{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:58:23Z","timestamp":1792151903213,"version":"4.4.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Wilderness &amp; Environmental Medicine"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effect of acetazolamide (Az) on exercise performance during early acclimatization to altitude.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Az (250 mg twice daily) or placebo was administered for 3 days in a double-blind, randomized manner followed by a rapid ascent to 3459 m in the Italian Alps. Twenty healthy adults (age range, 18\u201367 years) were tested at 60% of sea-level peak power output for 15 minutes on a bicycle ergometer after 16 to 27 hours of altitude exposure. Exercise performance was measured in relation to peripheral oxygen saturations measured from pulse oximetry (Spo\n                      <jats:sub>2<\/jats:sub>\n                      ), Lake Louise acute mountain sickness (AMS) score, and perceived difficulty.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At altitude, resting Spo\n                      <jats:sub>2<\/jats:sub>\n                      was higher in the Az group compared with placebo ( P &lt; .001). The highest AMS scores were in 4 of the placebo individuals with the lowest resting Spo\n                      <jats:sub>2<\/jats:sub>\n                      ( P &lt; .05). During the exercise test, Spo\n                      <jats:sub>2<\/jats:sub>\n                      fell in all but 1 subject ( P &lt; .001) and was reduced more in the Az group ( P &lt; .01). Four Az and 1 placebo subject were unable to complete the exercise test; 4 of these 5 had the largest fall in Spo\n                      <jats:sub>2<\/jats:sub>\n                      . The perception of exercise difficulty was higher in the Az subjects compared with those taking the placebo ( P &lt; .01). There was an age relationship with exercise limitation; 4 of the 9 older than 50 years failed to complete the test whereas only 1 of 11 younger than 50 years failed, and there were no failures in the 6 younger than 30 years ( P &lt; .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this study group, and despite higher resting Spo\n                      <jats:sub>2<\/jats:sub>\n                      , Az may have compromised exercise at 3459 m altitude during early acclimatization, particularly in older subjects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.wem.2014.04.003","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T21:47:19Z","timestamp":1402609639000},"page":"272-277","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Exercise Limitation of Acetazolamide at Altitude (3459 m)"],"prefix":"10.1177","volume":"25","author":[{"given":"Arthur R.","family":"Bradwell","sequence":"first","affiliation":[{"name":"School of Medicine, University of Birmingham, Birmingham (Drs Bradwell and Wright)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Sport & Exercise Sciences, University of Chichester, Chichester (Dr Myers and Ms Ashdown)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Beazley","sequence":"additional","affiliation":[{"name":"Spencer Street Surgery, Carlisle (Dr Beazley)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Ashdown","sequence":"additional","affiliation":[{"name":"Department of Sport & Exercise Sciences, University of Chichester, Chichester (Dr Myers and Ms Ashdown)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick G.","family":"Harris","sequence":"additional","affiliation":[{"name":"Merrist Wood College Worplesdon Guildford (Mr Harris)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie B.","family":"Bradwell","sequence":"additional","affiliation":[{"name":"University College London, London (Ms Bradwell)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Goodhart","sequence":"additional","affiliation":[{"name":"The University of Warwick, Coventry (Mr Goodhart and Dr Imray)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris H.","family":"Imray","sequence":"additional","affiliation":[{"name":"The University of Warwick, Coventry (Mr Goodhart and Dr Imray)"},{"name":"University Hospital Coventry and Warwickshire NHS Trust, Coventry (Drs Imray and Wimalasena)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashvi","family":"Wimalasena","sequence":"additional","affiliation":[{"name":"University Hospital Coventry and Warwickshire NHS Trust, Coventry (Drs Imray and Wimalasena)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Edsell","sequence":"additional","affiliation":[{"name":"St George\u2019s Healthcare NHS Trust, London (Dr Edsell)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle T.S.","family":"Pattinson","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford (Dr Pattinson)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex D.","family":"Wright","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Birmingham, Birmingham (Drs Bradwell and Wright)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Harris","sequence":"additional","affiliation":[{"name":"QinetiQ, Farnborough (Mr Harris), United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"key":"bibr1-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2011.1084"},{"key":"bibr2-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6779"},{"key":"bibr3-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7077"},{"key":"bibr4-j.wem.2014.04.003","first-page":"1772","volume":"55","author":"Schoene R.B.","year":"1983","journal-title":"J App Physiol Respir Environ Exerc Physiol"},{"key":"bibr5-j.wem.2014.04.003","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1249\/00005768-199002000-00009","volume":"22","author":"Stager J.M.","year":"1990","journal-title":"Med Sci Sports Exerc"},{"key":"bibr6-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417991"},{"key":"bibr7-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00746.2001"},{"key":"bibr8-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.120949"},{"key":"bibr9-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1053\/ajem.2002.33777"},{"key":"bibr10-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198510000-00013"},{"key":"bibr11-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00180.2007"},{"key":"bibr12-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91272-9"},{"key":"bibr13-j.wem.2014.04.003","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00973.2004"},{"key":"bibr14-j.wem.2014.04.003","unstructured":"Roach RC, Bartsch P, Hackett PH, Oelz O. The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Houston CS, Coates G, eds.\n                      Hypoxia and Molecular Medicine: Proceedings of the 8th International Hypoxia Symposium Held at Lake Louise, Canada, February 9\u201313, 1993\n                      . Burlington, VT: Charles S Houston; 1993:272\u2013274."},{"key":"bibr15-j.wem.2014.04.003","first-page":"180","volume":"1","author":"Bradwell A.R.","year":"1981","journal-title":"Lancet"}],"container-title":["Wilderness &amp; Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1080603214001100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1080603214001100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.wem.2014.04.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1016\/j.wem.2014.04.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1016\/j.wem.2014.04.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T13:38:54Z","timestamp":1741613934000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1016\/j.wem.2014.04.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1016\/j.wem.2014.04.003"],"URL":"https:\/\/doi.org\/10.1016\/j.wem.2014.04.003","relation":{},"ISSN":["1080-6032","1545-1534"],"issn-type":[{"value":"1080-6032","type":"print"},{"value":"1545-1534","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}