{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T10:35:16Z","timestamp":1792924516819,"version":"4.5.0"},"reference-count":145,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008459","name":"University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.vph.2026.107712","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:57:56Z","timestamp":1792652276000},"page":"107712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Epigenetic regulation of vascular smooth muscle cell plasticity in vascular injury, repair, and aging"],"prefix":"10.1016","volume":"165","author":[{"given":"Xi-Long","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2026.107712_bb0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1146\/annurev-physiol-012110-142315","article-title":"Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease","volume":"74","author":"Alexander","year":"2012","journal-title":"Annu. Rev. Physiol."},{"issue":"4","key":"10.1016\/j.vph.2026.107712_bb0010","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bbagrm.2014.06.004","article-title":"Epigenetic regulation of smooth muscle cell plasticity","volume":"1849","author":"Liu","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3390\/biom16010173","article-title":"A comprehensive review of epigenetic regulation of vascular smooth muscle cells during development and disease","volume":"16","author":"Natali","year":"2026","journal-title":"Biomolecules"},{"issue":"7","key":"10.1016\/j.vph.2026.107712_bb0020","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3390\/biom13071135","article-title":"Epigenetic reader bromodomain-containing protein 4 in aging-related vascular pathologies and diseases: molecular basis, functional relevance, and clinical potential","volume":"13","author":"Zheng","year":"2023","journal-title":"Biomolecules"},{"issue":"7","key":"10.1016\/j.vph.2026.107712_bb0025","doi-asserted-by":"crossref","first-page":"e250","DOI":"10.1161\/ATVBAHA.124.322158","article-title":"Roles of Brd4 in vascular smooth muscle cells: implications for aging and vascular dysfunction","volume":"45","author":"Sun","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0310","doi-asserted-by":"crossref","first-page":"8826","DOI":"10.1038\/s41467-025-63876-3","article-title":"The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity","volume":"16","author":"Li","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.vph.2026.107712_bb0295","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1161\/ATVBAHA.124.322179","article-title":"SUV39H1 regulates KLF4 and chromatin remodeling in smooth muscle cell phenotypic plasticity","volume":"45","author":"Chatterjee","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0305","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/ATVBAHA.124.322048","article-title":"Suv39h1 regulates phenotypic modulation of smooth muscle cells and contributes to vascular injury by repressing HIC1 transcription","volume":"45","author":"Yang","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.vph.2026.107712_bb0315","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/s12276-026-01702-6","article-title":"EHMT2 aggravates vascular remodeling via epigenetic inhibition of GADD45G","volume":"58","author":"Wang","year":"2026","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.vph.2026.107712_bb0320","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/CIRCRESAHA.124.325374","article-title":"Mineral stress drives loss of heterochromatin: an early harbinger of vascular inflammaging and calcification","volume":"136","author":"Ho","year":"2025","journal-title":"Circ. Res."},{"issue":"11","key":"10.1016\/j.vph.2026.107712_bb0450","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1161\/ATVBAHA.121.316600","article-title":"Six shades of vascular smooth muscle cells illuminated by KLF4 (Kr\u00fcppel-like factor 4)","volume":"41","author":"Yap","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.vph.2026.107712_bb0455","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41591-019-0512-5","article-title":"Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis","volume":"25","author":"Wirka","year":"2019","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0460","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nm.3866","article-title":"KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis","volume":"21","author":"Shankman","year":"2015","journal-title":"Nat. Med."},{"issue":"21","key":"10.1016\/j.vph.2026.107712_bb0465","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1161\/CIRCULATIONAHA.120.046672","article-title":"Stem cell pluripotency genes Klf4 and Oct4 regulate complex SMC phenotypic changes critical in late-stage atherosclerotic lesion pathogenesis","volume":"142","author":"Alencar","year":"2020","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.vph.2026.107712_bb0470","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/s43587-025-00889-z","article-title":"Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice","volume":"5","author":"Mazan-Mamczarz","year":"2025","journal-title":"Nat. Aging"},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0480","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/CIRCULATIONAHA.121.057789","article-title":"ZEB2 shapes the epigenetic landscape of