{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:51:05Z","timestamp":1777693865668,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Wilderness &amp; Environmental Medicine"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p> Compared with other crotaline envenomations, copperhead envenomations have historically been reported as having less severe hematologic venom effects and rarely hemorrhage. We report a case of clinically significant gastrointestinal bleeding after a copperhead ( Agkistrodon contortrix) envenomation. A 52-year-old woman with a history of systemic lupus erythematosus was bitten on her right medial ankle after which hypofibrinogenemia and hematochezia developed. The symptoms resolved after repeated administration of Crotalidae polyvalent immune Fab (ovine) antivenom. She was discharged without further complications 2 days later. Although copperhead envenomations are classically considered less severe than other crotaline envenomations, this case demonstrates the potential of the venom to produce clinically significant hematologic effects. <\/jats:p>","DOI":"10.1016\/j.wem.2015.07.002","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T05:52:54Z","timestamp":1443765174000},"page":"488-490","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Marked Hypofibrinogenemia and Gastrointestinal Bleeding After Copperhead (<i>Agkistrodon contortrix<\/i>) Envenomation"],"prefix":"10.1177","volume":"26","author":[{"given":"Kathryn T.","family":"Kopec","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC (Dr Kopec); Department of Emergency Medicine, University of North Carolina, Chapel Hill, NC (Dr Yen); Division of Emergency Medicine, Duke University Medical Center, Durham, NC (Dr Gerardo)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC (Dr Kopec); Department of Emergency Medicine, University of North Carolina, Chapel Hill, NC (Dr Yen); Division of Emergency Medicine, Duke University Medical Center, Durham, NC (Dr Gerardo)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Bitner","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Greenville Health System, Greenville, SC (Dr Bitner)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Scott","family":"Evans","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Palo Alto VA Medical Center, Palo Alto, CA (Dr Evans)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J.","family":"Gerardo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC (Dr Kopec); Department of Emergency Medicine, University of North Carolina, Chapel Hill, NC (Dr Yen); Division of Emergency Medicine, Duke University Medical Center, Durham, NC (Dr Gerardo)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,1]]},"reference":[{"key":"bibr1-j.wem.2015.07.002","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2014.08.006"},{"key":"bibr2-j.wem.2015.07.002","unstructured":"Braswell AL, Palmer WM, Beane JC. Venomous Snakes of North Carolina. 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