{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:11:38Z","timestamp":1789938698825,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.watres.2006.03.026","type":"journal-article","created":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T11:19:17Z","timestamp":1147346357000},"page":"1957-1964","source":"Crossref","is-referenced-by-count":28,"title":["The combined toxic effects of nonpolar narcotic chemicals to Pseudokirchneriella subcapitata"],"prefix":"10.1016","volume":"40","author":[{"given":"Shih-Hung","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Pei","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.watres.2006.03.026_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1382-6689(98)00048-9","article-title":"Structure\u2013toxicity relationships for selected halogenated aliphatic chemicals","volume":"7","author":"Akers","year":"1999","journal-title":"Environ. Toxicol. Pharmacol"},{"key":"10.1016\/j.watres.2006.03.026_bib2","unstructured":"American Society for Testing and Materials (ASTM), 1994. Standard guide for conducting static 96h toxicity tests with microalgae. Annual Book of ASTM Standards. ASTM E1218-90, Philadelphia, PA."},{"key":"10.1016\/j.watres.2006.03.026_bib3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","article-title":"The toxicity of poisons applied jointly","volume":"26","author":"Bliss","year":"1939","journal-title":"Ann. Appl. Biol."},{"key":"10.1016\/j.watres.2006.03.026_bib4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF02986534","article-title":"Toxicity testing of highly volatile chemicals with green algae\u2014a new assay","volume":"1","author":"Brack","year":"1994","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.watres.2006.03.026_bib5","first-page":"181","article-title":"Introduction: structural properties for determining mechanisms of toxic action","volume":"87","author":"Bradbury","year":"1990","journal-title":"Environ. Health Persp."},{"key":"10.1016\/j.watres.2006.03.026_bib6","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0166-445X(85)90026-8","article-title":"Acute toxicity of organic chemical mixtures to the fathead minnow","volume":"6","author":"Broderius","year":"1985","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.watres.2006.03.026_bib7","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/etc.5620140920","article-title":"Use of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals","volume":"14","author":"Broderius","year":"1995","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.watres.2006.03.026_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/tox.2530100204","article-title":"Toxicity of binary mixtures of organic chemicals","volume":"10","author":"Chen","year":"1995","journal-title":"Enviro. Toxicol. Water Qual."},{"key":"10.1016\/j.watres.2006.03.026_bib9","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/etc.5620160701","article-title":"Optimization and performance evaluation of the continuous algal toxicity test","volume":"16","author":"Chen","year":"1997","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.watres.2006.03.026_bib10","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1897\/04-147R.1","article-title":"Individual and combined toxicity of nitriles and aldehydes to Raphidocelis subcapitata","volume":"24","author":"Chen","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.watres.2006.03.026_bib11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2307\/2531291","article-title":"A general noninteractive multiple toxicity model including probit, logit, and Weibull transformations","volume":"41","author":"Christensen","year":"1985","journal-title":"Biometrics"},{"key":"10.1016\/j.watres.2006.03.026_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0048-9697(97)00179-4","article-title":"Validation of Vibrio fisheri acute toxicity data: mechanism of action-based QSARs for non-polar narcotics and polar narcotic phenols","volume":"204","author":"Cronin","year":"1997","journal-title":"Sci Total. Environ."},{"key":"10.1016\/j.watres.2006.03.026_bib13","unstructured":"European Centre for Ecotoxicology and Toxicology of Chemicals (ECETC), 1996. Aquatic toxicity testing of sparingly soluble, volatile and unstable substances. Monograph 26. Brussels, Belgium."},{"key":"10.1016\/j.watres.2006.03.026_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1289\/ehp.9087199","article-title":"Mechanisms of general anesthesia","volume":"87","author":"Franks","year":"1990","journal-title":"Environ. Health Persp."},{"key":"10.1016\/j.watres.2006.03.026_bib15","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0045-6535(81)90182-X","article-title":"Testing toxicity of volatile substances with algae","volume":"10","author":"Galassi","year":"1981","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2006.03.026_bib16","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1897\/1551-5028(1998)017<1917:COTAMO>2.3.CO;2","article-title":"Comparison of toxicities and mechanism of n-alkanols in bioluminescence (Mictrotox) bioassay","volume":"17","author":"Gustavson","year":"1998","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.watres.2006.03.026_bib17","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/0045-6535(96)00059-8","article-title":"Algal toxicity tests with volatile and hazardous compounds in air-tight test flasks with CO2 enriched headspace","volume":"32","author":"Halling-S\u00f8rensen","year":"1996","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2006.03.026_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0166-445X(90)90020-P","article-title":"Impact of volatile aromatic hydrocarbons, alone and in combination, on growth of the freshwater alga Selenastrum capricornutum","volume":"18","author":"Herman","year":"1990","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.watres.2006.03.026_bib19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/0147-6513(82)90020-3","article-title":"Joint toxicity of mixtures of 8 and 24 chemicals to the guppy","volume":"6","author":"Hermens","year":"1982","journal-title":"Ecotoxicol Environ Safety"},{"key":"10.1016\/j.watres.2006.03.026_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2307\/2527657","article-title":"A unified theory for quantal responses to mixtures of drugs: non-interactive action","volume":"15","author":"Hewlett","year":"1959","journal-title":"Biometrics"},{"key":"10.1016\/j.watres.2006.03.026_bib21","unstructured":"International Organization for Standardization (ISO), 1987. Water quality\u2014Algal growth inhibition test. Draft International Standard ISO\/DIS 8692. Geneva, Switzerland."