{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:30:47Z","timestamp":1786998647128,"version":"build-2736575974"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003550","name":"Queensland Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016058","name":"Townsville Hospital and Health Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"National Institute of Health and Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001516","name":"National Heart Foundation of New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001516","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025520","name":"Medical Research Future Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100025520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.vph.2026.107610","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T01:20:50Z","timestamp":1775438450000},"page":"107610","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The effect of drugs and stem cell therapies on established abdominal aortic aneurysms in mice: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"163","author":[{"given":"Callan D.","family":"Wesley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivshankar","family":"Thanigaimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Yerramothu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen S.","family":"Barratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Golledge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.vph.2026.107610_bb0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41569-018-0114-9","article-title":"Abdominal aortic aneurysm: update on pathogenesis and medical treatments","volume":"16","author":"Golledge","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.vph.2026.107610_bb0010","article-title":"Global trends and stratified analysis of aortic aneurysm mortality: insights from the GBD 2021 study","volume":"12","author":"Yang","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0015","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gheart.2013.12.010","article-title":"Global and regional burden of aortic dissection and aneurysms: mortality trends in 21 world regions, 1990 to 2010","volume":"9","author":"Sampson","year":"2014","journal-title":"Glob. Heart"},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejvs.2018.09.020","article-title":"Editor\u2019s choice - European society for vascular surgery (ESVS) 2019 clinical practice guidelines on the management of abdominal aorto-iliac artery aneurysms","volume":"57","author":"Wanhainen","year":"2019","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/joim.12958","article-title":"Lack of an effective drug therapy for abdominal aortic aneurysm","volume":"288","author":"Golledge","year":"2020","journal-title":"J. Intern. Med."},{"issue":"2","key":"10.1016\/j.vph.2026.107610_bb0030","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0741-5214(96)70279-3","article-title":"Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase","volume":"23","author":"Petrinec","year":"1996","journal-title":"J. Vasc. Surg."},{"issue":"22","key":"10.1016\/j.vph.2026.107610_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201700671","article-title":"Thermosensitive hydrogel containing doxycycline exerts inhibitory effects on abdominal aortic aneurysm induced by pancreatic elastase in mice","volume":"6","author":"Yu","year":"2017","journal-title":"Adv. Healthc. Mater."},{"issue":"2","key":"10.1016\/j.vph.2026.107610_bb0040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.carpath.2014.10.004","article-title":"Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms","volume":"24","author":"Mata","year":"2015","journal-title":"Cardiovasc. Pathol."},{"issue":"3","key":"10.1016\/j.vph.2026.107610_bb0045","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.ATV.0000058404.92759.32","article-title":"Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms","volume":"23","author":"Manning","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.vph.2026.107610_bb0050","first-page":"450","article-title":"The effect of ticagrelor on growth of small abdominal aortic aneurysms-a randomized controlled trial","volume":"116","author":"Wanhainen","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0055","first-page":"52","article-title":"Impaired results of a randomised double blinded clinical trial of propranolol versus placebo on the expansion rate of small abdominal aortic aneurysms","volume":"18","author":"Lindholt","year":"1999","journal-title":"Int. Angiol."},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0060","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1067\/mva.2002.121308","article-title":"Propranolol for small abdominal aortic aneurysms: results of a randomized trial","volume":"35","author":"Investigators P","year":"2002","journal-title":"J. Vasc. Surg."},{"issue":"42","key":"10.1016\/j.vph.2026.107610_bb0065","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1093\/eurheartj\/ehw257","article-title":"An evaluation of the effect of an angiotensin-converting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: a randomized placebo-controlled trial (AARDVARK)","volume":"37","author":"Bicknell","year":"2016","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.vph.2026.107610_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamacardio.2020.3524","article-title":"Efficacy of telmisartan to slow growth of small abdominal aortic aneurysms: a randomized clinical trial","volume":"5","author":"Golledge","year":"2020","journal-title":"JAMA Cardiol."},{"issue":"4","key":"10.1016\/j.vph.2026.107610_bb0075","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1067\/mva.2001.117891","article-title":"Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study","volume":"34","author":"Mosorin","year":"2001","journal-title":"J. Vasc. Surg."