atherosclerosis","volume":"145","author":"Cheng","year":"2022","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0485","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1038\/s41467-026-70530-z","article-title":"Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk","volume":"17","author":"Li","year":"2026","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.vph.2026.107712_bb0500","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1093\/cvr\/cvab347","article-title":"Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells","volume":"118","author":"Wang","year":"2022","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0505","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s41588-022-01069-0","article-title":"Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk","volume":"54","author":"Turner","year":"2022","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.vph.2026.107712_bb0475","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1161\/ATVBAHA.122.318135","article-title":"Aortic stress activates an adaptive program in thoracic aortic smooth muscle cells that maintains aortic strength and protects against aneurysm and dissection in mice","volume":"43","author":"Zhang","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"19","key":"10.1016\/j.vph.2026.107712_bb0495","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1016\/j.devcel.2021.09.001","article-title":"H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity","volume":"56","author":"Liu","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.vph.2026.107712_bb0555","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.biomaterials.2017.11.033","article-title":"Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: role of DNA methyltransferase 1","volume":"155","author":"Xie","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.vph.2026.107712_bb0560","first-page":"406","article-title":"Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis","volume":"17","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"issue":"7","key":"10.1016\/j.vph.2026.107712_bb0565","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jbiomech.2009.01.012","article-title":"Histone deacetylases modulate vascular smooth muscle cell migration induced by cyclic mechanical strain","volume":"42","author":"Yan","year":"2009","journal-title":"J. Biomech."},{"key":"10.1016\/j.vph.2026.107712_bb0570","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biocel.2014.01.016","article-title":"The role of SIRT6 in the differentiation of vascular smooth muscle cells in response to cyclic strain","volume":"49","author":"Yao","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0575","doi-asserted-by":"crossref","first-page":"e565","DOI":"10.1161\/ATVBAHA.123.319010","article-title":"Focal adhesion kinase promotes calcification of vascular smooth muscle cells via regulation of histone deacetylase 4 and 5","volume":"45","author":"Tian","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"18","key":"10.1016\/j.vph.2026.107712_bb0030","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1161\/CIRCULATIONAHA.113.002887","article-title":"Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity","volume":"128","author":"Liu","year":"2013","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.vph.2026.107712_bb0035","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1161\/ATVBAHA.125.322645","article-title":"GRK2 orchestrates VSMC phenotypic modulation via DNMT1-mediated DNA methylation reprogramming","volume":"45","author":"Kong","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0040","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1161\/CIRCRESAHA.121.319066","article-title":"FAK activation promotes SMC dedifferentiation via increased DNA methylation in contractile genes","volume":"129","author":"Jeong","year":"2021","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/CIRCULATIONAHA.120.050553","article-title":"TET2 protects against vascular smooth muscle cell apoptosis and intimal thickening in transplant vasculopathy","volume":"144","author":"Ostriker","year":"2021","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.vph.2026.107712_bb0050","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/cvr\/cvaa040","article-title":"Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation","volume":"117","author":"Wang","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0055","article-title":"Epigenetic reprogramming via TET2 prevents medial calcification and restores vascular smooth muscle cell identity","volume":"11","author":"Lee","year":"2026","journal-title":"JACC Basic Transl. Sci."},{"issue":"9","key":"10.1016\/j.vph.2026.107712_bb0060","doi-asserted-by":"crossref","first-page":"e186673","DOI":"10.1172\/JCI186673","article-title":"TET2 suppresses vascular calcification by forming an inhibitory complex with HDAC1\/2 and SNIP1 independent of demethylation","volume":"135","author":"He","year":"2025","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0065","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/ATVBAHA.116.307923","article-title":"The Yin-Yang dynamics of DNA methylation is the key regulator for smooth muscle cell phenotype switch and vascular remodeling","volume":"37","author":"Zhuang","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.vph.2026.107712_bb0690","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1470-2045(09)70003-8","article-title":"Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study","volume":"10","author":"Fenaux","year":"2009","journal-title":"Lancet Oncol."