{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T01:29:13Z","timestamp":1783560553437,"version":"3.55.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015803","name":"Tencent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008868","name":"Jiangsu Province Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.watres.2022.119358","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T05:25:20Z","timestamp":1668317120000},"page":"119358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"PA","title":["Insights into antibiotic stewardship of lake-rivers-basin complex systems for resistance risk control"],"prefix":"10.1016","volume":"228","author":[{"given":"Zhiyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8744-9382","authenticated-orcid":false,"given":"Qiuwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.watres.2022.119358_bib0001","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1021\/acs.est.5b00302","article-title":"Improving environmental risk assessment of human pharmaceuticals","volume":"49","author":"\u00c5gerstrand","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"10.1016\/j.watres.2022.119358_bib0002","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/bi5000564","article-title":"Mechanism of quinolone action and resistance","volume":"53","author":"Aldred","year":"2014","journal-title":"Biochemistry"},{"issue":"8","key":"10.1016\/j.watres.2022.119358_bib0003","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1093\/nar\/gkt124","article-title":"Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance","volume":"41","author":"Aldred","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.watres.2022.119358_bib0004","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41579-019-0218-1","article-title":"Mechanisms and clinical relevance of bacterial heteroresistance","volume":"17","author":"Andersson","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.watres.2022.119358_bib0005","doi-asserted-by":"crossref","first-page":"16053","DOI":"10.1038\/nmicrobiol.2016.53","article-title":"Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae","volume":"1","author":"Band","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.watres.2022.119358_bib0006","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.envres.2018.11.040","article-title":"Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review","volume":"169","author":"Ben","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.watres.2022.119358_bib0007","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.envint.2015.10.015","article-title":"Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation","volume":"86","author":"Bengtsson-Palme","year":"2016","journal-title":"Environ. Int."},{"issue":"5","key":"10.1016\/j.watres.2022.119358_bib0008","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nrmicro3439","article-title":"Tackling antibiotic resistance: the environmental framework","volume":"13","author":"Berendonk","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"issue":"7713","key":"10.1016\/j.watres.2022.119358_bib0009","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-018-0278-9","article-title":"Species-specific activity of antibacterial drug combinations","volume":"559","author":"Brochado","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.watres.2022.119358_bib0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/etc.5620170112","article-title":"A critical evaluation of safety (uncertainty) factors for ecological risk assessment","volume":"17","author":"Chapman","year":"1998","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.watres.2022.119358_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105538","article-title":"Characterization and source identification of antibiotic resistance genes in the sediments of an interconnected river-lake system","volume":"137","author":"Chen","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2022.119358_bib0012","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.envpol.2016.11.004","article-title":"Migration and degradation of swine farm tetracyclines at the river catchment scale: Can the multi-pond system mitigate pollution risk to receiving rivers?","volume":"220","author":"Chen","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.watres.2022.119358_bib0013","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.scitotenv.2018.10.167","article-title":"Deciphering the role of cyanobacteria in water resistome: Hypothesis justifying the antibiotic resistance (phenotype and genotype) in Planktothrix genus","volume":"652","author":"Dias","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2022.119358_bib0014","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.chemosphere.2017.05.148","article-title":"Occurrence, distribution, and risk assessment of antibiotics in the surface water of Poyang Lake, the largest freshwater lake in China","volume":"184","author":"Ding","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2022.119358_bib0015","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jenvman.2013.02.007","article-title":"Removal and degradation characteristics of quinolone antibiotics in laboratory-scale activated sludge reactors under aerobic, nitrifying and anoxic conditions","volume":"120","author":"Dorival-Garc\u00eda","year":"2013","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.watres.2022.119358_bib0016","unstructured":"European Commission, 2003. Technical guidance document on risk assessment in support of Commission Directive 93\/67\/EEC on risk assessment for new notified substances, Commission Regulation (EC) No 1488\/94 on Risk Assessment for existing substances, and Directive 98\/8\/EC of the European Parliament and of the Council concerning the placing of biocidal products on the market. Rome, Italy."