{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:56:14Z","timestamp":1789797374553,"version":"4.0.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007567","name":"Association of Anaesthetists of Great Britain and Ireland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007567","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Halley Stuart Foundation"},{"name":"UK Intensive Care Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Wilderness &amp; Environmental Medicine"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> This study aimed to compare 3 treatment modalities during sleep at an altitude of 5300 m to identify strategies for reducing the incidence of periodic breathing at high altitude. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Fifteen trekkers, with identical ascent profiles and no signs or symptoms of altitude illness, served as subjects. All study participants arrived at 5300 m after a gradual ascent from 1300 m. On their second night at 5300 m, subjects were randomly assigned (with a computer-based random assignment procedure) to 1 of 4 different treatment groups: control ( n = 4); 1 L\/min O<jats:sub>2<\/jats:sub> via a demand system during sleep ( n = 3); 1 L\/min O<jats:sub>2<\/jats:sub>\/CO<jats:sub>2<\/jats:sub> mix (1.5% CO<jats:sub>2<\/jats:sub>) via a demand system during sleep ( n = 4); or 125 mg acetazolamide 30 minutes before bedtime ( n = 4). Heart rate, respiration rate, blood oxygen saturation, tidal volume, minute volume, and apnea hypopnea index were measured. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Upon comparing the 4 groups, there were no statistically significant differences between the variables. One-way analysis of variance indicated a trend toward statistical significance for SaO<jats:sub>2<\/jats:sub> between groups (F = 2.9, P = .08), and Tukey Honestly Significant Difference (HSD) post hoc tests indicated a trend in the SaO<jats:sub>2<\/jats:sub> difference between the 1 L\/min oxygen and control groups ( P = .07). While 1-way analysis of variance suggested no difference for respiratory rate between groups (F = 2.5, P = .1), Tukey HSD indicated a trend in statistical difference of the respiratory rate between 1 L\/min O<jats:sub>2<\/jats:sub> and 1 L\/min O<jats:sub>2<\/jats:sub>\/CO<jats:sub>2<\/jats:sub> mixture ( P = .08). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> These statistical trends found between control and treatment groups indicate that further study is warranted. <\/jats:p><\/jats:sec>","DOI":"10.1016\/j.wem.2011.07.002","type":"journal-article","created":{"date-parts":[[2011,10,15]],"date-time":"2011-10-15T13:42:31Z","timestamp":1318686151000},"page":"316-320","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Improving Sleep at Altitude: A Comparison of Therapies"],"prefix":"10.1177","volume":"22","author":[{"given":"George W.","family":"Rodway","sequence":"first","affiliation":[{"name":"University of Utah College of Nursing and School of Medicine, Salt Lake City, UT"},{"name":"The Centre for Altitude, Space and Extreme Environment Medicine (CASE), University College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Edsell","sequence":"additional","affiliation":[{"name":"The Centre for Altitude, Space and Extreme Environment Medicine (CASE), University College, London, UK"},{"name":"St George's Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob","family":"Wong","sequence":"additional","affiliation":[{"name":"University of Utah College of Nursing and School of Medicine, Salt Lake City, UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy S.","family":"Windsor","sequence":"additional","affiliation":[{"name":"The Centre for Altitude, Space and Extreme Environment Medicine (CASE), University College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"bibr1-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1089\/15270290260131948"},{"key":"bibr2-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1089\/1527029041352162"},{"key":"bibr3-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(98)00068-1"},{"key":"bibr4-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2006.7.307"},{"key":"bibr5-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-999-0089-1"},{"key":"bibr6-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.4_Pt_1.817"},{"key":"bibr7-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014906"},{"key":"bibr8-j.wem.2011.07.002","first-page":"2","volume-title":"Wilderness Medicine","author":"Hackett P.H.","year":"2001","edition":"4"},{"key":"bibr9-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1905.sp001081"},{"key":"bibr10-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1909.sp001314"},{"key":"bibr11-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(83)90086-5"},{"key":"bibr12-j.wem.2011.07.002","first-page":"340","volume":"11","author":"Mosko S.S.","year":"1988","journal-title":"Sleep"},{"key":"bibr13-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.61.4.299"},{"key":"bibr14-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.2.353"},{"key":"bibr15-j.wem.2011.07.002","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.3.756"}],"container-title":["Wilderness &amp; 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