{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:08:50Z","timestamp":1792807730684,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001467","name":"Public Utilities Board","doi-asserted-by":"publisher","award":["1102-IRIS- 12-02"],"award-info":[{"award-number":["1102-IRIS- 12-02"]}],"id":[{"id":"10.13039\/501100001467","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National University of Singapore Environmental Institute"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.watres.2018.08.060","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T17:24:59Z","timestamp":1535477099000},"page":"498-508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":342,"special_numbering":"C","title":["Removal of antibiotic residues, antibiotic resistant bacteria and antibiotic resistance genes in municipal wastewater by membrane bioreactor systems"],"prefix":"10.1016","volume":"145","author":[{"given":"Thai-Hoang","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmaine","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Han","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Yew-Hoong","family":"Gin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.watres.2018.08.060_bib1","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/j.watres.2009.02.005","article-title":"The fate of selected micropollutants in a single-house MBR","volume":"43","author":"Abegglen","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2018.08.060_bib2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.watres.2015.01.036","article-title":"Removal of bacterial contaminants and antibiotic resistance genes by conventional wastewater treatment processes in Saudi Arabia: is the treated wastewater safe to reuse for agricultural irrigation?","volume":"73","author":"Al-Jassim","year":"2015","journal-title":"Water Res."},{"issue":"8","key":"10.1016\/j.watres.2018.08.060_bib3","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1093\/jac\/dkq167","article-title":"Quantitative multiplex real-time PCR for detecting class 1, 2 and 3 integrons","volume":"65","author":"Barraud","year":"2010","journal-title":"J.\u00a0Antimicrob. Chemother."},{"issue":"5","key":"10.1016\/j.watres.2018.08.060_bib4","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nrmicro3439","article-title":"Tackling antibiotic resistance: the environmental framework","volume":"13","author":"Berendonk","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.watres.2018.08.060_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ecoenv.2013.01.016","article-title":"Detection and fate of antibiotic resistant bacteria in wastewater treatment plants: a review","volume":"91","author":"Bouki","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2\u20133","key":"10.1016\/j.watres.2018.08.060_bib6","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.scitotenv.2005.10.007","article-title":"Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico","volume":"366","author":"Brown","year":"2006","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2018.08.060_bib7","series-title":"Antibiotic Resistance Threats in the United States","first-page":"114","author":"CDC","year":"2013"},{"issue":"15","key":"10.1016\/j.watres.2018.08.060_bib8","first-page":"8157","article-title":"Effects of advanced treatment systems on the removal of antibiotic resistance genes in wastewater treatment plants from Hangzhou, China","volume":"47","author":"Chen","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2018.08.060_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.envint.2013.01.019","article-title":"Occurrence and removal of antibiotic resistance genes in municipal wastewater and rural domestic sewage treatment systems in eastern China","volume":"55","author":"Chen","year":"2013","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2018.08.060_bib10","doi-asserted-by":"crossref","first-page":"j3393","DOI":"10.1136\/bmj.j3393","article-title":"Risk assessment for antibiotic resistance in South East Asia","volume":"358","author":"Chereau","year":"2017","journal-title":"BMJ"},{"issue":"7","key":"10.1016\/j.watres.2018.08.060_bib11","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.trac.2005.05.005","article-title":"LC\u2013MS2 trace analysis of antimicrobials in water, sediment and soil","volume":"24","author":"D\u00edaz-Cruz","year":"2005","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.watres.2018.08.060_bib12","first-page":"75","article-title":"Removal and degradation characteristics of quinolone antibiotics in laboratory-scale activated sludge reactors under aerobic, nitrifying and anoxic conditions","volume":"120","author":"Dorival-Garcia","year":"2013","journal-title":"J.\u00a0Environ. Manag."},{"issue":"5","key":"10.1016\/j.watres.2018.08.060_bib13","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1007\/s11356-014-3552-x","article-title":"Variation of antibiotic resistance genes in municipal wastewater treatment plant with A(2)O-MBR system","volume":"22","author":"Du","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"2","key":"10.1016\/j.watres.2018.08.060_bib14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1574-6941.2005.00032.x","article-title":"Antibiotic resistance of enterococci and related bacteria in an urban wastewater treatment plant","volume":"55","author":"Ferreira da Silva","year":"2006","journal-title":"FEMS Microbiol. Ecol."