{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T14:31:44Z","timestamp":1794580304104,"version":"4.9.1"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Korea Ministry of Education","doi-asserted-by":"publisher","award":["2019R1A6A1A10072987"],"award-info":[{"award-number":["2019R1A6A1A10072987"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003562","name":"Korea Ministry of Environment","doi-asserted-by":"publisher","award":["2016001350006"],"award-info":[{"award-number":["2016001350006"]}],"id":[{"id":"10.13039\/501100003562","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015515","name":"Kementerian Pendidikan Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015515","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.watres.2021.117882","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T05:29:30Z","timestamp":1637299770000},"page":"117882","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":157,"special_numbering":"C","title":["Higher abundance of core antimicrobial resistant genes in effluent from wastewater treatment plants"],"prefix":"10.1016","volume":"208","author":[{"given":"Shahbaz","family":"Raza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanseob","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hor-Gil","family":"Hur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Unno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6478","key":"10.1016\/j.watres.2021.117882_bib0001","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.aba3432","article-title":"Using sewage for surveillance of antimicrobial resistance","volume":"367","author":"Aarestrup","year":"2020","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.watres.2021.117882_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13201-018-0846-z","article-title":"Antibiotics in wastewaters: a review with focus on Oman","volume":"8","author":"Al-Riyami","year":"2018","journal-title":"Appl. Water Sci."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-65635-4","article-title":"Evaluation of antibiotic resistance dissemination by wastewater treatment plant effluents with different catchment areas in Germany","volume":"10","author":"Alexander","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.watres.2021.117882_bib0004","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.scitotenv.2016.03.154","article-title":"Ozone treatment of conditioned wastewater selects antibiotic resistance genes, opportunistic bacteria, and induce strong population shifts","volume":"559","author":"Alexander","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2021.117882_bib0005","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.envint.2018.05.011","article-title":"Tracking antibiotic resistome during wastewater treatment using high throughput quantitative PCR","volume":"117","author":"An","year":"2018","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.watres.2021.117882_bib0006","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1093\/bioinformatics\/btaa095","article-title":"ARGminer: a web platform for the crowdsourcing-based curation of antibiotic resistance genes","volume":"36","author":"Arango-Argoty","year":"2020","journal-title":"Bioinformatics"},{"issue":"23","key":"10.1016\/j.watres.2021.117882_bib0007","doi-asserted-by":"crossref","first-page":"8866","DOI":"10.3390\/ijerph17238866","article-title":"Treatment processes for microbial resistance mitigation: the technological contribution to tackle the problem of antibiotic resistance","volume":"17","author":"Bair\u00e1n","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.watres.2021.117882_bib0008","doi-asserted-by":"crossref","unstructured":"Bastian, M., Heymann, S. and Jacomy, M. (2009) Gephi: an open source software for exploring and manipulating networks.","DOI":"10.1609\/icwsm.v3i1.13937"},{"key":"10.1016\/j.watres.2021.117882_bib0009","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.chemosphere.2017.01.041","article-title":"Distribution of antibiotic resistance in the effluents of ten municipal wastewater treatment plants in China and the effect of treatment processes","volume":"172","author":"Ben","year":"2017","journal-title":"Chemosphere"},{"issue":"6","key":"10.1016\/j.watres.2021.117882_bib0010","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/1755-0998.12399","article-title":"METAXA2: improved identification and taxonomic classification of small and large subunit rRNA in metagenomic data","volume":"15","author":"Bengtsson-Palme","year":"2015","journal-title":"Mol. Ecol. Resources"},{"issue":"Supplement_2","key":"10.1016\/j.watres.2021.117882_bib0011","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1086\/504477","article-title":"Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa","volume":"43","author":"Bonomo","year":"2006","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0012","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and sensitive protein alignment using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat. Methods"},{"issue":"6-7","key":"10.1016\/j.watres.2021.117882_bib0013","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijmm.2013.02.001","article-title":"Plasmids and the spread of