{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:16:48Z","timestamp":1783045008854,"version":"3.54.6"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52131002"],"award-info":[{"award-number":["52131002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52200172"],"award-info":[{"award-number":["52200172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.watres.2026.125989","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T14:58:00Z","timestamp":1776697080000},"page":"125989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Making waves: Wastewater sludge holds untapped antimicrobial potential"],"prefix":"10.1016","volume":"300","author":[{"given":"Yu","family":"Hua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.watres.2026.125989_bib0001","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.drup.2016.04.002","article-title":"Mechanisms and consequences of bacterial resistance to antimicrobial peptides","volume":"26","author":"Andersson","year":"2016","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.watres.2026.125989_bib0002","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.watres.2026.125989_bib0003","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nrmicro3439","article-title":"Tackling antibiotic resistance: the environmental framework","volume":"13","author":"Berendonk","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.watres.2026.125989_bib0004","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/s41467-022-29438-7","article-title":"MiDAS 4: a global catalogue of full-length 16S rRNA gene sequences and taxonomy for studies of bacterial communities in wastewater treatment plants","volume":"13","author":"Dueholm","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.watres.2026.125989_bib0005","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/s41467-019-08853-3","article-title":"Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage","volume":"10","author":"Hendriksen","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.watres.2026.125989_bib0006","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1038\/s41564-023-01524-6","article-title":"Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra","volume":"8","author":"King","year":"2023","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.watres.2026.125989_bib0007","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1073\/pnas.1521291113","article-title":"Scaling laws predict global microbial diversity","volume":"113","author":"Locey","year":"2016","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.watres.2026.125989_bib0008","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/s41587-022-01226-0","article-title":"Identification of antimicrobial peptides from the human gut microbiome using deep learning","volume":"40","author":"Ma","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.watres.2026.125989_bib0009","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bav062","article-title":"MiDAS: the field guide to the microbes of activated sludge","author":"McIlroy","year":"2015","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.watres.2026.125989_bib0010","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1038\/s41467-022-34312-7","article-title":"Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance","volume":"13","author":"Munk","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.watres.2026.125989_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.115955","article-title":"MiDAS 3: an ecosystem-specific reference database, taxonomy and knowledge platform for activated sludge and anaerobic digesters reveals species-level microbiome composition of activated sludge","volume":"182","author":"Nierychlo","year":"2020","journal-title":"Water Res."},{"key":"10.1016\/j.watres.2026.125989_bib0012","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1038\/s41467-023-42434-9","article-title":"Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides","volume":"14","author":"Pandi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.watres.2026.125989_bib0013","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1016\/j.cell.2024.05.013","article-title":"Discovery of antimicrobial peptides in the global microbiome with machine learning","volume":"187","author":"Santos-J\u00fanior","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.watres.2026.125989_bib0014","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1038\/s41467-021-22203-2","article-title":"Connecting structure to function with the recovery of over 1000 high-quality metagenome-assembled genomes from activated sludge using long-read sequencing","volume":"12","author":"Singleton","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.watres.2026.125989_bib0015","doi-asserted-by":"crossref","first-page":"eads8932","DOI":"10.1126\/sciadv.ads8932","article-title":"Discovery of antimicrobial peptides with notable antibacterial potency by an LLM-based foundation model","volume":"11","author":"Wang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.watres.2026.125989_bib0016","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41564-019-0426-5","article-title":"Global diversity and biogeography of bacterial communities in wastewater treatment plants","volume":"4","author":"Wu","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.watres.2026.125989_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.108574","article-title":"Waste to resource: mining antimicrobial peptides in sludge from metagenomes using machine learning","volume":"186","author":"Xu","year":"2024","journal-title":"Environ. Int."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135426006706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135426006706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:24:44Z","timestamp":1783041884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135426006706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":17,"alternative-id":["S0043135426006706"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2026.125989","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Making waves: Wastewater sludge holds untapped antimicrobial potential","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2026.125989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125989"}}