},{"issue":"17","key":"10.1016\/j.watres.2018.08.060_bib15","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1016\/j.watres.2011.08.021","article-title":"Diversity and antibiotic resistance of Aeromonas spp. in drinking and waste water treatment plants","volume":"45","author":"Figueira","year":"2011","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.watres.2018.08.060_bib16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.talanta.2009.12.009","article-title":"Determination of 19 sulfonamides in environmental water samples by automated on-line solid-phase extraction-liquid chromatography\u2013tandem mass spectrometry (SPE-LC\u2013MS\/MS)","volume":"81","author":"Garc\u00eda-Gal\u00e1n","year":"2010","journal-title":"Talanta"},{"key":"10.1016\/j.watres.2018.08.060_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.envint.2011.03.001","article-title":"Monitoring and evaluation of antibiotic-resistant bacteria at a municipal wastewater treatment plant in China","volume":"42","author":"Huang","year":"2012","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.watres.2018.08.060_bib18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chemosphere.2008.11.086","article-title":"Antibiotics in the aquatic environment--a review--part I","volume":"75","author":"Kummerer","year":"2009","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.watres.2018.08.060_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103705","article-title":"Abundances of tetracycline, sulphonamide and beta-lactam antibiotic resistance genes in conventional wastewater treatment plants (WWTPs) with different waste load","volume":"9","author":"Laht","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.watres.2018.08.060_bib20","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","article-title":"Antibiotic resistance\u2014the need for global solutions","volume":"13","author":"Laxminarayan","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"15","key":"10.1016\/j.watres.2018.08.060_bib21","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1016\/j.watres.2010.06.020","article-title":"Fate of antibiotics during municipal water recycling treatment processes","volume":"44","author":"Le-Minh","year":"2010","journal-title":"Water Res."},{"issue":"12","key":"10.1016\/j.watres.2018.08.060_bib22","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1128\/AAC.01556-16","article-title":"Occurrences and characterization of antibiotic-resistant bacteria and genetic determinants of hospital wastewater in a tropical country","volume":"60","author":"Le","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.watres.2018.08.060_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mimet.2014.08.010","article-title":"Quantification of polyketide synthase genes in tropical urban soils using real-time PCR","volume":"106","author":"Le","year":"2014","journal-title":"J.\u00a0Microbiol. Meth."},{"key":"10.1016\/j.watres.2018.08.060_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fmicb.2012.00018","article-title":"Origin and evolution of antibiotic resistance: the common mechanisms of emergence and spread in water bodies","volume":"3","author":"Lupo","year":"2012","journal-title":"Front. Microbiol."},{"issue":"8","key":"10.1016\/j.watres.2018.08.060_bib25","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1016\/j.biortech.2011.01.068","article-title":"Removal of microbial indicators from municipal wastewater by a membrane bioreactor (MBR)","volume":"102","author":"Marti","year":"2011","journal-title":"Bioresour. Technol."},{"issue":"2","key":"10.1016\/j.watres.2018.08.060_bib26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.watres.2010.08.033","article-title":"Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan","volume":"45","author":"Munir","year":"2011","journal-title":"Water Res."},{"issue":"11","key":"10.1016\/j.watres.2018.08.060_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143123","article-title":"A\u00a0comparison of microbial water quality and diversity for ballast and tropical harbor waters","volume":"10","author":"Ng","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.watres.2018.08.060_bib28","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.3389\/fmicb.2017.02200","article-title":"Characterization of metagenomes in urban aquatic compartments reveals high prevalence of clinically relevant antibiotic resistance genes in wastewaters","volume":"8","author":"Ng","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.watres.2018.08.060_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.chroma.2014.04.058","article-title":"Simultaneous determination of diclofenac, its human metabolites and microbial nitration\/nitrosation transformation products in wastewaters by liquid chromatography\/quadrupole-linear ion trap mass spectrometry","volume":"1347","author":"Osorio","year":"2014","journal-title":"J.\u00a0Chromatogr. A"},{"issue":"7","key":"10.1016\/j.watres.2018.08.060_bib30","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.watres.2006.01.039","article-title":"Removal of viruses, parasitic protozoa and microbial indicators in conventional and membrane processes in a wastewater pilot plant","volume":"40","author":"Ottoson","year":"2006","journal-title":"Water Res."},{"issue":"14","key":"10.1016\/j.watres.2018.08.060_bib31","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1021\/es070051x","article-title":"Response of antibiotic resistance genes (ARG) to biological treatment in dairy lagoon water","volume":"41","author":"Pei","year":"2007","journal-title":"Environ. Sci. Technol."},{"issue":"1\u20132","key":"10.1016\/j.watres.2018.08.060_bib32","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jviromet.2005.03.020","article-title":"Optimized SYBR green real-time PCR assay to quantify the absolute copy number of measles virus RNAs using gene specific primers","volume":"128","author":"Plumet","year":"2005","journal-title":"J.\u00a0Virol. Methods"},{"issue":"3","key":"10.1016\/j.watres.2018.08.060_bib33","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.watres.2008.11.043","article-title":"Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment","volume":"43","author":"Radjenovic","year":"2009","journal-title":"Water Res."