{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:21:41Z","timestamp":1790270501166,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.vph.2024.107369","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T07:39:53Z","timestamp":1711697993000},"page":"107369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A novel inducible von Willebrand Factor Cre recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo"],"prefix":"10.1016","volume":"155","author":[{"given":"Dinesh","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Conner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eroboghene E.","family":"Ubogu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.vph.2024.107369_bb0005","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/MOH.0000000000000649","article-title":"Mouse models of vascular development and disease","volume":"28","author":"Cleaver","year":"2021","journal-title":"Curr. Opin. Hematol."},{"issue":"4","key":"10.1016\/j.vph.2024.107369_bb0010","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0022-2836(81)90375-2","article-title":"Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites","volume":"150","author":"Sternberg","year":"1981","journal-title":"J. Mol. Biol."},{"issue":"1\u20132","key":"10.1016\/j.vph.2024.107369_bb0015","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0378-1119(00)00008-1","article-title":"Mammalian genomes contain active recombinase recognition sites","volume":"244","author":"Thyagarajan","year":"2000","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.vph.2024.107369_bb0020","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1093\/nar\/gkl1108","article-title":"Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC\/PAC recombineering techniques","volume":"35","author":"Semprini","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.vph.2024.107369_bb0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11248-011-9512-z","article-title":"Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers","volume":"21","author":"Crouthamel","year":"2012","journal-title":"Transgenic Res."},{"issue":"5","key":"10.1016\/j.vph.2024.107369_bb0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tig.2017.12.008","article-title":"Detecting and avoiding problems when using the Cre-lox system","volume":"34","author":"Song","year":"2018","journal-title":"Trends Genet."},{"issue":"1","key":"10.1016\/j.vph.2024.107369_bb0035","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11248-019-00177-8","article-title":"Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines","volume":"29","author":"Alvarez-Aznar","year":"2020","journal-title":"Transgenic Res."},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.0.CO;2-B","article-title":"Cre recombinase: the universal reagent for genome tailoring","volume":"26","author":"Nagy","year":"2000","journal-title":"Genesis"},{"issue":"14","key":"10.1016\/j.vph.2024.107369_bb0045","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1073\/pnas.89.14.6232","article-title":"Targeted oncogene activation by site-specific recombination in transgenic mice","volume":"89","author":"Lakso","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0050","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/01.RES.0000255691.76142.4a","article-title":"Phenotypic heterogeneity of the endothelium: I. structure, function, and mechanisms","volume":"100","author":"Aird","year":"2007","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0055","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/01.RES.0000255690.03436.ae","article-title":"Phenotypic heterogeneity of the endothelium: II. Representative vascular beds","volume":"100","author":"Aird","year":"2007","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1182\/blood-2006-05-026401","article-title":"Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium","volume":"109","author":"Yano","year":"2007","journal-title":"Blood"},{"issue":"Pt 4","key":"10.1016\/j.vph.2024.107369_bb0065","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1242\/jcs.114.4.671","article-title":"Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice","volume":"114","author":"Gustafsson","year":"2001","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0070","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/dbio.2000.0106","article-title":"Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo","volume":"230","author":"Kisanuki","year":"2001","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0075","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1084\/jem.20082150","article-title":"Anaphylactic shock depends on endothelial Gq\/G11","volume":"206","author":"Korhonen","year":"2009","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0080","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physiolgenomics.00059.2002","article-title":"Inducible and selective transgene expression in murine vascular endothelium","volume":"11","author":"Teng","year":"2002","journal-title":"Physiol. Genomics"},{"issue":"28","key":"10.1016\/j.vph.2024.107369_bb0085","doi-asserted-by":"crossref","first-page":"9884","DOI":"10.1073\/pnas.0504391102","article-title":"Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice","volume":"102","author":"Carlson","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vph.2024.107369_bb0090","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58591","article-title":"Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)","volume":"10","author":"Gerber","year":"2021","journal-title":"Elife"},{"issue":"13","key":"10.1016\/j.vph.2024.107369_bb0095","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1182\/blood-2014-06-528406","article-title":"von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends","volume":"125","author":"Lenting","year":"2015","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.vph.2024.107369_bb0100","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1073\/pnas.92.10.4567","article-title":"Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice","volume":"92","author":"Aird","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0105","first-page":"999","article-title":"Endothelial-cell-specific regulation of von Willebrand factor gene