{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:29:56Z","timestamp":1793683796338,"version":"4.5.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22478045"],"award-info":[{"award-number":["22478045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22178072"],"award-info":[{"award-number":["22178072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["KJZD-K202301202"],"award-info":[{"award-number":["KJZD-K202301202"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-QCXMX0099"],"award-info":[{"award-number":["CSTB2024NSCQ-QCXMX0099"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2025NSCQ-LZX0099"],"award-info":[{"award-number":["CSTB2025NSCQ-LZX0099"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Water Research"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.watres.2026.126658","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:04:59Z","timestamp":1786201499000},"page":"126658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Toxicity-guided assessment of disinfection by-products via machine learning and network toxicology"],"prefix":"10.1016","volume":"307","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0490-5357","authenticated-orcid":false,"given":"Jie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhujun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2084-8236","authenticated-orcid":false,"given":"Ruipeng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-9152","authenticated-orcid":false,"given":"Xianyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9547-4860","authenticated-orcid":false,"given":"Shuangliang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.watres.2026.126658_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2025.115970","article-title":"Urban wastewater treatment by ozonation: disinfection by-products and toxicity assessment","volume":"13","author":"Casta\u00f1eda-Retavizca","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.watres.2026.126658_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132792","article-title":"Database and review of disinfection by-products since 1974: constituent elements, molecular weights, and structures","volume":"462","author":"Chen","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"45","key":"10.1016\/j.watres.2026.126658_bib0052","doi-asserted-by":"crossref","first-page":"20190","DOI":"10.1021\/acs.est.4c07223","article-title":"Estro-androgenic disrupting effects of halogenated disinfection byproducts: a comprehensive evaluation and comparison","volume":"58","author":"Chen","year":"2024","journal-title":"Env. Sci. Technol."},{"issue":"7","key":"10.1016\/j.watres.2026.126658_bib0040","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0305-0548(94)00059-H","article-title":"Determining objective weights in multiple criteria problems: the critic method","volume":"22","author":"Diakoulaki","year":"1995","journal-title":"Comput. Oper. Res."},{"key":"10.1016\/j.watres.2026.126658_bib0037","series-title":"Estimation Programs Interface suite\u2122 For Microsoft\u00ae windows, v 4.11","year":"2012"},{"issue":"23","key":"10.1016\/j.watres.2026.126658_bib0034","doi-asserted-by":"crossref","first-page":"15191","DOI":"10.1021\/acs.est.0c03144","article-title":"Monohaloacetic acids and monohaloacetamides attack distinct cellular proteome thiols","volume":"54","author":"Hall","year":"2020","journal-title":"Env. Sci Technol."},{"key":"10.1016\/j.watres.2026.126658_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2025.126277","article-title":"Elucidating environmental fate and toxicological mechanisms of ultrashort- and short-chain PFAS: integrating machine learning, molecular modeling, and experimental validation","volume":"390","author":"Hu","year":"2025","journal-title":"J. Env. Manage."},{"key":"10.1016\/j.watres.2026.126658_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136283","article-title":"Bioaccumulation mechanisms of perfluoroalkyl substances (PFASs) in aquatic environments: theoretical and experimental insights","volume":"480","author":"Hu","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.watres.2026.126658_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2025.124772","article-title":"Oxidative stress induced by emerging halohydroxybenzonitrile disinfection byproducts and their binding interaction with catalase","volume":"378","author":"Hu","year":"2025","journal-title":"J Env. Manage"},{"key":"10.1016\/j.watres.2026.126658_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2026.125656","article-title":"Control of aromatic halogenated disinfection byproducts in chlorinated and chloraminated drinking water through pre-oxidation: effects and mechanisms","volume":"296","author":"Hu","year":"2026","journal-title":"Water. Res."