{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:50:17Z","timestamp":1785333017751,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/13176-3"],"award-info":[{"award-number":["2020\/13176-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/10173-6"],"award-info":[{"award-number":["2019\/10173-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/09174-8"],"award-info":[{"award-number":["2019\/09174-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309399\/2021-1"],"award-info":[{"award-number":["309399\/2021-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["401725\/2016-2"],"award-info":[{"award-number":["401725\/2016-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.vph.2023.107211","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T19:36:12Z","timestamp":1692560172000},"page":"107211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension"],"prefix":"10.1016","volume":"152","author":[{"given":"Viviano Gomes","family":"de Oliveira Neves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela M.","family":"Blascke de Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laena","family":"Pernomian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora Sousa","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana M.","family":"Parente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane Candiani","family":"Arantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita C.","family":"Tostes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele M.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2023.107211_bb0005","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/HYPERTENSIONAHA.122.20601","article-title":"Angiotensin II type 1A receptor expressed in smooth muscle cells is required for hypertensive vascular remodeling in mice infused with angiotensin II","volume":"80","author":"Okuno","year":"2023","journal-title":"Hypertension"},{"key":"10.1016\/j.vph.2023.107211_bb0010","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/HYPERTENSIONAHA.113.01744","article-title":"Arterial stiffening precedes systolic hypertension in diet-induced obesity","volume":"62","author":"Weisbrod","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.vph.2023.107211_bb0015","doi-asserted-by":"crossref","first-page":"H905","DOI":"10.1152\/ajpheart.00126.2023","article-title":"Arterial stiffness preceding metabolic syndrome in 3,862 adolescents: a mediation and temporal causal longitudinal birth cohort study","volume":"324","author":"Agbaje","year":"2023","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.vph.2023.107211_bb0020","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1242\/jcs.023820","article-title":"The extracellular matrix at a glance","volume":"123","author":"Frantz","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.vph.2023.107211_bb0025","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000441621","article-title":"Matrix metalloproteinase 2 as a potential mediator of vascular smooth muscle cell migration and chronic vascular remodeling in hypertension","volume":"52","author":"Belo","year":"2015","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.vph.2023.107211_bb0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrc727","article-title":"Role of integrins in cell invasion and migration","volume":"2","author":"Hood","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.vph.2023.107211_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2022.07.006","article-title":"Integrins in cardiac fibrosis","volume":"172","author":"Li","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.vph.2023.107211_bb0040","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cardiores.2005.08.002","article-title":"Matrix metalloproteinase regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates","volume":"69","author":"Newby","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vph.2023.107211_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2022.104398","article-title":"Matrix metalloproteinases in vascular pathology","volume":"143","author":"Sim\u00f5es","year":"2022","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.vph.2023.107211_bb0050","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vph.2019.03.004","article-title":"Oxidative stress and vascular stiffness in hypertension: a review interest for antioxidant therapies","volume":"116","author":"Massaro","year":"2019","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.vph.2023.107211_bb0055","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.atherosclerosis.2007.10.011","article-title":"Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats","volume":"198","author":"Castro","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.vph.2023.107211_bb0060","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/01.ATV.0000100402.69997.C3","article-title":"Matrix metalloproteinase-2 and -9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization","volume":"24","author":"Johnson","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2023.107211_bb0065","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0002-9440(10)64929-2","article-title":"Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury","volume":"160","author":"Bendeck","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.vph.2023.107211_bb0070","doi-asserted-by":"crossref","first-page":"6736","DOI":"10.1111\/febs.16061","article-title":"Matrix metalloproteinase-2 mediates ribosomal RNA transcription by cleving nucleolar histones","volume":"288","author":"Ali","year":"2021","journal-title":"FEBS J."},{"key":"10.1016\/j.vph.2023.107211_bb0075","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bcp.2016.08.012","article-title":"Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension","volume":"118","author":"Belo","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vph.2023.107211_bb0080","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"The UniProt Consortium","year":"2021","journal-title":"Nucleic Ac. Res."