{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:19:09Z","timestamp":1788340749124,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.watres.2023.119927","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T08:44:11Z","timestamp":1680079451000},"page":"119927","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Degradation kinetics and formation of regulated and emerging disinfection by-products during chlorination of two expectorants ambroxol and bromhexine"],"prefix":"10.1016","volume":"235","author":[{"given":"Wuming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunke","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhai","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7327-8984","authenticated-orcid":false,"given":"Zuxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.watres.2023.119927_bib0001","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.watres.2018.02.002","article-title":"Characterization and risk assessment of seasonal and weather dynamics in organic pollutant mixtures from discharge of a separate sewer system","volume":"135","author":"Beckers","year":"2018","journal-title":"Water Res."},{"issue":"15","key":"10.1016\/j.watres.2023.119927_bib0002","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1016\/j.watres.2011.05.034","article-title":"Occurrence and control of nitrogenous disinfection by-products in drinking water \u2013 a review","volume":"45","author":"Bond","year":"2011","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.watres.2023.119927_bib0003","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0043-1354(02)00363-9","article-title":"Sonolytic debromination of ambroxol process wastewater","volume":"37","author":"Br\u00fcggemann","year":"2003","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2023.119927_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117265","article-title":"Roles and knowledge gaps of point-of-use technologies for mitigating health risks from disinfection byproducts in tap water: a critical review","volume":"200","author":"Chen","year":"2021","journal-title":"Water Res."},{"issue":"7","key":"10.1016\/j.watres.2023.119927_bib0005","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1021\/acs.est.0c04394","article-title":"Intensified disinfection amid COVID-19 pandemic poses potential risks to water quality and safety","volume":"55","author":"Chu","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2023.119927_bib0006","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.envpol.2011.09.037","article-title":"Formation of halogenated C-, N-DBPs from chlor(am)ination and UV irradiation of tyrosine in drinking water","volume":"161","author":"Chu","year":"2012","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.watres.2023.119927_bib0007","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jhazmat.2016.12.058","article-title":"Production of trihalomethanes, haloacetaldehydes and haloacetonitriles during chlorination of microcystin-LR and impacts of pre-oxidation on their formation","volume":"327","author":"Chu","year":"2017","journal-title":"J. Hazard. Mater."},{"issue":"24","key":"10.1016\/j.watres.2023.119927_bib0008","doi-asserted-by":"crossref","first-page":"14432","DOI":"10.1021\/acs.est.5b04783","article-title":"Formation pathways and trade-offs between haloacetamides and haloacetaldehydes during combined chlorination and chloramination of lignin phenols and natural waters","volume":"49","author":"Chuang","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"21","key":"10.1016\/j.watres.2023.119927_bib0009","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1021\/es040006e","article-title":"Aqueous chlorination kinetics of some endocrine disruptors","volume":"38","author":"Deborde","year":"2004","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.watres.2023.119927_bib0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.watres.2007.07.025","article-title":"Reactions of chlorine with inorganic and organic compounds during water treatment\u2014kinetics and mechanisms: a critical review","volume":"42","author":"Deborde","year":"2008","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.watres.2023.119927_bib0011","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/17425255.2019.1578748","article-title":"Enhancement of lung levels of antibiotics by ambroxol and bromhexine","volume":"15","author":"Deretic","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.watres.2023.119927_bib0012","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jhazmat.2017.07.049","article-title":"Formation and estimated toxicity of trihalomethanes, haloacetonitriles, and haloacetamides from the chlor(am)ination of acetaminophen","volume":"341","author":"Ding","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.watres.2023.119927_bib0013","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cej.2018.12.069","article-title":"Effect of reduced sulfur group on the formation of CX3R-type disinfection by-products during chlor(am)ination of reduced sulfur compounds","volume":"361","author":"Ding","year":"2019","journal-title":"Chem. Eng. J."