},{"key":"10.1016\/j.watres.2026.126658_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118421","article-title":"Halonaphthoquinones: a group of emerging disinfection byproducts of high toxicity in drinking water","volume":"217","author":"Jiang","year":"2022","journal-title":"Water. Res."},{"key":"10.1016\/j.watres.2026.126658_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.122575","article-title":"Metabolism exploration of disinfection byproducts halonitromethanes (HNMs) by cytochrome P450 enzymes and toxicity evaluation","volume":"285","author":"Jin","year":"2025","journal-title":"Env. Res."},{"issue":"4","key":"10.1016\/j.watres.2026.126658_bib0035","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1021\/acsestwater.3c00664","article-title":"Assessing the health impact of disinfection byproducts in drinking water","volume":"4","author":"Kalita","year":"2024","journal-title":"ACS Est Water"},{"issue":"31","key":"10.1016\/j.watres.2026.126658_bib0043","doi-asserted-by":"crossref","first-page":"20593","DOI":"10.1039\/C7CP02557B","article-title":"Developing force fields when experimental data is sparse: aMBER\/GAFF-compatible parameters for inorganic and alkyl oxoanions","volume":"19","author":"Kashefolgheta","year":"2017","journal-title":"PCCP"},{"key":"10.1016\/j.watres.2026.126658_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125198","article-title":"Characterizing the potential estrogenic and androgenic activities of two disinfection byproducts, mono-haloacetic acids and haloacetamides, using in vitro bioassays","volume":"242","author":"Kim","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.watres.2026.126658_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118301","article-title":"Network toxicology and molecular docking to investigate the mechanism of bisphenol a toxicity in human diabetic cardiomyopathy","volume":"299","author":"Li","year":"2025","journal-title":"Ecotoxicol Env. Saf."},{"key":"10.1016\/j.watres.2026.126658_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139916","article-title":"Investigation on toxicity mechanism of halogenated aromatic disinfection by-products to zebrafish based on molecular docking and QSAR model","volume":"341","author":"Li","year":"2023","journal-title":"Chemosphere"},{"issue":"10","key":"10.1016\/j.watres.2026.126658_bib0030","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3390\/toxins17100484","article-title":"Evaluating the potential inhibition of PP2A by nodularin-R disinfection by-products: effect and mechanism","volume":"17","author":"Li","year":"2025","journal-title":"Toxins. (Basel)"},{"key":"10.1016\/j.watres.2026.126658_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.119458","article-title":"Comparative cytotoxicity, endocrine-disrupting effects, oxidative stress of halophenolic disinfection byproducts and the underlying molecular mechanisms revealed by transcriptome analysis","volume":"229","author":"Li","year":"2023","journal-title":"Water. Res."},{"key":"10.1016\/j.watres.2026.126658_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.117966","article-title":"Air pollution and prostate cancer: unraveling the connection through network toxicology and machine learning","volume":"292","author":"Li","year":"2025","journal-title":"Ecotoxicol. Env. Saf."},{"issue":"1","key":"10.1016\/j.watres.2026.126658_bib0012","first-page":"204","article-title":"Development of models and a tool (DBPCytoGenoTOX predictor) for predicting the cytotoxicity and genotoxicity of disinfection byproducts","volume":"28","author":"Liu","year":"2026","journal-title":"Environ. Sci.: Process. Impacts"},{"issue":"10","key":"10.1016\/j.watres.2026.126658_bib0058","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1021\/acs.est.4c13298","article-title":"Biodegradation of hexagonal boron nitride nanomaterials by neutrophils","volume":"59","author":"Liu","year":"2025","journal-title":"Env. Sci. Technol."},{"issue":"25","key":"10.1016\/j.watres.2026.126658_bib0044","doi-asserted-by":"crossref","first-page":"12990","DOI":"10.1021\/acs.est.5c02725","article-title":"Comparative nontargeted analysis and toxicity of brominated disinfection byproducts from chlorination and chloramination of natural organic matter","volume":"59","author":"Lu","year":"2025","journal-title":"Env. Sci. Technol."},{"issue":"1","key":"10.1016\/j.watres.2026.126658_bib0031","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13321-018-0263-1","article-title":"OPERA models for predicting physicochemical properties and environmental fate endpoints","volume":"10","author":"Mansouri","year":"2018","journal-title":"J. Cheminform."