resistance","volume":"303","author":"Carattoli","year":"2013","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.watres.2021.117882_bib0014","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.envint.2016.06.025","article-title":"Antibiotics in the aquatic environments: a review of the European scenario","volume":"94","author":"Carvalho","year":"2016","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms10333","article-title":"Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments","volume":"7","author":"Chait","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-019-0663-0","article-title":"Mobile antibiotic resistome in wastewater treatment plants revealed by Nanopore metagenomic sequencing","volume":"7","author":"Che","year":"2019","journal-title":"Microbiome"},{"issue":"suppl_1","key":"10.1016\/j.watres.2021.117882_bib0017","first-page":"D325","article-title":"VFDB: a reference database for bacterial virulence factors","volume":"33","author":"Chen","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.watres.2021.117882_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2016.03.026","article-title":"Long-term field application of sewage sludge increases the abundance of antibiotic resistance genes in soil","volume":"92","author":"Chen","year":"2016","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.watres.2021.117882_bib0019","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1021\/es505521w","article-title":"Metagenomics shows that low-energy anaerobic\u2212 aerobic treatment reactors reduce antibiotic resistance gene levels from domestic wastewater","volume":"49","author":"Christgen","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.watres.2021.117882_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002394","article-title":"Horizontal DNA transfer mechanisms of bacteria as weapons of intragenomic conflict","volume":"14","author":"Croucher","year":"2016","journal-title":"PLoS Biol."},{"issue":"5","key":"10.1016\/j.watres.2021.117882_bib0021","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giaa046","article-title":"Global ocean resistome revealed: exploring antibiotic resistance gene abundance and distribution in TARA Oceans samples","volume":"9","author":"Cuadrat","year":"2020","journal-title":"GigaScience"},{"issue":"11","key":"10.1016\/j.watres.2021.117882_bib0022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002184","article-title":"Will 10 million people die a year due to antimicrobial resistance by 2050?","volume":"13","author":"de Kraker","year":"2016","journal-title":"PLoS Med."},{"key":"10.1016\/j.watres.2021.117882_bib0023","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jhazmat.2016.03.014","article-title":"\u03b2-lactams resistance gene quantification in an antibiotic resistant escherichia coli water suspension treated by advanced oxidation with UV\/H2O2","volume":"323","author":"Ferro","year":"2017","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.watres.2021.117882_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2019.06.017","article-title":"Hijacking the hijackers: escherichia coli pathogenicity islands redirect helper phage packaging for their own benefit","volume":"75","author":"Fillol-Salom","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.watres.2021.117882_bib0025","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.scitotenv.2012.01.061","article-title":"Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant","volume":"421-422","author":"Gao","year":"2012","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0026","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ismej.2014.106","article-title":"Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology","volume":"9","author":"Gibson","year":"2015","journal-title":"ISME J."},{"key":"10.1016\/j.watres.2021.117882_bib0027","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.watres.2017.07.002","article-title":"Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements","volume":"123","author":"Guo","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2021.117882_bib0028","first-page":"147","author":"Guo","year":"2020","journal-title":"Antibiot. Res. Environ. A Worldw. Overv."},{"issue":"16","key":"10.1016\/j.watres.2021.117882_bib0029","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1016\/j.watres.2013.08.012","article-title":"Microbial selectivity of UV treatment on antibiotic-resistant heterotrophic bacteria in secondary effluents of a municipal wastewater treatment plant","volume":"47","author":"Guo","year":"2013","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0030","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1128\/AAC.01310-13","article-title":"ARG-ANNOT, a new bioinformatic tool to discover antibiotic resistance genes in bacterial genomes","volume":"58","author":"Gupta","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.watres.2021.117882_bib0031","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s12275-018-8195-z","article-title":"Metagenomic analysis reveals the prevalence and persistence of antibiotic- and heavy metal-resistance genes in wastewater treatment plant","volume":"56","author":"Gupta","year":"2018","journal-title":"J. Microbiol."