},{"issue":"3","key":"10.1016\/j.watres.2023.119927_bib0014","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.watres.2006.10.029","article-title":"Aqueous chlorination of the antibacterial agent trimethoprim: reaction kinetics and pathways","volume":"41","author":"Dodd","year":"2007","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.watres.2023.119927_bib0015","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1021\/acs.est.0c00014","article-title":"Effect-directed analysis (EDA): a promising tool for nontarget identification of unknown disinfection byproducts in drinking water","volume":"54","author":"Dong","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"20","key":"10.1016\/j.watres.2023.119927_bib0016","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1056\/NEJMoa030747","article-title":"Identification of a novel coronavirus in patients with severe acute respiratory syndrome","volume":"348","author":"Drosten","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.watres.2023.119927_bib0017","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.chemosphere.2004.03.001","article-title":"Chlorination of bisphenol a: kinetics and by-products formation","volume":"56","author":"Gallard","year":"2004","journal-title":"Chemosphere"},{"issue":"8","key":"10.1016\/j.watres.2023.119927_bib0018","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/S0043-1354(98)00361-3","article-title":"Hydrolysis of haloacetonitriles: linear free energy relationship, kinetics and products","volume":"33","author":"Glezer","year":"1999","journal-title":"Water Res."},{"issue":"9","key":"10.1016\/j.watres.2023.119927_bib0019","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1021\/acs.est.0c08565","article-title":"How much of the total organic halogen and developmental toxicity of chlorinated drinking water might be attributed to aromatic halogenated DBPs?","volume":"55","author":"Han","year":"2021","journal-title":"Environ. Sci. Technol."},{"issue":"13","key":"10.1016\/j.watres.2023.119927_bib0020","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1016\/j.watres.2012.05.031","article-title":"Evaluation of bromine substitution factors of DBPs during chlorination and chloramination","volume":"46","author":"Hua","year":"2012","journal-title":"Water Res."},{"issue":"3","key":"10.1016\/j.watres.2023.119927_bib0021","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1021\/acs.estlett.0c00011","article-title":"Novel chlorination byproducts of tryptophan: initial high-yield transformation products versus small molecule disinfection byproducts","volume":"7","author":"Hua","year":"2020","journal-title":"Environ. Sci. Technol. Lett."},{"issue":"3","key":"10.1016\/j.watres.2023.119927_bib0022","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1021\/acs.est.9b06403","article-title":"Nonhalogenated aromatic DBPs in drinking water chlorination: a gap between NOM and halogenated aromatic DBPs","volume":"54","author":"Jiang","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"23","key":"10.1016\/j.watres.2023.119927_bib0023","doi-asserted-by":"crossref","first-page":"16929","DOI":"10.1021\/acs.est.2c06394","article-title":"Formation of larger molecular weight disinfection byproducts from acetaminophen in chlorine disinfection","volume":"56","author":"Li","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2023.119927_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111958","article-title":"Fate of sulfamethoxazole and potential formation of haloacetic acids during chlorine disinfection process in aquaculture water","volume":"204","author":"Lou","year":"2022","journal-title":"Environ. Res."},{"issue":"11","key":"10.1016\/j.watres.2023.119927_bib0025","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1158\/2159-8290.CD-13-1010","article-title":"The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis","volume":"4","author":"Lucas","year":"2014","journal-title":"Cancer Discov"},{"issue":"6","key":"10.1016\/j.watres.2023.119927_bib0026","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jpha.2021.09.001","article-title":"Drug repurposing against coronavirus disease 2019 (COVID-19): a review","volume":"11","author":"Luo","year":"2021","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.watres.2023.119927_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110247","article-title":"Formation, speciation and toxicity of CX3R-type disinfection by-products (DBPs) from chlor(am)ination of 2,4-diaminobutyric acid (DAB)","volume":"191","author":"Luo","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.watres.2023.119927_bib0028","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1021\/es0617441","article-title":"Haloacetonitriles vs. regulated haloacetic acids:\u2009 are nitrogen-containing DBPs more toxic?","volume":"41","author":"Muellner","year":"2007","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.watres.2023.119927_bib0029","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1021\/es303729n","article-title":"Four groups of new aromatic halogenated disinfection byproducts: effect of bromide concentration on their formation and speciation in chlorinated drinking water","volume":"47","author":"Pan","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"9366","key":"10.1016\/j.watres.2023.119927_bib0030","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0140-6736(03)13077-2","article-title":"Coronavirus as a possible cause of severe acute respiratory syndrome","volume":"361","author":"Peiris","year":"2003","journal-title":"Lancet"},{"issue":"7297","key":"10.1016\/j.watres.2023.119927_bib0031","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1136\/bmj.322.7297.1271","article-title":"Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review","volume":"322","author":"Poole","year":"2001","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.watres.2023.119927_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2166\/aqua.2001.0001","article-title":"Formation and degradation of dichloroacetonitrile in drinking waters","volume":"50","author":"Reckhow","year":"2001","journal-title":"J. Water Supply Res. Technol. AQUA"},{"issue":"1","key":"10.1016\/j.watres.2023.119927_bib0033","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mrrev.2007.09.001","article-title":"Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research","volume":"636","author":"Richardson","year":"2007","journal-title":"Mutat. Res.