},{"key":"10.1016\/j.vph.2023.107211_bb0085","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/cells9051076","article-title":"Structure and function of human matrix metalloproteinases","volume":"9","author":"Laronha","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.vph.2023.107211_bb0090","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/ajh\/hpaa195","article-title":"Mechanisms of vascular remodeling in hypertension","volume":"34","author":"Humphrey","year":"2021","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.vph.2023.107211_bb0095","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/cvr\/cvs247","article-title":"Hypertension impairs myocardin function: a novel mechanism facilitating arterial remodelling","volume":"96","author":"Pfisterer","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vph.2023.107211_bb0100","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1742-7843.2010.00656.x","article-title":"Doxycycline dose-dependently inhibits MMP-2-mediated vascular changes in 2K1C hypertension","volume":"108","author":"Guimaraes","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.vph.2023.107211_bb0105","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.matbio.2009.11.005","article-title":"Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling","volume":"29","author":"Castro","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.vph.2023.107211_bb0110","doi-asserted-by":"crossref","first-page":"H87","DOI":"10.1152\/ajpheart.01206.2010","article-title":"Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats","volume":"301","author":"Pires","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.vph.2023.107211_bb0115","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.matbio.2012.01.009","article-title":"Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension","volume":"31","author":"Ceron","year":"2012","journal-title":"Matrix Biol."},{"key":"10.1016\/j.vph.2023.107211_bb0120","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1242\/jcs.113.11.2055","article-title":"Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells","volume":"113","author":"Stringa","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.vph.2023.107211_bb0125","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1128\/MCB.21.5.1565-1572.2001","article-title":"Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells","volume":"21","author":"Taylor","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.vph.2023.107211_bb0130","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41580-019-0134-2","article-title":"Integrins as biomechanical sensors of the microenvironment","volume":"20","author":"Kechagia","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.vph.2023.107211_bb0135","first-page":"C947","article-title":"Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts","volume":"303","author":"Hori","year":"2012","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.vph.2023.107211_bb0140","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000365479","article-title":"\u03b2 Integrins mediate FAK Y397 autophosphorylation of resistance arteries during eutrophic inward remodeling in hypertension","volume":"51","author":"Heerkens","year":"2014","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.vph.2023.107211_bb0145","doi-asserted-by":"crossref","first-page":"13310","DOI":"10.1074\/jbc.RA118.004406","article-title":"Targeting the MMP-14\/MMP-2\/integrin v3 axis with multispecific N-TIMP-2-based antagonists for cancer therapy","volume":"293","author":"Yosef","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2023.107211_bb0150","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1161\/CIRCRESAHA.118.314344","article-title":"Nuclear focal adhesion kinase controls vascular smooth muscle cell proliferation and neointimal hyperplasia through GATA4-mediated cyclin D1 transcription","volume":"125","author":"Jeong","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.vph.2023.107211_bb0155","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1242\/jcs.039446","article-title":"Adhesion signaling-crosstalk between integrins, Src and rho","volume":"122","author":"Huveneers","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.vph.2023.107211_bb0160","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1038\/sj.onc.1207688","article-title":"Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are sythetic lethal in mice","volume":"23","author":"Oh","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.vph.2023.107211_bb0165","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrm2125","article-title":"Matrix metalloproteinases and the regulation of tissue remodelling","volume":"8","author":"Page-McCaw","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.vph.2023.107211_bb0170","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1084\/jem.20050607","article-title":"MT-1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells","volume":"202","author":"Filippov","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.vph.2023.107211_bb0175","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/01.HYP.0000154680.44184.01","article-title":"Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition","volume":"45","author":"Bouvet","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.vph.2023.107211_bb0180","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4161\/cam.36224","article-title":"An introduction to the wound healing assay using live-cell microscopy","volume":"8","author":"Jonkman","year":"2014","journal-title":"Cell Adhes. Migr."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153718912300071X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153718912300071X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:26:21Z","timestamp":1778617581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153718912300071X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":36,"alternative-id":["S153718912300071X"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2023.107211","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2023.107211","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107211"}}