{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:00:50Z","timestamp":1774008050558,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFE0104900"],"award-info":[{"award-number":["2022YFE0104900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220818101010022"],"award-info":[{"award-number":["JCYJ20220818101010022"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["RCJC20221008092758099"],"award-info":[{"award-number":["RCJC20221008092758099"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004147","name":"Tsinghua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.watres.2026.125487","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T15:45:53Z","timestamp":1769874353000},"page":"125487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Removal, transformation and toxicity changes of halobenzoquinones by digestive enzymes"],"prefix":"10.1016","volume":"294","author":[{"given":"Liu","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Xiu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian-Yuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.watres.2026.125487_bib0001","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/17435390.2019.1675794","article-title":"Impact of in vitro digestion on gastrointestinal fate and uptake of silver nanoparticles with different surface modifications","volume":"14","author":"Abdelkhaliq","year":"2020","journal-title":"Nanotoxicology"},{"issue":"4","key":"10.1016\/j.watres.2026.125487_bib0002","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s41596-018-0119-1","article-title":"INFOGEST static in vitro simulation of gastrointestinal food digestion","volume":"14","author":"Brodkorb","year":"2019","journal-title":"Nat. Protoc."},{"issue":"18","key":"10.1016\/j.watres.2026.125487_bib0003","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1039\/D0SC07017C","article-title":"Conceptual density functional theory based electronic structure principles","volume":"12","author":"Chakraborty","year":"2021","journal-title":"Chem. Sci."},{"issue":"6","key":"10.1016\/j.watres.2026.125487_bib0004","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1021\/cr040109f","article-title":"Electrophilicity Index","volume":"106","author":"Chattaraj","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.watres.2026.125487_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108054","article-title":"Substrate-enzyme interactions and catalytic mechanism in a novel family VI esterase with dibutyl phthalate-hydrolyzing activity","volume":"178","author":"Cheng","year":"2023","journal-title":"Environ. Int."},{"issue":"3","key":"10.1016\/j.watres.2026.125487_bib0006","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.chembiol.2023.09.004","article-title":"Advancing protein therapeutics through proximity-induced chemistry","volume":"31","author":"Cheng","year":"2024","journal-title":"Cell Chem. Biol."},{"issue":"7","key":"10.1016\/j.watres.2026.125487_bib0007","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1021\/acs.est.8b06711","article-title":"Comparison of toxicity-weighted disinfection byproduct concentrations in potable reuse waters and conventional drinking waters as a new approach to assessing the quality of advanced treatment train waters","volume":"53","author":"Chuang","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.watres.2026.125487_bib0008","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0022-2836(90)90156-G","article-title":"X-ray analyses of aspartic proteinases: II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A\u00b0resolution","volume":"214","author":"Cooper","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.watres.2026.125487_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2019.460642","article-title":"A novel automated method for the quantification of ten halobenzoquinones in drinking water using online solid-phase extraction coupled with liquid chromatography tandem mass spectrometry","volume":"1612","author":"Cuthbertson","year":"2020","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.watres.2026.125487_bib0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-48715-1","article-title":"H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours","volume":"15","author":"Dibitetto","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.watres.2026.125487_bib0011","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jes.2021.03.023","article-title":"Disinfection by-product (DBP) research in China: are we on the track?","volume":"110","author":"Dong","year":"2021","journal-title":"J. Environ. Sci."},{"issue":"6","key":"10.1016\/j.watres.2026.125487_bib0012","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1021\/es303762p","article-title":"Cytotoxicity and oxidative damage induced by halobenzoquinones to T24 bladder cancer cells","volume":"47","author":"Du","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2026.125487_bib0013","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.watres.2017.06.007","article-title":"Transformation of halobenzoquinones with the presence of amino acids in water: products, pathways and toxicity","volume":"122","author":"Du","year":"2017","journal-title":"Water Res"},{"issue":"2","key":"10.1016\/j.watres.2026.125487_bib0014","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0003-2697(81)90474-7","article-title":"Fluorescence quenching studies with proteins","volume":"114","author":"Eftink","year":"1981","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.watres.2026.125487_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2023.120424","article-title":"Multiple