{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:23:46Z","timestamp":1791559426140,"version":"4.3.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"am","delay-in-days":285,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["23POST1023206"],"award-info":[{"award-number":["23POST1023206"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL164581"],"award-info":[{"award-number":["R01HL164581"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL153915"],"award-info":[{"award-number":["R01HL153915"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.vph.2025.107547","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:19:35Z","timestamp":1757542775000},"page":"107547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Pulmonary veno-occlusive disease: Insights from animal models"],"prefix":"10.1016","volume":"161","author":[{"given":"Akiko","family":"Hata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengisu","family":"Gur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspreet","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.vph.2025.107547_bb0005","doi-asserted-by":"crossref","first-page":"2401324","DOI":"10.1183\/13993003.01324-2024","article-title":"Definition, classification and diagnosis of pulmonary hypertension","volume":"64","author":"Kovacs","year":"2024","journal-title":"Eur. Respir. J."},{"issue":"156","key":"10.1016\/j.vph.2025.107547_bb0010","doi-asserted-by":"crossref","first-page":"190168","DOI":"10.1183\/16000617.0168-2019","article-title":"Pulmonary capillary haemangiomatosis: a distinct entity?","volume":"29","author":"Weatherald","year":"2020","journal-title":"Eur. Resp. Rev."},{"issue":"5","key":"10.1016\/j.vph.2025.107547_bb0015","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1183\/13993003.00026-2016","article-title":"Pulmonary veno-occlusive disease","volume":"47","author":"Montani","year":"2016","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.vph.2025.107547_bb0020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1378\/chest.113.1.237","article-title":"Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease","volume":"113","author":"Palmer","year":"1998","journal-title":"Chest"},{"issue":"38","key":"10.1016\/j.vph.2025.107547_bb0025","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.vph.2025.107547_bb0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.rmed.2017.10.015","article-title":"Pulmonary veno-occlusive disease: an important consideration in patients with pulmonary hypertension","volume":"132","author":"Balko","year":"2017","journal-title":"Respir. Med."},{"issue":"113","key":"10.1016\/j.vph.2025.107547_bb0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1183\/09059180.00003909","article-title":"Pulmonary veno-occlusive disease misdiagnosed as idiopathic pulmonary arterial hypertension","volume":"18","author":"Palazzini","year":"2009","journal-title":"Eur. Resp. Rev."},{"issue":"11","key":"10.1016\/j.vph.2025.107547_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2023.100925","article-title":"Defining the clinical validity of genes reported to cause pulmonary arterial hypertension","volume":"25","author":"Welch","year":"2023","journal-title":"Genet. Med."},{"issue":"1","key":"10.1016\/j.vph.2025.107547_bb0045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/ng.2844","article-title":"EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension","volume":"46","author":"Eyries","year":"2014","journal-title":"Nat. Genet."},{"issue":"171","key":"10.1016\/j.vph.2025.107547_bb0050","doi-asserted-by":"crossref","first-page":"230156","DOI":"10.1183\/16000617.0156-2023","article-title":"Pulmonary veno-occlusive disease: illustrative cases and literature review","volume":"33","author":"Lechartier","year":"2024","journal-title":"Eur. Resp. Rev."},{"issue":"2","key":"10.1016\/j.vph.2025.107547_bb0055","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1378\/chest.13-2366","article-title":"EIF2AK4 mutations in pulmonary capillary hemangiomatosis","volume":"145","author":"Best","year":"2014","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.vph.2025.107547_bb0060","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.chest.2016.11.014","article-title":"EIF2AK4 mutations in patients diagnosed with pulmonary arterial hypertension","volume":"151","author":"Best","year":"2017","journal-title":"Chest"},{"issue":"21","key":"10.1016\/j.vph.2025.107547_bb0065","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1161\/CIRCULATIONAHA.117.028351","article-title":"Phenotypic characterization of EIF2AK4 mutation carriers in a large cohort of patients diagnosed clinically with pulmonary arterial hypertension","volume":"136","author":"Hadinnapola","year":"2017","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.vph.2025.107547_bb0070","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1164\/rccm.200208-861OC","article-title":"Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II","volume":"167","author":"Runo","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.vph.2025.107547_bb0075","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020931315","article-title":"A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype","volume":"10","author":"Oriaku","year":"2020","journal-title":"Pulm. Circ."