{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:01:23Z","timestamp":1791302483653,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Funds from FCT \u2013 Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.watres.2014.02.003","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T23:47:05Z","timestamp":1392162425000},"page":"327-336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":130,"special_numbering":"C","title":["Insights into the relationship between antimicrobial residues and bacterial populations in\u00a0a hospital-urban wastewater treatment plant system"],"prefix":"10.1016","volume":"54","author":[{"given":"Ana Rita","family":"Varela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Andr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga C.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia M.","family":"Manaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.watres.2014.02.003_bib1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrmicro2319","article-title":"Antibiotic resistance and its cost: is it possible to reverse resistance?","volume":"8","author":"Andersson","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.watres.2014.02.003_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.drup.2012.03.005","article-title":"Evolution of antibiotic resistance at non-lethal drug concentrations","volume":"15","author":"Andersson","year":"2012","journal-title":"Drug. Resist. Updat."},{"key":"10.1016\/j.watres.2014.02.003_bib3","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nrmicro909","article-title":"From pieces to patterns: evolutionary engineering in bacterial pathogens","volume":"2","author":"Baquero","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.watres.2014.02.003_bib4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.copbio.2008.05.006","article-title":"Antibiotics and antibiotic resistance in water environments","volume":"19","author":"Baquero","year":"2008","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.watres.2014.02.003_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2013.00015","article-title":"Antibiotic resistance shaping multi-level population biology of bacteria","volume":"4","author":"Baquero","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.watres.2014.02.003_bib6","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1099\/mic.0.2007\/015297-0","article-title":"New insights into a bacterial metabolic and detoxifying association responsible for the mineralization of the thiocarbamate herbicide molinate","volume":"154","author":"Barreiros","year":"2008","journal-title":"Microbiology"},{"issue":"15","key":"10.1016\/j.watres.2014.02.003_bib7","first-page":"8153","article-title":"Effects of advanced treatment systems on the removal of antibiotic resistance genes in wastewater treatment plants from Hangzhou, China","volume":"47","author":"Chen","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2014.02.003_bib8","series-title":"Performance Standards for Antimicrobial Susceptibility Testing; Twenty-first Informational Supplement","author":"CLSI","year":"2012"},{"key":"10.1016\/j.watres.2014.02.003_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2012.00106","article-title":"Increased levels of multiresistant bacteria and resistance genes after wastewater treatment and their dissemination into Lake Geneva, Switzerland","volume":"3","author":"Czekalski","year":"2012","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.watres.2014.02.003_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/MMBR.00016-10","article-title":"Origins and evolution of antibiotic resistance origins and evolution of antibiotic resistance","volume":"74","author":"Davies","year":"2010","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.watres.2014.02.003_bib11","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0924-8579(10)70003-0","article-title":"The continuing crisis in antibiotic resistance","volume":"36","author":"French","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"14","key":"10.1016\/j.watres.2014.02.003_bib12","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1128\/AEM.02898-09","article-title":"Enumeration and characterization of antimicrobial-resistant Escherichia coli bacteria in effluent from municipal, hospital, and secondary treatment facility sources","volume":"76","author":"Galvin","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.watres.2014.02.003_bib13","series-title":"Manual of Methods for General Bacteriology","author":"Gerhard","year":"1981"},{"key":"10.1016\/j.watres.2014.02.003_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2013.00004","article-title":"Evolutionary consequences of antibiotic use for the resistome, mobilome and microbial pangenome","volume":"4","author":"Gillings","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.watres.2014.02.003_bib15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1021\/es102473z","article-title":"Antibiotic resistance gene abundances associated with waste discharges to the Almendares River near Havana, Cuba","volume":"45","author":"Graham","year":"2011","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.watres.2014.02.003_bib16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0045-6535(97)00354-8","article-title":"Occurrence, fate and effects of pharmaceutical substances in the environment \u2013 a review","volume":"36","author":"Halling-S\u00f8rensen","year":"1998","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2014.02.003_bib17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1039\/c2em30934c","article-title":"The effect of hospital effluent on antimicrobial resistant E. coli within a municipal wastewater system","volume":"15","author":"Harris","year":"2013","journal-title":"Environ. Sci. Process. Impacts"},{"key":"10.1016\/j.watres.2014.02.003_bib18","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/1574-6941.12019","article-title":"Escherichia coli adapts to tetracycline resistance plasmid (pBR322) by mutating endogenous potassium transport: in silico hypothesis testing","volume":"83","author":"Hellweger","year":"2013","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.watres.2014.02.003_bib19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.scitotenv.2013.03.071","article-title":"Exploring the links between antibiotic occurrence, antibiotic resistance, and bacterial communities in water supply reservoirs","volume":"456\u2013457","author":"Huerta","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2014.02.003_bib20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.envint.2007.07.011","article-title":"Characterisation, dissemination and persistence of