spectroscopic insights into the interaction mechanisms between proteins and humic acid","volume":"243","author":"Gong","year":"2023","journal-title":"Water Res"},{"key":"10.1016\/j.watres.2026.125487_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108314","article-title":"Vacuum ultraviolet irradiation for reduction of the toxicity of wastewater towards mammalian cells: removal mechanism, changes in organic compounds, and toxicity alternatives","volume":"182","author":"He","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.watres.2026.125487_bib0017","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.watcyc.2023.05.003","article-title":"The exposure dose of reclaimed water in daily life: a mini review","volume":"4","author":"He","year":"2023","journal-title":"Water Cycle"},{"key":"10.1016\/j.watres.2026.125487_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.121562","article-title":"Cytotoxicity of emerging halophenylacetamide disinfection byproducts in drinking water: mechanism and prediction","volume":"256","author":"Hu","year":"2024","journal-title":"Water Res."},{"issue":"13","key":"10.1016\/j.watres.2026.125487_bib0019","doi-asserted-by":"crossref","first-page":"9536","DOI":"10.1021\/acs.est.2c01307","article-title":"Covalent protein modification: an unignorable factor for bisphenol A-induced hepatotoxicity","volume":"56","author":"Hu","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"12","key":"10.1016\/j.watres.2026.125487_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29122856","article-title":"A ng\/L level LC-MS method using membrane SPE as sampling technology: determination of nine halobenzoquinones in potable water","volume":"29","author":"Huang","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.watres.2026.125487_bib0021","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.chemosphere.2019.06.086","article-title":"Assessment of the in vitro toxicity of the disinfection byproduct 2,6-dichloro-1,4-benzoquinone and its transformed derivatives","volume":"234","author":"Hung","year":"2019","journal-title":"Chemosphere"},{"issue":"9","key":"10.1016\/j.watres.2026.125487_bib0022","article-title":"An automated organoid platform with inter-organoid homogeneity and inter-patient heterogeneity","volume":"1","author":"Jiang","year":"2020","journal-title":"Cell Rep. Med."},{"issue":"3","key":"10.1016\/j.watres.2026.125487_bib0023","first-page":"311","article-title":"The first structure at 1.8 \u00c5 resolution of an active autolysate form of porcine [alpha]-trysoin","volume":"53","author":"Johnson","year":"1997","journal-title":"Acta Crystallogr., Sect. A"},{"key":"10.1016\/j.watres.2026.125487_bib0024","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.envint.2019.02.010","article-title":"Ingested nitrate, disinfection by-products, and risk of colon and rectal cancers in the Iowa Women's Health Study cohort","volume":"126","author":"Jones","year":"2019","journal-title":"Environ. Int."},{"issue":"13","key":"10.1016\/j.watres.2026.125487_bib0025","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.1021\/jf200965s","article-title":"Thiol\u2013quinone adduct formation in myofibrillar proteins detected by LC-MS","volume":"59","author":"Jongberg","year":"2011","journal-title":"J. Agric. Food. Chem."},{"issue":"4","key":"10.1016\/j.watres.2026.125487_bib0026","doi-asserted-by":"crossref","first-page":"627","DOI":"10.18388\/abp.2011_2234","article-title":"Influence of 2,5-dichloro-1,4-benzoquinone on jack bean urease activity. Inhibitory effect, total reducing capacity and DPPH radical scavenging activity","volume":"58","author":"Kot","year":"2011","journal-title":"Acta Biochim. Pol."},{"issue":"20","key":"10.1016\/j.watres.2026.125487_bib0027","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27207031","article-title":"Influence of the active site flexibility on the efficiency of substrate activation in the active sites of bi-zinc metallo-\u03b2-lactamases","volume":"27","author":"Krivitskaya","year":"2022","journal-title":"Molecules"},{"issue":"38","key":"10.1016\/j.watres.2026.125487_bib0028","doi-asserted-by":"crossref","first-page":"8043","DOI":"10.1016\/S0040-4020(01)91002-6","article-title":"Nucleophilic reactions of quinones","volume":"47","author":"Kutyrev","year":"1991","journal-title":"Tetrahedron"},{"issue":"21","key":"10.1016\/j.watres.2026.125487_bib0029","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1021\/bi00745a020","article-title":"Quenching of fluorescence by oxygen. Probe for structural fluctuations in macromolecules","volume":"12","author":"Lakowicz","year":"1973","journal-title":"Biochemistry"},{"issue":"17","key":"10.1016\/j.watres.2026.125487_bib0030","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/bi00793a015","article-title":"Solute perturbation of protein fluorescence. Quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion","volume":"10","author":"Lehrer","year":"1971","journal-title":"Biochemistry"},{"issue":"13","key":"10.1016\/j.watres.2026.125487_bib0031","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.1021\/acs.est.5b05585","article-title":"Emerging disinfection byproducts, halobenzoquinones: effects of isomeric structure and halogen substitution on cytotoxicity, formation of reactive oxygen species, and genotoxicity","volume":"50","author":"Li","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.watres.2026.125487_bib0032","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1021\/tx500494r","article-title":"Chemical and toxicological characterization of halobenzoquinones, an emerging class of disinfection byproducts","volume":"28","author":"Li","year":"2015","journal-title":"Chem. Res. Toxicol."