{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:13:39Z","timestamp":1788884019738,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["9067-00032A"],"award-info":[{"award-number":["9067-00032A"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.watres.2022.118599","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T05:44:57Z","timestamp":1652679897000},"page":"118599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["From data to reliable conclusions: Identification and comparison of persistent micropollutants and transformation products in 37 wastewater samples by non-target screening prioritization"],"prefix":"10.1016","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3366-7499","authenticated-orcid":false,"given":"Selina","family":"Tisler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolina","family":"Engler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias B.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer","family":"Kilpinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0576-6868","authenticated-orcid":false,"given":"Giorgio","family":"Tomasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.watres.2022.118599_bib0001","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aca.2016.06.030","article-title":"General strategies to increase the repeatability in non-target screening by liquid chromatography-high resolution mass spectrometry","volume":"935","author":"Bader","year":"2016","journal-title":"Anal. Chim. Acta"},{"issue":"24","key":"10.1016\/j.watres.2022.118599_bib0002","doi-asserted-by":"crossref","first-page":"13219","DOI":"10.1021\/acs.analchem.7b03037","article-title":"LC-HRMS data processing strategy for reliable sample comparison exemplified by the assessment of water treatment processes","volume":"89","author":"Bader","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.watres.2022.118599_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138388","article-title":"Unraveling longitudinal pollution patterns of organic micropollutants in a river by non-target screening and cluster analysis","volume":"727","author":"Beckers","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"4","key":"10.1016\/j.watres.2022.118599_bib0004","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.watres.2008.11.056","article-title":"Monitoring of opiates, cannabinoids and their metabolites in wastewater, surface water and finished water in Catalonia, Spain","volume":"43","author":"Boleda","year":"2009","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.118599_bib0005","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jhazmat.2016.08.022","article-title":"Occurrence and fate of amisulpride, sulpiride, and lamotrigine in municipal wastewater treatment plants with biological treatment and ozonation","volume":"320","author":"Bollmann","year":"2016","journal-title":"J. Hazard. Mater."},{"issue":"6","key":"10.1016\/j.watres.2022.118599_bib0006","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11306-018-1367-3","article-title":"Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies","volume":"14","author":"Broadhurst","year":"2018","journal-title":"Metabolomics"},{"key":"10.1016\/j.watres.2022.118599_bib0007","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.scitotenv.2017.05.271","article-title":"Suspect screening of micropollutants and their transformation products in advanced wastewater treatment","volume":"601-602","author":"Deeb","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2022.118599_bib0008","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.scitotenv.2019.06.173","article-title":"Wide-scope target and suspect screening methodologies to investigate the occurrence of new psychoactive substances in influent wastewater from Athens","volume":"685","author":"Diamanti","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.watres.2022.118599_bib0009","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1021\/acs.est.5b05186","article-title":"Systematic exploration of biotransformation reactions of amine-containing micropollutants in activated sludge","volume":"50","author":"Gulde","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.118599_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.115034","article-title":"Biological transformation of fexofenadine and sitagliptin by carrier-attached biomass and suspended sludge from a hybrid moving bed biofilm reactor","volume":"167","author":"Henning","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.118599_bib0011","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.watres.2018.01.027","article-title":"Biotransformation of gabapentin in surface water matrices under different redox conditions and the occurrence of one major TP in the aquatic environment","volume":"137","author":"Henning","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.118599_bib0012","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jtice.2017.07.005","article-title":"Degradation kinetics and DBP formation during chlorination of metribuzin","volume":"80","author":"Hu","year":"2017","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"10.1016\/j.watres.2022.118599_bib0013","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.envpol.2013.07.048","article-title":"Identification of novel micropollutants in wastewater by a combination of suspect and nontarget screening","volume":"184","author":"Hug","year":"2014","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.watres.2022.118599_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131952","article-title":"Removal of drug losartan in environmental aquatic matrices by heat-activated persulfate: kinetics, transformation products and synergistic effects","volume":"287","author":"Ioannidi","year":"2022","journal-title":"Chemosphere"},{"issue":"6476","key":"10.1016\/j.watres.2022.118599_bib0015","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.aay6637","article-title":"Learning from the past and considering the future of chemicals in the environment","volume":"367","author":"Johnson","year":"2020","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.watres.2022.118599_bib0016","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1080\/00498254.2019.1572938","article-title":"An evaluation of metabolite profiling of six drugs using dried blood spot","volume":"49","author":"Katyayan","year":"2019","journal-title":"Xenobiotica"},{"key":"10.1016\/j.watres.2022.118599_bib0017","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cej.2019.02.157","article-title":"An investigation of the transformation, kinetics and bioactivity of ozone treatment of DEET in water","volume":"368","author":"Li","year":"2019","journal-title":"Chem. Eng. J."