},{"key":"10.1016\/j.watres.2026.126658_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.138976","article-title":"Review of the zebrafish (Danio rerio) model in disinfection by-products (DBPs) toxicity research: opportunities and challenges","volume":"495","author":"Pei","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"5","key":"10.1016\/j.watres.2026.126658_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2023.110612","article-title":"Predicting the formation of disinfection by-products using multiple linear and machine learning regression","volume":"11","author":"Peng","year":"2023","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.watres.2026.126658_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.123092","article-title":"Non-regulated haloaromatic water disinfection byproducts act as endocrine and lipid disrupters in human placental cells","volume":"342","author":"P\u00e9rez-Albaladejo","year":"2024","journal-title":"Env. Pollut."},{"issue":"1","key":"10.1016\/j.watres.2026.126658_bib0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1021\/es030477l","article-title":"Halonitromethane drinking water disinfection byproducts: chemical characterization and mammalian cell cytotoxicity and genotoxicity","volume":"38","author":"Plewa","year":"2004","journal-title":"Env. Sci. Technol."},{"issue":"10","key":"10.1016\/j.watres.2026.126658_bib0028","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1021\/acs.chemrestox.5b00283","article-title":"In vitro cytotoxicity and adaptive stress responses to selected haloacetic acid and halobenzoquinone water disinfection byproducts","volume":"28","author":"Proch\u00e1zka","year":"2015","journal-title":"Chem. Res. Toxicol."},{"issue":"16","key":"10.1016\/j.watres.2026.126658_bib0021","doi-asserted-by":"crossref","first-page":"16606","DOI":"10.1007\/s11356-019-04947-z","article-title":"Predicting the cytotoxicity of disinfection by-products to Chinese hamster ovary by using linear quantitative structure\u2013activity relationship models","volume":"26","author":"Qin","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"6","key":"10.1016\/j.watres.2026.126658_bib0038","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1021\/ci6004299","article-title":"Validation studies of the site-directed docking program LibDock","volume":"47","author":"Rao","year":"2007","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.watres.2026.126658_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115925","article-title":"Exposure to disinfection by-products and risk of cancer: a systematic review and dose-response meta-analysis","volume":"270","author":"Shi","year":"2024","journal-title":"Ecotoxicol. Env. Saf."},{"key":"10.1016\/j.watres.2026.126658_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2026.120036","article-title":"Mechanism-based QSAR and molecular simulation reveal the toxicity of marine disinfection byproducts to Vibrio fischeri","volume":"314","author":"Shi","year":"2026","journal-title":"Ecotoxicol Env. Saf."},{"key":"10.1016\/j.watres.2026.126658_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2025.125252","article-title":"A review of ecotoxicity and developmental toxicity of disinfection byproducts (DBPs): are aromatic DBPs more toxic than aliphatic DBPs?","volume":"291","author":"Shi","year":"2026","journal-title":"Water. Res."},{"issue":"2","key":"10.1016\/j.watres.2026.126658_bib0018","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1021\/acs.estlett.5c01145","article-title":"Multi-endpoint semisupervised learning identifies high-priority unregulated disinfection byproducts","volume":"13","author":"Sikder","year":"2026","journal-title":"Env. Sci Technol Lett."},{"key":"10.1016\/j.watres.2026.126658_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.133989","article-title":"Machine learning framework for predicting cytotoxicity and identifying toxicity drivers of disinfection byproducts","volume":"469","author":"Sikder","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"14","key":"10.1016\/j.watres.2026.126658_bib0053","doi-asserted-by":"crossref","first-page":"15015","DOI":"10.1021\/acs.jmedchem.5c01196","article-title":"Noncovalent interaction thresholds control translocation and cytotoxicity: a combined computational\u2013Experimental study","volume":"68","author":"Song","year":"2025","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.watres.2026.126658_bib0013","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/toxsci\/kfae012","article-title":"A critical review of