{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:43:24Z","timestamp":1787957004674,"version":"build-2784847793"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42406140"],"award-info":[{"award-number":["42406140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.watres.2025.124800","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T22:28:49Z","timestamp":1760394529000},"page":"124800","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PA","title":["DNA methylation plasticity drives copepod resilience to coastal high pCO2 and cadmium pollution under multigenerational exposure"],"prefix":"10.1016","volume":"289","author":[{"given":"Hui","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaolu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fankang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-5172","authenticated-orcid":false,"given":"Jae-Seong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-4745","authenticated-orcid":false,"given":"Minghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.watres.2025.124800_bib0001","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.nbd.2003.11.017","article-title":"Sialin expression in the CNS implicates extralysosomal function in neurons","volume":"15","author":"Aula","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.watres.2025.124800_bib0002","doi-asserted-by":"crossref","first-page":"30101","DOI":"10.1007\/s11356-021-12691-6","article-title":"DNA methylation and gene expression alterations in zebrafish embryos exposed to cadmium","volume":"28","author":"Bian","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.watres.2025.124800_bib0003","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1038\/s41467-019-13767-1","article-title":"Standing genetic variation fuels rapid adaptation to ocean acidification","volume":"10","author":"Bitter","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.watres.2025.124800_bib0004","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics."},{"key":"10.1016\/j.watres.2025.124800_bib0005","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.scitotenv.2018.06.126","article-title":"Seawater acidification aggravated cadmium toxicity in the oyster crassostrea gigas: metal bioaccumulation, subcellular distribution and multiple physiological responses","volume":"642","author":"Cao","year":"2018","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.watres.2025.124800_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.137234","article-title":"Effects of seawater acidification and cadmium on the antioxidant defense of flounder paralichthys olivaceus larvae","volume":"718","author":"Cui","year":"2020","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.watres.2025.124800_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.132919","article-title":"Toxicological effects of cadmium on the immune response and biomineralization of larval flounder paralichthys olivaceus under seawater acidification","volume":"291","author":"Cui","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2025.124800_bib0008","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41558-021-01131-5","article-title":"Rapid, but limited, zooplankton adaptation to simultaneous warming and acidification","volume":"11","author":"Dam","year":"2021","journal-title":"Nat. Clim. Change"},{"key":"10.1016\/j.watres.2025.124800_bib0009","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/15592294.2020.1795603","article-title":"DNA methylation patterns respond to thermal stress in the viviparous cockroach Diploptera punctata","volume":"16","author":"de la Pe\u00f1a","year":"2021","journal-title":"Epigenetics"},{"key":"10.1016\/j.watres.2025.124800_bib0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics."},{"key":"10.1016\/j.watres.2025.124800_bib0011","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev.marine.010908.163834","article-title":"Ocean acidification: the other CO2 problem","volume":"1","author":"Doney","year":"2009","journal-title":"Annu. Rev. Mar. Sci."},{"key":"10.1016\/j.watres.2025.124800_bib0012","doi-asserted-by":"crossref","first-page":"E2183","DOI":"10.1073\/pnas.1209329109","article-title":"Widespread dynamic DNA methylation in response to biotic stress","volume":"109","author":"Dowen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.watres.2025.124800_bib0013","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gku154","article-title":"A Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data","volume":"42","author":"Feng","year":"2014","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.watres.2025.124800_bib0014","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/gcb.12485","article-title":"Can variable pH and low oxygen moderate ocean acidification outcomes for mussel larvae?","volume":"20","author":"Frieder","year":"2014","journal-title":"Global Change Biol."},{"key":"10.1016\/j.watres.2025.124800_bib0015","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.1148766","article-title":"Transgenerational plasticity is adaptive in the wild","volume":"318","author":"Galloway","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.watres.2025.124800_bib0016","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.envint.2013.09.019","article-title":"Pollution status of the Bohai Sea: an overview of the environmental quality assessment related trace metals","volume":"62","author":"Gao","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2025.124800_bib0017","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0079-6107(95)00008-9","article-title":"Class I aldolases: substrate specificity, mechanism, inhibitors and structural aspects","volume":"63","author":"Gefflaut","year":"1995","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.watres.2025.124800_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2020.105091","article-title":"Season specific influence of projected ocean changes on the response to cadmium of stress-related genes in Mytilus galloprovincialis","volume":"162","author":"Giuliani","year":"2020","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.watres.2025.124800_bib0019","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.aquatox.2014.01.027","article-title":"Interactive effects of CO2 and trace metals on the proteasome activity and cellular stress response of marine bivalves Crassostrea virginica and Mercenaria mercenaria","volume":"149","author":"Gotze","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.watres.2025.124800_bib0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41586-021-03981-7","article-title":"Biogeochemical extremes and compound events in the