},{"issue":"21","key":"10.1016\/j.watres.2021.117882_bib0032","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.1128\/AEM.00736-15","article-title":"The ocean as a global reservoir of antibiotic resistance genes","volume":"81","author":"Hatosy","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"issue":"22","key":"10.1016\/j.watres.2021.117882_bib0033","doi-asserted-by":"crossref","first-page":"13120","DOI":"10.1021\/es5041267","article-title":"Dissemination of antibiotic resistance genes in representative broiler feedlots environments: identification of indicator ARGs and correlations with environmental variables","volume":"48","author":"He","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"10014","key":"10.1016\/j.watres.2021.117882_bib0034","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0140-6736(15)00473-0","article-title":"Understanding the mechanisms and drivers of antimicrobial resistance","volume":"387","author":"Holmes","year":"2016","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.watres.2021.117882_bib0035","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fiy038","article-title":"Host range of antibiotic resistance genes in wastewater treatment plant influent and effluent","volume":"94","author":"Hultman","year":"2018","journal-title":"FEMS Microbiol. Ecol."},{"issue":"4","key":"10.1016\/j.watres.2021.117882_bib0036","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fiy038","article-title":"Host range of antibiotic resistance genes in wastewater treatment plant influent and effluent","volume":"94","author":"Hultman","year":"2018","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.watres.2021.117882_bib0037","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2105-11-119","article-title":"Prodigal: prokaryotic gene recognition and translation initiation site identification","volume":"11","author":"Hyatt","year":"2010","journal-title":"BMC Bioinform."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0038","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1469-0691.2008.02097.x","article-title":"Chromosomal mechanisms of aminoglycoside resistance in pseudomonas aeruginosa isolates from cystic fibrosis patients","volume":"15","author":"Islam","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.watres.2021.117882_bib0039","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.biortech.2017.10.073","article-title":"Fate of antibiotic resistance genes and metal resistance genes during thermophilic aerobic digestion of sewage sludge","volume":"249","author":"Jang","year":"2018","journal-title":"Bioresour. Technol."},{"issue":"3","key":"10.1016\/j.watres.2021.117882_bib0040","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/jam.14851","article-title":"Bacteriophages as antibiotic resistance genes carriers in agro-food systems","volume":"130","author":"Jebri","year":"2021","journal-title":"J. Appl. Microbiol."},{"issue":"20","key":"10.1016\/j.watres.2021.117882_bib0041","doi-asserted-by":"crossref","first-page":"12271","DOI":"10.1021\/acs.est.5b03521","article-title":"Bacterial community shift drives antibiotic resistance promotion during drinking water chlorination","volume":"49","author":"Jia","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2021.117882_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116764","article-title":"Fish farm effluents as a source of antibiotic resistance gene dissemination on Jeju Island, South Korea","volume":"276","author":"Jo","year":"2021","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.watres.2021.117882_bib0043","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41396-018-0277-8","article-title":"Wastewater treatment plant resistomes are shaped by bacterial composition, genetic exchange, and upregulated expression in the effluent microbiomes","volume":"13","author":"Ju","year":"2019","journal-title":"ISME J."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-020-00867-0","article-title":"VIBRANT: automated recovery, annotation and curation of microbial viruses, and evaluation of viral community function from genomic sequences","volume":"8","author":"Kieft","year":"2020","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0045","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1038\/s41598-018-23656-0","article-title":"Outer membrane vesicles from \u03b2-lactam-resistant Escherichia coli enable the survival of \u03b2-lactam-susceptible E. coli in the presence of \u03b2-lactam antibiotics","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.watres.2021.117882_bib0046","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1093\/nar\/gkx1321","article-title":"PlasFlow: predicting plasmid sequences in metagenomic data using genome signatures","volume":"46","author":"Krawczyk","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.watres.2021.117882_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109179","article-title":"Treatment enhances the prevalence of antibiotic-resistant bacteria and antibiotic resistance genes in the wastewater of Sri Lanka, and India","volume":"183","author":"Kumar","year":"2020","journal-title":"Environ. Res."