},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0070","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1093\/cvr\/cvad110","article-title":"Epigenetic regulation of vascular smooth muscle cell phenotypic switch and neointimal formation by PRMT5","volume":"119","author":"Zhu","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.vph.2026.107712_bb0075","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1093\/cvr\/cvad080","article-title":"Protein arginine methyltransferase 5-mediated arginine methylation stabilizes Kruppel-like factor 4 to accelerate neointimal formation","volume":"119","author":"Liu","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vph.2026.107712_bb0695","doi-asserted-by":"crossref","DOI":"10.1177\/20406207241275376","article-title":"Phase I\/II study of the clinical activity and safety of GSK3326595 in patients with myeloid neoplasms","volume":"15","author":"Watts","year":"2024","journal-title":"Ther. Adv. Hematol."},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0700","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.annonc.2024.08.2339","article-title":"First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted solid tumors: results from phase I dose exploration","volume":"35","author":"Rodon","year":"2024","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.vph.2026.107712_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114947","article-title":"LSD1 downregulates p21 expression in vascular smooth muscle cells and promotes neointima formation","volume":"198","author":"Yuan","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"36","key":"10.1016\/j.vph.2026.107712_bb0100","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1200\/JCO.19.03250","article-title":"First-in-human phase I study of iadademstat (ORY-1001): a first-in-class lysine-specific histone demethylase 1A inhibitor, in relapsed or refractory acute myeloid leukemia","volume":"38","author":"Salamero","year":"2020","journal-title":"J. Clin. Oncol."},{"issue":"13","key":"10.1016\/j.vph.2026.107712_bb0705","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1182\/bloodadvances.2025018141","article-title":"The lysine-specific demethylase 1 (LSD1) inhibitor bomedemstat in myelofibrosis: results from a phase 1\/2 study","volume":"10","author":"Gill","year":"2026","journal-title":"Blood Adv."},{"issue":"17","key":"10.1016\/j.vph.2026.107712_bb0110","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1111\/bph.14754","article-title":"Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells","volume":"176","author":"Liang","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"5\u20136","key":"10.1016\/j.vph.2026.107712_bb0175","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.vph.2011.07.001","article-title":"Trichostatin A prevents neointimal hyperplasia via activation of Kr\u00fcppel like factor 4","volume":"55","author":"Kee","year":"2011","journal-title":"Vasc. Pharmacol."},{"issue":"11","key":"10.1016\/j.vph.2026.107712_bb0180","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/01.ATV.0000184758.07257.88","article-title":"Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice","volume":"25","author":"Choi","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0185","doi-asserted-by":"crossref","first-page":"538","DOI":"10.5551\/jat.15826","article-title":"Trichostatin A, an HDAC class I\/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase","volume":"20","author":"Azechi","year":"2013","journal-title":"J. Atheroscler. Thromb."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0195","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s41467-018-03394-7","article-title":"An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm","volume":"9","author":"Lino Cardenas","year":"2018","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.vph.2026.107712_bb0200","doi-asserted-by":"crossref","first-page":"e124706","DOI":"10.1172\/jci.insight.124706","article-title":"HDAC9 complex inhibition improves smooth muscle-dependent stenotic vascular disease","volume":"4","author":"Lino Cardenas","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.vph.2026.107712_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10492","article-title":"MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification","volume":"7","author":"Kwon","year":"2016","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.vph.2026.107712_bb0210","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1161\/HYPERTENSIONAHA.113.01843","article-title":"Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells","volume":"63","author":"Usui","year":"2014","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0215","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jacbts.2018.08.010","article-title":"HDAC6 regulates the MRTF-A\/SRF axis and vascular smooth muscle cell plasticity","volume":"3","author":"Zhang","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"issue":"11","key":"10.1016\/j.vph.2026.107712_bb0220","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1161\/ATVBAHA.111.230888","article-title":"Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear \u03b2-catenin translocation","volume":"31","author":"Zhou","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.vph.2026.107712_bb0225","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.apsb.2023.11.012","article-title":"The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis","volume":"14","author":"Zhong","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"11","key":"10.1016\/j.vph.2026.107712_bb0235","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.ebiom.2015.09.045","article-title":"BET bromodomain blockade mitigates intimal hyperplasia in rat carotid arteries","volume":"2","author":"Wang","year":"2015","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.vph.2026.107712_bb0240","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/cvr\/cvaa121","article-title":"BET bromodomain-containing epigenetic reader proteins