},{"issue":"4","key":"10.1016\/j.watres.2018.08.060_bib34","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00216-006-0883-6","article-title":"Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor","volume":"387","author":"Radjenovic","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.watres.2018.08.060_bib35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.scitotenv.2013.01.032","article-title":"Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review","volume":"447","author":"Rizzo","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2018.08.060_bib50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.talanta.2016.06.006","article-title":"Simultaneous analysis of multiple classes of antimicrobials in environmental water samples using SPE coupled with UHPLC-ESI-MS\/MS and isotope dilution","volume":"159","author":"Tran","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.watres.2018.08.060_bib36","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.watres.2016.08.040","article-title":"Occurrence and removal of multiple classes of antibiotics and antimicrobial agents in biological wastewater treatment processes","volume":"104","author":"Tran","year":"2016","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2018.08.060_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.biortech.2015.08.083","article-title":"Sorption and biodegradation of artificial sweeteners in activated sludge processes","volume":"197","author":"Tran","year":"2015","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.watres.2018.08.060_bib38","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.scitotenv.2017.05.097","article-title":"Occurrence and removal of pharmaceuticals, hormones, personal care products, and endocrine disrupters in a full-scale water reclamation plant","volume":"599\u2013600","author":"Tran","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2018.08.060_bib39","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.watres.2017.12.029","article-title":"Occurrence and fate of emerging contaminants in municipal wastewater treatment plants from different geographical regions-a review","volume":"133","author":"Tran","year":"2018","journal-title":"Water Res."},{"issue":"2","key":"10.1016\/j.watres.2018.08.060_bib40","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1128\/CMR.18.2.306-325.2005","article-title":"Metallo-beta-lactamases: the quiet before the storm?","volume":"18","author":"Walsh","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.watres.2018.08.060_bib41","series-title":"Antimicrobial Resistance. Global Report on Surveillance","first-page":"256","author":"WHO","year":"2014"},{"issue":"4","key":"10.1016\/j.watres.2018.08.060_bib42","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.watres.2008.11.051","article-title":"Evaluation of public health risks at recreational beaches in Lake Michigan via detection of enteric viruses and a human-specific bacteriological marker","volume":"43","author":"Wong","year":"2009","journal-title":"Water Res."},{"issue":"14","key":"10.1016\/j.watres.2018.08.060_bib43","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1039\/c0cc05111j","article-title":"Molecular mechanisms of antibiotic resistance","volume":"47","author":"Wright","year":"2011","journal-title":"Chem. Commun."},{"issue":"6","key":"10.1016\/j.watres.2018.08.060_bib44","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1007\/s00253-012-4082-4","article-title":"Bacterial communities in different sections of a municipal wastewater treatment plant revealed by 16S rDNA 454 pyrosequencing","volume":"97","author":"Ye","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.watres.2018.08.060_bib45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.watres.2017.05.008","article-title":"Removal of selected PPCPs, EDCs, and antibiotic resistance genes in landfill leachate by a full-scale constructed wetlands system","volume":"121","author":"Yi","year":"2017","journal-title":"Water Res."},{"issue":"10","key":"10.1016\/j.watres.2018.08.060_bib46","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1021\/es803309m","article-title":"Tetracycline resistance genes and tetracycline resistant lactose-fermenting Enterobacteriaceae in activated sludge of sewage treatment plants","volume":"43","author":"Zhang","year":"2009","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.watres.2018.08.060_bib47","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00253-008-1829-z","article-title":"Antibiotic resistance genes in water environment","volume":"82","author":"Zhang","year":"2009","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.watres.2018.08.060_bib48","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.watres.2016.04.072","article-title":"Abiotic amidine and guanidine hydrolysis of lamotrigine-N2-glucuronide and related compounds in wastewater: the role of pH and N2-substitution on reaction kinetics","volume":"100","author":"Zonja","year":"2016","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.watres.2018.08.060_bib49","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1021\/acs.est.5b03691","article-title":"Human metabolite lamotrigine-N2-glucuronide is the principal source of lamotrigine-derived compounds in wastewater treatment plants and surface water","volume":"50","author":"Zonja","year":"2016","journal-title":"Environ. Sci. Technol."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135418306900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135418306900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T01:56:54Z","timestamp":1758592614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135418306900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":50,"alternative-id":["S0043135418306900"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2018.08.060","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Removal of antibiotic residues, antibiotic resistant bacteria and antibiotic resistance genes in municipal wastewater by membrane bioreactor systems","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2018.08.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}