},{"issue":"4","key":"10.1016\/j.watres.2021.117882_bib0048","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0049","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40168-019-0774-7","article-title":"Mobile resistome of human gut and pathogen drives anthropogenic bloom of antibiotic resistance","volume":"8","author":"Lee","year":"2020","journal-title":"Microbiome"},{"issue":"10","key":"10.1016\/j.watres.2021.117882_bib0050","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/bioinformatics\/btv033","article-title":"MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph","volume":"31","author":"Li","year":"2015","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.watres.2021.117882_bib0051","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with burrows\u2013wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"issue":"16","key":"10.1016\/j.watres.2021.117882_bib0052","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0053","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/nar\/gkw1027","article-title":"Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform","volume":"45","author":"Li","year":"2017","journal-title":"Nucl. Acids Res."},{"issue":"13","key":"10.1016\/j.watres.2021.117882_bib0054","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","article-title":"Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences","volume":"22","author":"Li","year":"2006","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0055","doi-asserted-by":"crossref","first-page":"8174","DOI":"10.1038\/s41598-020-65031-y","article-title":"Metagenomic analysis of an urban resistome before and after wastewater treatment","volume":"10","author":"Lira","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.watres.2021.117882_bib0056","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.watres.2018.02.036","article-title":"Chlorine disinfection increases both intracellular and extracellular antibiotic resistance genes in a full-scale wastewater treatment plant","volume":"136","author":"Liu","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2021.117882_bib0057","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.scitotenv.2018.01.271","article-title":"Antibiotics in the aquatic environments: a review of lakes, China","volume":"627","author":"Liu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2021.117882_bib0058","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12859-014-0366-2","article-title":"Rapid evaluation and quality control of next generation sequencing data with FaQCs","volume":"15","author":"Lo","year":"2014","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.watres.2021.117882_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.113998","article-title":"Spread of chloramphenicol and tetracycline resistance genes by plasmid mobilization in agricultural soil","volume":"260","author":"Lu","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.watres.2021.117882_bib0060","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.scitotenv.2015.04.101","article-title":"Fate of sulfonamide resistance genes in estuary environment and effect of anthropogenic activities","volume":"527","author":"Lu","year":"2015","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0061","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/acs.est.5b03522","article-title":"Metagenomic assembly reveals hosts of antibiotic resistance genes and the shared resistome in pig, chicken, and human feces","volume":"50","author":"Ma","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.watres.2021.117882_bib0062","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/10495390600956953","article-title":"Tetracycline residues and tetracycline resistance genes in groundwater impacted by swine production facilities","volume":"17","author":"Mackie","year":"2006","journal-title":"Anim. Biotechnol."},{"key":"10.1016\/j.watres.2021.117882_bib0063","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.watres.2016.10.066","article-title":"Decay of sewage-sourced microbial source tracking markers and fecal indicator bacteria in marine waters","volume":"108","author":"Mattioli","year":"2017","journal-title":"Water Res."},{"issue":"7","key":"10.1016\/j.watres.2021.117882_bib0064","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1128\/AAC.00419-13","article-title":"The comprehensive antibiotic resistance database","volume":"57","author":"McArthur","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.watres.2021.117882_bib0065","doi-asserted-by":"crossref","first-page":"11257","DOI":"10.1038\/ncomms11257","article-title":"Fast and sensitive taxonomic classification for metagenomics with Kaiju","volume":"7","author":"Menzel","year":"2016","journal-title":"Nat. Commun."