regulate vascular smooth muscle cell proliferation and neointima formation","volume":"117","author":"Dutzmann","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"16","key":"10.1016\/j.vph.2026.107712_bb0255","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1001\/jama.2020.3308","article-title":"Effect of apabetalone added to standard therapy on major adverse cardiovascular events in patients with recent acute coronary syndrome and type 2 diabetes: a randomized clinical trial","volume":"323","author":"Ray","year":"2020","journal-title":"Jama"},{"issue":"2","key":"10.1016\/j.vph.2026.107712_bb0710","doi-asserted-by":"crossref","DOI":"10.1093\/jncics\/pkz093","article-title":"Phase 1 study of molibresib (GSK525762), a bromodomain and extra-terminal domain protein inhibitor, in NUT carcinoma and other solid tumors","volume":"4","author":"Piha-Paul","year":"2020","journal-title":"JNCI Cancer Spectr."},{"issue":"9","key":"10.1016\/j.vph.2026.107712_bb0270","doi-asserted-by":"crossref","first-page":"e164862","DOI":"10.1172\/jci.insight.164862","article-title":"Redistribution of the chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and vascular fibrosis","volume":"8","author":"Jolly","year":"2023","journal-title":"JCI Insight"},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0290","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1158\/1078-0432.CCR-24-3790","article-title":"A phase I study of FHD-286, a dual BRG1\/BRM (SMARCA4\/SMARCA2) inhibitor, in patients with advanced myeloid malignancies","volume":"31","author":"DiNardo","year":"2025","journal-title":"Clin. Cancer Res."},{"issue":"3","key":"10.1016\/j.vph.2026.107712_bb0300","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/cvr\/cvx236","article-title":"Cbx3 inhibits vascular smooth muscle cell proliferation, migration, and neointima formation","volume":"114","author":"Zhang","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0115","first-page":"C1721","article-title":"NEAT1 regulates VSMC differentiation and calcification in as long noncoding RNA NEAT1 enhances phenotypic and osteogenic switching of vascular smooth muscle cells in atherosclerosis via scaffolding EZH2","volume":"326","author":"Yin","year":"2024","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"4","key":"10.1016\/j.vph.2026.107712_bb0350","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCRESAHA.108.185363","article-title":"A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia","volume":"104","author":"Liu","year":"2009","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.vph.2026.107712_bb0355","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1161\/ATVBAHA.116.307879","article-title":"MYOSLID is a novel serum response factor-dependent long noncoding RNA that amplifies the vascular smooth muscle differentiation program","volume":"36","author":"Zhao","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"23","key":"10.1016\/j.vph.2026.107712_bb0360","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1161\/CIRCULATIONAHA.121.055949","article-title":"CARMN is an evolutionarily conserved smooth muscle cell-specific LncRNA that maintains contractile phenotype by binding myocardin","volume":"144","author":"Dong","year":"2021","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.vph.2026.107712_bb0365","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1161\/CIRCRESAHA.120.318688","article-title":"CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice","volume":"128","author":"Vacante","year":"2021","journal-title":"Circ. Res."},{"issue":"37","key":"10.1016\/j.vph.2026.107712_bb0370","doi-asserted-by":"crossref","first-page":"E8660","DOI":"10.1073\/pnas.1803725115","article-title":"Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells","volume":"115","author":"Ahmed","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"18","key":"10.1016\/j.vph.2026.107712_bb0715","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1101\/gad.1842409","article-title":"MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury","volume":"23","author":"Xin","year":"2009","journal-title":"Genes Dev."},{"issue":"11","key":"10.1016\/j.vph.2026.107712_bb0720","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41416-020-0802-1","article-title":"Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours","volume":"122","author":"Hong","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0725","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1124\/dmd.121.000418","article-title":"Adverse drug reactions and toxicity of the food and drug administration-approved antisense oligonucleotide drugs","volume":"50","author":"Alhamadani","year":"2022","journal-title":"Drug Metab. Dispos."},{"issue":"6489","key":"10.1016\/j.vph.2026.107712_bb0585","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1126\/science.aaz8455","article-title":"Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation","volume":"368","author":"Gilan","year":"2020","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.vph.2026.107712_bb0655","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/13543776.2024.2327300","article-title":"Successes and challenges in the development of BD1-selective BET inhibitors: a patent review","volume":"34","author":"Viviano","year":"2024","journal-title":"Expert Opin. Ther. Pat."