{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:42:01Z","timestamp":1789594921189,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000139","name":"United States Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.watres.2024.121437","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T07:28:41Z","timestamp":1709796521000},"page":"121437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Assessment of antibiotic-resistant infection risks associated with reclaimed wastewater irrigation in intensive tomato cultivation"],"prefix":"10.1016","volume":"254","author":[{"given":"Samira","family":"Nahim-Granados","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter","family":"Quon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Inmaculada","family":"Polo-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Oller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ag\u00fcera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.watres.2024.121437_bib0001","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.agwat.2007.06.008","article-title":"Effects of reclaimed wastewater irrigation on soil and tomato fruits: a case study in Sicily (Italy)","volume":"93","author":"Aiello","year":"2007","journal-title":"Agric. Water Manag."},{"key":"10.1016\/j.watres.2024.121437_bib0002","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/426241","article-title":"Diversity of antimicrobial resistance and virulence determinants in Pseudomonas aeruginosa associated with fresh vegetables","author":"Allydice-Francis","year":"2012","journal-title":"Int. J. Microbiol."},{"key":"10.1016\/j.watres.2024.121437_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12889-016-3266-8","article-title":"A faecal exposure assessment of farm workers in\\ Accra, Ghana: a cross sectional study","volume":"16","author":"Antwi-Agyei","year":"2016","journal-title":"BMC Public Health"},{"issue":"3","key":"10.1016\/j.watres.2024.121437_bib0004","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.watres.2012.12.012","article-title":"A probabilistic model of norovirus disease burden associated with greywater irrigation of home-produced lettuce in Melbourne, Australia","volume":"47","author":"Barker","year":"2013","journal-title":"Water Res."},{"issue":"19","key":"10.1016\/j.watres.2024.121437_bib0005","doi-asserted-by":"crossref","first-page":"10159","DOI":"10.3390\/app121910159","article-title":"Quantitative microbial risk assessment of North Carolina type 2 reclaimed water for agricultural reuse","volume":"12","author":"Bailey","year":"2022","journal-title":"Appl. Sci."},{"issue":"1","key":"10.1016\/j.watres.2024.121437_bib0006","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jcf.2020.12.005","article-title":"Environmental risks of Pseudomonas aeruginosa\u2013What to advise patients and parents","volume":"20","author":"Balfour-Lynn","year":"2021","journal-title":"J. Cystic Fibrosis"},{"issue":"3","key":"10.1016\/j.watres.2024.121437_bib0007","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2166\/wst.2003.0175","article-title":"Detection, enumeration andisolation of strains carrying the STX2 gene from urban sewage","volume":"47","author":"Blanch","year":"2003","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.watres.2024.121437_bib0008","article-title":"Pesticide residue intake model-EFSA PRIMo revision 3.1","volume":"16","author":"Brancato","year":"2019","journal-title":"EFSA Support. Publ"},{"issue":"1","key":"10.1016\/j.watres.2024.121437_bib0009","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","article-title":"Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis","volume":"19","author":"Cassini","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.watres.2024.121437_bib0010","series-title":"Antibiotic Resistance Threats in the United States, 2019","year":"2019"},{"key":"10.1016\/j.watres.2024.121437_bib0011","series-title":"Outbreak of Extensively Drug-Resistant Pseudomonas Aeruginosa Associated With Artificial Tears, 2023","year":"2023"},{"issue":"1","key":"10.1016\/j.watres.2024.121437_bib0012","doi-asserted-by":"crossref","first-page":"17093","DOI":"10.1038\/s41598-019-52947-3","article-title":"A dose response model for quantifying the infection risk of antibiotic-resistant bacteria","volume":"9","author":"Chandrasekaran","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.watres.2024.121437_bib0013","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.watres.2017.07.004","article-title":"The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment: the knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes\u2013a review","volume":"123","author":"Christou","year":"2017","journal-title":"Water Res."