},{"issue":"W1","key":"10.1016\/j.watres.2021.117882_bib0066","doi-asserted-by":"crossref","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.watres.2021.117882_bib0067","doi-asserted-by":"crossref","first-page":"e3269","DOI":"10.7717\/peerj.3269","article-title":"Accumulation and expression of horizontally acquired genes in Arcobacter cryaerophilus that thrives in sewage","volume":"5","author":"Millar","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.watres.2021.117882_bib0068","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3389\/fmicb.2021.657353","article-title":"Increased Antimicrobial and multidrug resistance downstream of wastewater treatment plants in an urban watershed","volume":"12","author":"Mukherjee","year":"2021","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.watres.2021.117882_bib0069","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.watres.2010.08.033","article-title":"Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in michigan","volume":"45","author":"Munir","year":"2011","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10889868.2011.628348","article-title":"Biodegradation of 2-chlorophenol by rhodopseudomonas palustris","volume":"16","author":"Mutharasaiah","year":"2012","journal-title":"Bioremed. J."},{"key":"10.1016\/j.watres.2021.117882_bib0071","unstructured":"O'Neill, J. (2016) Tackling drug-resistant infections globally: final report and recommendations."},{"issue":"7","key":"10.1016\/j.watres.2021.117882_bib0072","doi-asserted-by":"crossref","first-page":"e40117","DOI":"10.1371\/journal.pone.0040117","article-title":"Ecology of root colonizing Massilia (Oxalobacteraceae)","volume":"7","author":"Ofek","year":"2012","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.watres.2021.117882_bib0073","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fiy079","article-title":"MetaCompare: a computational pipeline for prioritizing environmental resistome risk","volume":"94","author":"Oh","year":"2018","journal-title":"FEMS Microbiol. Ecol."},{"issue":"11","key":"10.1016\/j.watres.2021.117882_bib0074","doi-asserted-by":"crossref","first-page":"10818","DOI":"10.1007\/s11356-016-6221-4","article-title":"Prevalence of plasmid-mediated multidrug resistance determinants in fluoroquinolone-resistant bacteria isolated from sewage and surface water","volume":"23","author":"Osi\u0144ska","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"D1","key":"10.1016\/j.watres.2021.117882_bib0075","doi-asserted-by":"crossref","first-page":"D737","DOI":"10.1093\/nar\/gkt1252","article-title":"BacMet: antibacterial biocide and metal resistance genes database","volume":"42","author":"Pal","year":"2014","journal-title":"Nucl. Acids Res."},{"issue":"21","key":"10.1016\/j.watres.2021.117882_bib0076","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","article-title":"STAMP: statistical analysis of taxonomic and functional profiles","volume":"30","author":"Parks","year":"2014","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.watres.2021.117882_bib0077","doi-asserted-by":"crossref","first-page":"eaau9124","DOI":"10.1126\/sciadv.aau9124","article-title":"Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence","volume":"5","author":"P\u00e4rn\u00e4nen","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.watres.2021.117882_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134023","article-title":"Antibiotic resistance genes identified in wastewater treatment plant systems \u2013 a review","volume":"697","author":"Pazda","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2021.117882_bib0079","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142755","article-title":"Metagenomic exploration of antibiotic resistome in treated wastewater effluents and their receiving water","volume":"765","author":"Raza","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2021.117882_bib0080","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.scitotenv.2013.01.032","article-title":"Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review","volume":"447","author":"Rizzo","year":"2013","journal-title":"Sci. Total Environ."},{"issue":"12","key":"10.1016\/j.watres.2021.117882_bib0081","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.tim.2018.06.007","article-title":"Evolution of plasmid-mediated antibiotic resistance in the clinical context","volume":"26","author":"San Millan","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.watres.2021.117882_bib0082","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3389\/fmicb.2016.01728","article-title":"Review of antimicrobial resistance in the environment and its relevance to environmental regulators","volume":"7","author":"Singer","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.watres.2021.117882_bib0083","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.scitotenv.2018.11.211","article-title":"Distribution of clinically relevant antibiotic resistance genes in Lake Tai, China","volume":"655","author":"Stange","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2021.117882_bib0084","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.scitotenv.2017.10.318","article-title":"Persistence of antibiotic resistance genes and bacterial community changes in drinking water treatment system: from drinking water source to tap water","volume":"616","author":"Su","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.watres.2021.117882_bib0085","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.17826\/cumj.514157","article-title":"WHO ten threats to global health in 2019: antimicrobial resistance","volume":"44","author":"Thangaraju","year":"2019","journal-title":"Cukurova Med. J."