},{"key":"10.1016\/j.watres.2006.03.026_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0048-9697(91)90204-R","article-title":"Regression and cluster analysis of the acute toxicity of 267 chemicals to six species of biota and the octanol\/water parition coefficient","volume":"109\/110","author":"Kaiser","year":"1991","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2006.03.026_bib23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0300-483X(81)90130-X","article-title":"QSAR in fish toxicity studies: relationship for 50 industrial pollutants","volume":"19","author":"Konemann","year":"1981","journal-title":"Toxicology"},{"key":"10.1016\/j.watres.2006.03.026_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0098-8472(98)00016-1","article-title":"Molecular structure and biochemical toxicity of four halogeno-benzenes on the unicellular green alga Selenastrum capricornutum","volume":"40","author":"Kong","year":"1998","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.watres.2006.03.026_bib25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s001289900066","article-title":"Toxicity QSAR of substituted benzenes to yeast Saccharomyces cerevisiae","volume":"56","author":"Liao","year":"1996","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.watres.2006.03.026_bib26","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/BF00129963","article-title":"Patterns of toxicity behavior in different types of microbial cultures","volume":"18","author":"Lin","year":"1996","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.watres.2006.03.026_bib27","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.watres.2005.02.015","article-title":"A novel algal toxicity testing technique for assessing the toxicity of both metallic and organic toxicants","volume":"39","author":"Lin","year":"2005","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2006.03.026_bib28","series-title":"Toxicological Chemistry","author":"Manaham","year":"1992"},{"key":"10.1016\/j.watres.2006.03.026_bib29","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/etc.5620191022","article-title":"Algal growth inhibition test in filled, closed bottles for volatile and sorptive materials","volume":"19","author":"Mayer","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.watres.2006.03.026_bib30","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/etc.5620110716","article-title":"Toxicokinetic modeling of mixtures of organic chemicals","volume":"11","author":"McCarty","year":"1992","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.watres.2006.03.026_bib31","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1021\/jm00300a040","article-title":"On the parabolic relationship between potency and hydrophobicity","volume":"13","author":"McFarland","year":"1970","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.watres.2006.03.026_bib32","unstructured":"Organization for Economic Cooperation and Development (OECD), 1984. Guideline for Testing Chemicals, No. 201. Alga growth inhibition test. Paris, France."},{"key":"10.1016\/j.watres.2006.03.026_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2307\/2528279","article-title":"A comparison of two approaches to the construction of models for quantal responses to mixtures of drugs","volume":"23","author":"Plackett","year":"1967","journal-title":"Biometrics"},{"key":"10.1016\/j.watres.2006.03.026_bib34","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0043-1354(02)00518-3","article-title":"Use of multidimensional scaling in the selection of wastewater toxicity test battery components","volume":"37","author":"Ren","year":"2003","journal-title":"Water Res"},{"key":"10.1016\/j.watres.2006.03.026_bib35","series-title":"Comparative QSAR","first-page":"51","article-title":"QSAR in aquatic toxicology: a mechanism of action approach comparing toxic potency to Pimephales promelas, Tetrahymena pyriformis, and Vibrio fischeri","author":"Schultz","year":"1998"},{"key":"10.1016\/j.watres.2006.03.026_bib36","unstructured":"United States Environmental Protection Agency (US EPA), 1996. Ecological Effect Test Guidelines, OPPTS 850.5400. Algal Toxicity, Tiers I and II."},{"key":"10.1016\/j.watres.2006.03.026_bib37","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/eesa.1996.0105","article-title":"Use of the lethal body burden in the evaluation of mixture toxicity","volume":"35","author":"Van","year":"1996","journal-title":"Ecotoxicol Environ. Safety"},{"key":"10.1016\/j.watres.2006.03.026_bib38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0166-445X(88)90018-5","article-title":"Quantitative structure activity relationships and mixture toxicity studies of alcohols and chlorohydrocarbons","volume":"12","author":"Wolf","year":"1988","journal-title":"Aquat. Toxicol."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135406001746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135406001746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T15:23:55Z","timestamp":1547652235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135406001746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0043135406001746"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2006.03.026","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}