},{"issue":"11","key":"10.1016\/j.watres.2024.121437_bib0014","doi-asserted-by":"crossref","first-page":"861","DOI":"10.4315\/0362-028X-44.11.861","article-title":"Experimental infection by waterborne enteroviruses","volume":"44","author":"Cliver","year":"1981","journal-title":"J. Food Prot."},{"issue":"3","key":"10.1016\/j.watres.2024.121437_bib0015","doi-asserted-by":"crossref","DOI":"10.1061\/(ASCE)EE.1943-7870.0001641","article-title":"Reverse QMRA for Pseudomonas aeruginosa in premise plumbing to inform risk management","volume":"146","author":"Dean","year":"2020","journal-title":"J. Environ. Eng."},{"issue":"5","key":"10.1016\/j.watres.2024.121437_bib0016","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1128\/AAC.26.5.715","article-title":"Multiple-dose pharmacokinetics of imipenem-cilastatin","volume":"26","author":"Drusano","year":"1984","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.watres.2024.121437_bib0017","unstructured":"EC, 2022. Short-term outlook for EU agricultural markets, Summer 2022. European Commission, DG Agriculture and Rural Development, Brussels. Annex for EU-27. Available at: http:\/\/ec.europa.eu\/environment\/water\/blueprint\/pdf\/Final%20Report_Water%20Reuse_April%202012.pdf. (Accessed January 2023)."},{"issue":"10","key":"10.1016\/j.watres.2024.121437_bib0018","first-page":"e05017","article-title":"ECDC, EFSA and EMA Joint Scientific Opinion on a list of outcome indicators as regards surveillance of antimicrobial resistance and antimicrobial consumption in humans and food-producing animals","volume":"15","year":"2017","journal-title":"EFSA J."},{"issue":"6","key":"10.1016\/j.watres.2024.121437_bib0019","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1089\/fpd.2014.1928","article-title":"Genetic lineages and antimicrobial resistance in Pseudomonas spp. isolates recovered from food samples","volume":"12","author":"Estepa","year":"2015","journal-title":"Foodborne Pathog. Dis."},{"issue":"6","key":"10.1016\/j.watres.2024.121437_bib0020","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1128\/AEM.70.6.3535-3540.2004","article-title":"Prevalence of the stx 2 gene in coliform populations from aquatic environments","volume":"70","author":"Garc\u00eda-Aljaro","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.watres.2024.121437_bib0021","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.watres.2018.12.070","article-title":"Quantitative risk assessment of norovirus and adenovirus for the use of reclaimed water to irrigate lettuce in Catalonia","volume":"153","author":"Gonzales-Gustavson","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2024.121437_bib0022","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.watres.2017.07.002","article-title":"Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements","volume":"123","author":"Guo","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2024.121437_bib0023","series-title":"Quantitative Microbial Risk Assessment","author":"Haas","year":"2014"},{"issue":"5","key":"10.1016\/j.watres.2024.121437_bib0024","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1128\/AEM.72.5.3284-3290.2006","article-title":"Quantitative microbial risk assessment models for consumption of raw vegetables irrigated with reclaimed water","volume":"72","author":"Hamilton","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"issue":"5","key":"10.1016\/j.watres.2024.121437_bib0025","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1089\/fpd.2011.1044","article-title":"Human enteric pathogen internalization by root uptake into food crops","volume":"9","author":"Hirneisen","year":"2012","journal-title":"Foodborne Pathog. Dis."},{"issue":"11","key":"10.1016\/j.watres.2024.121437_bib0026","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1089\/fpd.2018.2501","article-title":"Unraveling the role of vegetables in spreading antimicrobial-resistant bacteria: a need for quantitative risk assessment","volume":"15","author":"H\u00f6lzel","year":"2018","journal-title":"Foodborne Pathog. Dis."},{"issue":"2","key":"10.1016\/j.watres.2024.121437_bib0027","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01059394","article-title":"The human pharmacokinetics of cefotaxime and its metabolites and the role of renal tubular secretion on their elimination","volume":"13","author":"Ings","year":"1985","journal-title":"J. Pharmacokinet. Biopharm."