{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:11:20Z","timestamp":1782123080963,"version":"3.54.5"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1-EY026029"],"award-info":[{"award-number":["RO1-EY026029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001286","name":"Pan-Massachusetts Challenge","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017291","name":"Health and Social Care Services in Northern Ireland","doi-asserted-by":"publisher","award":["STL\/4748\/13"],"award-info":[{"award-number":["STL\/4748\/13"]}],"id":[{"id":"10.13039\/100017291","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_PC_15026"],"award-info":[{"award-number":["MC_PC_15026"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["14\/US\/B3116"],"award-info":[{"award-number":["14\/US\/B3116"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.vph.2021.106919","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T09:21:06Z","timestamp":1632734466000},"page":"106919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["COMP-Ang1: Therapeutic potential of an engineered Angiopoietin-1 variant"],"prefix":"10.1016","volume":"141","author":[{"given":"Robert G.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Rochfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Barabas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balamurali K.","family":"Ambati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Cummins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2021.106919_bb0005","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","article-title":"Blood-brain barrier dysfunction and recovery after ischemic stroke","volume":"163\u2013164","author":"Jiang","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.vph.2021.106919_bb0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.devcel.2007.10.019","article-title":"Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia","volume":"14","author":"Gavard","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.vph.2021.106919_bb0015","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1073\/pnas.0307574101","article-title":"COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity","volume":"101","author":"Cho","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2021.106919_bb0020","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1016\/j.ajpath.2011.02.008","article-title":"Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation","volume":"178","author":"Fuxe","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.vph.2021.106919_bb0025","doi-asserted-by":"crossref","first-page":"15732","DOI":"10.1074\/jbc.274.22.15732","article-title":"Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells","volume":"274","author":"Oh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2021.106919_bb0030","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1007\/s10439-015-1342-3","article-title":"Cartilage oligomeric matrix protein angiopoeitin-1 provides benefits during nerve regeneration in vivo and in vitro","volume":"43","author":"Qiu","year":"2015","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.vph.2021.106919_bb0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.bjp.0705259","article-title":"Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production","volume":"139","author":"Pizurki","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2021.106919_bb0040","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1159\/000486155","article-title":"Dachengqi decoction attenuates intestinal vascular endothelial injury in severe acute pancreatitis in vitro and in vivo","volume":"44","author":"Pan","year":"2017","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.vph.2021.106919_bb0045","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1073\/pnas.0307575101","article-title":"Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis","volume":"101","author":"Cho","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2021.106919_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140502","article-title":"The Angiopoietin-1 variant COMP-Ang1 enhances BMP2-induced bone regeneration with recruiting Pericytes in critical sized Calvarial defects","volume":"10","author":"Choi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2021.106919_bb0055","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1002\/jbm.a.36390","article-title":"Silk fibroin enhances peripheral nerve regeneration by improving vascularization within nerve conduits","volume":"106","author":"Wang","year":"2018","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.vph.2021.106919_bb0060","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1167\/iovs.19-27644","article-title":"COMP-Ang1 stabilizes hyperglycemic disruption of blood-retinal barrier phenotype in human retinal microvascular endothelial cells","volume":"60","author":"Rochfort","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.vph.2021.106919_bb0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2639","article-title":"Control of vascular morphogenesis and homeostasis through the angiopoietin-tie system","volume":"10","author":"Augustin","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.vph.2021.106919_bb0070","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.isci.2019.10.006","article-title":"Angiopoietin-tie signaling pathway in endothelial cells: a computational model","volume":"20","author":"Zhang","year":"2019","journal-title":"IScience"},{"key":"10.1016\/j.vph.2021.106919_bb0075","article-title":"The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFalpha and regulates angiopoietin signalling","volume":"7","author":"Singh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2021.106919_bb0080","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1126\/science.286.5449.2511","article-title":"Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1","volume":"286","author":"Thurston","year":"1999","journal-title":"Science."