expression","volume":"14","author":"Jahroudi","year":"1994","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.vph.2024.107369_bb0110","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1073\/pnas.2235688100","article-title":"Electroporation and RNA interference in the rodent retina in vivo and in vitro","volume":"101","author":"Matsuda","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vph.2024.107369_bb0115","series-title":"Advanced Protocols for Animal Transgenesis: An ISTT Manual","first-page":"99","article-title":"Generation of transgenic mice by pronuclear microinjection","author":"Becker","year":"2011"},{"issue":"9","key":"10.1016\/j.vph.2024.107369_bb0120","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"issue":"4","key":"10.1016\/j.vph.2024.107369_bb0125","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1538\/expanim.62.295","article-title":"Novel ROSA26 Cre-reporter knock-in C57BL\/6N mice exhibiting green emission before and red emission after Cre-mediated recombination","volume":"62","author":"Hasegawa","year":"2013","journal-title":"Exp. Anim."},{"issue":"1","key":"10.1016\/j.vph.2024.107369_bb0130","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1038\/s41598-018-24085-9","article-title":"Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia","volume":"8","author":"Jahn","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vph.2024.107369_bb0135","article-title":"Murine hind limb long bone dissection and bone marrow isolation","volume":"110","author":"Amend","year":"2016","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.vph.2024.107369_bb0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.vph.2024.107369_bb0145","article-title":"Whole animal perfusion fixation for rodents","volume":"65","author":"Gage","year":"2012","journal-title":"J. Vis. Exp."},{"issue":"5","key":"10.1016\/j.vph.2024.107369_bb0150","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3988","article-title":"Transcardiac perfusion of the mouse for brain tissue dissection and fixation","volume":"11","author":"Wu","year":"2021","journal-title":"Bio-Protoc."},{"issue":"21","key":"10.1016\/j.vph.2024.107369_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111554","article-title":"Not all lectins are equally suitable for labeling rodent vasculature","volume":"22","author":"Battistella","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21688370.2018.1479570","article-title":"Glial-derived neurotrophic factor is essential for blood-nerve barrier functional recovery in an experimental murine model of traumatic peripheral neuropathy","volume":"6","author":"Dong","year":"2018","journal-title":"Tissue Barriers"},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0165","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1021\/ac202578x","article-title":"Evaluation of a droplet digital polymerase chain reaction format for DNA copy number quantification","volume":"84","author":"Pinheiro","year":"2012","journal-title":"Anal. Chem."},{"issue":"10","key":"10.1016\/j.vph.2024.107369_bb0170","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/nbt.2959","article-title":"Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping","volume":"32","author":"de Vree","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0175","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41581-021-00489-1","article-title":"Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury","volume":"18","author":"Molema","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"issue":"7","key":"10.1016\/j.vph.2024.107369_bb0180","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1128\/MCB.21.7.2404-2412.2001","article-title":"Molecular distinction between specification and differentiation in the myogenic basic helix-loop-helix transcription factor family","volume":"21","author":"Bergstrom","year":"2001","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.vph.2024.107369_bb0185","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1128\/MCB.20.2.648-655.2000","article-title":"Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications","volume":"20","author":"Zheng","year":"2000","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.vph.2024.107369_bb0190","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s12974-017-1001-8","article-title":"Novel pathomechanisms in inflammatory neuropathies","volume":"14","author":"Schafflick","year":"2017","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.vph.2024.107369_bb0195","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/ilar\/ilt054","article-title":"Animal models of autoimmune neuropathy","volume":"54","author":"Soliven","year":"2014","journal-title":"ILAR J.\/Nat. Res. Counc. Instit. Labor. Anim. Resourc."},{"issue":"1\u20132","key":"10.1016\/j.vph.2024.107369_bb0200","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jneuroim.2009.11.019","article-title":"Clinical, electrophysiological and pathologic correlations in a severe murine experimental autoimmune neuritis model of Guillain-Barre syndrome","volume":"219","author":"Xia","year":"2010","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.vph.2024.107369_bb0205","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12565-015-0300-3","article-title":"Overview and assessment of the histochemical methods and reagents for the detection of beta-galactosidase activity in transgenic animals","volume":"91","author":"Trifonov","year":"2016","journal-title":"Anat. Sci. Int."},{"issue":"1","key":"10.1016\/j.vph.2024.107369_bb0210","doi-asserted-by":"crossref","first-page":"17477","DOI":"10.1038\/s41598-017-17475-y","article-title":"The human blood-nerve barrier transcriptome","volume":"7","author":"Palladino","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189124000946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189124000946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T12:56:24Z","timestamp":1733403384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189124000946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":42,"alternative-id":["S1537189124000946"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2024.107369","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel inducible von Willebrand Factor Cre recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2024.107369","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107369"}}