},{"key":"10.1016\/j.watres.2022.119358_bib0017","unstructured":"European Commission, 2019. Communication from the Commission to the European Parliament, the Council and the European Econominc and Social Committee: European Union Strategic Approach to Pharmaceuticals in the Environment. Brussels, Belgium."},{"key":"10.1016\/j.watres.2022.119358_bib0018","unstructured":"European Committee on Antimicrobial Susceptibility Testing, 2019. Antimicrobial susceptibility testing: Clinical breakpoints for bacteria (Version 9.0)."},{"key":"10.1016\/j.watres.2022.119358_bib0019","unstructured":"European Medicines Agency, 2018. Guideline on the environmental risk assessment of medicinal products for human use. London, United Kingdom."},{"key":"10.1016\/j.watres.2022.119358_bib0020","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.scitotenv.2014.02.087","article-title":"Changes in water and sediment exchange between the Changjiang River and Poyang Lake under natural and anthropogenic conditions","volume":"481","author":"Gao","year":"2014","journal-title":"China. Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.watres.2022.119358_bib0021","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.watres.2013.01.020","article-title":"Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment","volume":"47","author":"Gonz\u00e1lez-Pleiter","year":"2013","journal-title":"Water Res."},{"issue":"5","key":"10.1016\/j.watres.2022.119358_bib0022","doi-asserted-by":"crossref","first-page":"e01914","DOI":"10.1128\/mBio.01918-14","article-title":"Selection of a multidrug resistance plasmid by sublethal levels of antibiotics and heavy metals","volume":"5","author":"Gullberg","year":"2014","journal-title":"mBio"},{"issue":"7","key":"10.1016\/j.watres.2022.119358_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002158","article-title":"Selection of resistant bacteria at very low antibiotic concentrations","volume":"7","author":"Gullberg","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.watres.2022.119358_bib0024","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.envint.2018.02.003","article-title":"Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China: Its potential for resistance development and ecological and human risk","volume":"114","author":"Hanna","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2022.119358_bib0025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fmicb.2011.00022","article-title":"Quinolone resistance: much more than predicted","volume":"2","author":"Hern\u00e1ndez","year":"2011","journal-title":"Front. microbiol."},{"key":"10.1016\/j.watres.2022.119358_bib0026","series-title":"The Freshwater Algae of China-Systematics, Taxonomy and Ecology","first-page":"1","author":"Hu","year":"2006"},{"issue":"8","key":"10.1016\/j.watres.2022.119358_bib0027","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41579-018-0040-1","article-title":"Cyanobacterial blooms","volume":"16","author":"Huisman","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.watres.2022.119358_bib0028","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.envint.2017.09.013","article-title":"Integrating human and environmental health in antibiotic risk assessment: A critical analysis of protection goals, species sensitivity and antimicrobial resistance","volume":"109","author":"Le Page","year":"2017","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2022.119358_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117050","article-title":"Unraveling the riverine antibiotic resistome: The downstream fate of anthropogenic inputs","volume":"197","author":"Lee","year":"2021","journal-title":"Water Res."},{"issue":"7","key":"10.1016\/j.watres.2022.119358_bib0030","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s10661-016-5439-4","article-title":"Sources identification of antibiotic pollution combining land use information and multivariate statistics","volume":"188","author":"Li","year":"2016","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.watres.2022.119358_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2019.109396","article-title":"Occurrence and ecological risk assessment of selected antibiotics in the freshwater lakes along the middle and lower reaches of Yangtze River Basin","volume":"249","author":"Li","year":"2019","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.watres.2022.119358_bib0032","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.scitotenv.2018.01.271","article-title":"Antibiotics in the aquatic environments: a review of lakes","volume":"627","author":"Liu","year":"2018","journal-title":"China. Sci. Total Environ."},{"issue":"5887","key":"10.1016\/j.watres.2022.119358_bib0033","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1126\/science.1159483","article-title":"Antibiotics and antibiotic resistance genes in natural environments","volume":"321","author":"Mart\u00ednez","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.watres.2022.119358_bib0034","unstructured":"Ministry of Health of China, 2012. Guidelines for clinical application of antibiotics (No. 84 Decree). http:\/\/www.gov.cn\/flfg\/2012-05\/08\/content_2132174.htm."},{"key":"10.1016\/j.watres.2022.119358_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117233","article-title":"Dawning of a new ERA: Environmental risk assessment of antibiotics and their potential to select for antimicrobial resistance","volume":"200","author":"Murray","year":"2021","journal-title":"Water Res."