},{"issue":"2","key":"10.1016\/j.vph.2025.107547_bb0080","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S2213-2600(15)00544-5","article-title":"BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis","volume":"4","author":"Evans","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.vph.2025.107547_bb0085","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1465-9921-10-87","article-title":"Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension","volume":"10","author":"Austin","year":"2009","journal-title":"Respir. Res."},{"issue":"10","key":"10.1016\/j.vph.2025.107547_bb0090","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.rmr.2020.09.004","article-title":"Familial pulmonary veno-occlusive disease with a composite biallelic heterozygous EIF2AK4 mutation","volume":"37","author":"Treffel","year":"2020","journal-title":"Rev. Mal. Respir."},{"issue":"39","key":"10.1016\/j.vph.2025.107547_bb0095","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000005030","article-title":"EIF2AK4 mutation in pulmonary veno-occlusive disease: a case report and review of the literature","volume":"95","author":"Liang","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"6489","key":"10.1016\/j.vph.2025.107547_bb0100","doi-asserted-by":"crossref","first-page":"eaat5314","DOI":"10.1126\/science.aat5314","article-title":"The integrated stress response: from mechanism to disease","volume":"368","author":"Costa-Mattioli","year":"2020","journal-title":"Science"},{"issue":"6716","key":"10.1016\/j.vph.2025.107547_bb0105","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.vph.2025.107547_bb0110","first-page":"1495","article-title":"Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension","volume":"33","author":"Emanuelli","year":"2024","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/j.vph.2025.107547_bb0115","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/CIRCULATIONAHA.115.014207","article-title":"Mitomycin-induced pulmonary Veno-occlusive disease: evidence from human disease and animal models","volume":"132","author":"Perros","year":"2015","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.vph.2025.107547_bb0120","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ajpath.2014.10.021","article-title":"Chemotherapy-induced pulmonary hypertension: role of alkylating agents","volume":"185","author":"Ranchoux","year":"2015","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.vph.2025.107547_bb0125","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0046-8177(83)80052-5","article-title":"Pulmonary veno-occlusive disease after chemotherapy","volume":"14","author":"Joselson","year":"1983","journal-title":"Hum. Pathol."},{"issue":"5","key":"10.1016\/j.vph.2025.107547_bb0130","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1378\/chest.109.5.1388","article-title":"Pulmonary veno-occlusive disease in an adult following bone marrow transplantation. Case report and review of the literature","volume":"109","author":"Williams","year":"1996","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.vph.2025.107547_bb0135","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/00007890-198906000-00014","article-title":"Pulmonary venoocclusive disease following bone marrow transplantation","volume":"47","author":"Hackman","year":"1989","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.vph.2025.107547_bb0140","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/bph.15314","article-title":"Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats","volume":"178","author":"Zhang","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.vph.2025.107547_bb0145","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1165\/rcmb.2019-0015OC","volume":"63","author":"Manaud","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.vph.2025.107547_bb0150","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s44161-024-00495-z","article-title":"Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response","volume":"3","author":"Prabhakar","year":"2024","journal-title":"Nat. Cardiovasc. Res."