{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:39:13Z","timestamp":1776134353109,"version":"3.50.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Wilderness &amp; Environmental Medicine"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p> The purpose of this study was to determine whether 400 \u00b5g\/kg oral ivermectin is able to kill Ixodes scapularis nymphs and adult female ticks feeding on humans. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Ten study subjects each wore 2 ostomy bags, the one containing 24 I scapularis nymphs, and the other containing 24 I scapularis adult females. Twenty-four hours after the ostomy bags were attached, study subjects received either 400 \u00b5g\/kg ivermectin or placebo. Thirty hours after the ivermectin or placebo was consumed, the ticks were removed, and mortality determined in a double-blinded manner. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Eleven percent of the I scapularis nymphs attached in the ivermectin group compared with 17% in the placebo. Mortality for the I scapularis nymphs that attached at the time of removal was 55% in the ivermectin group and 47% in the placebo group. Mortality for the I scapularis nymphs 5 days after removal was 92% in the ivermectin group and 88% for the placebo. Three percent of the I scapularis adults attached in the ivermectin group compared with 9% in the placebo group. Mortality for I scapularis adults was 0% on day 3 and 33% on day 8 for both the ivermectin and placebo groups. There were statistically insignificant differences in the mortality rates between I scapularis nymphs and adults exposed to ivermectin or placebo. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> There were a high number of ticks that died in both groups but the data do not support our hypothesis that ivermectin can kill I scapularis. The study was not designed to determine whether it could prevent the transmission of tick-borne illness. <\/jats:p><\/jats:sec>","DOI":"10.1016\/j.wem.2013.09.008","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T06:30:47Z","timestamp":1389249047000},"page":"29-34","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Use of Ivermectin to Kill <i>Ixodes Scapularis<\/i> Ticks Feeding on Humans"],"prefix":"10.1177","volume":"25","author":[{"given":"Johnathan M.","family":"Sheele","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Eastern Virginia Medical School, Norfolk, VA (Drs Sheele, Tse, and Chidester, and Ms Ford)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie R.","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Eastern Virginia Medical School, Norfolk, VA (Drs Sheele, Tse, and Chidester, and Ms Ford)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Eastern Virginia Medical School, Norfolk, VA (Drs Sheele, Tse, and Chidester, and Ms Ford)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Chidester","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Eastern Virginia Medical School, Norfolk, VA (Drs Sheele, Tse, and Chidester, and Ms Ford)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Byers","sequence":"additional","affiliation":[{"name":"Emergency Medicine Physician, Presbyterian Healthcare Services, Albuquerque, NM (Dr Byers)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Sonenshine","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Old Dominion University, Norfolk, VA (Dr Sonenshine)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"bibr1-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.25.3.557-558.1987"},{"key":"bibr2-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32833890e2"},{"key":"bibr3-jwem201309008","unstructured":"Connecticut Experimental Agricultural Station. 2005 Tick bite prevention and the use of insect repellentshttp:\/\/www.ct.gov\/caes\/lib\/caes\/documents\/publications\/fact_sheets\/tickbiteprevention05.pdf. Accessed May 12, 2013."},{"key":"bibr4-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e318209f0b3"},{"key":"bibr5-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0077-3"},{"key":"bibr6-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908313210906"},{"key":"bibr7-jwem201309008","unstructured":"US Centers for Disease Control and Prevention. 2011 Measures to prevent bites from mosquitoes, ticks, fleas and other insects and arthropodshttp:\/\/wwwnc.cdc.gov\/travel\/page\/mosquito-tick.htm. Accessed May 12, 2013."},{"key":"bibr8-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.08.023"},{"key":"bibr9-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905471"},{"key":"bibr10-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-153"},{"key":"bibr11-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2012.08.003"},{"key":"bibr12-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2013.05.014"},{"key":"bibr13-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2008.02049.x"},{"key":"bibr14-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.08.014"},{"key":"bibr15-jwem201309008","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-007-9000-9"}],"container-title":["Wilderness &amp; Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1080603213002585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1080603213002585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.wem.2013.09.008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1016\/j.wem.2013.09.008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.wem.2013.09.008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T09:43:16Z","timestamp":1741686196000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1016\/j.wem.2013.09.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1016\/j.wem.2013.09.008"],"URL":"https:\/\/doi.org\/10.1016\/j.wem.2013.09.008","relation":{},"ISSN":["1080-6032","1545-1534"],"issn-type":[{"value":"1080-6032","type":"print"},{"value":"1545-1534","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}