},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0660","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/s41416-020-01077-z","article-title":"First-in-human phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours","volume":"123","author":"Ameratunga","year":"2020","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0260","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12933-020-01199-x","article-title":"Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study","volume":"20","author":"Nicholls","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0530","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/ATVBAHA.123.319909","article-title":"FAM222A, part of the BET-regulated basal endothelial transcriptome, is a novel determinant of endothelial biology and angiogenesis-brief report","volume":"44","author":"Tzani","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"49","key":"10.1016\/j.vph.2026.107712_bb0605","doi-asserted-by":"crossref","first-page":"19754","DOI":"10.1073\/pnas.1310658110","article-title":"RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain","volume":"110","author":"Picaud","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vph.2026.107712_bb0610","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.atherosclerosis.2022.11.015","article-title":"Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells","volume":"364","author":"Wasiak","year":"2023","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0615","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.atherosclerosis.2014.06.008","article-title":"A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice","volume":"236","author":"Jahagirdar","year":"2014","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0640","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13148-019-0696-z","article-title":"Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism","volume":"11","author":"Tsujikawa","year":"2019","journal-title":"Clin. Epigenetics"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0265","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40256-015-0146-z","article-title":"Effect of the BET protein inhibitor, RVX-208, on progression of coronary atherosclerosis: results of the phase 2b, randomized, double-blind, multicenter, ASSURE trial","volume":"16","author":"Nicholls","year":"2016","journal-title":"Am. J. Cardiovasc. Drugs"},{"issue":"17","key":"10.1016\/j.vph.2026.107712_bb0590","doi-asserted-by":"crossref","first-page":"9070","DOI":"10.1021\/acs.jmedchem.0c00605","article-title":"Design and synthesis of a highly selective and in vivo-capable inhibitor of the second bromodomain of the bromodomain and extra terminal domain family of proteins","volume":"63","author":"Preston","year":"2020","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.vph.2026.107712_bb0595","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1021\/acs.jmedchem.0c00628","article-title":"Discovery of N-ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET bromodomain inhibitor with selectivity for the second bromodomain","volume":"63","author":"Sheppard","year":"2020","journal-title":"J. Med. Chem."},{"issue":"7794","key":"10.1016\/j.vph.2026.107712_bb0600","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41586-020-1930-8","article-title":"Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer","volume":"578","author":"Faivre","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0665","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13148-020-00943-0","article-title":"BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes","volume":"12","author":"Wasiak","year":"2020","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.vph.2026.107712_bb0670","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9397109","article-title":"Epigenetic modulation by apabetalone counters cytokine-driven acute phase response in vitro, in mice and in patients with cardiovascular disease","volume":"2020","author":"Wasiak","year":"2020","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.vph.2026.107712_bb0675","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.atherosclerosis.2018.11.002","article-title":"Apabetalone downregulates factors and pathways associated with vascular calcification","volume":"280","author":"Gilham","year":"2019","journal-title":"Atherosclerosis"},{"issue":"7","key":"10.1016\/j.vph.2026.107712_bb0680","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1164\/rccm.201812-2275OC","article-title":"Multicenter preclinical validation of BET inhibition for the treatment of pulmonary arterial hypertension","volume":"200","author":"Van der Feen","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.vph.2026.107712_bb0685","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.atherosclerosis.2016.01.036","article-title":"RVX-208, a BET-inhibitor for treating atherosclerotic cardiovascular disease, raises ApoA-I\/HDL and represses pathways that contribute to cardiovascular disease","volume":"247","author":"Gilham","year":"2016","journal-title":"Atherosclerosis"},{"issue":"16","key":"10.1016\/j.vph.2026.107712_bb0580","doi-asserted-by":"crossref","first-page":"8074","DOI":"10.3390\/ijms26168074","article-title":"BRD4 mediates transforming growth factor-\u03b2-induced smooth muscle cell differentiation from mesenchymal progenitor cells","volume":"26","author":"Olajuyin","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0620","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tips.2025.09.006","article-title":"Targeting BRD4 bromodomains and beyond: exploring new therapeutic frontiers","volume":"47","author":"Zhang","year":"2026","journal-title":"Trends Pharmacol. Sci."