stress in vascular remodeling induced by angiotensin II","volume":"65","author":"Takayanagi","year":"2015","journal-title":"Hypertension"},{"issue":"5695","key":"10.1016\/j.vph.2018.11.004_bb0105","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"Ozcan","year":"2004","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.vph.2018.11.004_bb0110","article-title":"Differential responses of hepatic endoplasmic reticulum stress and inflammation in diet-induced obese rats with high-fat diet rich in lard oil or soybean oil","volume":"6","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2018.11.004_bb0115","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/687938","article-title":"Glycolipid metabolism disorder in the liver of obese mice is improved by TUDCA via the restoration of defective hepatic autophagy","volume":"2015","author":"Guo","year":"2015","journal-title":"Int. J. Endocrinol."},{"issue":"1","key":"10.1016\/j.vph.2018.11.004_bb0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tcb.2003.11.001","article-title":"A trip to the ER: coping with stress","volume":"14","author":"Rutkowski","year":"2004","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.vph.2018.11.004_bb0125","doi-asserted-by":"crossref","unstructured":"Cui, W., Li, J., Ron, D. ve Sha, B. (2011). The structure of the PERK kinase domain suggests the mechanism for its activation. Acta Crystallographica Section D Biological Crystallography, 67, 423\u2013428.","DOI":"10.1107\/S0907444911006445"},{"issue":"6","key":"10.1016\/j.vph.2018.11.004_bb0130","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.bbamcr.2014.02.009","article-title":"Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction","volume":"1843","author":"Gal\u00e1n","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.vph.2018.11.004_bb0135","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ceb.2010.09.007","article-title":"The critical role of GRP78 in physiologic and pathologic stress","volume":"23","author":"Pfaffenbach","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"issue":"8","key":"10.1016\/j.vph.2018.11.004_bb0140","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11906-017-0762-x","article-title":"Endoplasmic reticulum stress, a driver or an innocent bystander in endothelial dysfunction associated with hypertension?","volume":"19","author":"Cunard","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"issue":"6","key":"10.1016\/j.vph.2018.11.004_bb0145","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00424-010-0786-4","article-title":"Endothelial dysfunction: a strategic target in the treatment of hypertension?","volume":"459","author":"Tang","year":"2010","journal-title":"Pflugers Arch."},{"issue":"5","key":"10.1016\/j.vph.2018.11.004_bb0150","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/CIRCRESAHA.109.203711","article-title":"Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis","volume":"105","author":"Civelek","year":"2009","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.vph.2018.11.004_bb0155","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1248\/bpb.b16-00254","article-title":"Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric arteries of Rats","volume":"39","author":"Matsumoto","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.vph.2018.11.004_bb0160","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bcp.2016.07.013","article-title":"Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK\/PPAR\u03b4 signaling pathway","volume":"116","author":"Choy","year":"2016","journal-title":"Biochem. Pharmacol."},{"issue":"8","key":"10.1016\/j.vph.2018.11.004_bb0165","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1097\/HJH.0000000000000943","article-title":"Endoplasmic reticulum stress inhibition reduces hypertension through the preservation of resistance blood vessel structure and function","volume":"34","author":"Carlisle","year":"2016","journal-title":"J. Hypertens."},{"issue":"5","key":"10.1016\/j.vph.2018.11.004_bb0170","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.phrs.2007.01.007","article-title":"Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid","volume":"55","author":"Ajay","year":"2007","journal-title":"Pharmacol. Res."},{"issue":"17\u201318","key":"10.1016\/j.vph.2018.11.004_bb0175","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.lfs.2011.07.022","article-title":"NO donors-relaxation is impaired in aorta from hypertensive rats due to a reduced involvement of K(+) channels and sarcoplasmic reticulum Ca(2+)-ATPase","volume":"89","author":"Bonaventura","year":"2011","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.vph.2018.11.004_bb0180","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/1440-1681.12595","article-title":"Orchidectomy attenuates high-salt diet-induced increases in blood pressure, renovascular resistance, and hind limb vascular dysfunction: role of testosterone","volume":"43","author":"Oloyo","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.vph.2018.11.004_bb0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5301\/JN.2010.4729","article-title":"Inflammation in the pathophysiology of essential hypertension","volume":"24","author":"Montecucco","year":"2011","journal-title":"J. Nephrol."