},{"issue":"19","key":"10.1016\/j.vph.2025.107547_bb0155","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.181877","article-title":"Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease","volume":"9","author":"Prabhakar","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.vph.2025.107547_bb0160","doi-asserted-by":"crossref","first-page":"e193495","DOI":"10.1172\/jci.insight.193495","article-title":"Essential role of protein kinase R in the pathogenesis of pulmonary veno-occlusive disease","author":"Prabhakar","year":"2025","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.vph.2025.107547_bb0165","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1177\/10742484211015535","article-title":"GCN2 regulates ATF3-p38 MAPK signaling transduction in pulmonary Veno-occlusive disease","volume":"26","author":"Chen","year":"2021","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.vph.2025.107547_bb0170","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1164\/rccm.202408-1655OC","article-title":"Deficient FANCL predisposes to endothelial damage: a new therapeutic target for pulmonary hypertension","volume":"211","author":"Liu","year":"2025","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.vph.2025.107547_bb0175","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s13287-025-04400-8","article-title":"Intravenous mesenchymal stem cell transplantation mitigates pulmonary vascular remodeling but poses dose related risks in a pulmonary veno-occlusive disease model","volume":"16","author":"Katagiri","year":"2025","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"10.1016\/j.vph.2025.107547_bb0180","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1183\/13993003.00814-2015","article-title":"Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease","volume":"46","author":"Montani","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.vph.2025.107547_bb0185","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020907884","article-title":"Trichloroethylene increases pulmonary endothelial permeability: implication for pulmonary veno-occlusive disease","volume":"10","author":"Caliez","year":"2020","journal-title":"Pulm. Circ."},{"issue":"4","key":"10.1016\/j.vph.2025.107547_bb0190","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/MD.0b013e31818193bb","article-title":"Pulmonary veno-occlusive disease: clinical, functional, radiologic, and hemodynamic characteristics and outcome of 24 cases confirmed by histology","volume":"87","author":"Montani","year":"2008","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"10.1016\/j.vph.2025.107547_bb0195","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/MCP.0000000000001184","article-title":"Pulmonary veno-occlusive disease: a paradigm of diagnosis and therapeutic challenges in pulmonary hypertension","volume":"31","author":"Aguado","year":"2025","journal-title":"Curr. Opin. Pulm. Med."},{"issue":"15","key":"10.1016\/j.vph.2025.107547_bb0200","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1093\/eurheartj\/ehq170","article-title":"Long-term response to calcium-channel blockers in non-idiopathic pulmonary arterial hypertension","volume":"31","author":"Montani","year":"2010","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.vph.2025.107547_bb0205","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1183\/13993003.00464-2016","article-title":"BMPR2 mutation status influences bronchial vascular changes in pulmonary arterial hypertension","volume":"48","author":"Ghigna","year":"2016","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.vph.2025.107547_bb0210","doi-asserted-by":"crossref","first-page":"2401830","DOI":"10.1183\/13993003.01830-2024","article-title":"Drugs targeting novel pathways in pulmonary arterial hypertension","volume":"66","author":"Sitbon","year":"2025","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.vph.2025.107547_bb0215","doi-asserted-by":"crossref","first-page":"2401180","DOI":"10.1183\/13993003.01180-2024","article-title":"Management of pulmonary hypertension in special conditions","volume":"64","author":"Preston","year":"2024","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.vph.2025.107547_bb0220","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12168","article-title":"Efficacy and safety of oral pulmonary vasodilators in pulmonary veno-occlusive disease","volume":"12","author":"Nakamura","year":"2022","journal-title":"Pulm. Circ."},{"issue":"2","key":"10.1016\/j.vph.2025.107547_bb0225","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S2213-2600(16)30438-6","article-title":"Clinical phenotypes and outcomes of heritable and sporadic pulmonary veno-occlusive disease: a population-based study","volume":"5","author":"Montani","year":"2017","journal-title":"Lancet Respir. Med."},{"issue":"6","key":"10.1016\/j.vph.2025.107547_bb0230","doi-asserted-by":"crossref","first-page":"2004354","DOI":"10.1183\/13993003.04354-2020","article-title":"A case series on the use of steroids and mycophenolate mofetil in idiopathic and heritable pulmonary veno-occlusive disease: is there a role for immunosuppression?","volume":"57","author":"Bergbaum","year":"2021","journal-title":"Eur. Respir. J."},{"issue":"6","key":"10.1016\/j.vph.2025.107547_bb0235","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3109\/s10165-011-0440-9","article-title":"Long-term remission of pulmonary veno-occlusive disease associated with primary Sj\u00f6gren\u2019s syndrome following immunosuppressive therapy","volume":"21","author":"Naniwa","year":"2011","journal-title":"Mod. Rheumatol."