},{"key":"10.1016\/j.vph.2021.106919_bb0085","doi-asserted-by":"crossref","first-page":"16106","DOI":"10.1038\/ncomms16106","article-title":"Pericyte-expressed Tie2 controls angiogenesis and vessel maturation","volume":"8","author":"Teichert","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vph.2021.106919_bb0090","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ncb1714","article-title":"Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1","volume":"10","author":"Fukuhara","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.vph.2021.106919_bb0095","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1038\/sj.onc.1202992","article-title":"Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2","volume":"18","author":"Fachinger","year":"1999","journal-title":"Oncogene."},{"key":"10.1016\/j.vph.2021.106919_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051245","article-title":"Ve-ptp modulates vascular integrity by promoting adherens junction maturation","volume":"7","author":"Carra","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2021.106919_bb0105","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.277.5322.55","article-title":"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis","volume":"277","author":"Maisonpierre","year":"1997","journal-title":"Science."},{"key":"10.1016\/j.vph.2021.106919_bb0110","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI58832","article-title":"Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling","volume":"122","author":"Felcht","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vph.2021.106919_bb0115","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00592-009-0099-2","article-title":"Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia","volume":"47","author":"Pfister","year":"2010","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.vph.2021.106919_bb0120","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/cells8050471","article-title":"Role of Angiopoietin-2 in vascular physiology and pathophysiology","volume":"8","author":"Akwii","year":"2019","journal-title":"Cells."},{"key":"10.1016\/j.vph.2021.106919_bb0125","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/01.RES.86.9.974","article-title":"Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: in vivo evidence of the importance of NF-kappaB in endothelial cell regulation","volume":"86","author":"Matsushita","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.vph.2021.106919_bb0130","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1161\/CIRCRESAHA.109.196154","article-title":"Angiopoietin-2 confers Atheroprotection in apoE\u2212\/\u2212 mice by inhibiting LDL oxidation via nitric oxide","volume":"104","author":"Ahmed","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.vph.2021.106919_bb0135","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1083\/jcb.200411105","article-title":"Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2","volume":"169","author":"Saharinen","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.vph.2021.106919_bb0140","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1172\/JCI42040","article-title":"Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner","volume":"121","author":"Woo","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vph.2021.106919_bb0145","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1172\/JCI84923","article-title":"Tie1 controls angiopoietin function in vascular remodeling and inflammation","volume":"126","author":"Korhonen","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vph.2021.106919_bb0150","first-page":"3377","article-title":"The angiopoietin-TIE2 pathway is a potential therapeutic target in urothelial carcinoma","volume":"34","author":"Jian","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.vph.2021.106919_bb0155","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10930-008-9140-5","article-title":"High-level expression and purification of a designed angiopoietin-1 chimeric protein, COMP-Ang1, produced in Chinese hamster ovary cells","volume":"27","author":"Hwang","year":"2008","journal-title":"Protein J."},{"key":"10.1016\/j.vph.2021.106919_bb0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1478-811X-8-30","article-title":"Tyrosine phosphorylation of Grb14 by Tie2","volume":"8","author":"Sturk","year":"2010","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.vph.2021.106919_bb0165","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1269\/jrr.07064","article-title":"COMP-Ang1, angiopoietin-1 variant protects radiation-induced bone marrow damage in C57BL\/6 mice","volume":"49","author":"Lee","year":"2008","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.vph.2021.106919_bb0170","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1073\/pnas.0506352103","article-title":"COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model","volume":"103","author":"Cho","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2021.106919_bb0175","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/01.ATV.0000256458.82320.be","article-title":"In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin","volume":"27","author":"Kim","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2021.106919_bb0180","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.2353\/ajpath.2007.070142","article-title":"Cartilage oligometric matrix protein-angiopoietin-1 promotes revascularization through increased survivin expression in dermal endothelial cells of skin grafts in