-Rev. Mutat. Res."},{"key":"10.1016\/j.watres.2023.119927_bib0034","first-page":"234","article-title":"Formation of haloforms during chlorination of natural waters","volume":"23","author":"Rook","year":"1974","journal-title":"Water Treat. Exam."},{"issue":"6013","key":"10.1016\/j.watres.2023.119927_bib0035","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1126\/science.1196397","article-title":"The chlorine dilemma","volume":"331","author":"Sedlak","year":"2011","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.watres.2023.119927_bib0036","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.watres.2003.12.014","article-title":"Reactivity of natural organic matter with aqueous chlorine and bromine","volume":"38","author":"Westerhoff","year":"2004","journal-title":"Water Res."},{"issue":"1","key":"10.1016\/j.watres.2023.119927_bib0037","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jhazmat.2009.03.147","article-title":"Ametryn degradation by aqueous chlorine: kinetics and reaction influences","volume":"169","author":"Xu","year":"2009","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.watres.2023.119927_bib0038","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.watres.2019.04.033","article-title":"Application of (LC\/)MS\/MS precursor ion scan for evaluating the occurrence, formation and control of polar halogenated DBPs in disinfected waters: a review","volume":"158","author":"Yang","year":"2019","journal-title":"Water Res."},{"issue":"20","key":"10.1016\/j.watres.2023.119927_bib0039","doi-asserted-by":"crossref","first-page":"12362","DOI":"10.1021\/es503621e","article-title":"Toxic impact of bromide and iodide on drinking water disinfected with chlorine or chloramines","volume":"48","author":"Yang","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2023.119927_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128628","article-title":"Tetracycline antibiotics as precursors of dichloroacetamide and other disinfection byproducts during chlorination and chloramination","volume":"270","author":"Ye","year":"2021","journal-title":"Chemosphere"},{"issue":"18","key":"10.1016\/j.watres.2023.119927_bib0041","doi-asserted-by":"crossref","first-page":"11028","DOI":"10.1021\/acs.est.5b02772","article-title":"Kinetic analysis of haloacetonitrile stability in drinking waters","volume":"49","author":"Yu","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"19","key":"10.1016\/j.watres.2023.119927_bib0042","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia","volume":"367","author":"Zaki","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.watres.2023.119927_bib0043","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1021\/es1034427","article-title":"Formation and decomposition of new and unknown polar brominated disinfection byproducts during chlorination","volume":"45","author":"Zhai","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2023.119927_bib0044","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.watres.2019.05.047","article-title":"Integrated control of CX3R-type DBP formation by coupling thermally activated persulfate pre-oxidation and chloramination","volume":"160","author":"Zhang","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2023.119927_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114113","article-title":"Efficient multiresidue determination method for 168 pharmaceuticals and metabolites: optimization and application to raw wastewater, wastewater effluent, and surface water in Beijing","volume":"261","author":"Zhang","year":"2020","journal-title":"China. Environ. Pollut."},{"key":"10.1016\/j.watres.2023.119927_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.115283","article-title":"Comparative cytotoxicity of halogenated aromatic DBPs and implications of the corresponding developed QSAR model to toxicity mechanisms of those DBPs: binding interactions between aromatic DBPs and catalase play an important role","volume":"170","author":"Zhang","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2023.119927_bib0047","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ecoenv.2014.05.008","article-title":"Chlorination and chloramination of tetracycline antibiotics: disinfection by-products formation and influential factors","volume":"107","author":"Zhou","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135423003639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135423003639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:41:13Z","timestamp":1758602473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135423003639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":47,"alternative-id":["S0043135423003639"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2023.119927","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Degradation kinetics and formation of regulated and emerging disinfection by-products during chlorination of two expectorants ambroxol and bromhexine","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2023.119927","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119927"}}