{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:12:35Z","timestamp":1788581555717,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.vph.2026.107657","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:03:16Z","timestamp":1780718596000},"page":"107657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Genomic and proteogenomic insights into Spontaneous Coronary Artery Dissection (SCAD): A systematic review of emerging multi-omic evidence"],"prefix":"10.1016","volume":"164","author":[{"given":"Alice","family":"Russo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Biondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Donato","family":"Aquaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doralisa","family":"Morrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalinda","family":"Madonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Caterina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.vph.2026.107657_bb0005","doi-asserted-by":"crossref","first-page":"e523","DOI":"10.1161\/CIR.0000000000000564","article-title":"Spontaneous coronary artery dissection: current state of the science: a scientific statement from the American Heart Association","volume":"137","author":"Hayes","year":"2018","journal-title":"Circulation"},{"issue":"36","key":"10.1016\/j.vph.2026.107657_bb0010","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1093\/eurheartj\/ehy080","article-title":"European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection","volume":"39","author":"Adlam","year":"2018","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.vph.2026.107657_bb0015","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/CIRCINTERVENTIONS.114.001760","article-title":"Spontaneous coronary artery dissection: association with predisposing arteriopathies and precipitating stressors and cardiovascular outcomes","volume":"7","author":"Saw","year":"2014","journal-title":"Circ. Cardiovasc. Interv."},{"issue":"1","key":"10.1016\/j.vph.2026.107657_bb0020","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.amjcard.2015.03.039","article-title":"Management and long-term prognosis of spontaneous coronary artery dissection","volume":"116","author":"Lettieri","year":"2015","journal-title":"Am. J. Cardiol."},{"issue":"1","key":"10.1016\/j.vph.2026.107657_bb0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4244\/EIJ-E-23-00023","article-title":"Observational studies play little role in guiding evidence-based medicine: pros and cons","volume":"20","author":"Steg","year":"2024","journal-title":"EuroIntervention"},{"issue":"37","key":"10.1016\/j.vph.2026.107657_bb0030","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.vph.2026.107657_bb0035","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.vph.2026.107657_bb0040","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.vph.2026.107657_bb0045","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1038\/s41467-020-17558-x","article-title":"Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction","volume":"11","author":"Saw","year":"2020","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.vph.2026.107657_bb0050","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/jamacardio.2020.0872","article-title":"Identification of susceptibility loci for spontaneous coronary artery dissection","volume":"5","author":"Turley","year":"2020","journal-title":"JAMA Cardiol."},{"issue":"6","key":"10.1016\/j.vph.2026.107657_bb0055","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/s41588-023-01410-1","article-title":"Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation","volume":"55","author":"Adlam","year":"2023","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.vph.2026.107657_bb0060","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.121.003398","article-title":"Susceptibility locus for pregnancy-associated spontaneous coronary artery dissection","volume":"14","author":"Turley","year":"2021","journal-title":"Circ Genom Precis Med."},{"issue":"6","key":"10.1016\/j.vph.2026.107657_bb0065","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.120.003030","article-title":"Spontaneous coronary artery dissection: insights on rare genetic variation from genome sequencing","volume":"13","author":"Carss","year":"2020","journal-title":"Circ Genom Precis Med."},{"issue":"4","key":"10.1016\/j.vph.2026.107657_bb0070","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.118.002437","article-title":"Rare missense variants in TLN1 are associated with familial and sporadic spontaneous coronary artery dissection","volume":"12","author":"Turley","year":"2019","journal-title":"Circ Genom Precis Med"},{"issue":"4","key":"10.1016\/j.vph.2026.107657_bb0075","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1001\/jamacardio.2022.0001","article-title":"Fibrillar collagen variants in spontaneous coronary artery dissection","volume":"7","author":"Zekavat","year":"2022","journal-title":"JAMA Cardiol."},{"issue":"10","key":"10.1016\/j.vph.2026.107657_bb0080","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/jamacardio.2022.2970","article-title":"Burden of rare genetic variants in spontaneous coronary artery dissection with high-risk features","volume":"7","author":"Wang","year":"2022","journal-title":"JAMA Cardiol."},{"issue":"9","key":"10.1016\/j.vph.2026.107657_bb0085","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/jcdd10090393","article-title":"Identification of rare genetic variants in familial spontaneous coronary artery dissection and evidence for shared biological pathways","volume":"10","author":"Turley","year":"2023","journal-title":"J Cardiovasc Dev Dis."},{"issue":"11","key":"10.1016\/j.vph.2026.107657_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015151","article-title":"Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells","volume":"5","author":"Maioli","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.vph.2026.107657_bb0095","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jacc.2019.04.062","article-title":"Association of TSR1 variants and spontaneous coronary artery dissection","volume":"74","author":"Sun","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.vph.2026.107657_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.874912","article-title":"Genome-wide identification of associations of circulating molecules with spontaneous coronary artery dissection and aortic aneurysm and dissection","volume":"9","author":"Chai","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.vph.2026.107657_bb0105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12964-019-0449-9","article-title":"Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-\u03b2 signalling: implications for PAH vascular remodelling","volume":"17","author":"De la Cuesta","year":"2019","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.vph.2026.107657_bb0110","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.125.005330","article-title":"Genetic association of circulating proteins and gene transcripts with spontaneous coronary artery dissection","volume":"19","author":"Ardissino","year":"2026","journal-title":"Circ Genom Precis Med."},{"issue":"11","key":"10.1016\/j.vph.2026.107657_bb0115","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/CIRCRESAHA.124.325269","article-title":"LRP1 repression by SNAIL results in ECM remodeling in genetic risk for vascular diseases","volume":"135","author":"Liu","year":"2024","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.vph.2026.107657_bb0120","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036525","article-title":"Cross-ancestry associations of spontaneous coronary artery dissection genetic risk with coronary atherosclerosis and migraine headache","volume":"14","author":"Xu","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"8","key":"10.1016\/j.vph.2026.107657_bb0125","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.037921","article-title":"Spontaneous coronary artery dissection and a family history of aortic dissection: a genetic association study","volume":"14","author":"McGrath-Cadell","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.vph.2026.107657_bb0130","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/0003319720946974","article-title":"Spontaneous coronary artery dissection in the Gulf: G-SCAD registry","volume":"72","author":"Daoulah","year":"2021","journal-title":"Angiology"},{"issue":"1","key":"10.1016\/j.vph.2026.107657_bb0135","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12881-020-01058-2","article-title":"The pregnancy-associated spontaneous coronary artery dissection in a young woman with a novel missense mutation in NOTCH1: a case report","volume":"21","author":"Bai","year":"2020","journal-title":"BMC Med. Genet."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189126000777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189126000777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:31:08Z","timestamp":1788579068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189126000777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"alternative-id":["S1537189126000777"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2026.107657","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic and proteogenomic insights into Spontaneous Coronary Artery Dissection (SCAD): A systematic review of emerging multi-omic evidence","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2026.107657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107657"}}