},{"issue":"26","key":"10.1016\/j.vph.2026.107712_bb0625","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1073\/pnas.1521738113","article-title":"PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer","volume":"113","author":"Raina","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6241","key":"10.1016\/j.vph.2026.107712_bb0630","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.aab1433","article-title":"Drug development. Phthalimide conjugation as a strategy for in vivo target protein degradation","volume":"348","author":"Winter","year":"2015","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0635","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41392-024-02004-x","article-title":"Targeted protein degradation: advances in drug discovery and clinical practice","volume":"9","author":"Zhong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0645","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12951-026-04036-7","article-title":"Design of RGD-functionalized GSH-responsive pegylated polymeric protacs for selective BRD4 degradation and EndMT-driven cardiac fibrosis inhibition","volume":"24","author":"Bi","year":"2026","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0650","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12974-022-02533-8","article-title":"Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity","volume":"19","author":"Liu","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0085","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12711","article-title":"Inhibition of lysine-specific demethylase 1A suppresses neointimal hyperplasia by targeting bone morphogenetic protein 2 and mediating vascular smooth muscle cell phenotype","volume":"53","author":"Zhang","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.vph.2026.107712_bb0090","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ydbio.2023.06.012","article-title":"LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition","volume":"501","author":"Tamaoki","year":"2023","journal-title":"Dev. Biol."},{"issue":"45","key":"10.1016\/j.vph.2026.107712_bb0095","doi-asserted-by":"crossref","first-page":"13922","DOI":"10.1073\/pnas.1517326112","article-title":"LSD1\/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2","volume":"112","author":"Takeuchi","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"39","key":"10.1016\/j.vph.2026.107712_bb0105","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1038\/onc.2017.158","article-title":"LSD1 demethylates HIF1\u03b1 to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis","volume":"36","author":"Lee","year":"2017","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.vph.2026.107712_bb0120","doi-asserted-by":"crossref","first-page":"e97493","DOI":"10.1172\/jci.insight.97493","article-title":"Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm","volume":"3","author":"Lino Cardenas","year":"2018","journal-title":"JCI Insight"},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0125","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1161\/CIRCULATIONAHA.123.063332","article-title":"Epigenetic induction of smooth muscle cell phenotypic alterations in aortic aneurysms and dissections","volume":"148","author":"Chakraborty","year":"2023","journal-title":"Circulation"},{"issue":"46","key":"10.1016\/j.vph.2026.107712_bb0130","doi-asserted-by":"crossref","first-page":"38495","DOI":"10.1074\/jbc.M112.353649","article-title":"Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes","volume":"287","author":"Cao","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0135","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1128\/MCB.25.1.364-376.2005","article-title":"Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin","volume":"25","author":"Cao","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"23","key":"10.1016\/j.vph.2026.107712_bb0140","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1161\/CIRCULATIONAHA.121.057599","article-title":"Histone acetyltransferases p300 and CBP coordinate distinct chromatin remodeling programs in vascular smooth muscle plasticity","volume":"145","author":"Chakraborty","year":"2022","journal-title":"Circulation"},{"issue":"7674","key":"10.1016\/j.vph.2026.107712_bb0145","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nature24028","article-title":"Discovery of a selective catalytic p300\/CBP inhibitor that targets lineage-specific tumours","volume":"550","author":"Lasko","year":"2017","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0150","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1016\/j.ccell.2023.11.001","article-title":"Therapeutic targeting of EP300\/CBP by bromodomain inhibition in hematologic malignancies","volume":"41","author":"Nicosia","year":"2023","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.vph.2026.107712_bb0155","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S1470-2045(16)30375-8","article-title":"Ricolinostat plus lenalidomide, and dexamethasone in relapsed or refractory multiple myeloma: a multicentre phase 1b trial","volume":"17","author":"Yee","year":"2016","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.vph.2026.107712_bb0160","article-title":"Phase Ib study of the histone deacetylase 6 inhibitor citarinostat in combination with paclitaxel in patients with advanced solid tumors","volume":"11","author":"Gordon","year":"2021","journal-title":"Front. Oncol."},{"issue":"13","key":"10.1016\/j.vph.2026.107712_bb0165","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1158\/1078-0432.CCR-21-0238","article-title":"Wistuba, II, preclinical development and first-in-human study of KA2507, a selective and potent inhibitor of histone deacetylase 6, for patients with refractory solid tumors","volume":"27","author":"Tsimberidou","year":"2021","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.vph.2026.107712_bb0170","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ana.24260","article-title":"Epigenetic therapy for Friedreich ataxia","volume":"76","author":"Soragni","year":"2014","journal-title":"Ann. Neurol."