advances in tumor metabolism abnormalities induced by nitrosamine disinfection by-products in drinking water","volume":"199","author":"Sun","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.watres.2026.126658_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.171387","article-title":"Formation of halogenated hydroxybenzaldehydes from pharmaceuticals and personal care products (PPCPs) in chlorinated swimming pool water: a novel pathway via precursor dimerization","volume":"526","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"49","key":"10.1016\/j.watres.2026.126658_bib0004","doi-asserted-by":"crossref","first-page":"21782","DOI":"10.1021\/acs.est.4c08239","article-title":"Formation of aromatic halogenated disinfection byproducts in swimming pool water during chlorination: organic precursors and mechanisms","volume":"58","author":"Wang","year":"2024","journal-title":"Env. Sci Technol."},{"issue":"24","key":"10.1016\/j.watres.2026.126658_bib0005","doi-asserted-by":"crossref","first-page":"17763","DOI":"10.1021\/acs.est.2c07175","article-title":"Occurrence and cytotoxicity of aliphatic and aromatic halogenated disinfection byproducts in indoor swimming pool water and their incoming tap water","volume":"56","author":"Wang","year":"2022","journal-title":"Env. Sci Technol."},{"issue":"4","key":"10.1016\/j.watres.2026.126658_bib0002","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s44221-025-00413-y","article-title":"Nanofiltration and reverse osmosis technologies for disinfection by-product removal","volume":"3","author":"Wang","year":"2025","journal-title":"Nat. Water"},{"key":"10.1016\/j.watres.2026.126658_bib0019","article-title":"MLSE machine learning algorithm-assisted priority screening of aquatic toxicity risk of DBPs and the guidance of environmental regulations","volume":"499","author":"Wang","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.watres.2026.126658_bib0010","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jes.2020.06.020","article-title":"New methods for identification of disinfection byproducts of toxicological relevance: progress and future directions","volume":"99","author":"Wawryk","year":"2021","journal-title":"J. Environ. Sci."},{"issue":"14","key":"10.1016\/j.watres.2026.126658_bib0055","doi-asserted-by":"crossref","first-page":"8909","DOI":"10.1021\/acs.est.0c02035","article-title":"Comparative quantitative toxicology and QSAR modeling of the haloacetonitriles: forcing agents of water disinfection byproduct toxicity","volume":"54","author":"Wei","year":"2020","journal-title":"Env. Sci. Technol."},{"issue":"8","key":"10.1016\/j.watres.2026.126658_bib0033","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9985","article-title":"Estimating national exposures and potential bladder cancer cases associated with chlorination DBPs in US drinking water","volume":"130","author":"Weisman","year":"2022","journal-title":"Env. Health Perspect."},{"issue":"4","key":"10.1016\/j.watres.2026.126658_bib0060","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1021\/jm3012068","article-title":"Principles and applications of halogen bonding in medicinal chemistry and chemical biology","volume":"56","author":"Wilcken","year":"2013","journal-title":"J. Med. Chem."},{"issue":"42","key":"10.1016\/j.watres.2026.126658_bib0026","doi-asserted-by":"crossref","first-page":"22334","DOI":"10.1021\/acs.est.4c13900","article-title":"Disinfection byproducts confirmed over 50 years: systematic curation, modes of toxic action, and toxicogenomics","volume":"59","author":"Xiang","year":"2025","journal-title":"Env. Sci Technol."},{"key":"10.1016\/j.watres.2026.126658_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137833","article-title":"Association between drinking water disinfection byproducts exposure and human bladder cancer: a time-updated meta-analysis of trihalomethanes","volume":"490","author":"Xie","year":"2025","journal-title":"J. Hazard. Mater."},{"issue":"1","key":"10.1016\/j.watres.2026.126658_bib0046","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1021\/acsenvironau.4c00068","article-title":"Haloacetonitriles induce structure-related cellular toxicity through distinct proteome thiol reaction mechanisms","volume":"5","author":"Yeung","year":"2025","journal-title":"ACS Environ. Au."