},{"issue":"20","key":"10.1016\/j.vph.2026.107610_bb0080","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1001\/jama.2020.5230","article-title":"Effect of doxycycline on aneurysm growth among patients with small infrarenal abdominal aortic aneurysms: a randomized clinical trial","volume":"323","author":"Baxter","year":"2020","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.vph.2026.107610_bb0085","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7326\/0003-4819-159-12-201312170-00007","article-title":"Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial","volume":"159","author":"Meijer","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.vph.2026.107610_bb0090","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.vph.2026.107610_bb0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"issue":"7","key":"10.1016\/j.vph.2026.107610_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181832","article-title":"Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein e deficient mice: a systematic review and meta-analysis","volume":"12","author":"Phie","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0105","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2020-001676","article-title":"Animal models of ischemic limb ulcers: a systematic review and meta-analysis","volume":"8","author":"Thanigaimani","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"issue":"4","key":"10.1016\/j.vph.2026.107610_bb0110","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J. Natl. Cancer Inst."},{"issue":"11","key":"10.1016\/j.vph.2026.107610_bb0115","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"issue":"4","key":"10.1016\/j.vph.2026.107610_bb0120","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/ATVBAHA.112.300329","article-title":"Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression","volume":"33","author":"Iida","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2026.107610_bb0125","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.atherosclerosis.2016.06.021","article-title":"IL-6: a Janus-like factor in abdominal aortic aneurysm disease","volume":"251","author":"Kokje","year":"2016","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.vph.2026.107610_bb0130","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/SLA.0b013e31827df7cb","article-title":"Recombinant human thrombomodulin suppresses experimental abdominal aortic aneurysms induced by calcium chloride in mice","volume":"258","author":"Lai","year":"2013","journal-title":"Ann. Surg."},{"issue":"3","key":"10.1016\/j.vph.2026.107610_bb0135","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/sj.gt.3303069","article-title":"Overexpression of PAI-1 prevents the development of abdominal aortic aneurysm in mice","volume":"15","author":"Qian","year":"2008","journal-title":"Gene Ther."},{"issue":"3","key":"10.1016\/j.vph.2026.107610_bb0140","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/cvr\/cvw112","article-title":"Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice","volume":"111","author":"Tarin","year":"2016","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.vph.2026.107610_bb0145","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.jvs.2017.09.030","article-title":"Hypoxia-inducible factor 1 in clinical and experimental aortic aneurysm disease","volume":"68","author":"Wang","year":"2018","journal-title":"J. Vasc. Surg."},{"issue":"2","key":"10.1016\/j.vph.2026.107610_bb0150","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/bph.14515","article-title":"Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms","volume":"176","author":"Wang","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.vph.2026.107610_bb0155","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jvs.2016.12.110","article-title":"Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms","volume":"67","author":"Xuan","year":"2018","journal-title":"J. Vasc. Surg."},{"issue":"4","key":"10.1016\/j.vph.2026.107610_bb0160","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/ATVBAHA.109.200527","article-title":"Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein e-deficient mice","volume":"30","author":"Yamanouchi","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"18","key":"10.1016\/j.vph.2026.107610_bb0165","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400414RRR","article-title":"Resolvin D2\/GPR18 signaling enhances monocytic myeloid-derived suppressor cell function to mitigate abdominal aortic aneurysm formation","volume":"38","author":"Bellotti","year":"2024","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.vph.2026.107610_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177117","article-title":"Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms","volume":"12","author":"Bridge","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.vph.2026.107610_bb0175","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001064","article-title":"Pharmacological inhibitor of notch signaling stabilizes the progression of small abdominal aortic aneurysm in a mouse model","volume":"3","author":"Cheng","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.vph.2026.107610_bb0180","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ijcard.2016.08.238","article-title":"Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE(\u2212\/\u2212) mice","volume":"223","author":"Duan","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"10","key":"10.1016\/j.vph.2026.107610_bb0185","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/lsm.22306","article-title":"Arrest of progression of pre-induced abdominal aortic aneurysm in apolipoprotein e-deficient mice by low level laser phototherapy","volume":"46","author":"Gavish","year":"2014","journal-title":"Lasers Surg. Med."},{"issue":"11","key":"10.1016\/j.vph.2026.107610_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044369","article-title":"Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice","volume":"7","author":"Ghoshal","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.vph.2026.107610_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067098","article-title":"Beta-carotene attenuates angiotensin II-induced aortic aneurysm by alleviating macrophage recruitment in apoe(\u2212\/\u2212) mice","volume":"8","author":"Gopal","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.vph.2026.107610_bb0200","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41401-018-0017-7","article-title":"Ginkgo biloba extracts prevent aortic rupture in angiotensin II-infused hypercholesterolemic mice","volume":"40","author":"Huang","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"24","key":"10.1016\/j.vph.2026.107610_bb0205","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1161\/CIRCULATIONAHA.109.852467","article-title":"Rosiglitazone reduces the development and rupture