},{"issue":"5","key":"10.1016\/j.watres.2022.118599_bib0018","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/wat2.1090","article-title":"A review of the fate of micropollutants in wastewater treatment plants","volume":"2","author":"Margot","year":"2015","journal-title":"WIREs Water"},{"issue":"1","key":"10.1016\/j.watres.2022.118599_bib0019","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1021\/acs.est.6b02373","article-title":"Assessment of N-oxide formation during wastewater ozonation","volume":"51","author":"Merel","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.118599_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.07.009","article-title":"Nontarget analysis: a new tool for the evaluation of wastewater processes","volume":"163","author":"N\u00fcrenberg","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.118599_bib0021","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chroma.2015.11.014","article-title":"Development and validation of a generic nontarget method based on liquid chromatography \u2013 high resolution mass spectrometry analysis for the evaluation of different wastewater treatment options","volume":"1426","author":"N\u00fcrenberg","year":"2015","journal-title":"J. Chromatogr. A"},{"issue":"2","key":"10.1016\/j.watres.2022.118599_bib0022","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s13280-019-01219-5","article-title":"Micropollutants in treated wastewater","volume":"49","author":"Rogowska","year":"2020","journal-title":"Ambio"},{"key":"10.1016\/j.watres.2022.118599_bib0023","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.watres.2014.05.031","article-title":"Characterization of metoprolol biodegradation and its transformation products generated in activated sludge batch experiments and in full scale WWTPs","volume":"63","author":"Rubirola","year":"2014","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.118599_bib0024","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.watres.2018.05.045","article-title":"Non-target screening to trace ozonation transformation products in a wastewater treatment train including different post-treatments","volume":"142","author":"Scholl\u00e9e","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.118599_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117209","article-title":"Characterization of advanced wastewater treatment with ozone and activated carbon using LC-HRMS based non-target screening with automated trend assignment","volume":"200","author":"Scholl\u00e9e","year":"2021","journal-title":"Water Res."},{"issue":"24","key":"10.1016\/j.watres.2022.118599_bib0026","doi-asserted-by":"crossref","first-page":"12121","DOI":"10.1021\/acs.analchem.5b02905","article-title":"Prioritizing unknown transformation products from biologically-treated wastewater using high-resolution mass spectrometry, multivariate statistics, and metabolic logic","volume":"87","author":"Scholl\u00e9e","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.watres.2022.118599_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2020.116063","article-title":"An assessment of quality assurance\/quality control efforts in high resolution mass spectrometry non-target workflows for analysis of environmental samples","volume":"133","author":"Schulze","year":"2020","journal-title":"TrAC Trends Anal. Chem."},{"issue":"4","key":"10.1016\/j.watres.2022.118599_bib0028","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/es5002105","article-title":"Identifying small molecules via high resolution mass spectrometry: communicating confidence","volume":"48","author":"Schymanski","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"24","key":"10.1016\/j.watres.2022.118599_bib0029","doi-asserted-by":"crossref","first-page":"8432","DOI":"10.1021\/acs.analchem.1c00357","article-title":"Correction of matrix effects for reliable non-target screening LC\u2013ESI\u2013MS analysis of wastewater","volume":"93","author":"Tisler","year":"2021","journal-title":"Anal. Chem."},{"issue":"13","key":"10.1016\/j.watres.2022.118599_bib0030","doi-asserted-by":"crossref","first-page":"7400","DOI":"10.1021\/acs.est.9b00789","article-title":"Transformation products of fluoxetine formed by photodegradation in water and biodegradation in zebrafish embryos (Danio rerio)","volume":"53","author":"Tisler","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.118599_bib0031","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s11306-016-1015-8","article-title":"Improved batch correction in untargeted MS-based metabolomics","volume":"12","author":"Wehrens","year":"2016","journal-title":"Metabolomics"},{"key":"10.1016\/j.watres.2022.118599_bib0032","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.watres.2018.11.042","article-title":"Identification of potentially mobile and persistent transformation products of REACH-registered chemicals and their occurrence in surface waters","volume":"150","author":"Zahn","year":"2019","journal-title":"Water Res."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135422005528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135422005528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:23:54Z","timestamp":1758601434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135422005528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":32,"alternative-id":["S0043135422005528"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2022.118599","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From data to reliable conclusions: Identification and comparison of persistent micropollutants and transformation products in 37 wastewater samples by non-target screening prioritization","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2022.118599","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"118599"}}