{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:23:35Z","timestamp":1785835415091,"version":"3.56.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Wilderness Medical Society Hultgren Grant"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","wemjournal.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Wilderness & Environmental Medicine"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.wem.2018.09.002","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T03:03:59Z","timestamp":1547003039000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Reduced Acetazolamide Dosing in Countering Altitude Illness: A Comparison of 62.5 vs 125 mg (the RADICAL Trial)"],"prefix":"10.1177","volume":"30","author":[{"given":"Scott E.","family":"McIntosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-1487","authenticated-orcid":false,"given":"Mika","family":"Hemphill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion C.","family":"McDevitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsering Yangzom","family":"Gurung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukhiya","family":"Ghale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Knott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8525-4311","authenticated-orcid":false,"given":"Ghan Bahadur","family":"Thapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buddha","family":"Basnyat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Dow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"K. Grissom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.1016\/j.wem.2018.09.002_bib0001","series-title":"Hypoxia and Molecular Medicine","first-page":"272","article-title":"Lake Louise AMS Scoring Consensus Committee. The Lake Louise acute mountain sickness scoring system","author":"Roach","year":"1993"},{"issue":"1","key":"10.1016\/j.wem.2018.09.002_bib0002","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1089\/ham.2017.0164","article-title":"The 2018 Lake Louise acute mountain sickness score","volume":"19","author":"Roach","year":"2018","journal-title":"High Alt Med Biol"},{"issue":"2","key":"10.1016\/j.wem.2018.09.002_bib0003","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJM200107123450206","article-title":"High-altitude illness","volume":"345","author":"Hackett","year":"2001","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.wem.2018.09.002_bib0004","first-page":"742","article-title":"Acute mountain sickness and ascent rates in trekkers above 2500 m in the Nepali Himalaya","volume":"77","author":"Vardy","year":"2006","journal-title":"Aviat Space Environ Med"},{"issue":"4","key":"10.1016\/j.wem.2018.09.002_bib0005","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1089\/ham.2008.1008","article-title":"Prevalence of acute mountain sickness among Finnish trekkers on Mount Kilimanjaro, Tanzania: an observational study","volume":"9","author":"Karinen","year":"2008","journal-title":"High Alt Med Biol"},{"issue":"3","key":"10.1016\/j.wem.2018.09.002_bib0006","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/ham.2010.1003","article-title":"Incidence and predictors of acute mountain sickness among trekkers on Mount Kilimanjaro","volume":"11","author":"Jackson","year":"2010","journal-title":"High Alt Med Biol"},{"issue":"6","key":"10.1016\/j.wem.2018.09.002_bib0007","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/jramc-2015-000524","article-title":"Incidence of acute mountain sickness in UK military personnel on Mount Kenya","volume":"162","author":"Hazlerigg","year":"2016","journal-title":"J R Army Med Corps"},{"issue":"4","key":"10.1016\/j.wem.2018.09.002_bib0008","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/ham.2008.1029","article-title":"Prophylactic low-dose acetazolamide reduces the incidence and severity of acute mountain sickness","volume":"9","author":"van Patot","year":"2008","journal-title":"High Alt Med Biol"},{"issue":"8","key":"10.1016\/j.wem.2018.09.002_bib0009","doi-asserted-by":"crossref","first-page":"587","DOI":"10.7326\/0003-4819-118-8-199304150-00003","article-title":"Acute mountain sickness in a general tourist population at moderate altitudes","volume":"118","author":"Honigman","year":"1993","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1016\/j.wem.2018.09.002_bib0010","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0140-6736(76)91677-9","article-title":"The incidence, importance, and prophylaxis of acute mountain