},{"issue":"2","key":"10.1016\/j.watres.2026.125487_bib0033","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/toxsci\/kfu088","article-title":"Glutathione-mediated detoxification of halobenzoquinone drinking water disinfection byproducts in T24 cells","volume":"141","author":"Li","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.watres.2026.125487_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.144394","article-title":"Hydrolysis characteristics and risk assessment of a widely detected emerging drinking water disinfection-by-product\u20142,6-dichloro-1,4-benzoquinone\u2014In the water environment of Tianjin (China)","volume":"765","author":"Li","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"9","key":"10.1016\/j.watres.2026.125487_bib0035","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1007\/s00216-017-0188-y","article-title":"Release of free amino acids upon oxidation of peptides and proteins by hydroxyl radicals","volume":"409","author":"Liu","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"issue":"8","key":"10.1016\/j.watres.2026.125487_bib0036","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41893-022-00898-5","article-title":"Spatial assessment of tap-water safety in China","volume":"5","author":"Liu","year":"2022","journal-title":"Nat. Sustainability"},{"key":"10.1016\/j.watres.2026.125487_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117239","article-title":"The key to 2,6-dichloro-1,4-benzoquinone reproductive toxicity and green tea detoxification: covalent binding and competitive binding","volume":"286","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"46","key":"10.1016\/j.watres.2026.125487_bib0038","doi-asserted-by":"crossref","first-page":"14733","DOI":"10.1021\/jacs.5b08687","article-title":"Reduction of \u03b1,\u03b2-unsaturated ketones by old yellow enzymes: mechanistic insights from quantum mechanics\/molecular mechanics calculations","volume":"137","author":"Lonsdale","year":"2015","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"10.1016\/j.watres.2026.125487_bib0039","doi-asserted-by":"crossref","first-page":"11860","DOI":"10.1021\/acs.est.9b03163","article-title":"Occurrence, formation, and oxidative stress of emerging disinfection byproducts, halobenzoquinones, in tea","volume":"53","author":"Lou","year":"2019","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.watres.2026.125487_bib0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2965\/jswe.38.67","article-title":"Analysis and ocurrence of 2,6-dichloro-1,4-benzoquinone in drinking water by liquid chromatography-tandem mass spectrometry","volume":"38","author":"Nakai","year":"2015","journal-title":"J. Japan Society Water Environ."},{"issue":"11","key":"10.1016\/j.watres.2026.125487_bib0041","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1021\/tx050204z","article-title":"Characterization of a deoxyguanosine adduct of tetrachlorobenzoquinone:\u2009 dichlorobenzoquinone-1,N2-etheno-2\u2019-deoxyguanosine","volume":"18","author":"Nguyen","year":"2005","journal-title":"Chem. Res. Toxicol."},{"issue":"5","key":"10.1016\/j.watres.2026.125487_bib0042","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/acs.jpca.9b07012","article-title":"Atom-condensed Fukui function in condensed phases and biological systems and its application to enzymatic fixation of carbon dioxide","volume":"124","author":"Oller","year":"2020","journal-title":"J. Phys. Chem. A"},{"issue":"10","key":"10.1016\/j.watres.2026.125487_bib0043","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41573-022-00501-8","article-title":"Avidity in antibody effector functions and biotherapeutic drug design","volume":"21","author":"Oostindie","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.watres.2026.125487_bib0044","series-title":"Density-functional Theory of Atoms and Molecules","author":"Parr","year":"1995"},{"issue":"10","key":"10.1016\/j.watres.2026.125487_bib0045","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1021\/acs.chemrestox.5b00283","article-title":"In vitro cytotoxicity and adaptive stress responses to selected haloacetic acid and halobenzoquinone water disinfection byproducts","volume":"28","author":"Proch\u00e1zka","year":"2015","journal-title":"Chem. Res. Toxicol."},{"issue":"9","key":"10.1016\/j.watres.2026.125487_bib0046","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1021\/es305044k","article-title":"UV-induced transformation of four halobenzoquinones in drinking water","volume":"47","author":"Qian","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2026.125487_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2021.103243","article-title":"Recent advances in \u03b3H2AX biomarker-based genotoxicity assays: a marker of DNA damage and repair","volume":"108","author":"Rahmanian","year":"2021","journal-title":"DNA Repair (Amst)"},{"issue":"3","key":"10.1016\/j.watres.2026.125487_bib0048","first-page":"435","article-title":"Structure of human salivary [alpha]-amylase at 1.6 \u00c5 resolution: implications for its role in the oral cavity","volume":"52","author":"Ramasubbu","year":"1996","journal-title":"Acta Crystallogr., Sect. A"},{"key":"10.1016\/j.watres.2026.125487_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.136763","article-title":"Quantitative structure-toxicity relationships of halobenzoquinone isomers on DNA reactivity and