},{"issue":"4","key":"10.1016\/j.watres.2024.121437_bib0028","doi-asserted-by":"crossref","first-page":"784","DOI":"10.4315\/0362-028X.JFP-14-376","article-title":"Belgian and Spanish consumption data and consumer handling practices for fresh fruits and vegetables useful for further microbiological and chemical exposure assessment","volume":"78","author":"Jacxsens","year":"2015","journal-title":"J. Food Prot."},{"issue":"4","key":"10.1016\/j.watres.2024.121437_bib0029","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1473-3099(15)00350-3","article-title":"Public funding for research on antibacterial resistance in the JPIAMR countries, the European Commission, and related European Union agencies: a systematic observational analysis","volume":"16","author":"Kelly","year":"2016","journal-title":"Lancet Infect. Dis."},{"issue":"2","key":"10.1016\/j.watres.2024.121437_bib0030","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4315\/0362-028X-69.2.330","article-title":"Efficacy of home washing methods in controlling surface microbial contamination on fresh produce","volume":"69","author":"Kilonzo-Nthenge","year":"2006","journal-title":"J. Food Prot."},{"issue":"1","key":"10.1016\/j.watres.2024.121437_bib0031","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/00003226-199301000-00003","article-title":"Effect of Pseudomonas aeruginosa concentration in experimental contact lens-related microbial keratitis","volume":"12","author":"Lawin-Br\u00fcssel","year":"1993","journal-title":"Cornea"},{"issue":"2","key":"10.1016\/j.watres.2024.121437_bib0032","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jchromb.2008.09.020","article-title":"Simultaneous determination of three carbapenem antibiotics in plasma by HPLC with ultraviolet detection","volume":"875","author":"Legrand","year":"2008","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.watres.2024.121437_bib0033","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3389\/fcimb.2019.00303","article-title":"High-throughput detection of bacterial community and its drug-resistance profiling from local reclaimed wastewater plants","volume":"9","author":"Limayem","year":"2019","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.watres.2024.121437_bib0034","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.watres.2014.01.060","article-title":"A probabilistic quantitative microbial risk assessment model of norovirus disease burden from wastewater irrigation of vegetables in Shepparton, Australia","volume":"54","author":"Mok","year":"2014","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2024.121437_bib0035","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fcimb.2017.00039","article-title":"Pseudomonas aeruginosa lifestyle: a paradigm for adaptation, survival, and persistence","volume":"7","author":"Moradali","year":"2017","journal-title":"Front. Cell Infect Microbiol."},{"issue":"5","key":"10.1016\/j.watres.2024.121437_bib0036","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0363-5023(97)80094-9","article-title":"A cadaver study on volume and surface area of the fingertip","volume":"22","author":"Murai","year":"1997","journal-title":"J. Hand Surg. Am."},{"key":"10.1016\/j.watres.2024.121437_bib0037","article-title":"Bacterial load detected in three greenhouses irrigated with reclaimed wastewater. (Version 1) [Data set]","author":"Nahim-Granados","year":"2023","journal-title":"Zenodo"},{"issue":"6","key":"10.1016\/j.watres.2024.121437_bib0038","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/15459620802003896","article-title":"A study quantifying the hand-to-face contact rate and its potential application to predicting respiratory tract infection","volume":"5","author":"Nicas","year":"2008","journal-title":"J. Occup. Environ. Hyg."},{"key":"10.1016\/j.watres.2024.121437_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6743826","article-title":"Microbial assessment of tomatoes (Lycopersicon esculentum) sold at some central markets in ghana","author":"Obeng","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.watres.2024.121437_bib0041","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.envint.2018.11.022","article-title":"Human exposure to antibiotic resistant-Escherichia coli through irrigated lettuce","volume":"122","author":"O'Flaherty","year":"2019","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2024.121437_bib0042","first-page":"677","article-title":"Risk management during effluent application for irrigation","author":"Oron","year":"2015","journal-title":"Environ. Indic."