sickness","volume":"2","author":"Hackett","year":"1976","journal-title":"Lancet"},{"issue":"6756","key":"10.1016\/j.wem.2018.09.002_bib0011","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1136\/bmj.301.6756.853","article-title":"Prevalence of acute mountain sickness in the Swiss Alps","volume":"301","author":"Maggiorini","year":"1990","journal-title":"BMJ"},{"issue":"24","key":"10.1016\/j.wem.2018.09.002_bib0012","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1056\/NEJMcp1214870","article-title":"Clinical practice: acute high-altitude illnesses","volume":"368","author":"Bartsch","year":"2013","journal-title":"N Engl J Med"},{"issue":"4 suppl","key":"10.1016\/j.wem.2018.09.002_bib0013","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.wem.2014.06.017","article-title":"Wilderness Medical Society practice guidelines for the prevention and treatment of acute altitude illness: 2014 update","volume":"25","author":"Luks","year":"2014","journal-title":"Wilderness Environ Med"},{"issue":"5","key":"10.1016\/j.wem.2018.09.002_bib0014","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/bja\/58.5.512","article-title":"Dissociation of renal and respiratory effects of acetazolamide in the critically ill","volume":"58","author":"Berthelsen","year":"1986","journal-title":"Br J Anaesth"},{"issue":"6","key":"10.1016\/j.wem.2018.09.002_bib0015","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1183\/09031936.98.12061242","article-title":"Carbonic anhydrase inhibitors and ventilation: a complex interplay of stimulation and suppression","volume":"12","author":"Swenson","year":"1998","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.wem.2018.09.002_bib0016","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1152\/japplphysiol.01407.2006","article-title":"Prevention of acute mountain sickness by acetazolamide: as yet an unfinished story","volume":"102","author":"Swenson","year":"2007","journal-title":"J Appl Physiol (1985)"},{"issue":"2","key":"10.1016\/j.wem.2018.09.002_bib0017","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1580\/0953-9859-2.2.110","article-title":"Acute mountain sickness in western tourists around the Thorong Pass (5400 m) in Nepal","volume":"2","author":"Kayser","year":"1991","journal-title":"J Wilderness Med"},{"issue":"4","key":"10.1016\/j.wem.2018.09.002_bib0018","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1089\/ham.2004.5.410","article-title":"Awareness, prevalence, medication use, and risk factors of acute mountain sickness in tourists trekking around the Annapurnas in Nepal: a 12-year follow-up","volume":"5","author":"Gaillard","year":"2004","journal-title":"High Alt Med Biol"},{"issue":"2","key":"10.1016\/j.wem.2018.09.002_bib0019","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.wem.2013.12.027","article-title":"Risk determinants of acute mountain sickness in trekkers in the Nepali Himalaya: a 24-year follow-up","volume":"25","author":"McDevitt","year":"2014","journal-title":"Wilderness Environ Med"},{"issue":"4","key":"10.1016\/j.wem.2018.09.002_bib0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/ham.2016.0077","article-title":"Medication use among Mount Everest climbers: practice and attitudes","volume":"17","author":"Luks","year":"2016","journal-title":"High Alt Med Biol"},{"issue":"6","key":"10.1016\/j.wem.2018.09.002_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156786","article-title":"Drug use on Mont Blanc: a study using automated urine collection","volume":"11","author":"Robach","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.wem.2018.09.002_bib0022","first-page":"34","article-title":"Acetazolamide or dexamethasone for prevention of acute mountain sickness: a meta-analysis","volume":"4","author":"Reid","year":"1994","journal-title":"Wilderness Environ Med"},{"issue":"7256","key":"10.1016\/j.wem.2018.09.002_bib0023","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/bmj.321.7256.267","article-title":"Efficacy and harm of pharmacological prevention of acute mountain sickness: quantitative systematic review","volume":"321","author":"Dumont","year":"2000","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.wem.2018.09.002_bib0024","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.annemergmed.2011.10.015","article-title":"Pharmacologic prophylaxis for acute mountain sickness: a systematic shortcut review","volume":"59","author":"Seupaul","year":"2012","journal-title":"Ann Emerg Med"},{"issue":"2","key":"10.1016\/j.wem.2018.09.002_bib0025","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1089\/ham.2011.1084","article-title":"Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysis","volume":"13","author":"Kayser","year":"2012","journal-title":"High