genotoxicity","volume":"309","author":"Tu","year":"2022","journal-title":"Chemosphere"},{"issue":"18","key":"10.1016\/j.watres.2026.125487_bib0051","doi-asserted-by":"crossref","first-page":"10590","DOI":"10.1021\/acs.est.8b02831","article-title":"Halobenzoquinone-induced developmental toxicity, oxidative stress, and apoptosis in zebrafish embryos","volume":"52","author":"Wang","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"16","key":"10.1016\/j.watres.2026.125487_bib0052","doi-asserted-by":"crossref","first-page":"9898","DOI":"10.1021\/acs.est.5b02308","article-title":"Precursors of halobenzoquinones and their removal duringdrinking water treatment processes","volume":"49","author":"Wang","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.watres.2026.125487_bib0053","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1021\/acs.est.7b05945","article-title":"Characterization of mechanisms of glutathione conjugation with halobenzoquinones in solution and HepG2 cells","volume":"52","author":"Wang","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2026.125487_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118036","article-title":"Evaluation of the binding mechanism of iodine with trypsin and pepsin: a spectroscopic and molecular docking","volume":"230","author":"Wang","year":"2020","journal-title":"Spectrochim. Acta, Part A"},{"issue":"21","key":"10.1016\/j.watres.2026.125487_bib0055","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1021\/acs.est.4c03308","article-title":"Comprehensive toxicological assessment of halobenzoquinones in drinking water at environmentally relevant concentration","volume":"58","author":"Wang","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.watres.2026.125487_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145277","article-title":"Occurrence and toxicity of halobenzoquinones as drinking water disinfection byproducts","volume":"770","author":"Wu","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"15","key":"10.1016\/j.watres.2026.125487_bib0057","doi-asserted-by":"crossref","first-page":"8792","DOI":"10.1021\/acs.est.8b01393","article-title":"Transformation and speciation analysis of silver nanoparticles of dietary supplement in simulated human gastrointestinal tract","volume":"52","author":"Wu","year":"2018","journal-title":"Environ. Sci. Technol."},{"issue":"43","key":"10.1016\/j.watres.2026.125487_bib0058","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1021\/acs.est.3c04483","article-title":"Gastrointestinal degradation and toxicity of disinfection byproducts in drinking water using in vitro models and the roles of gut microbiota","volume":"57","author":"Yin","year":"2023","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.watres.2026.125487_bib0059","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1038\/s41467-025-61226-x","article-title":"Molecular mechanism of drug inhibition of URAT1","volume":"16","author":"Yu","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.watres.2026.125487_bib0060","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/em.2850210405","article-title":"Benzene metabolite, 1,2,4-benzenetriol, induces micronuclei and oxidative DNA damage in human lymphocytes and HL60 cells","volume":"21","author":"Zhang","year":"1993","journal-title":"Environ. Mol. Mutagen."},{"issue":"3","key":"10.1016\/j.watres.2026.125487_bib0061","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/nar\/gkt1090","article-title":"Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism","volume":"42","author":"Zhao","year":"2013","journal-title":"Nucl. Acids Res."},{"issue":"14","key":"10.1016\/j.watres.2026.125487_bib0062","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1016\/j.watres.2012.05.032","article-title":"Occurrence and formation of chloro- and bromo-benzoquinones during drinking water disinfection","volume":"46","author":"Zhao","year":"2012","journal-title":"Water Res."},{"issue":"11","key":"10.1016\/j.watres.2026.125487_bib0063","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1021\/ac100708u","article-title":"Characterization and determination of chloro- and bromo-benzoquinones as new chlorination disinfection byproducts in drinking water","volume":"82","author":"Zhao","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.watres.2026.125487_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135525","article-title":"Fast coupling and detoxification of aqueous halobenzoquinones by extracellular nucleophiles: the relationship among structures, pathways and toxicity","volume":"438","author":"Zhong","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"4","key":"10.1016\/j.watres.2026.125487_bib0065","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1021\/acs.chemrev.7b00305","article-title":"Electrostatic interactions in protein structure, folding, binding, and condensation","volume":"118","author":"Zhou","year":"2018","journal-title":"Chem. Rev."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135426001697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135426001697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:45:19Z","timestamp":1773999919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135426001697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":64,"alternative-id":["S0043135426001697"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2026.125487","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Removal, transformation and toxicity changes of halobenzoquinones by digestive enzymes","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2026.125487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125487"}}