ocean","volume":"600","author":"Gruber","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.watres.2025.124800_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028983","article-title":"High-frequency dynamics of ocean pH: a multi-ecosystem comparison","volume":"6","author":"Hofmann","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.watres.2025.124800_bib0022","series-title":"Climate Change 2014\u2212Impacts, Adaptation and vulnerability: Regional aspects","first-page":"1039","year":"2014"},{"key":"10.1016\/j.watres.2025.124800_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbpc.2015.05.001","article-title":"Effects of environmental hypercapnia and metal (Cd and Cu) exposure on acid-base and metal homeostasis of marine bivalves. Comparative biochemistry and physiology","volume":"174-175","author":"Ivanina","year":"2015","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.watres.2025.124800_bib0024","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1021\/acs.est.8b03225","article-title":"Transgenerational inheritance of DNA hypomethylation in Daphnia magna in response to salinity stress","volume":"52","author":"Jeremias","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2025.124800_bib0025","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.3389\/fphys.2018.01952","article-title":"Diurnally fluctuating pCO2 modifies the physiological responses of coral recruits under ocean acidification","volume":"9","author":"Jiang","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.watres.2025.124800_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111048","article-title":"Differential gene expression profile of male and female copepods in response to cadmium exposure","volume":"204","author":"Kadiene","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.watres.2025.124800_bib0027","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1111\/j.1461-0248.2010.01518.x","article-title":"Meta-analysis reveals negative yet variable effects of ocean acidification on marine organisms","volume":"13","author":"Kroeker","year":"2010","journal-title":"Ecol. Lett."},{"key":"10.1016\/j.watres.2025.124800_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003118","article-title":"Software for computing and annotating genomic ranges","volume":"9","author":"Lawrence","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.watres.2025.124800_bib0029","doi-asserted-by":"crossref","first-page":"7858","DOI":"10.1021\/acs.est.0c01438","article-title":"Multigenerational mitigating effects of ocean acidification on In Vivo endpoints, antioxidant defense, DNA damage response, and epigenetic modification in an asexual monogonont rotifer","volume":"54","author":"Lee","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2025.124800_bib0030","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41558-022-01477-4","article-title":"Epigenetic plasticity enables copepods to cope with ocean acidification","volume":"12","author":"Lee","year":"2022","journal-title":"Nat. Clim. Change"},{"key":"10.1016\/j.watres.2025.124800_bib0031","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics."},{"key":"10.1016\/j.watres.2025.124800_bib0032","article-title":"Transcriptome analysis provides preliminary insights into the response of Sepia esculenta to high salinity stress","volume":"2","author":"Li","year":"2024","journal-title":"Agric. Commu."},{"key":"10.1016\/j.watres.2025.124800_bib0033","doi-asserted-by":"crossref","first-page":"eaar8028","DOI":"10.1126\/sciadv.aar8028","article-title":"Epigenome-associated phenotypic acclimatization to ocean acidification in a reef-building coral","volume":"4","author":"Liew","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.watres.2025.124800_bib0034","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.watres.2025.124800_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105428","article-title":"Copper and cadmium administration induce toxicity and oxidative stress in the marine flatworm Macrostomum lignano","volume":"221","author":"Ma","year":"2020","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.watres.2025.124800_bib0036","first-page":"1471","article-title":"Fluctuating seawater pH\/pCO2 regimes are more energetically expensive than static pH\/pCO2 levels in the mussel Mytilus edulis","volume":"284","author":"Mangan","year":"2017","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.watres.2025.124800_bib0037","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.aquatox.2014.04.004","article-title":"Gene networks and toxicity pathways induced by acute cadmium exposure in adult largemouth bass (Micropterus salmoides)","volume":"152","author":"Mehinto","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.watres.2025.124800_bib0038","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev-marine-010419-010658","article-title":"Ocean acidification and coastal marine invertebrates: tracking CO2 effects from seawater to the cell","volume":"12","author":"Melzner","year":"2020","journal-title":"Annu. Rev. Mar. Sci."},{"key":"10.1016\/j.watres.2025.124800_bib0039","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5670\/oceanog.2009.98","article-title":"Effect of ocean acidification on the speciation of metals in seawater","volume":"22","author":"Millero","year":"2009","journal-title":"Oceanography"},{"key":"10.1016\/j.watres.2025.124800_bib0040","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.aquatox.2018.01.008","article-title":"Oxidative and interactive challenge of cadmium and ocean acidification on the smooth scallop flexopecten glaber","volume":"196","author":"Nardi","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.watres.2025.124800_bib0041","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nature04095","article-title":"Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms","volume":"437","author":"Orr","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.watres.2025.124800_bib0042","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.envpol.2016.05.010","article-title":"Ecotoxicity and genotoxicity of cadmium in different marine trophic levels","volume":"215","author":"Pavlaki","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.watres.2025.124800_bib0043","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ecoenv.2017.07.008","article-title":"Influence of environmental conditions on the toxicokinetics of cadmium in the marine copepod Acartia tonsa","volume":"145","author":"Pavlaki","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.watres.2025.124800_bib0044","unstructured":"Pedersen, B.S., Eyring, K., De, S., Yang, I.V., Schwartz, D.A., 2014. Fast and accurate alignment of long bisulfite-seq reads. arXiv:1401.1129v2."