},{"issue":"4","key":"10.1016\/j.vph.2018.11.004_bb0190","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1440-1681.2008.04886.x","article-title":"Mechanical and circulating biomarkers in isolated clinic hypertension","volume":"35","author":"Martin","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.vph.2018.11.004_bb0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1023\/A:1007041532523","article-title":"Antioxidant status, lipid peroxidation, mixed function oxidase and UDP-glucuronyl transferase activities in livers from control and DOCA-salt hypertensive male Sprague Dawley rats","volume":"203","author":"Nicod","year":"2000","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.vph.2018.11.004_bb0200","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1023\/A:1007268825721","article-title":"Strain difference (WKY, SPRD) in the hepatic antioxidant status in rat and effect of hypertension (SHR, DOCA). Ex vivo and in vitro data","volume":"218","author":"Binda","year":"2001","journal-title":"Mol. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.vph.2018.11.004_bb0205","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00210-016-1239-1","article-title":"Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats","volume":"389","author":"Shirakura","year":"2016","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"1","key":"10.1016\/j.vph.2018.11.004_bb0210","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1515\/CCLM.2004.016","article-title":"In vivo total antioxidant capacity: comparison of two different analytical methods","volume":"42","author":"Vassalle","year":"2004","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.vph.2018.11.004_bb0215","doi-asserted-by":"crossref","first-page":"216964","DOI":"10.1155\/2014\/216964","article-title":"Cardiovascular risk factors and total serum antioxidant capacity in healthy men and in men with coronary heart disease","volume":"2014","author":"Gawron-Skarbek","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"3","key":"10.1016\/j.vph.2018.11.004_bb0220","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1161\/HYPERTENSIONAHA.113.02444","article-title":"Symphony of vascular contraction: how smooth muscle cells lose harmony to signal increased vascular resistance in hypertension","volume":"63","author":"Goulopoulou","year":"2014","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.vph.2018.11.004_bb0225","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.coph.2009.11.008","article-title":"Targeting the redox regulation of SERCA in vascular physiology and disease","volume":"10","author":"Tong","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"issue":"11","key":"10.1016\/j.vph.2018.11.004_bb0230","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1016\/S0021-9258(18)53099-4","article-title":"Sarcoplasmic reticulum calcium transport and Ca(2+)-ATPase gene expression in thoracic and abdominal aortas of normotensive and spontaneously hypertensive rats","volume":"268","author":"Levitsky","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.vph.2018.11.004_bb0235","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/01.HYP.37.1.135","article-title":"Expression of Ca(2+) Transport Genes in Platelets and Endothelial Cells in Hypertension","volume":"37","author":"Mountian","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.vph.2018.11.004_bb0240","doi-asserted-by":"crossref","first-page":"17067","DOI":"10.1016\/S0021-9258(19)47340-7","article-title":"Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps","volume":"266","author":"Lytton","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.vph.2018.11.004_bb0245","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004317","article-title":"Endoplasmic-reticulum calcium depletion and disease","volume":"1","author":"Mekahli","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"7","key":"10.1016\/j.vph.2018.11.004_bb0250","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.bbamcr.2013.01.026","article-title":"Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress","volume":"1833","author":"Kiviluoto","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"10","key":"10.1016\/j.vph.2018.11.004_bb0255","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/j.bbamcr.2014.03.007","article-title":"Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival","volume":"1843","author":"Ivanova","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"3 Pt 2","key":"10.1016\/j.vph.2018.11.004_bb0260","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/hy09t1.096249","article-title":"Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis","volume":"38","author":"Intengan","year":"2001","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.vph.2018.11.004_bb0265","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/sj.mn.7800141","article-title":"The inflammatory aspect of the microcirculation in hypertension: oxidative stress, leukocytes\/endothelial interaction, apoptosis","volume":"9","author":"Suematsu","year":"2002","journal-title":"Microcirculation"},{"issue":"7","key":"10.1016\/j.vph.2018.11.004_bb0270","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1152\/ajpcell.00258.2014","article-title":"Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview","volume":"307","author":"Dufey","year":"2014","journal-title":"American Journal of Physiology: Cell Physiology"},{"issue":"1","key":"10.1016\/j.vph.2018.11.004_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010308","article-title":"Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members","volume":"19","author":"Cui","year":"2018","journal-title":"Int J Mol Sci."