{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:38:23Z","timestamp":1793284703764,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["FI_SDUR 2020-00330"],"award-info":[{"award-number":["FI_SDUR 2020-00330"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["CTM2017-83598-R"],"award-info":[{"award-number":["CTM2017-83598-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Gobierno de Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-112615RA-I00"],"award-info":[{"award-number":["PID2020-112615RA-I00"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017-SGR-1552"],"award-info":[{"award-number":["2017-SGR-1552"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.watres.2022.119314","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T03:29:41Z","timestamp":1667186981000},"page":"119314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["NOM fractionation by HPSEC-DAD-OCD for predicting trihalomethane disinfection by-product formation potential in full-scale drinking water treatment plants"],"prefix":"10.1016","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-9487","authenticated-orcid":false,"given":"Meritxell","family":"Valenti-Quiroga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6134-9255","authenticated-orcid":false,"given":"Pepus","family":"Daunis-i-Estadella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0459-8113","authenticated-orcid":false,"given":"Pere","family":"Emiliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-9778","authenticated-orcid":false,"given":"Fernando","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.watres.2022.119314_bib0001","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1021\/es0496468","article-title":"Size exclusion chromatography to characterize DOC removal in drinking water treatment","volume":"39","author":"Allpike","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119314_bib0002","first-page":"779","article-title":"Selective removal of natural organic matter during drinking water production changes the composition of disinfection by-products","volume":"6","author":"Andersson","year":"2020","journal-title":"Environ. Sci."},{"key":"10.1016\/j.watres.2022.119314_bib0003","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jhazmat.2016.01.030","article-title":"Characterization of dissolved organic matter for prediction of trihalomethane formation potential in surface and sub-surface waters","volume":"308","author":"Awad","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.watres.2022.119314_bib0004","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2166\/wpt.2018.097","article-title":"UV spectroscopic properties of principal inorganic ionic species in natural waters","volume":"13","author":"Birkmann","year":"2018","journal-title":"Water Pract. Technol."},{"key":"10.1016\/j.watres.2022.119314_bib0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.chemosphere.2019.02.176","article-title":"Multi-spectral characterization of natural organic matter (NOM) from Manitoba surface waters using high performance size exclusion chromatography (HPSEC)","volume":"225","author":"Brezinski","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2022.119314_bib0006","article-title":"Sorptive removal of disinfection by-product precursors from UK lowland surface waters: impact of molecular weight and bromide","volume":"754","author":"Carra","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119314_bib0007","first-page":"185","article-title":"Interpreting main features of the differential absorbance spectra of chlorinated natural organic matter: comparison of the experimental and theoretical spectra of model compounds","author":"Chen","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.119314_bib0008","first-page":"4189","article-title":"Models for predicting disinfection byproduct (DBP) formation in drinking waters: a chronological review","volume":"407","author":"Chowdhury","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119314_bib0009","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.watres.2018.09.042","article-title":"Understanding the potential for selective natural organic matter removal by ion exchange","volume":"146","author":"Finkbeiner","year":"2018","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.119314_bib0010","article-title":"Benchmarking empirical models for THMs formation in drinking water systems: an application for decision support in Barcelona, Spain","volume":"763","author":"Godo-Pla","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119314_bib0011","unstructured":"Health Canada, 2020. Guidance on natural organic matter in drinking water. On line resource ISBN 9780660336282. https:\/\/www.canada.ca\/en\/health-canada\/services\/publications\/healthy-living\/guidance-natural-organic-matter-drinking-water.html."},{"key":"10.1016\/j.watres.2022.119314_bib0012","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jes.2015.12.011","article-title":"High-performance size exclusion chromatography with a multi-wavelength absorbance detector study on dissolved organic matter characterization along a water distribution system","volume":"44","author":"Huang","year":"2016","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.watres.2022.119314_bib0013","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.watres.2010.09.023","article-title":"Characterization of aquatic humic and non-humic matter with size-exclusion chromatography - organic carbon detection - organic nitrogen detection (LC-OCD-OND)","volume":"45","author":"Huber","year":"2011","journal-title":"Water Res."},{"issue":"2","key":"10.1016\/j.watres.2022.119314_bib0014","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0043-1354(98)00227-9","article-title":"Brominated trihalomethane formation in halogenation of humic acid in the coexistence of hypochlorite and hypobromite ions","volume":"33","author":"Ichihashi","year":"1999","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.119314_bib0015","first-page":"1568","article-title":"Step-by-step analysis of drinking water treatment trains using size-exclusion chromatography to fingerprint and track protein-like and humic\/fulvic-like fractions of dissolved organic matter","volume":"5","author":"Ignatev","year":"2019","journal-title":"Environ. Sci."