{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:33:00Z","timestamp":1782991980312,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011790","name":"Xiangya Hospital Central South University","doi-asserted-by":"publisher","award":["2024Q10"],"award-info":[{"award-number":["2024Q10"]}],"id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.vph.2026.107581","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:10:23Z","timestamp":1769533823000},"page":"107581","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Tirzepatide mitigates thoracic aortic aneurysm and dissection by alleviating the loss of the contractile phenotype in vascular smooth muscle cells and reducing vascular inflammation"],"prefix":"10.1016","volume":"162","author":[{"given":"Liao","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.vph.2026.107581_bb0005","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jacc.2009.08.084","article-title":"Thoracic aortic aneurysm clinically pertinent controversies and uncertainties","volume":"55","author":"Elefteriades","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9632","key":"10.1016\/j.vph.2026.107581_bb0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0140-6736(08)60994-0","article-title":"Acute aortic dissection","volume":"372","author":"Golledge","year":"2008","journal-title":"Lancet (London, England)"},{"issue":"3","key":"10.1016\/j.vph.2026.107581_bb0015","first-page":"993","article-title":"Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms","volume":"150","author":"L\u00f3pez-Candales","year":"1997","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.vph.2026.107581_bb0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0002-9149(77)80005-2","article-title":"Pathogenesis of dissecting aneurysm of aorta. Comparative histopathologic study of significance of medial changes","volume":"39","author":"Schlatmann","year":"1977","journal-title":"Am. J. Cardiol."},{"issue":"3","key":"10.1016\/j.vph.2026.107581_bb0025","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1161\/ATVBAHA.120.313991","article-title":"Aortic aneurysms and dissections series","volume":"40","author":"Shen","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"14","key":"10.1016\/j.vph.2026.107581_bb0030","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1001\/jama.2025.14092","article-title":"Semaglutide and tirzepatide in patients with heart failure with preserved ejection fraction","volume":"334","author":"Kr\u00fcger","year":"2025","journal-title":"Jama"},{"issue":"1","key":"10.1016\/j.vph.2026.107581_bb0035","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12933-025-02806-5","article-title":"Tirzepatide, a dual GIP\/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide","volume":"24","author":"Heged\u0171s","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"issue":"3","key":"10.1016\/j.vph.2026.107581_bb0040","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/cvr\/cvaf005","article-title":"Glucose-dependent insulinotropic polypeptide\/glucagon-like peptide 1 receptor agonist tirzepatide promotes branched chain amino acid catabolism to prevent myocardial infarction in non-diabetic mice","volume":"121","author":"Chen","year":"2025","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.vph.2026.107581_bb0045","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12933-024-02203-4","article-title":"Evidence that tirzepatide protects against diabetes-related cardiac damages","volume":"23","author":"Taktaz","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.vph.2026.107581_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2025.112279","article-title":"Clinical effectiveness of tirzepatide for patients with atrial fibrillation and type 2 diabetes: a retrospective cohort study","volume":"225","author":"Wu","year":"2025","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"3","key":"10.1016\/j.vph.2026.107581_bb0055","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s12020-019-02081-x","article-title":"Effects of glucagon-like peptide-1 analog liraglutide on the systemic inflammation in high-fat-diet-induced mice","volume":"66","author":"Sha","year":"2019","journal-title":"Endocrine"},{"issue":"12","key":"10.1016\/j.vph.2026.107581_bb0060","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/cvr\/cvaf033","article-title":"Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination","volume":"121","author":"Yang","year":"2025","journal-title":"Cardiovasc. Res."},{"issue":"14","key":"10.1016\/j.vph.2026.107581_bb0065","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1093\/eurheartj\/ehac823","article-title":"Targeting endothelial tight junctions to predict and protect thoracic aortic aneurysm and dissection","volume":"44","author":"Yang","year":"2023","journal-title":"Eur. Heart J."},{"issue":"7","key":"10.1016\/j.vph.2026.107581_bb0070","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1161\/ATVBAHA.123.320402","article-title":"\u0392-Aminopropionitrile induces distinct pathologies in the ascending and descending thoracic aortic regions of mice","volume":"44","author":"Franklin","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.vph.2026.107581_bb0075","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00109-023-02284-w","article-title":"ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and dissection in mice","volume":"101","author":"Gong","year":"2023","journal-title":"J. Mol. Med. (Berl)"},{"issue":"4","key":"10.1016\/j.vph.2026.107581_bb0080","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/ATVBAHA.112.300036","article-title":"Increased aortic stiffness and attenuated lysyl oxidase activity in obesity","volume":"33","author":"Chen","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.vph.2026.107581_bb0085","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1161\/ATVBAHA.122.318788","article-title":"Urate-lowering therapy inhibits thoracic aortic aneurysm and dissection formation in mice","volume":"43","author":"Yang","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2026.107581_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110311","article-title":"Tirzepatide attenuates lipopolysaccharide-induced left ventricular remodeling and dysfunction by inhibiting the TLR4\/NF-kB\/NLRP3 pathway","volume":"120","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.vph.2026.107581_bb0095","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.jvs.2010.05.089","article-title":"Vascular smooth muscle cell peroxisome proliferator-activated receptor-\u03b3 deletion promotes abdominal aortic aneurysms","volume":"52","author":"Hamblin","year":"2010","journal-title":"J. Vasc. Surg."},{"issue":"5","key":"10.1016\/j.vph.2026.107581_bb0100","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97167","article-title":"Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection","volume":"3","author":"Cikach","year":"2018","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.vph.2026.107581_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000342436","article-title":"Possible mechanical roles of glycosaminoglycans in thoracic aortic dissection and associations with dysregulated transforming growth factor-\u03b2","volume":"50","author":"Humphrey","year":"2013","journal-title":"J. Vasc. Res."