},{"issue":"8","key":"10.1016\/j.vph.2026.107712_bb0190","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1517\/13543784.10.8.1571","article-title":"Trichostatin A, an inhibitor of histone deacetylase, inhibits hypoxia-induced angiogenesis","volume":"10","author":"Williams","year":"2001","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.vph.2026.107712_bb0230","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jvssci.2021.11.002","article-title":"Vascular smooth muscle cell phenotype switching in carotid atherosclerosis","volume":"3","author":"Chou","year":"2022","journal-title":"JVS Vasc. Sci."},{"issue":"11","key":"10.1016\/j.vph.2026.107712_bb0245","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.3390\/cells12111461","article-title":"Impact of short-term (+)-JQ1 exposure on mouse aorta: unanticipated inhibition of smooth muscle contractility","volume":"12","author":"Yan","year":"2023","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.vph.2026.107712_bb0250","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1093\/nar\/gkad1175","article-title":"A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR","volume":"52","author":"Huber","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"21","key":"10.1016\/j.vph.2026.107712_bb0275","doi-asserted-by":"crossref","first-page":"e158309","DOI":"10.1172\/JCI158309","article-title":"BAF60c prevents abdominal aortic aneurysm formation through epigenetic control of vascular smooth muscle cell homeostasis","volume":"132","author":"Zhao","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.vph.2026.107712_bb0280","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/ATVBAHA.120.314955","article-title":"BAF60a deficiency in vascular smooth muscle cells prevents abdominal aortic aneurysm by reducing inflammation and extracellular matrix degradation","volume":"40","author":"Chang","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0285","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1161\/ATVBAHA.109.187229","article-title":"The SWI\/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression","volume":"29","author":"Zhou","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.vph.2026.107712_bb0325","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1139\/o11-052","article-title":"CTCF, cohesin, and histone variants: connecting the genome","volume":"89","author":"Millau","year":"2011","journal-title":"Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.vph.2026.107712_bb0330","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tcb.2025.08.002","article-title":"Physiological aging in three dimensions","volume":"36","author":"Ma","year":"2026","journal-title":"Trends Cell Biol."},{"issue":"7256","key":"10.1016\/j.vph.2026.107712_bb0335","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nature08195","article-title":"miR-145 and miR-143 regulate smooth muscle cell fate and plasticity","volume":"460","author":"Cordes","year":"2009","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.vph.2026.107712_bb0340","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/jcp.22230","article-title":"MicroRNA-1 inhibits myocardin-induced contractility of human vascular smooth muscle cells","volume":"225","author":"Jiang","year":"2010","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.vph.2026.107712_bb0345","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1161\/ATVBAHA.110.218149","article-title":"Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation","volume":"31","author":"Chen","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0375","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41392-022-00943-x","article-title":"An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1(+) vascular smooth muscle subtype involved in abdominal aortic aneurysm formation","volume":"7","author":"Yu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0380","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis","volume":"379","author":"Adams","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"16","key":"10.1016\/j.vph.2026.107712_bb0385","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1056\/NEJMoa1912387","article-title":"Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol","volume":"382","author":"Ray","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"18","key":"10.1016\/j.vph.2026.107712_bb0390","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa1702752","article-title":"Nusinersen versus sham control in infantile-onset spinal muscular atrophy","volume":"377","author":"Finkel","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"6327","key":"10.1016\/j.vph.2026.107712_bb0395","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice","volume":"355","author":"Fuster","year":"2017","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.vph.2026.107712_bb0400","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aee5560","article-title":"EZH2 inhibition via GSK-126 mitigates EndMT and atherosclerosis in diabetes: a translational epigenetic approach","volume":"12","author":"Aziz","year":"2026","journal-title":"Sci. Adv."