gentamicin resistant Escherichia coli from a Danish university hospital to the waste water environment","volume":"34","author":"Jakobsen","year":"2008","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2014.02.003_bib21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/15287390600975137","article-title":"Potential ecological and human health impacts of antibiotics and antibiotic-resistant bacteria from wastewater treatment plants","volume":"10","author":"Kim","year":"2007","journal-title":"J. Toxicol. Environ. Health, Part B"},{"issue":"4","key":"10.1016\/j.watres.2014.02.003_bib22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","article-title":"Antibiotics in the aquatic environment \u2013 a review \u2013 part I","volume":"75","author":"K\u00fcmmerer","year":"2009","journal-title":"Chemosphere"},{"issue":"12","key":"10.1016\/j.watres.2014.02.003_bib23","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/j.1469-0691.2003.00739.x","article-title":"Promoting resistance by the emission of antibiotics from hospitals and households into effluent","volume":"9","author":"K\u00fcmmerer","year":"2003","journal-title":"Clin. Microbiol. Infect. Dis."},{"issue":"11","key":"10.1016\/j.watres.2014.02.003_bib24","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1128\/AEM.02879-07","article-title":"Community-level assessment of the effects of the broad-spectrum antimicrobial chlorhexidine on the outcome of river microbial biofilm development","volume":"74","author":"Lawrence","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.watres.2014.02.003_bib25","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1016\/j.watres.2011.09.002","article-title":"Bacterial community characteristics under long-term antibiotic selection pressures","volume":"45","author":"Li","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2014.02.003_bib26","series-title":"The Handbook of Environmental Chemistry: Emerging Organic Contaminants and Human Health","article-title":"Antibiotic resistance in waste water and surface water and human health implications","author":"Manaia","year":"2012"},{"key":"10.1016\/j.watres.2014.02.003_bib27","series-title":"Bergey's Manual of Systematic Bacteriology","article-title":"Genus I. Aeromonas Stanier 1943, 213AL","author":"Martin-Carnahan","year":"2005"},{"key":"10.1016\/j.watres.2014.02.003_bib28","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/j.envpol.2009.05.051","article-title":"Environmental pollution by antibiotics and by antibiotic resistance determinants","volume":"157","author":"Martinez","year":"2009","journal-title":"Environ. Pollut."},{"issue":"3","key":"10.1016\/j.watres.2014.02.003_bib29","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.watres.2012.11.027","article-title":"Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: a review","volume":"47","author":"Michael","year":"2013","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.watres.2014.02.003_bib30","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/AEM.59.3.695-700.1993","article-title":"Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain Reaction-Amplified Genes coding for 16S rRNA","volume":"59","author":"Muyzer","year":"1993","journal-title":"Appl. Environ. Microbiol."},{"issue":"5","key":"10.1016\/j.watres.2014.02.003_bib31","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.watres.2013.01.010","article-title":"Antibiotic resistance, antimicrobial residues and bacterial community composition in urban wastewater","volume":"47","author":"Novo","year":"2013","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.watres.2014.02.003_bib32","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00253-010-2583-6","article-title":"Factors influencing antibiotic resistance burden in municipal wastewater treatment plants","volume":"87","author":"Novo","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.watres.2014.02.003_bib33","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1021\/es203399h","article-title":"Evidence for a complex relationship between antibiotics and antibiotic-resistant Escherichia coli: from medical center patients to a receiving environment","volume":"46","author":"Oberl\u00e9","year":"2012","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.watres.2014.02.003_bib34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jinf.2010.12.003","article-title":"Aeromonas spp. clinical microbiology and disease","volume":"62","author":"Parker","year":"2011","journal-title":"J. Infect."},{"issue":"6","key":"10.1016\/j.watres.2014.02.003_bib35","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.amjmed.2006.03.013","article-title":"Resistance in Gram-negative bacteria: Enterobacteriaceae","volume":"119","author":"Paterson","year":"2006","journal-title":"Am. J. Med."},{"key":"10.1016\/j.watres.2014.02.003_bib36","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.scitotenv.2013.01.032","article-title":"Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review","volume":"447","author":"Rizzo","year":"2013","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.watres.2014.02.003_bib37","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1289\/ehp.1104650","article-title":"Selective pressure of antibiotic pollution on bacteria of importance to public health","volume":"120","author":"Tello","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.watres.2014.02.003_bib38","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1007\/s11356-013-1594-0","article-title":"Human health implications of clinically relevant bacteria in wastewater habitats","volume":"20","author":"Varela","year":"2013","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.watres.2014.02.003_bib39","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.mib.2006.08.009","article-title":"Combinatorial genetic evolution of multiresistance","volume":"9","author":"Walsh","year":"2006","journal-title":"Curr. Opin. Microbiol."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135414001134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135414001134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T08:42:02Z","timestamp":1597480922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135414001134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":39,"alternative-id":["S0043135414001134"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2014.02.003","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into the relationship between antimicrobial residues and bacterial populations in\u00a0a hospital-urban wastewater treatment plant system","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2014.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}