of experimental aortic aneurysms","volume":"119","author":"Jones","year":"2009","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0210","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.atherosclerosis.2009.11.031","article-title":"Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation","volume":"210","author":"Kristo","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.vph.2026.107610_bb0215","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.atherosclerosis.2020.01.029","article-title":"Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice","volume":"297","author":"Lai","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.vph.2026.107610_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejvs.2020.01.008","article-title":"Pharmacological inhibition of cathepsin s suppresses abdominal aortic aneurysm in mice","author":"Lai","year":"2020","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.vph.2026.107610_bb0225","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.atherosclerosis.2017.03.024","article-title":"Recombinant adeno-associated virus vector carrying the thrombomodulin lectin-like domain for the treatment of abdominal aortic aneurysm","volume":"262","author":"Lai","year":"2017","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.vph.2026.107610_bb0230","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1161\/ATVBAHA.117.310129","article-title":"Resveratrol inhibits growth of experimental abdominal aortic aneurysm associated with upregulation of angiotensin-converting enzyme 2","volume":"37","author":"Moran","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.vph.2026.107610_bb0235","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1161\/ATVBAHA.115.306945","article-title":"Modulation of kinin b2 receptor signaling controls aortic dilatation and rupture in the angiotensin II-infused apolipoprotein E-deficient mouse","volume":"36","author":"Moran","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2026.107610_bb0240","doi-asserted-by":"crossref","DOI":"10.1038\/srep43079","article-title":"Parenteral administration of factor Xa\/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis","volume":"7","author":"Moran","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.vph.2026.107610_bb0245","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/ATVBAHA.115.305537","article-title":"Platelet inhibitors reduce rupture in a mouse model of established abdominal aortic aneurysm","volume":"35","author":"Owens","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2026.107610_bb0250","article-title":"Comparison of efficacy between Ramipril and carvedilol on limiting the expansion of abdominal aortic aneurysm in mouse model","author":"Park","year":"2018","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.vph.2026.107610_bb0255","doi-asserted-by":"crossref","first-page":"H1932","DOI":"10.1152\/ajpheart.00961.2009","article-title":"Weight loss in obese C57BL\/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms","volume":"298","author":"Police","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.vph.2026.107610_bb0260","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1042\/CS20130382","article-title":"Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein-E-deficient mouse model","volume":"127","author":"Seto","year":"2014","journal-title":"Clin. Sci. (Lond.)"},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0265","article-title":"Pharmacological inhibition of notch signaling regresses pre-established abdominal aortic aneurysm","volume":"9","author":"Sharma","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vph.2026.107610_bb0270","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13293-015-0030-1","article-title":"Exogenous 17-beta estradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice","volume":"6","author":"Thatcher","year":"2015","journal-title":"Biol. Sex Differ."},{"issue":"9","key":"10.1016\/j.vph.2026.107610_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046411","article-title":"Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice","volume":"7","author":"Xie","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.vph.2026.107610_bb0280","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1093\/ejcts\/ezu018","article-title":"Therapeutic potential of bone marrow-derived mesenchymal stem cells in formed aortic aneurysms of a mouse model","volume":"45","author":"Yamawaki-Ogata","year":"2014","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"10","key":"10.1016\/j.vph.2026.107610_bb0285","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.jcyt.2017.07.010","article-title":"Bone marrow-derived mesenchymal stromal cells regress aortic aneurysm via the NF-kB, smad3 and AKT signaling pathways","volume":"19","author":"Yamawaki-Ogata","year":"2017","journal-title":"Cytotherapy"},{"key":"10.1016\/j.vph.2026.107610_bb0290","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1196\/annals.1383.031","article-title":"Regression of abdominal aortic aneurysm by inhibition of c-Jun n-terminal kinase in mice","volume":"1085","author":"Yoshimura","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.vph.2026.107610_bb0295","doi-asserted-by":"crossref","DOI":"10.1007\/s11010-025-05374-0","article-title":"Administration of a recombinant secretory leukocyte protease inhibitor prevents aortic aneurysm growth in mice","author":"Yamawaki-Ogata","year":"2025","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.vph.2026.107610_bb0300","article-title":"Therapeutic effect of allogeneic bone marrow-derived mesenchymal stromal cells on aortic aneurysms","author":"Akita","year":"2020","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.vph.2026.107610_bb0305","article-title":"Modulating neuro-immune-induced macrophage polarization with topiramate attenuates experimental abdominal aortic aneurysm","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.vph.2026.107610_bb0310","article-title":"Factor Xa inhibitor rivaroxaban suppresses experimental abdominal aortic aneurysm progression via attenuating aortic inflammation","author":"Ding","year":"2020","journal-title":"Vasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0315","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/14712598.2022.2005575","article-title":"Alternative therapeutic strategy for existing aortic aneurysms using mesenchymal stem cell-derived exosomes","volume":"22","author":"Kozakai","year":"2022","journal-title":"Expert. Opin. Biol. Ther."