},{"issue":"1","key":"10.1016\/j.vph.2025.107547_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12046","article-title":"Progression of pulmonary veno-occlusive disease without pulmonary hypertension","volume":"12","author":"Beshay","year":"2022","journal-title":"Pulm. Circ."},{"issue":"6","key":"10.1016\/j.vph.2025.107547_bb0245","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1164\/rccm.202409-1698OC","article-title":"Consistent safety and efficacy of Sotatercept for pulmonary arterial hypertension in","volume":"211","author":"Montani","year":"2025","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"543","key":"10.1016\/j.vph.2025.107547_bb0250","doi-asserted-by":"crossref","first-page":"eaaz5660","DOI":"10.1126\/scitranslmed.aaz5660","article-title":"ACTRIIA-fc rebalances activin\/GDF versus BMP signaling in pulmonary hypertension","volume":"12","author":"Yung","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"20","key":"10.1016\/j.vph.2025.107547_bb0255","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.177926","article-title":"GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension","volume":"9","author":"Zhu","year":"2024","journal-title":"JCI Insight"},{"issue":"28","key":"10.1016\/j.vph.2025.107547_bb0260","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1073\/pnas.0603509103","article-title":"Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance","volume":"103","author":"Tuncman","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2025.107547_bb0265","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fcell.2016.00053","article-title":"ERK1 and ERK2 map kinases: specific roles or functional redundancy?","volume":"4","author":"Busc\u00e0","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.vph.2025.107547_bb0270","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12931-024-02906-y","article-title":"Inhalation of hydrogen gas protects against mitomycin-induced pulmonary veno-occlusive disease","volume":"25","author":"Zhang","year":"2024","journal-title":"Respir. Res."},{"issue":"19","key":"10.1016\/j.vph.2025.107547_bb0275","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1016\/j.cell.2023.07.036","article-title":"TGF-\u03b2 signaling in health and disease","volume":"186","author":"Massagu\u00e9","year":"2023","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.vph.2025.107547_bb0280","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2013.08.020","article-title":"VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity","volume":"26","author":"Giannotta","year":"2013","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.vph.2025.107547_bb0285","doi-asserted-by":"crossref","first-page":"e12720","DOI":"10.1111\/acel.12720","article-title":"ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis","volume":"17","author":"Bueno","year":"2018","journal-title":"Aging Cell"},{"issue":"6","key":"10.1016\/j.vph.2025.107547_bb0290","first-page":"1671","article-title":"Pulmonary veno-occlusive disease: a case series and new observations","volume":"118","author":"Holcomb","year":"2000","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.vph.2025.107547_bb0295","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.70016","article-title":"Bridging the species divide: the limits of rat models in capturing human PVOD mechanisms","volume":"14","author":"Perros","year":"2024","journal-title":"Pulm. Circ."},{"issue":"9","key":"10.1016\/j.vph.2025.107547_bb0300","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.121.319971","article-title":"The latest in animal models of pulmonary hypertension and right ventricular failure","volume":"130","author":"Boucherat","year":"2022","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.vph.2025.107547_bb0305","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.70015","article-title":"Reply to the letter to the editor entitled \u201cbridging the species divide: the limits of rat models in capturing human PVOD mechanisms\u201d by Perros F. Et al","volume":"14","author":"Prabhakar","year":"2024","journal-title":"Pulm. Circ."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189125000862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189125000862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:02:42Z","timestamp":1781208162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189125000862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":61,"alternative-id":["S1537189125000862"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2025.107547","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary veno-occlusive disease: Insights from animal models","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2025.107547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107547"}}