},{"issue":"3","key":"10.1016\/j.vph.2026.107581_bb0110","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jtcvs.2005.09.018","article-title":"Characterization of the inflammatory and apoptotic cells in the aortas of patients with ascending thoracic aortic aneurysms and dissections","volume":"131","author":"He","year":"2006","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"6","key":"10.1016\/j.vph.2026.107581_bb0115","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1172\/JCI117619","article-title":"Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques","volume":"94","author":"Galis","year":"1994","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.vph.2026.107581_bb0120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF02329378","article-title":"The role of inflammation in nonspecific abdominal aortic aneurysm disease","volume":"5","author":"Brophy","year":"1991","journal-title":"Ann. Vasc. Surg."},{"issue":"5 Pt 2","key":"10.1016\/j.vph.2026.107581_bb0125","article-title":"Cytokines that activate proteolysis are increased in abdominal aortic aneurysms","volume":"90","author":"Newman","year":"1994","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.vph.2026.107581_bb0130","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"issue":"33","key":"10.1016\/j.vph.2026.107581_bb0135","doi-asserted-by":"crossref","first-page":"29874","DOI":"10.1074\/jbc.M203915200","article-title":"PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing","volume":"277","author":"Wang","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.vph.2026.107581_bb0140","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 Inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"12","key":"10.1016\/j.vph.2026.107581_bb0145","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.vph.2026.107581_bb0150","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014044","article-title":"Targeting the NLRP3 Inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in mice","volume":"9","author":"Ren","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.vph.2026.107581_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175361","article-title":"Oltipraz, the activator of nuclear factor erythroid 2-related factor 2 (Nrf2), protects against the formation of BAPN-induced aneurysms and dissection of the thoracic aorta in mice by inhibiting activation of the ROS-mediated NLRP3 inflammasome","volume":"936","author":"Wang","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.vph.2026.107581_bb0160","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/1074248420919966","article-title":"PKM2 activator TEPP-46 attenuates thoracic aortic aneurysm and dissection by inhibiting NLRP3 Inflammasome-mediated IL-1\u03b2 secretion","volume":"25","author":"Le","year":"2020","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"209","key":"10.1016\/j.vph.2026.107581_bb0165","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007218","article-title":"Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans","volume":"5","author":"Finan","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.vph.2026.107581_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2025.03.011","article-title":"Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation","volume":"37","author":"Ravussin","year":"2025","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.vph.2026.107581_bb0175","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1111\/dom.16294","article-title":"Tirzepatide reduces body weight by increasing fat utilization via the central nervous system-adipose tissue axis in male mice","volume":"27","author":"Zhang","year":"2025","journal-title":"Diabetes Obes. Metab."},{"issue":"12","key":"10.1016\/j.vph.2026.107581_bb0180","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1253\/circj.CJ-21-0258","article-title":"NLRP3 Inflammasome as a common denominator of atherosclerosis and abdominal aortic aneurysm","volume":"85","author":"Takahashi","year":"2021","journal-title":"Circ J"},{"issue":"2","key":"10.1016\/j.vph.2026.107581_bb0185","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.vph.2026.107581_bb0190","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.vph.2026.107581_bb0195","doi-asserted-by":"crossref","first-page":"797","DOI":"10.36740\/WLek\/202970","article-title":"Tirzepatide therapy counters inflammatory and apoptotic responses induced by high-fat diet in rat liver","volume":"vol. 78","author":"Alathary","year":"2025","journal-title":"Wiadomosci Lekarskie (Warsaw, Poland\u202f: 1960)"},{"issue":"Pt 2","key":"10.1016\/j.vph.2026.107581_bb0200","article-title":"Tirzepatide\u2019s role in targeting adipose tissue macrophages to reduce obesity-related inflammation and improve insulin resistance","volume":"143","author":"Xia","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.vph.2026.107581_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2024.171245","article-title":"Tirzepatide protects against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and inflammation via PI3K\/Akt signaling","volume":"178","author":"Chen","year":"2024","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.vph.2026.107581_bb0210","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s11010-024-05066-1","article-title":"Tirzepatide alleviates oxidative stress and inflammation in diabetic nephropathy via IL-17 signaling pathway","volume":"480","author":"Yang","year":"2025","journal-title":"Mol. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.vph.2026.107581_bb0215","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70392","article-title":"Tirzepatide induces ferroptosis in glioblastoma cell lines via the SOX2\/SLC7A11 Axis: a potential therapeutic strategy for glioma treatment","volume":"39","author":"Wang","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.vph.2026.107581_bb0220","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-023-01325-7","article-title":"The mechanism and therapy of aortic aneurysms","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.vph.2026.107581_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175091","article-title":"Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome","volume":"928","author":"Li","year":"2022","journal-title":"Eur. J. Pharmacol."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189126000017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189126000017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:18:16Z","timestamp":1781335096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189126000017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":45,"alternative-id":["S1537189126000017"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2026.107581","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tirzepatide mitigates thoracic aortic aneurysm and dissection by alleviating the loss of the contractile phenotype in vascular smooth muscle cells and reducing vascular inflammation","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2026.107581","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107581"}}