{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:55:33Z","timestamp":1791176133512,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.watres.2007.05.001","type":"journal-article","created":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T09:33:38Z","timestamp":1178616818000},"page":"4177-4185","source":"Crossref","is-referenced-by-count":207,"title":["The role of extracellular polymeric substances in the toxicity response of activated sludge bacteria to chemical toxins"],"prefix":"10.1016","volume":"41","author":[{"given":"In\u00eas D.S.","family":"Henriques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy G.","family":"Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.watres.2007.05.001_bib1","unstructured":"American Public Health Association, American Water Works Association, Water Environment Federation, 1998. Standard Methods for the Examination of Water and Wastewater, 20th ed. Washington, DC."},{"key":"10.1016\/j.watres.2007.05.001_bib2","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/0043-1354(93)90107-S","article-title":"Physical and chemical properties of activated sludge floc","volume":"27","author":"Andreadakis","year":"1993","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2007.05.001_bib3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1006\/eesa.1999.1803","article-title":"Bioavailability, biodegradation, and acclimation of Tetrahymena pyriformis to 1-octanol","volume":"44","author":"Bearden","year":"1999","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.watres.2007.05.001_bib4","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/S0043-1354(99)00431-5","article-title":"Activated sludge flocculation: on-line determination of floc size and the effect of shear","volume":"34","author":"Biggs","year":"2000","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2007.05.001_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2166\/wst.2003.0612","article-title":"Modeling the effect of shear history on activated sludge flocculation","volume":"47","author":"Biggs","year":"2003","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.watres.2007.05.001_bib6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0003-2697(79)90690-0","article-title":"Assay for nanogram quantities of DNA in cellular homogenates","volume":"92","author":"Brunk","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.watres.2007.05.001_bib7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev.mi.49.100195.003431","article-title":"Microbial Biofilms","volume":"49","author":"Costerton","year":"1995","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.watres.2007.05.001_bib8","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.watres.2007.05.001_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2166\/wst.1998.0789","article-title":"Chemical description of extracellular polymers: implication on activated sludge floc structure","volume":"38","author":"Dignac","year":"1998","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.watres.2007.05.001_bib10","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Colorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Anal. Chem."},{"key":"10.1016\/j.watres.2007.05.001_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2166\/wst.1998.0664","article-title":"The relationship between the structure of activated sludge flocs and the sorption of hydrophobic pollutants","volume":"37","author":"Finlayson","year":"1998","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.watres.2007.05.001_bib12","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s002530050481","article-title":"Enzymatic activity in the activated sludge floc matrix","volume":"43","author":"Fr\u00f8lund","year":"1995","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.watres.2007.05.001_bib13","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/0043-1354(95)00323-1","article-title":"Extraction of extracellular polymers from activated sludge using a cation exchange resin","volume":"30","author":"Fr\u00f8lund","year":"1996","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2007.05.001_bib14","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.chemosphere.2004.10.028","article-title":"Comparison of the complexation potential of extracellular polymeric substances (EPS) extracted from activated sludges and produced by pure bacteria strains, for cadmium, lead and nickel","volume":"59","author":"Guibaud","year":"2005","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2007.05.001_bib15","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1016\/j.watres.2005.04.046","article-title":"The impact of floc size on respiration inhibition by soluble toxicants\u2014a comparative investigation","volume":"39","author":"Henriques","year":"2005","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2007.05.001_bib16","doi-asserted-by":"crossref","unstructured":"Henriques, I.D.S., Kelly, R.T., Dauphinais, J.L., Love, N.G., 2007. Activated sludge inhibition by chemical stressors: a comprehensive study. Water Environ. Res. 79, in press.","DOI":"10.2175\/106143007X156709"},{"key":"10.1016\/j.watres.2007.05.001_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2175\/106143097X125371","article-title":"The effect of cations on the settling and dewatering of activated sludges: laboratory results","volume":"69","author":"Higgins","year":"1997","journal-title":"Water Environ. Res."