Alt Med Biol"},{"key":"10.1016\/j.wem.2018.09.002_bib0026","doi-asserted-by":"crossref","first-page":"e6779","DOI":"10.1136\/bmj.e6779","article-title":"Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute mountain sickness: systematic review and meta-analysis","volume":"345","author":"Low","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.wem.2018.09.002_bib0027","article-title":"Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs","volume":"6","author":"Nieto Estrada","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.wem.2018.09.002_bib0028","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1152\/japplphysiol.01572.2005","article-title":"Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute mountain sickness","volume":"102","author":"Leaf","year":"2007","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"10.1016\/j.wem.2018.09.002_bib0029","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/ham.2006.7.17","article-title":"Acetazolamide 125 mg BD is not significantly different from 375 mg BD in the prevention of acute mountain sickness: the prophylactic acetazolamide dosage comparison for efficacy (PACE) trial","volume":"7","author":"Basnyat","year":"2006","journal-title":"High Alt Med Biol"},{"issue":"6","key":"10.1016\/j.wem.2018.09.002_bib0030","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.annemergmed.2012.01.019","article-title":"Ibuprofen prevents altitude illness: a randomized controlled trial for prevention of altitude illness with nonsteroidal anti-inflammatories","volume":"59","author":"Lipman","year":"2012","journal-title":"Ann Emerg Med"},{"issue":"4","key":"10.1016\/j.wem.2018.09.002_bib0031","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.wem.2012.08.001","article-title":"Altitude Sickness in Climbers and Efficacy of NSAIDs Trial (ASCENT): randomized, controlled trial of ibuprofen versus placebo for prevention of altitude illness","volume":"23","author":"Gertsch","year":"2012","journal-title":"Wilderness Environ Med"},{"issue":"16","key":"10.1016\/j.wem.2018.09.002_bib0032","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1056\/NEJM196810172791601","article-title":"Effect of acetazolamide on acute mountain sickness","volume":"279","author":"Forwand","year":"1968","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.wem.2018.09.002_bib0033","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/ham.2014.1110","article-title":"Study looking at end expiratory pressure for altitude illness decrease (SLEEP-AID)","volume":"16","author":"Lipman","year":"2015","journal-title":"High Alt Med Biol"},{"issue":"1","key":"10.1016\/j.wem.2018.09.002_bib0034","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/ham.2012.1084","article-title":"Acetazolamide for the prevention of acute mountain sickness: time to move on","volume":"14","author":"Penninga","year":"2013","journal-title":"High Alt Med Biol"},{"issue":"1","key":"10.1016\/j.wem.2018.09.002_bib0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/152702903321488979","article-title":"Efficacy of low-dose acetazolamide (125 mg BID) for the prophylaxis of acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial","volume":"4","author":"Basnyat","year":"2003","journal-title":"High Alt Med Biol"},{"key":"10.1016\/j.wem.2018.09.002_bib0036","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.wem.2010.06.009","article-title":"Prospective, double-blind, randomized, placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache: the Headache Evaluation at Altitude Trial (HEAT)","volume":"21","author":"Gertsch","year":"2010","journal-title":"Wilderness Environ Med"}],"container-title":["Wilderness & Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1080603218301625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1080603218301625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T05:32:14Z","timestamp":1741671134000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1016\/j.wem.2018.09.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1080603218301625"],"URL":"https:\/\/doi.org\/10.1016\/j.wem.2018.09.002","relation":{},"ISSN":["1080-6032"],"issn-type":[{"value":"1080-6032","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced Acetazolamide Dosing in Countering Altitude Illness: A Comparison of 62.5 vs 125 mg (the RADICAL Trial)","name":"articletitle","label":"Article Title"},{"value":"Wilderness & Environmental Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wem.2018.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}