},{"key":"10.1016\/j.watres.2025.124800_bib0045","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.pnsc.2008.10.014","article-title":"Plant genomic DNA methylation in response to stresses: potential applications and challenges in plant breeding","volume":"19","author":"Peng","year":"2009","journal-title":"Prog. Nat. Sci.: Mater. Int."},{"key":"10.1016\/j.watres.2025.124800_bib0046","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/es4048347","article-title":"Effect of low-dose cadmium exposure on DNA methylation in the endangered european eel","volume":"48","author":"Pierron","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2025.124800_bib0047","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1111\/gcb.15675","article-title":"Oyster biomineralization under ocean acidification: from genes to shell","volume":"27","author":"Rajan","year":"2021","journal-title":"Global Change Biol"},{"key":"10.1016\/j.watres.2025.124800_bib0048","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1111\/jbi.13414","article-title":"Copepod diapause and the biogeography of the marine lipidscape","volume":"45","author":"Record","year":"2018","journal-title":"J. Biogeogr."},{"key":"10.1016\/j.watres.2025.124800_bib0049","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41558-018-0159-0","article-title":"The epigenetic landscape of transgenerational acclimation to ocean warming","volume":"8","author":"Ryu","year":"2018","journal-title":"Nat. Clim. Change"},{"key":"10.1016\/j.watres.2025.124800_bib0050","article-title":"Ocean acidification increases cadmium accumulation in marine bivalves: a potential threat to seafood safety","volume":"6","author":"Shi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.watres.2025.124800_bib0051","first-page":"532","article-title":"TRIzol: a new reagent for optimal single-step isolation of RNA","volume":"15","author":"Simms","year":"1993","journal-title":"Focus (Madison)"},{"key":"10.1016\/j.watres.2025.124800_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127140","article-title":"Transcriptome-wide m6A methylation profile reveals regulatory networks in roots of barley under cadmium stress","volume":"423","author":"Su","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.watres.2025.124800_bib0053","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1101\/gr.6163007","article-title":"CpG methylation is targeted to transcription units in an invertebrate genome","volume":"17","author":"Suzuki","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.watres.2025.124800_bib0054","unstructured":"UNEP., 2020. Emissions Gap Report 2020. https:\/\/www.unep.org\/emissions-gap-report-2020."},{"key":"10.1016\/j.watres.2025.124800_bib0055","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1186\/s12864-022-08781-5","article-title":"Differential DNA methylation in Pacific oyster reproductive tissue in response to ocean acidification","volume":"23","author":"Venkataraman","year":"2022","journal-title":"BMC. Genomics."},{"key":"10.1016\/j.watres.2025.124800_bib0056","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1021\/acs.est.8b00149","article-title":"Quantitative shotgun proteomics associates molecular-level cadmium toxicity responses with compromised growth and reproduction in a marine copepod under multigenerational exposure","volume":"52","author":"Wang","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2025.124800_bib0057","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1021\/acs.est.7b01832","article-title":"Global proteome profiling of a marine copepod and the mitigating effect of ocean acidification on mercury toxicity after multigenerational exposure","volume":"51","author":"Wang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2025.124800_bib0058","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.aquatox.2018.01.004","article-title":"Effects of ocean acidification on copepods","volume":"196","author":"Wang","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.watres.2025.124800_bib0059","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.aquatox.2016.11.002","article-title":"Ocean acidification stimulates alkali signal pathway: a bicarbonate sensing soluble adenylyl cyclase from oyster Crassostrea gigas mediates physiological changes induced by CO2 exposure","volume":"181","author":"Wang","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.watres.2025.124800_bib0060","doi-asserted-by":"crossref","first-page":"13179","DOI":"10.1021\/acs.est.2c02677","article-title":"Diel fluctuation superimposed on steady high pCO2 generates the most serious cadmium toxicity to marine copepods","volume":"56","author":"Wei","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2025.124800_bib0061","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/nclimate1982","article-title":"Sensitivities of extant animal taxa to ocean acidification","volume":"3","author":"Wittmann","year":"2013","journal-title":"Nat. Clim. Change"},{"key":"10.1016\/j.watres.2025.124800_bib0062","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s10661-010-1432-5","article-title":"Study of heavy metal pollution in seawater of Kepez harbor of Canakkale (Turkey)","volume":"173","author":"Yilmaz","year":"2011","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.watres.2025.124800_bib0063","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.scitotenv.2019.04.395","article-title":"Cadmium exposure in living organisms: a short review","volume":"678","author":"Zhang","year":"2019","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/j.watres.2025.124800_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132804","article-title":"Mechanisms underlying the alleviated cadmium toxicity in marine diatoms adapted to ocean acidification","volume":"463","author":"Zhang","year":"2024","journal-title":"J. Hazard. Mater."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135425017038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135425017038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T23:16:30Z","timestamp":1773184590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135425017038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":64,"alternative-id":["S0043135425017038"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2025.124800","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA methylation plasticity drives copepod resilience to coastal high pCO2 and cadmium pollution under multigenerational exposure","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2025.124800","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124800"}}