mice","volume":"171","author":"Byun","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.vph.2021.106919_bb0185","doi-asserted-by":"crossref","first-page":"55","DOI":"10.5607\/en.2015.24.1.55","article-title":"COMP-Ang1 potentiates EPC treatment of ischemic brain injury by enhancing angiogenesis through activating AKT-mTOR pathway and promoting vascular migration through activating Tie2-FAK pathway","volume":"24","author":"Moon","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.vph.2021.106919_bb0190","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1016\/j.transproceed.2010.04.048","article-title":"Cartilage oligomeric matrix protein-angiopoientin-1 enhances angiogenesis of isolated islet and maintains normoglycemia following transplantation","volume":"42","author":"Park","year":"2010","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.vph.2021.106919_bb0195","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3346\/jkms.2013.28.5.725","article-title":"COMP-angiopoietin-1 promotes cavernous angiogenesis in a type 2 diabetic rat model","volume":"28","author":"Kim","year":"2013","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.vph.2021.106919_bb0200","doi-asserted-by":"crossref","first-page":"15291","DOI":"10.1038\/srep15291","article-title":"A designed Angiopoietin-1 variant, Dimeric CMP-Ang1 activates Tie2 and stimulates angiogenesis and vascular stabilization in N-glycan dependent manner","volume":"5","author":"Oh","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vph.2021.106919_bb0205","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bbrc.2009.02.096","article-title":"COMP-Ang1 ameliorates leukocyte adhesion and reinforces endothelial tight junctions during endotoxemia","volume":"381","author":"Hwang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vph.2021.106919_bb0210","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.2337\/db14-1030","article-title":"Intravitreal AAV2.COMP-Ang1 prevents neurovascular degeneration in a murine model of diabetic retinopathy","volume":"64","author":"Cahoon","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.vph.2021.106919_bb0215","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1167\/iovs.18-26182","article-title":"Intravitreal AAV2.COMP-Ang1 attenuates deep capillary plexus expansion in the aged diabetic mouse retina","volume":"60","author":"Carroll","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.vph.2021.106919_bb0220","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.exer.2016.01.009","article-title":"Subretinal AAV2.COMP-Ang1 suppresses choroidal neovascularization and vascular endothelial growth factor in a murine model of age-related macular degeneration","volume":"145","author":"Lambert","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.vph.2021.106919_bb0225","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/cvr\/cvn048","article-title":"Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor","volume":"78","author":"Lee","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vph.2021.106919_bb0230","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1161\/CIRCULATIONAHA.109.856815","article-title":"Priming with angiopoietin-1 augments the vasculogenic potential of the peripheral blood stem cells mobilized with granulocyte colony-stimulating factor through a novel Tie2\/Ets-1 pathway","volume":"120","author":"Kim","year":"2009","journal-title":"Circulation."},{"key":"10.1016\/j.vph.2021.106919_bb0235","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1111\/ajt.13296","article-title":"Donor heart treatment with COMP-Ang1 limits ischemia-reperfusion injury and rejection of cardiac allografts","volume":"15","author":"Syrj\u00e4l\u00e4","year":"2015","journal-title":"Am. J. Transplant. Off. J. Am. Soc. Transplant. Am. Soc. Transpl. Surg."},{"key":"10.1016\/j.vph.2021.106919_bb0240","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1038\/onc.2017.105","article-title":"Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1","volume":"36","author":"Hsu","year":"2017","journal-title":"Oncogene."},{"key":"10.1016\/j.vph.2021.106919_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2017.08.001","article-title":"Increased vascular permeability in the bone marrow microenvironment contributes to disease progression and drug response in acute myeloid leukemia","volume":"32","author":"Passaro","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.vph.2021.106919_bb0250","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/hep.29920","article-title":"Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins","volume":"68","author":"Fang","year":"2018","journal-title":"Hepatology."},{"key":"10.1016\/j.vph.2021.106919_bb0255","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1158\/1541-7786.MCR-09-0041","article-title":"COMP-Ang1 potentiates the antitumor activity of 5-fluorouracil by improving tissue perfusion in murine Lewis lung carcinoma","volume":"7","author":"Hwang","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.vph.2021.106919_bb0260","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.bone.2009.09.019","article-title":"COMP-Ang1, a chimeric form of Angiopoietin 1, enhances BMP2-induced osteoblast differentiation and bone formation","volume":"46","author":"Jeong","year":"2010","journal-title":"Bone."},{"key":"10.1016\/j.vph.2021.106919_bb0265","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bone.2016.09.002","article-title":"COMP-Ang1 prevents periodontitic damages and enhances mandible bone growth in an experimental animal model","volume":"92","author":"Bhattarai","year":"2016","journal-title":"Bone."