},{"issue":"5","key":"10.1016\/j.watres.2021.117882_bib0086","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.ajic.2005.03.006","article-title":"Ecology of Pseudomonas aeruginosa in the intensive care unit and the evolving role of water outlets as a reservoir of the organism","volume":"33","author":"Trautmann","year":"2005","journal-title":"Am. J. Infect. Control"},{"issue":"10","key":"10.1016\/j.watres.2021.117882_bib0087","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nmeth.3589","article-title":"MetaPhlAn2 for enhanced metagenomic taxonomic profiling","volume":"12","author":"Truong","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.watres.2021.117882_bib0088","unstructured":"UN (2016) REPORT emerging issues of environmental concern. emerging zoonotic diseases and links to ecosystem health\u2013UNEP frontiers."},{"issue":"1","key":"10.1016\/j.watres.2021.117882_bib0089","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-018-0424-5","article-title":"A reservoir of \u2018historical'antibiotic resistance genes in remote pristine Antarctic soils","volume":"6","author":"Van Goethem","year":"2018","journal-title":"Microbiome"},{"issue":"10","key":"10.1016\/j.watres.2021.117882_bib0090","doi-asserted-by":"crossref","first-page":"e76079","DOI":"10.1371\/journal.pone.0076079","article-title":"Metagenomic profiling of antibiotic resistance genes and mobile genetic elements in a tannery wastewater treatment plant","volume":"8","author":"Wang","year":"2013","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.watres.2021.117882_bib0091","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1128\/jb.112.2.1014-1016.1972","article-title":"Nutritional requirements of Acinetobacter strains isolated from soil, water, and sewage","volume":"112","author":"Warskow","year":"1972","journal-title":"J. Bacteriol."},{"issue":"12","key":"10.1016\/j.watres.2021.117882_bib0092","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1128\/AAC.43.12.2975","article-title":"Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability","volume":"43","author":"Westbrock-Wadman","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.watres.2021.117882_bib0093","series-title":"Technical Brief On Water, Sanitation, Hygiene (WASH) and Wastewater Management to Prevent Infections and Reduce the Spread of Antimicrobial Resistance (AMR)","year":"2020"},{"issue":"13","key":"10.1016\/j.watres.2021.117882_bib0094","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1093\/bioinformatics\/bty053","article-title":"ARGs-OAP v2.0 with an expanded SARG database and Hidden Markov Models for enhancement characterization and quantification of antibiotic resistance genes in environmental metagenomes","volume":"34","author":"Yin","year":"2018","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.watres.2021.117882_bib0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12275-020-9309-y","article-title":"Exploring the antibiotic resistome in activated sludge and anaerobic digestion sludge in an urban wastewater treatment plant via metagenomic analysis","volume":"58","author":"Yoo","year":"2020","journal-title":"J. Microbiol."},{"issue":"2","key":"10.1016\/j.watres.2021.117882_bib0096","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12275-020-9309-y","article-title":"Exploring the antibiotic resistome in activated sludge and anaerobic digestion sludge in an urban wastewater treatment plant via metagenomic analysis","volume":"58","author":"Yoo","year":"2020","journal-title":"J. Microbiol."},{"key":"10.1016\/j.watres.2021.117882_bib0097","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.104986","article-title":"Redistribution of intracellular and extracellular free & adsorbed antibiotic resistance genes through a wastewater treatment plant by an enhanced extracellular DNA extraction method with magnetic beads","volume":"131","author":"Yuan","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2021.117882_bib0098","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116455","article-title":"Antibiotics and antibiotic resistant genes (ARGs) in groundwater: a global review on dissemination, sources, interactions, environmental and human health risks","author":"Zainab","year":"2020","journal-title":"Water Res."},{"issue":"4","key":"10.1016\/j.watres.2021.117882_bib0099","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00253-016-7949-y","article-title":"Comparison of bacterial community characteristics between complete and shortcut denitrification systems for quinoline degradation","volume":"101","author":"Zhang","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135421010769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135421010769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T03:59:27Z","timestamp":1758599967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135421010769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":99,"alternative-id":["S0043135421010769"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2021.117882","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Higher abundance of core antimicrobial resistant genes in effluent from wastewater treatment plants","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2021.117882","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117882"}}