{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:26:44Z","timestamp":1759616804518},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.wneu.2012.07.012","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T23:57:31Z","timestamp":1343433451000},"page":"e69-e72","source":"Crossref","is-referenced-by-count":2,"title":["Can We Rebuild the Human Brain? The Exciting Promise and Early Evidence That Stem Cells May Provide a Real Clinical Cure for Stroke in Humans"],"prefix":"10.1016","volume":"80","author":[{"given":"Kyle M.","family":"Fargen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian L.","family":"Hoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2012.07.012_bib1","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue plasminogen activator for acute ischemic stroke","volume":"333","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.wneu.2012.07.012_bib2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2174\/187152708784936608","article-title":"Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies","volume":"7","author":"Adibhatla","year":"2008","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.wneu.2012.07.012_bib3","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ana.20501","article-title":"Autologous mesenchymal stem cell transplantation in stroke patients","volume":"57","author":"Bang","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.wneu.2012.07.012_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/157016110790226570","article-title":"Clinical studies in stem cells transplantation for stroke: a review","volume":"8","author":"Bersano","year":"2010","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.wneu.2012.07.012_bib5","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1212\/WNL.0b013e318200d741","article-title":"Endothelial progenitor cells correlate with lesion volume and growth in acute stroke","volume":"75","author":"Bogoslovsky","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2012.07.012_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cne.22038","article-title":"Stem cells for ischemic brain injury: a critical review","volume":"515","author":"Burns","year":"2009","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.wneu.2012.07.012_bib7","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1161\/hs1101.098367","article-title":"Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2012.07.012_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0166-2236(00)01562-9","article-title":"Recovery recapitulates ontogeny","volume":"23","author":"Cramer","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.wneu.2012.07.012_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/jnis.2010.002766","article-title":"Meta-analysis of randomized intra-arterial thrombolytic trials for the treatment of acute stroke due to middle cerebral artery occlusion","volume":"3","author":"Fields","year":"2011","journal-title":"J Neurointerv Surg"},{"key":"10.1016\/j.wneu.2012.07.012_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ilar.51.1.3","article-title":"Neural stem cell niches and homing: recruitment and integration into functional tissues","volume":"51","author":"Garzon-Muvdi","year":"2009","journal-title":"ILAR J"},{"key":"10.1016\/j.wneu.2012.07.012_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/14653240801949994","article-title":"Mobilization of CD34+ hematopoietic cells, colony-forming cells and long-term culture-initiating cells into the peripheral blood of patients with an acute cerebral ischemic insult","volume":"10","author":"Hennemann","year":"2008","journal-title":"Cytotherapy"},{"key":"10.1016\/j.wneu.2012.07.012_bib12","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1586\/14737175.8.8.1193","article-title":"Cell-based therapy in ischemic stroke","volume":"8","author":"Hess","year":"2008","journal-title":"Expert Rev Neurother"},{"issue":"Suppl 1","key":"10.1016\/j.wneu.2012.07.012_bib13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2184.2008.00486.x","article-title":"Stem cells and neurological diseases","volume":"41","author":"Hess","year":"2008","journal-title":"Cell Prolif"},{"key":"10.1016\/j.wneu.2012.07.012_bib14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00004647-200404000-00005","article-title":"Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat","volume":"24","author":"Jin","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.wneu.2012.07.012_bib15","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1161\/01.STR.0000179037.82647.48","article-title":"Use of animal models has not contributed to development of acute stroke therapies: pro","volume":"36","author":"Kaste","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2012.07.012_bib16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3171\/jns.2005.103.1.0038","article-title":"Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial","volume":"103","author":"Kondziolka","year":"2005","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2012.07.012_bib17","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1212\/WNL.55.4.565","article-title":"Transplantation of cultured human neuronal cells for patients with stroke","volume":"55","author":"Kondziolka","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2012.07.012_bib18","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMoa052980","article-title":"NXY-059 for acute ischemic stroke","volume":"354","author":"Lees","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.wneu.2012.07.012_bib19","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/00004647-200009000-00006","article-title":"Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice","volume":"20","author":"Li","year":"2000","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.wneu.2012.07.012_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/scrt79","article-title":"Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia","volume":"2","author":"Lim","year":"2011","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.wneu.2012.07.012_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0079-6123(00)27014-3","article-title":"Clinical observations after neural transplantation in Parkinson's disease","volume":"127","author":"Lindvall","year":"2000","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.wneu.2012.07.012_bib22","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/nature04960","article-title":"Stem