},{"key":"10.1016\/j.vph.2021.106919_bb0270","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1002\/jcb.24596","article-title":"COMP-Ang1 accelerates chondrocyte maturation by decreasing HO-1 expression","volume":"114","author":"Kim","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.vph.2021.106919_bb0275","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3858\/emm.2008.40.3.320","article-title":"Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury","volume":"40","author":"Kim","year":"2008","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.vph.2021.106919_bb0280","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/emm.2007.80","article-title":"Blockade of airway inflammation and hyper-responsiveness by an angiopoietin-1 variant, COMP-Ang1","volume":"39","author":"Lee","year":"2007","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.vph.2021.106919_bb0285","doi-asserted-by":"crossref","first-page":"12323","DOI":"10.1038\/s41598-018-30513-7","article-title":"COMP-Angiopoietin-1 accelerates muscle regeneration through N-cadherin activation","volume":"8","author":"Youn","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vph.2021.106919_bb0290","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5049\/EBP.2008.6.1.22","article-title":"The role of angiopoietin-1 in kidney disease","author":"Kim","year":"2008","journal-title":"Electrolyte Blood Press."},{"key":"10.1016\/j.vph.2021.106919_bb0295","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1681\/ASN.V132544","article-title":"Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor","volume":"13","author":"Satchell","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.vph.2021.106919_bb0300","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/ndt\/gfl598","article-title":"Renoprotective effect of COMP-angiopoietin-1 in db\/db mice with type 2 diabetes","volume":"22","author":"Lee","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.vph.2021.106919_bb0305","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1093\/ndt\/gfn168","article-title":"Protective effect of COMP-angiopoietin-1 on cyclosporine-induced renal injury in mice","volume":"23","author":"Lee","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.vph.2021.106919_bb0310","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2019-000882","article-title":"Systemic AAV10.COMP-Ang1 rescues renal glomeruli and pancreatic islets in type 2 diabetic mice","volume":"8","author":"Tian","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.vph.2021.106919_bb0315","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s41231-019-0050-7","article-title":"Lost in translation: the valley of death across preclinical and clinical divide \u2013 identification of problems and overcoming obstacles","volume":"4","author":"Seyhan","year":"2019","journal-title":"Transl. Med. Commun."},{"key":"10.1016\/j.vph.2021.106919_bb0320","doi-asserted-by":"crossref","first-page":"9051426","DOI":"10.1155\/2016\/9051426","article-title":"Experimental diabetes mellitus in different animal models","volume":"2016","author":"Al-Awar","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.vph.2021.106919_bb0325","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cbi.2015.11.032","article-title":"Challenges and issues with streptozotocin-induced diabetes - a clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics","volume":"244","author":"Goyal","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.vph.2021.106919_bb0330","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1167\/iovs.04-1340","article-title":"The Ins2Akita mouse as a model of early retinal complications in diabetes","volume":"46","author":"Barber","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.vph.2021.106919_bb0335","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/bjo.2004.049940","article-title":"Angiopoietin concentrations in diabetic retinopathy","volume":"89","author":"Patel","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.vph.2021.106919_bb0340","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.2337\/diabetes.53.4.1104","article-title":"Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy","volume":"53","author":"Hammes","year":"2004","journal-title":"Diabetes."},{"key":"10.1016\/j.vph.2021.106919_bb0345","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.bbrc.2018.03.210","article-title":"Genetic overexpression of COMP-Ang1 impairs BM microenvironment and induces senescence of BM HSCs","volume":"499","author":"Kook","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vph.2021.106919_bb0350","doi-asserted-by":"crossref","first-page":"254","DOI":"10.14348\/molcells.2021.2155","article-title":"Overexpression of COMP-angiopoietin-1 in K14-expressing cells impairs hematopoiesis and disturbs erythrocyte maturation","volume":"44","author":"Sim","year":"2021","journal-title":"Mol. Cells"},{"key":"10.1016\/j.vph.2021.106919_bb0355","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cytogfr.2013.05.009","article-title":"The angiopoietin:tie 2 interaction: a potential target for future therapies in human vascular disease","volume":"24","author":"Moss","year":"2013","journal-title":"Cytokine Growth Factor Rev."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189121000914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189121000914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:22:01Z","timestamp":1761528121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189121000914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":71,"alternative-id":["S1537189121000914"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2021.106919","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"COMP-Ang1: Therapeutic potential of an engineered Angiopoietin-1 variant","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2021.106919","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106919"}}