},{"issue":"6","key":"10.1016\/j.watres.2022.119358_bib0036","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ijantimicag.2019.03.001","article-title":"Comparing the selective and co-selective effects of different antimicrobials in bacterial communities","volume":"53","author":"Murray","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"4","key":"10.1016\/j.watres.2022.119358_bib0037","doi-asserted-by":"crossref","first-page":"e00918","DOI":"10.1128\/mBio.00969-18","article-title":"Novel insights into selection for antibiotic resistance in complex microbial communities","volume":"9","author":"Murray","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.watres.2022.119358_bib0038","unstructured":"National Health and Family Planning Commission of China, 2016. National Action Plan to Contain Antimicrobial Resistance (2016-2020)."},{"key":"10.1016\/j.watres.2022.119358_bib0039","unstructured":"O'Neill, J., 2016. Tackling drug-resistant infections globally: final report and recommendations, review on antimicrobial resistance. London, United Kingdom."},{"issue":"11","key":"10.1016\/j.watres.2022.119358_bib0040","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1021\/acs.est.1c00939","article-title":"Developing surrogate markers for predicting antibiotic resistance \u201chot spots\u201d in rivers where limited data are available","volume":"55","author":"Ott","year":"2021","journal-title":"Environ. Sci. Technol."},{"issue":"23","key":"10.1016\/j.watres.2022.119358_bib0041","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.1021\/es060413l","article-title":"Antibiotic resistance genes as emerging contaminants: studies in Northern Colorado","volume":"40","author":"Pruden","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119358_bib0042","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.envint.2017.10.016","article-title":"Review of antibiotic resistance in China and its environment","volume":"110","author":"Qiao","year":"2018","journal-title":"Environ. Int."},{"issue":"10","key":"10.1016\/j.watres.2022.119358_bib0043","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1473-3099(06)70599-0","article-title":"The worldwide emergence of plasmid-mediated quinolone resistance","volume":"6","author":"Robicsek","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.watres.2022.119358_bib0044","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/s41579-022-00700-5","article-title":"The physiology and genetics of bacterial responses to antibiotic combinations","volume":"20","author":"Roemhild","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"issue":"9","key":"10.1016\/j.watres.2022.119358_bib0045","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1021\/acs.est.5b01519","article-title":"Antibiotic stewardship should consider environmental fate of antibiotics","volume":"49","author":"Rosi-Marshall","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119358_bib0046","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0221568","article-title":"Translating antibiotic prescribing into antibiotic resistance in the environment: a hazard characterisation case study","volume":"14","author":"Singer","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.watres.2022.119358_bib0047","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s42003-020-01176-w","article-title":"Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration","volume":"3","author":"Stanton","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.watres.2022.119358_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135131","article-title":"Dynamic behavior of sediment resuspension and nutrients release in the shallow and wind-exposed Meiliang Bay of Lake Taihu","volume":"708","author":"Tang","year":"2020","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.watres.2022.119358_bib0049","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41540-018-0069-9","article-title":"Prevalence and patterns of higher-order drug interactions in Escherichia coli","volume":"4","author":"Tekin","year":"2018","journal-title":"npj Syst. Biol. Appl."},{"key":"10.1016\/j.watres.2022.119358_bib0050","unstructured":"United Nation Environment Programme, 2019. Frontiers 2018\/19 Emerging Issues of Environmental Concern. Nairobi, Kenya."},{"issue":"2","key":"10.1016\/j.watres.2022.119358_bib0051","doi-asserted-by":"crossref","DOI":"10.3390\/su9020301","article-title":"Emission control in river network system of the Taihu Basin for water quality assurance of water environmentally sensitive areas","volume":"9","author":"Wang","year":"2017","journal-title":"Sustainability"},{"issue":"1","key":"10.1016\/j.watres.2022.119358_bib0052","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s11356-017-0475-3","article-title":"Combined effects of binary antibiotic mixture on growth, microcystin production, and extracellular release of Microcystis aeruginosa: application of response surface methodology","volume":"25","author":"Wang","year":"2017","journal-title":"Environ. Sci. Pollut. R."},{"key":"10.1016\/j.watres.2022.119358_bib0053","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.chemosphere.2019.06.192","article-title":"Long-term exposure to antibiotic mixtures favors microcystin synthesis and release in Microcystis aeruginosa with different morphologies","volume":"235","author":"Wang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2022.119358_bib0054","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jenvman.2019.04.070","article-title":"Characterization and source identification of tetracycline antibiotics in the drinking water sources of the lower Yangtze River","volume":"244","author":"Wang","year":"2019","journal-title":"J. Environ. Manage."