},{"issue":"1","key":"10.1016\/j.watres.2026.126658_bib0017","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1386207326666230426105412","article-title":"Network toxicology prediction and molecular docking-based strategy to explore the potential toxicity mechanism of metformin chlorination byproducts in drinking water","volume":"27","author":"Zhang","year":"2024","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.watres.2026.126658_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108407","article-title":"The alternation of halobenzoquinone disinfection byproduct on toxicogenomics of DNA damage and repair in uroepithelial cells","volume":"183","author":"Zhang","year":"2024","journal-title":"Env. Int."},{"key":"10.1016\/j.watres.2026.126658_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108407","article-title":"The alternation of halobenzoquinone disinfection byproduct on toxicogenomics of DNA damage and repair in uroepithelial cells","volume":"183","author":"Zhang","year":"2024","journal-title":"Env. Int."},{"issue":"6","key":"10.1016\/j.watres.2026.126658_bib0024","article-title":"Advancing toxicity AI-based prediction with multilevel systems biology: a case study on genotoxicity","volume":"26","author":"Zhang","year":"2025","journal-title":"Br. Bioinform."},{"issue":"36","key":"10.1016\/j.watres.2026.126658_bib0047","doi-asserted-by":"crossref","first-page":"50718","DOI":"10.1007\/s11356-021-14161-5","article-title":"Toxicity of disinfection byproducts formed during the chlorination of sulfamethoxazole, norfloxacin, and 17\u03b2-estradiol in the presence of bromide","volume":"28","author":"Zhang","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.watres.2026.126658_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2019.115283","article-title":"Comparative cytotoxicity of halogenated aromatic DBPs and implications of the corresponding developed QSAR model to toxicity mechanisms of those DBPs: binding interactions between aromatic DBPs and catalase play an important role","volume":"170","author":"Zhang","year":"2020","journal-title":"Water. Res."},{"key":"10.1016\/j.watres.2026.126658_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127001","article-title":"Genome-wide alterations of DNA methylation and hydroxymethylation in uroepithelial cells revealed potential carcinogenicity of halobenzoquinone disinfection byproducts","volume":"384","author":"Zhao","year":"2025","journal-title":"Env. Pollut."},{"key":"10.1016\/j.watres.2026.126658_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125230","article-title":"Halobenzoquinone-induced potential carcinogenicity associated with p53-mediated cell cycle pathway","volume":"363","author":"Zhong","year":"2024","journal-title":"Env. Pollut."},{"key":"10.1016\/j.watres.2026.126658_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109134","article-title":"Metabolite identification of emerging disinfection byproduct dibromo-benzoquinone in vivo and in vitro: multi-strategy mass-spectrometry annotation and toxicity characterization","volume":"193","author":"Zhou","year":"2024","journal-title":"Env. Int."},{"key":"10.1016\/j.watres.2026.126658_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175489","article-title":"Determining high priority disinfection byproducts based on experimental aquatic toxicity data and predictive models: virtual screening and in vivo study","volume":"951","author":"Zhou","year":"2024","journal-title":"Sci. Total Env."},{"key":"10.1016\/j.watres.2026.126658_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117122","article-title":"Role of iron homeostasis in the mutagenicity of disinfection by-products in mammalian cells","volume":"285","author":"Zhou","year":"2024","journal-title":"Ecotoxicol. Env. Saf."},{"issue":"1","key":"10.1016\/j.watres.2026.126658_bib0048","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11783-025-1928-4","article-title":"Bromide and its associated brominated disinfection byproducts: occurrence, toxicity and control strategies","volume":"19","author":"Zhou","year":"2025","journal-title":"Front. Environ. Sci. Eng."}],"container-title":["Water Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135426013321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0043135426013321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:18:22Z","timestamp":1793683102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0043135426013321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":62,"alternative-id":["S0043135426013321"],"URL":"https:\/\/doi.org\/10.1016\/j.watres.2026.126658","relation":{},"ISSN":["0043-1354"],"issn-type":[{"value":"0043-1354","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxicity-guided assessment of disinfection by-products via machine learning and network toxicology","name":"articletitle","label":"Article Title"},{"value":"Water Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.watres.2026.126658","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126658"}}