cells for the treatment of neurological disorders","volume":"441","author":"Lindvall","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.wneu.2012.07.012_bib23","first-page":"e46","article-title":"Heart disease and stroke statistics\u20142010 update: a report from the American Heart Association","volume":"121","author":"Lloyd-Jones","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.wneu.2012.07.012_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00018-008-8346-1","article-title":"Stem cell therapy in stroke","volume":"66","author":"Locatelli","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.wneu.2012.07.012_bib25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2217\/17460751.2.4.417","article-title":"Potential roles of bone marrow stem cells in stroke therapy","volume":"2","author":"Mendez-Otero","year":"2007","journal-title":"Regen Med"},{"key":"10.1016\/j.wneu.2012.07.012_bib26","first-page":"394","article-title":"Stem cell treatment of ischemic brain injury","volume":"11","author":"Miljan","year":"2009","journal-title":"Curr Opin Mol Ther"},{"key":"10.1016\/j.wneu.2012.07.012_bib27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2040-7378-1-2","article-title":"Granulocyte-colony stimulating factor for stroke treatment: mechanisms of action and efficacy in preclinical studies","volume":"1","author":"Minnerup","year":"2009","journal-title":"Exp Transl Stroke Med"},{"key":"10.1016\/j.wneu.2012.07.012_bib28","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/16060","article-title":"Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient","volume":"2","author":"Piccini","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.wneu.2012.07.012_bib29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10517-005-0229-y","article-title":"Cell therapy of brain stroke","volume":"139","author":"Rabinovich","year":"2005","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.wneu.2012.07.012_bib30","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/01.STR.0000258112.14918.24","article-title":"The impact of recanalization on ischemic stroke outcome: a meta-analysis","volume":"38","author":"Rha","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2012.07.012_bib31","unstructured":"Ringelstein EB. Axis 2. AX200 for the treatment of acute ischemic stroke. Presented at: Proceedings of the International Stroke Conference; New Orleans, LA, February 3, 2012."},{"key":"10.1016\/j.wneu.2012.07.012_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1747-4949.2011.00724.x","article-title":"Stem cells and stroke: are we further away than anyone is willing to admit?","volume":"7","author":"Savitz","year":"2012","journal-title":"Int J Stroke"},{"key":"10.1016\/j.wneu.2012.07.012_bib33","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1161\/STROKEAHA.108.513978","article-title":"Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury","volume":"39","author":"Schwarting","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2012.07.012_bib34","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1161\/01.CIR.0000142616.07367.66","article-title":"Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells","volume":"110","author":"Shyu","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.wneu.2012.07.012_bib35","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1096\/fj.11-195719","article-title":"The potential of stem cell therapy for stroke: is PISCES the sign?","volume":"26","author":"Smith","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.wneu.2012.07.012_bib36","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/STROKEAHA.107.497115","article-title":"Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial","volume":"39","author":"Smith","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2012.07.012_bib37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/jcbfm.2008.92","article-title":"Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction","volume":"29","author":"Taguchi","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.wneu.2012.07.012_bib38","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/jnis.2010.002600","article-title":"The POST trial: initial post-market experience of the Penumbra system: revascularization of large vessel occlusion in acute ischemic stroke in the United States and Europe","volume":"2","author":"Tarr","year":"2010","journal-title":"J Neurointerv Surg"},{"key":"10.1016\/j.wneu.2012.07.012_bib39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/neurintsurg-2011-010067","article-title":"CT perfusion-guided patient selection for endovascular treatment of acute ischemic stroke is safe and effective","volume":"4","author":"Turk","year":"2012","journal-title":"J Neurointerv Surg"},{"key":"10.1016\/j.wneu.2012.07.012_bib40","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/01.STR.0000132196.49028.a4","article-title":"Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats","volume":"35","author":"Wang","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2012.07.012_bib41","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1161\/01.STR.0000083461.80316.55","article-title":"Cell therapy: replacement","volume":"34","author":"Wechsler","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2012.07.012_bib42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/STROKEAHA.107.489401","article-title":"Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke","volume":"39","author":"Yip","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2012.07.012_bib43","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ana.1249","article-title":"A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats","volume":"50","author":"Zhang","year":"2001","journal-title":"Ann Neurol"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875012007899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875012007899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T14:51:44Z","timestamp":1714229504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875012007899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S1878875012007899"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2012.07.012","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}