},{"issue":"19","key":"10.1016\/j.vph.2026.107712_bb0405","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1161\/CIRCULATIONAHA.124.072384","article-title":"Ezh2 shapes T cell plasticity to drive atherosclerosis","volume":"151","author":"Bonfiglio","year":"2025","journal-title":"Circulation"},{"issue":"5930","key":"10.1016\/j.vph.2026.107712_bb0410","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.1164097","article-title":"ATP-citrate lyase links cellular metabolism to histone acetylation","volume":"324","author":"Wellen","year":"2009","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0415","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2012.06.001","article-title":"Metabolic regulation of epigenetics","volume":"16","author":"Lu","year":"2012","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0420","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1101\/gad.191056.112","article-title":"Inhibition of \u03b1-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors","volume":"26","author":"Xiao","year":"2012","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0425","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41467-018-03421-7","article-title":"Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults","volume":"9","author":"Martens","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0430","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1038\/s41598-023-29787-3","article-title":"Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial","volume":"13","author":"Katayoshi","year":"2023","journal-title":"Sci. Rep."},{"issue":"26","key":"10.1016\/j.vph.2026.107712_bb0435","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1073\/pnas.0803623105","article-title":"Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes","volume":"105","author":"Villeneuve","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.vph.2026.107712_bb0440","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1161\/CIRCULATIONAHA.112.124404","article-title":"Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis","volume":"127","author":"Gorenne","year":"2013","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.vph.2026.107712_bb0445","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1161\/CIRCRESAHA.116.310022","article-title":"Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aortic aneurysm disease","volume":"120","author":"Watson","year":"2017","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.vph.2026.107712_bb0490","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/CIRCRESAHA.112.269811","article-title":"Cooperative binding of KLF4, pELK-1, and HDAC2 to a G\/C repressor element in the SM22\u03b1 promoter mediates transcriptional silencing during SMC phenotypic switching in vivo","volume":"111","author":"Salmon","year":"2012","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0510","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s44161-024-00582-1","article-title":"Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis","volume":"4","author":"Bleckwehl","year":"2025","journal-title":"Nat. Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.vph.2026.107712_bb0515","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/s42003-022-04255-2","article-title":"Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1\u03b2\/STAT3 signaling","volume":"5","author":"Xue","year":"2022","journal-title":"Commun. Biol."},{"issue":"8","key":"10.1016\/j.vph.2026.107712_bb0520","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2017.12.037","article-title":"Tet2-mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1\u03b2\/NLRP3 inflammasome","volume":"71","author":"Sano","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"43","key":"10.1016\/j.vph.2026.107712_bb0525","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1093\/eurheartj\/ehae546","article-title":"Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis","volume":"45","author":"Zuriaga","year":"2024","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.vph.2026.107712_bb0535","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.celrep.2015.09.049","article-title":"Matrix remodeling promotes pulmonary hypertension through feedback mechanoactivation of the YAP\/TAZ-miR-130\/301 circuit","volume":"13","author":"Bertero","year":"2015","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.vph.2026.107712_bb0540","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1172\/JCI86387","article-title":"Vascular stiffness mechanoactivates YAP\/TAZ-dependent glutaminolysis to drive pulmonary hypertension","volume":"126","author":"Bertero","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.vph.2026.107712_bb0545","first-page":"L628","article-title":"Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP\/TAZ-mediated repression of cyclooxygenase-2","volume":"313","author":"Dieffenbach","year":"2017","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"issue":"4","key":"10.1016\/j.vph.2026.107712_bb0550","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/eurheartj\/ehad534","article-title":"The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture","volume":"45","author":"Luo","year":"2024","journal-title":"Eur. Heart J."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189126001321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189126001321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T10:12:10Z","timestamp":1792923130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189126001321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":145,"alternative-id":["S1537189126001321"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2026.107712","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic regulation of vascular smooth muscle cell plasticity in vascular injury, repair, and aging","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2026.107712","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107712"}}