},{"issue":"1","key":"10.1016\/j.watres.2024.121437_bib0043","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3390\/ijerph19010360","article-title":"Contamination of fresh produce with antibiotic-resistant bacteria and associated risks to human health: a scoping review","volume":"19","author":"Rahman","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"7","key":"10.1016\/j.watres.2024.121437_bib0044","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1056\/NEJM198102123040730","article-title":"Please don't eat the salads","volume":"304","author":"Remington","year":"1981","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.watres.2024.121437_bib0045","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1574-6941.12403","article-title":"Exploring the immediate and long-term impact on bacterial communities in soil amended with animal and urban organic waste fertilizers using pyrosequencing and screening for horizontal transfer of antibiotic resistance","volume":"90","author":"Riber","year":"2014","journal-title":"FEMS Microbiol. Ecol."},{"issue":"4","key":"10.1016\/j.watres.2024.121437_bib0046","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.1365-2672.2002.01734.x","article-title":"Comparative surface-to-hand and fingertip-to-mouth transfer efficiency of gram-positive bacteria, gram-negative bacteria, and phage","volume":"93","author":"Rusin","year":"2002","journal-title":"J. Appl. Microbiol."},{"issue":"Suppl 2","key":"10.1016\/j.watres.2024.121437_bib0047","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s15010-005-8202-2","article-title":"Kinetics and quantification of antibacterial effects of beta-lactams, macrolides, and quinolones against gram-positive and gram-negative RTI pathogens","volume":"33","author":"Schaper","year":"2005","journal-title":"Infection"},{"issue":"11\u201312","key":"10.1016\/j.watres.2024.121437_bib0048","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2166\/wst.1997.0703","article-title":"Development of a risk assessment approach for evaluating wastewater reuse standards for agriculture","volume":"35","author":"Shuval","year":"1997","journal-title":"Water Sci. Technol."},{"issue":"6","key":"10.1016\/j.watres.2024.121437_bib0049","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1128\/IAI.68.6.3689-3695.2000","article-title":"Role of EspB in experimental human enteropathogenic Escherichia coli infection","volume":"68","author":"Tacket","year":"2000","journal-title":"Infect. Immun."},{"issue":"42","key":"10.1016\/j.watres.2024.121437_bib0050","doi-asserted-by":"crossref","first-page":"15202","DOI":"10.1073\/pnas.1409836111","article-title":"Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization","volume":"111","author":"Udikovic-Kolic","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.watres.2024.121437_bib0051","series-title":"Antimicrobial Resistance Surveillance in Europe 2022 \u20132020 Data","year":"2022"},{"key":"10.1016\/j.watres.2024.121437_bib0053","series-title":"Prioritization of Pathogens to Guide discovery, Research and Development of New Antibiotics For Drug-Resistant Bacterial infections, Including Tuberculosis (No. WHO\/EMP\/IAU\/2017.12)","year":"2017"},{"key":"10.1016\/j.watres.2024.121437_bib0054","series-title":"Microbiological Risk Assessment\u2013Guidance For Food (Vol. 36)","year":"2021"},{"issue":"10","key":"10.1016\/j.watres.2024.121437_bib0055","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1021\/js9801337","article-title":"Application of logistic growth model to pharmacodynamic analysis of in vitro bactericidal kinetics","volume":"87","author":"Yano","year":"1998","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.watres.2024.121437_bib0056","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.2165\/00003495-200767070-00006","article-title":"Comparative review of the carbapenems","volume":"67","author":"Zhanel","year":"2007","journal-title":"Drugs"}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135424003397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135424003397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T06:24:35Z","timestamp":1738391075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135424003397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":54,"alternative-id":["S0043135424003397"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2024.121437","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of antibiotic-resistant infection risks associated with reclaimed wastewater irrigation in intensive tomato cultivation","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2024.121437","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"121437"}}