},{"key":"10.1016\/j.watres.2007.05.001_bib18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1061\/(ASCE)0733-9372(1997)123:5(479)","article-title":"Characterization of exocellular protein and its role in bioflocculation","volume":"123","author":"Higgins","year":"1997","journal-title":"J. Environ. Eng. ASCE"},{"key":"10.1016\/j.watres.2007.05.001_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2166\/wst.2001.0336","article-title":"Effect of heavy metals (Cu, Pb, and Ni) on the composition of EPS in biofilms","volume":"43","author":"Jang","year":"2001","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.watres.2007.05.001_bib20","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/0043-1354(94)00350-G","article-title":"Chemical and structural (2D) linkage between bacteria within activated sludge flocs","volume":"29","author":"Jorand","year":"1995","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2007.05.001_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2166\/wst.1998.0652","article-title":"Hydrophobic\/hydrophilic properties of activated sludge exopolymeric substances","volume":"37","author":"Jorand","year":"1998","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.watres.2007.05.001_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1046\/j.1462-2920.2003.00394.x","article-title":"Ecology of mixed biofilms subjected daily to a chlorinated alkaline solution: spatial distribution of bacterial species suggests a protective effect of one species to another","volume":"5","author":"Leriche","year":"2003","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.watres.2007.05.001_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0043-1354(00)00277-3","article-title":"Surface properties of sludge and their role in bioflocculation and settleability","volume":"35","author":"Liao","year":"2001","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2007.05.001_bib24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2166\/wst.2002.0512","article-title":"Effect of solids retention time on floc structure","volume":"46","author":"Liss","year":"2002","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.watres.2007.05.001_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2166\/wst.2001.0340","article-title":"Adsorption of heavy metals by EPS of activated sludge","volume":"43","author":"Liu","year":"2001","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.watres.2007.05.001_bib26","unstructured":"Love, N.G., Henriques, I.D.S., Kelly, R.T., 2005. Upset early warning systems for biological treatment processes\u2014source and effect relationships. Report No. 01-CTS-2, Water Environment Research Foundation. Alexandria, VA."},{"key":"10.1016\/j.watres.2007.05.001_bib27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.watres.2007.05.001_bib28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0966-842X(00)01913-2","article-title":"Mechanisms of biofilm resistance to antimicrobial agents","volume":"9","author":"Mah","year":"2001","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.watres.2007.05.001_bib29","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.watres.2004.12.027","article-title":"Activated sludge deflocculation under temperature upshifts from 30 to 45\u00b0C","volume":"39","author":"Morgan-Sagastume","year":"2005","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2007.05.001_bib30","unstructured":"Muller, C.D., 2001. High-intensity shear as a wet sludge disintegration technology and a mechanism for floc structure analysis. M.S. Thesis, Virginia Polytechnic Institute and State University, Blacksburg, VA."},{"key":"10.1016\/j.watres.2007.05.001_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1128\/MMBR.59.2.201-222.1995","article-title":"Mechanisms of membrane toxicity of hydrocarbons","volume":"59","author":"Sikkema","year":"1995","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.watres.2007.05.001_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1078\/1438-4221-00196","article-title":"Mechanisms of antibiotic resistance in bacterial biofilms","volume":"292","author":"Stewart","year":"2002","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.watres.2007.05.001_bib33","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1128\/AEM.69.4.2313-2320.2003","article-title":"Heavy metal resistance of biofilm and planktonic Pseudomonas aeruginosa","volume":"69","author":"Teitzel","year":"2003","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.watres.2007.05.001_bib34","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1016\/S0043-1354(00)00274-8","article-title":"Anaerobic deflocculation and aerobic reflocculation of activated sludge","volume":"34","author":"Wilen","year":"2000","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2007.05.001_bib35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0927-7765(99)00138-1","article-title":"Influence of microbial activity on the stability of activated sludge flocs","volume":"18","author":"Wilen","year":"2000","journal-title":"Colloid. Surface. B"},{"key":"10.1016\/j.watres.2007.05.001_bib36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2166\/wst.2003.0633","article-title":"Relationship between flocculation of activated sludge and composition of extracellular polymeric substances","volume":"47","author":"Wilen","year":"2003","journal-title":"Water Sci. Technol."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135407002941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135407002941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T01:57:20Z","timestamp":1628819840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135407002941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":36,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0043135407002941"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2007.05.001","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}