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However, the image quality is not satisfying after intravenous injection of gadolinium chelate (GdC), and occasional failure in GdC uptake has been noticed after traditional intratympanic injection. In the present report, targeted delivery of GdC and using a cost\u2010effective MRI system to obtain high quality images of EH in only 8\u00a0min will be introduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>39 MD patients were recruited in the study. First, 0.1\u00a0ml of 20\u2010fold diluted gadolinium\u2010diethylenetriamine acid (Gd\u2010DTPA) was delivered onto the posterior upper part of the tympanic medial wall using a soft\u2010tipped micro\u2010irrigation catheter through an artificially perforated tympanic membrane. Inner ear MRI was performed 24\u00a0h after Gd\u2010DTPA administration using a 3T MR machine and a 20\u2010channel head\/neck coil with an 8\u00a0min sequence of medium inversion time inversion recovery imaging with magnitude reconstruction (MIIRMR). The parameters were as follows: TR 16000\u00a0ms, TE 663\u00a0ms, inversion time 2700\u00a0ms, flip angle 180\u00b0, slices per slab 60.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Efficient inner ear uptake of Gd\u2010DTPA was detected 24\u00a0h after delivery and it created excellent contrast in the inner ear of all cases. High quality images demonstrating EH in the vestibule and cochlea were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Targeted delivery of minimum Gd\u2010DTPA (0.1\u00a0ml, 20\u2010fold dilution) onto the posterior upper portion of the tympanic medial wall and MRI with MIIRMR in a 3T machine and 20\u2010channel head\/neck coil are clinically practical to obtain high quality images displaying EH.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.wjorl.2019.04.001","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T05:36:26Z","timestamp":1578029786000},"page":"180-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["MRI detection of endolymphatic hydrops in Meniere's disease in 8\u00a0minutes using MIIRMR and a 20\u2010channel coil after targeted gadolinium delivery"],"prefix":"10.1002","volume":"5","author":[{"given":"Jing","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Center for Otolaryngology\u2010Head &amp; Neck Surgery of Chinese PLA Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Center for Otolaryngology\u2010Head &amp; Neck Surgery of Chinese PLA Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luguang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology Changhai Hospital Second Military Medical University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Endolymphatic Hydrops Is Caused by Increased Porosity of Stria Vascularis?","author":"Zou 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