},{"issue":"1","key":"10.1016\/j.vph.2018.11.004_bb0280","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1161\/CIRCULATIONAHA.112.133413","article-title":"Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension","volume":"127","author":"Dromparis","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2018.11.004_bb0285","doi-asserted-by":"crossref","unstructured":"Laurent S, Boutouyrie P. (2015) The structural factor of hypertension: large and small artery alterations. Circ. Res. Mar 13;116(6):1007\u201321. doi: https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.303596.","DOI":"10.1161\/CIRCRESAHA.116.303596"},{"key":"10.1016\/j.vph.2018.11.004_bb0290","first-page":"105","article-title":"Small artery remodeling and significance in the development of hypertension","volume":"17","author":"Mulvany","year":"2002","journal-title":"News Physiol Sci. Jun"},{"issue":"6","key":"10.1016\/j.vph.2018.11.004_bb0295","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF02253359","article-title":"Novel signaling pathways contributing to vascular changes in hypertension","volume":"7","author":"Johns","year":"2000","journal-title":"J Biomed Sci. Nov-Dec"},{"key":"10.1016\/j.vph.2018.11.004_bb0300","first-page":"797","article-title":"Epidermal growth factor stimulation of DNA synthesis and its inhibition by tyrosine kinase inhibition in aortic smooth muscle cells from SHR","volume":"13","author":"Sambhi","year":"1991","journal-title":"Clin. Exp. Hypertens."},{"issue":"1","key":"10.1016\/j.vph.2018.11.004_bb0305","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1139\/y06-097","article-title":"Therapeutic potential of the epidermal growth factor receptor transactivation in hypertension: a convergent signaling pathway of vascular tone, oxidative stress, and hypertrophic growth downstream of vasoactive G-protein-coupled receptors?","volume":"85","author":"Fernandez-Patron","year":"2007","journal-title":"Can J Physiol Pharmacol."},{"key":"10.1016\/j.vph.2018.11.004_bb0310","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1749-6632.2001.tb03929.x","article-title":"EGFR transactivation in the regulation of SMC function","volume":"947","author":"Kalmes","year":"2001","journal-title":"Ann N YAcad Sci."},{"issue":"9","key":"10.1016\/j.vph.2018.11.004_bb0315","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1440-1681.1996.tb01181.x","article-title":"Elevated epidermal growth factor receptor levels in hypertensive Lyon rat kidney and aorta","volume":"23","author":"Swaminathan","year":"1996","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.vph.2018.11.004_bb0320","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/HYPERTENSIONAHA.112.192500","article-title":"A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus","volume":"60","author":"Gal\u00e1n","year":"2012","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.vph.2018.11.004_bb0325","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1172\/JCI25900","article-title":"Akt1 in the cardiovascular system: friend or foe?","volume":"115","author":"O'Neill","year":"2005","journal-title":"J Clin Invest."},{"key":"10.1016\/j.vph.2018.11.004_bb0330","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1161\/01.CIR.0000129768.35536.FA","article-title":"AKT participates in endothelial dysfunction in hypertension","volume":"109","author":"Iaccarino","year":"2004","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.vph.2018.11.004_bb0335","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0008-6363(99)00386-7","article-title":"Signalling via stress-activated mitogen-activated protein kinases in the cardiovascular system","volume":"45","author":"Bogoyevitch","year":"2000","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.vph.2018.11.004_bb0340","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.bcp.2006.04.011","article-title":"NF-kappaB activation by reactive oxygen species: fifteen years later","volume":"72","author":"Gloire","year":"2006","journal-title":"Biochem. Pharmacol."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189118301964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189118301964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:17:38Z","timestamp":1761527858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189118301964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":68,"alternative-id":["S1537189118301964"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2018.11.004","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2018.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}