},{"key":"10.1016\/j.watres.2022.119358_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106034","article-title":"Critical roles of cyanobacteria as reservoir and source for antibiotic resistance genes","volume":"144","author":"Wang","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2022.119358_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117430","article-title":"High prevalence of unstable antibiotic heteroresistance in cyanobacteria causes resistance underestimation","volume":"202","author":"Wang","year":"2021","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2022.119358_bib0057","unstructured":"World Health Organization, 2014. Antimicrobial resistance: global report on surveillance. Geneva, Switzerland."},{"key":"10.1016\/j.watres.2022.119358_bib0058","unstructured":"World Health Organisation, 2015. Global action plan on antimicrobial resistance. Geneva, Switzerland."},{"key":"10.1016\/j.watres.2022.119358_bib0059","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.scitotenv.2018.06.175","article-title":"Spatiotemporal heterogeneity of antibiotic pollution and ecological risk assessment in Taihu Lake Basin, China","volume":"643","author":"Xu","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.watres.2022.119358_bib0060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.envpol.2012.12.008","article-title":"Antibiotics in the surface water of the Yangtze estuary: occurrence, distribution and risk assessment","volume":"175","author":"Yan","year":"2013","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.watres.2022.119358_bib0061","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.envint.2018.04.011","article-title":"Antibiotics and antibiotic resistance genes in global lakes: a review and meta-analysis","volume":"116","author":"Yang","year":"2018","journal-title":"Environ. Int."},{"issue":"10","key":"10.1016\/j.watres.2022.119358_bib0062","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1021\/acs.est.6b06278","article-title":"Tracking nitrogen sources, transformation, and transport at a basin scale with complex plain river networks","volume":"51","author":"Yi","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.watres.2022.119358_bib0063","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s42003-020-01468-1","article-title":"Cyanobacterial blooms contribute to the diversity of antibiotic-resistance genes in aquatic ecosystems","volume":"3","author":"Zhang","year":"2020","journal-title":"Commun. Biol."},{"issue":"11","key":"10.1016\/j.watres.2022.119358_bib0064","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","article-title":"Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance","volume":"49","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"15","key":"10.1016\/j.watres.2022.119358_bib0065","doi-asserted-by":"crossref","first-page":"11412","DOI":"10.1007\/s11356-015-4371-4","article-title":"Prevalence of antibiotic resistance genes in antibiotic-resistant Escherichia coli isolates in surface water of Taihu Lake Basin","volume":"22","author":"Zhang","year":"2015","journal-title":"China. Environ. Sci. Pollut. R."},{"key":"10.1016\/j.watres.2022.119358_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.136518","article-title":"Emission and fate of antibiotics in the Dongjiang River Basin, China: Implication for antibiotic resistance risk","volume":"712","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2022.119358_bib0067","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.watres.2016.08.033","article-title":"A pilot plant study using conventional and advanced water treatment processes: Evaluating removal efficiency of indicator compounds representative of pharmaceuticals and personal care products","volume":"105","author":"Zhang","year":"2016","journal-title":"Water Res."},{"issue":"8","key":"10.1016\/j.watres.2022.119358_bib0068","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1021\/acs.est.8b07334","article-title":"New insights into sediment transport in interconnected river\u2013lake systems through tracing microorganisms","volume":"53","author":"Zhang","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2022.119358_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139128","article-title":"Ecotoxicological risk assessment and source apportionment of antibiotics in the waters and sediments of a peri-urban river","volume":"731","author":"Zhang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.watres.2022.119358_bib0070","article-title":"Tissue concentrations, trophic transfer and human risks of antibiotics in freshwater food web in Lake Taihu","volume":"197","author":"Zhou","year":"2020","journal-title":"China. Ecotox. Environ. Safe."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135422013033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135422013033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:21:30Z","timestamp":1758601290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135422013033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":70,"alternative-id":["S0043135422013033"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2022.119358","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into antibiotic stewardship of lake-rivers-basin complex systems for resistance risk control","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2022.119358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119358"}}