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Patient reported age at disease onset of asthma, nasal polyposis, and age of first NSAID reaction were obtained from 2013 to 2019\u00a0at enrollment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 697 patients identified, diagnosis of asthma preceded diagnosis of nasal polyposis and first NSAID reaction, although there was considerable variability between patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prompt diagnosis of AERD is important for patient and provider education and improved care of this difficult\u2010to\u2010treat population of patients. Consider diagnostic aspirin challenge in patients without historical reactions to NSAIDs who have an otherwise compatible clinical history, specifically in patients who take daily low\u2010dose aspirin, leukotriene modifiers, avoid NSAIDs, or who are severely symptomatic at baseline where it would be difficult to identify an acute worsening of symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.wjorl.2020.07.003","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T03:07:42Z","timestamp":1599534462000},"page":"203-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["The importance of timely diagnosis of aspirin\u2010exacerbated respiratory disease for patient health and safety"],"prefix":"10.1002","volume":"6","author":[{"given":"Kathleen","family":"Buchheit","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Allergy and Clinical Immunology Brigham and Women's Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian C.","family":"Bensko","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Allergy and Clinical Immunology Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Allergy and Clinical Immunology Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Gakpo","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Allergy and Clinical Immunology Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya M.","family":"Laidlaw","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Allergy and Clinical Immunology Brigham and Women's Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.01.007"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.048"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.07.017"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2913"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.12.003"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.03.001"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.016003432.x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-68-5-975"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.6_Pt_1.1447"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62575-6"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2011.3.1.3"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.05.007"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.11.017"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(84)90361-0"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61803-0"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70123-9"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.02.041"},{"issue":"2","key":"e_1_2_3_19_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2016.12.924","article-title":"Efficacy of zileuton in patients with asthma and history of aspirin sensitivity: a retrospective analysis of data from two phase 3 studies","volume":"139","author":"Laidlaw T.M.","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.03.044"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.12.597"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.04.042"}],"container-title":["World Journal of Otorhinolaryngology - 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