},{"issue":"15","key":"10.1016\/j.vph.2026.107610_bb0320","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140364","article-title":"Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility","volume":"6","author":"Busch","year":"2021","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0325","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1039\/D3FO01235B","article-title":"Pterostilbene alleviates abdominal aortic aneurysm via inhibiting macrophage pyroptosis by activating the miR-146a-5p\/TRAF6 axis","volume":"15","author":"Cai","year":"2024","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0330","doi-asserted-by":"crossref","first-page":"29123","DOI":"10.1038\/s41598-025-14268-6","article-title":"ALOX5 regulates vascular smooth muscle cells pyroptosis to affect abdominal aortic aneurysm formation","volume":"15","author":"Wang","year":"2025","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.vph.2026.107610_bb0335","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2217\/rme.14.61","article-title":"Periadventitial adipose-derived stem cell treatment halts elastase-induced abdominal aortic aneurysm progression","volume":"9","author":"Blose","year":"2014","journal-title":"Regen. Med."},{"issue":"2","key":"10.1016\/j.vph.2026.107610_bb0340","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000504848","article-title":"Ulinastatin inhibits the formation and progression of experimental abdominal aortic aneurysms","volume":"57","author":"Li","year":"2020","journal-title":"J. Vasc. Res."},{"issue":"5","key":"10.1016\/j.vph.2026.107610_bb0345","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ejvs.2014.02.006","article-title":"Rapamycin limits the growth of established experimental abdominal aortic aneurysms","volume":"47","author":"Rouer","year":"2014","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.vph.2026.107610_bb0350","article-title":"Inhibition of receptor-interacting protein kinase 1 with necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.vph.2026.107610_bb0355","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5246\/jcps.2024.03.016","article-title":"Enhanced protective effects of naringenin on elastase-induced mouse abdominal aortic aneurysm through nanoliposome delivery","volume":"33","author":"Chen","year":"2024","journal-title":"J. Chin. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.vph.2026.107610_bb0360","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/ptr.7358","article-title":"Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-\u03baB and COX-2","volume":"36","author":"Zhai","year":"2022","journal-title":"Phytother. Res."},{"issue":"9","key":"10.1016\/j.vph.2026.107610_bb0365","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152373","article-title":"Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms","volume":"132","author":"Morrell","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.vph.2026.107610_bb0370","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1161\/ATVBAHA.121.315942","article-title":"Systematic review and Meta-analysis of interventions to slow progression of abdominal aortic aneurysm in mouse models","volume":"41","author":"Phie","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0375","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jvs.2016.08.003","article-title":"Challenges and opportunities in limiting abdominal aortic aneurysm growth","volume":"65","author":"Golledge","year":"2017","journal-title":"J. Vasc. Surg."},{"issue":"22","key":"10.1016\/j.vph.2026.107610_bb0380","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201700671","article-title":"Thermosensitive hydrogel containing doxycycline exerts inhibitory effects on abdominal aortic aneurysm induced by pancreatic elastase in mice","volume":"6","author":"Yu","year":"2017","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.vph.2026.107610_bb0385","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jss.2014.01.057","article-title":"Inhibition of AAA in a rat model by treatment with ACEI perindopril","volume":"189","author":"Xiong","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.vph.2026.107610_bb0390","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.atherosclerosis.2018.08.004","article-title":"A diet enriched with tree nuts reduces severity of atherosclerosis but not abdominal aneurysm in angiotensin II-infused apolipoprotein e deficient mice","volume":"277","author":"Phie","year":"2018","journal-title":"Atherosclerosis"},{"issue":"7","key":"10.1016\/j.vph.2026.107610_bb0395","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","article-title":"Guidelines for reporting experiments involving animals: the ARRIVE guidelines","volume":"160","author":"McGrath","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2026.107610_bb0400","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c723","article-title":"The quality of reports of randomised trials in 2000 and 2006: comparative study of articles indexed in PubMed","volume":"340","author":"Hopewell","year":"2010","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.vph.2026.107610_bb0405","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5246\/jcps.2024.03.016","article-title":"Enhanced protective effects of naringenin on elastase-induced mouse abdominal aortic aneurysm through nanoliposome deliver","volume":"33","author":"Chen","year":"2024","journal-title":"J. Chin. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.vph.2026.107610_bb0410","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189126000303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189126000303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:34:18Z","timestamp":1786995258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189126000303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":82,"alternative-id":["S1537189126000303"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2026.107610","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of drugs and stem cell therapies on established abdominal aortic aneurysms in mice: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2026.107610","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107610"}}