},{"issue":"3","key":"10.1016\/j.watres.2022.119314_bib0016","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1021\/acs.est.9b06403","article-title":"Nonhalogenated aromatic DBPs in drinking water chlorination: a gap between NOM and halogenated aromatic DBPs","volume":"54","author":"Jiang","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119314_bib0017","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1016\/j.watres.2011.09.021","article-title":"Fast and precise method for HPLC-size exclusion chromatography with UV and TOC (NDIR) detection: importance of multiple detectors to evaluate the characteristics of dissolved organic matter","volume":"45","author":"Kawasaki","year":"2011","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.119314_bib0018","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.watres.2008.12.041","article-title":"Absorbance spectroscopy-based examination of effects of coagulation on the reactivity of fractions of natural organic matter with varying apparent molecular weights","volume":"43","author":"Korshin","year":"2009","journal-title":"Water Res."},{"issue":"23","key":"10.1016\/j.watres.2022.119314_bib0019","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1021\/es060353j","article-title":"Occurrence of a new generation of disinfection by-products","volume":"40","author":"Krasner","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119314_bib0020","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.watres.2010.01.036","article-title":"Multi-wavelength spectroscopic and chromatography study on the photocatalytic oxidation of natural organic matter","volume":"44","author":"Liu","year":"2010","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.119314_bib0021","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jes.2017.04.014","article-title":"TIC-Tox: a preliminary discussion on identifying the forcing agents of DBP-mediated toxicity of disinfected water","volume":"58","author":"Plewa","year":"2017","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.watres.2022.119314_bib0022","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jhazmat.2018.07.022","article-title":"Chemical characterization and relative toxicity assessment of disinfection byproduct mixtures in a large drinking water supply network","volume":"359","author":"Postigo","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.watres.2022.119314_bib0023","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.scitotenv.2013.12.095","article-title":"The impact of climate change on the treatability of dissolved organic matter (DOM) in upland water supplies: a UK perspective","volume":"473\u2013474","author":"Ritson","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2022.119314_bib0024","first-page":"623","article-title":"Monitoring changes in the structure and properties of humic substances following ozonation using UV\u2013vis, FTIR and 1H NMR techniques","volume":"541","author":"Rodr\u00edguez","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119314_bib0025","series-title":"Advances in the Physicochemical Characterization of Dissolved Organic Matter: Impact on Natural and Engineered Systems","author":"Rosario-Ortiz","year":"2015"},{"key":"10.1016\/j.watres.2022.119314_bib0026","doi-asserted-by":"crossref","unstructured":"Sillanp\u00e4\u00e4, M., 2014. Natural Organic Matter in Water: Characterization and Treatment Methods. Butterworth-Heinemann. doi:10.1016\/C2013-0-19213-6.","DOI":"10.1016\/C2013-0-19213-6"},{"key":"10.1016\/j.watres.2022.119314_bib0027","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.chemosphere.2010.05.007","article-title":"The application of HPLC-SEC for the simultaneous characterization of NOM and nitrate in well waters","volume":"80","author":"Szabo","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2022.119314_bib0028","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.desal.2009.11.011","article-title":"Desalination of brackish river water using Electrodialysis Reversal (EDR). Control of the THMs formation in the Barcelona (NE Spain) area","volume":"253","author":"Valero","year":"2010","journal-title":"Desalination"},{"issue":"4","key":"10.1016\/j.watres.2022.119314_bib0029","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1021\/acs.est.6b04817","article-title":"New insights into trihalomethane and haloacetic acid formation potentials: correlation with the molecular composition of natural organic matter in source water","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119314_bib0030","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.chemosphere.2012.01.029","article-title":"Characterization of dissolved organic matter using high-performance liquid chromatography (HPLC)-size exclusion chromatography (SEC) with a multiple wavelength absorbance detector","volume":"87","author":"Yan","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2022.119314_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.115283","article-title":"Comparative cytotoxicity of halogenated aromatic DBPs and implications of the corresponding developed QSAR model to toxicity mechanisms of those DBPs: binding interactions between aromatic DBPs and catalase play an important role","volume":"170","author":"Zhang","year":"2020","journal-title":"Water Res."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135422012593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135422012593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:21:24Z","timestamp":1758601284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135422012593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":31,"alternative-id":["S0043135422012593"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2022.119314","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NOM fractionation by HPSEC-DAD-OCD for predicting trihalomethane disinfection by-product formation potential in full-scale drinking water treatment plants","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2022.119314","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"119314"}}