{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:59:25Z","timestamp":1791543565235,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"China National \u201c11th Five Years\u201d Scientific Support Plan project","award":["2007BAI0703"],"award-info":[{"award-number":["2007BAI0703"]}]},{"name":"Shaanxi Province Government","award":["2005KT-027"],"award-info":[{"award-number":["2005KT-027"]}]},{"name":"Health Subdepartment of the General Logistics Department of Peoples Liberation Army","award":["2010gxjs080"],"award-info":[{"award-number":["2010gxjs080"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.wneu.2012.10.007","type":"journal-article","created":{"date-parts":[[2012,10,6]],"date-time":"2012-10-06T20:32:21Z","timestamp":1349555541000},"page":"S28.e9-S28.e19","source":"Crossref","is-referenced-by-count":42,"title":["Nucleus Accumbens Surgery for Addiction"],"prefix":"10.1016","volume":"80","author":[{"given":"Nan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-lian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-wang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-nan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-ming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-kang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-dong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2012.10.007_bib1","article-title":"Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification","author":"Amato","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.wneu.2012.10.007_bib2","first-page":"63","article-title":"Stereotaxic cingulumotomy for drug addiction","volume":"21","author":"Balasubramaniam","year":"1973","journal-title":"Neurol India"},{"key":"10.1016\/j.wneu.2012.10.007_bib3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2174\/1568007023339076","article-title":"Neuroplasticity within the mesoaccumbens dopamine system and its role in tobacco dependence","volume":"1","author":"Balfour","year":"2002","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"10.1016\/j.wneu.2012.10.007_bib4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.biopsych.2009.09.013","article-title":"Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression","volume":"67","author":"Bewernick","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.wneu.2012.10.007_bib5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/syn.10226","article-title":"Alcohol promotes dopamine release in the human nucleus accumbens","volume":"49","author":"Boileau","year":"2003","journal-title":"Synapse"},{"key":"10.1016\/j.wneu.2012.10.007_bib6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2008.02.025","article-title":"Cocaine-paired cues activate aversive representations in accumbens neurons","volume":"57","author":"Calu","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.wneu.2012.10.007_bib7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0031-9384(02)00760-6","article-title":"Nucleus accumbens cell firing during goal-directed behaviors for cocaine vs. \u2019natural\u2019 reinforcement","volume":"76","author":"Carelli","year":"2002","journal-title":"Physiol Behav"},{"key":"10.1016\/j.wneu.2012.10.007_bib8","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0006-8993(02)02312-0","article-title":"Heroin sensitization as mapped by c-Fos immunoreactivity in the rat striatum","volume":"933","author":"D\u2019Este","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.wneu.2012.10.007_bib9","first-page":"93","article-title":"Influence of stereotactic hypothalamotomy on alcohol and drug addiction","volume":"41","author":"Dieckmann","year":"1978","journal-title":"Appl Neurophysiol"},{"key":"10.1016\/j.wneu.2012.10.007_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002208","article-title":"Methadone maintenance at different dosages for opioid dependence","author":"Faggiano","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.wneu.2012.10.007_bib11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000075111","article-title":"Clinical study for alleviating opiate drug psychological dependence by a method of ablating the nucleus accumbens with stereotactic surgery","volume":"81","author":"Gao","year":"2003","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1016\/j.wneu.2012.10.007_bib12","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0079-6123(08)61883-X","article-title":"The nucleus accumbens: gateway for limbic structures to reach the motor system?","volume":"107","author":"Groenewegen","year":"1996","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.wneu.2012.10.007_bib13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000160155","article-title":"Evaluation of short-term psychological functions in opiate addicts after ablating the nucleus accumbens via stereotactic surgery","volume":"86","author":"He","year":"2008","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1016\/j.wneu.2012.10.007_bib14","first-page":"62","article-title":"The effect of the nucleus accumbens and ventral pallidum lesions on seeking behavior in rats","volume":"5","author":"He","year":"2001","journal-title":"Mod Rehabil"},{"key":"10.1016\/j.wneu.2012.10.007_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuroscience.2005.03.065","article-title":"Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens","volume":"135","author":"Hirose","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.wneu.2012.10.007_bib16","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1523\/JNEUROSCI.3667-06.2007","article-title":"Cocaine-associated stimuli increase cocaine seeking and activate accumbens core neurons after abstinence","volume":"27","author":"Hollander","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.wneu.2012.10.007_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.clineuro.2009.11.006","article-title":"Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: outcomes after one year","volume":"112","author":"Huff","year":"2010","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.wneu.2012.10.007_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/13556210412331284748","article-title":"Long-term gene expression in the nucleus accumbens following heroin administration is subregion-specific and depends on the nature of drug administration","volume":"10","author":"Jacobs","year":"2005","journal-title":"Addict Biol"},{"key":"10.1016\/j.wneu.2012.10.007_bib19","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1096\/fj.02-0272fje","article-title":"Active heroin administration induces specific genomic responses in the nucleus accumbens shell","volume":"16","author":"Jacobs","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.wneu.2012.10.007_bib20","first-page":"86","article-title":"Stereotactic cingulumotomy for drug addiction","volume":"41","author":"Kanaka","year":"1978","journal-title":"Appl Neurophysiol"},{"key":"10.1016\/j.wneu.2012.10.007_bib21","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000228930","article-title":"Observations on unaided smoking cessation after deep brain stimulation of the nucleus accumbens","volume":"15","author":"Kuhn","year":"2009","journal-title":"Eur Addict Res"},{"key":"10.1016\/j.wneu.2012.10.007_bib22","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1136\/jnnp.2006.113092","article-title":"Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications?","volume":"78","author":"Kuhn","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.wneu.2012.10.007_bib23","first-page":"113","article-title":"Further results of stereotaxis in the human hypothalamus in sexual deviations","volume":"16","author":"M\u00fcller","year":"1973","journal-title":"Neurochirurgia (Stuttg)"},{"key":"10.1016\/j.wneu.2012.10.007_bib24","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nn1713","article-title":"Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens","volume":"9","author":"Martin","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.wneu.2012.10.007_bib25","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1023\/A:1024945927301","article-title":"Physiological mechanisms of the effectiveness of bilateral stereotactic cingulotomy against strong psychological dependence in drug addicts","volume":"29","author":"Medvedev","year":"2003","journal-title":"Human Physiology"},{"key":"10.1016\/j.wneu.2012.10.007_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.0953-816x.2001.01860.x","article-title":"Mu and kappa opioid agonists modulate ventral tegmental area input to the ventral pallidum","volume":"15","author":"Mitrovic","year":"2002","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.wneu.2012.10.007_bib27","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1055\/s-0029-1233489","article-title":"Successful treatment of chronic resistant alcoholism by deep brain stimulation of nucleus accumbens: first experience with three cases","volume":"42","author":"Muller","year":"2009","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.wneu.2012.10.007_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1525-1403.2007.00138.x","article-title":"The human nucleus accumbens: where is it? A stereotactic, anatomical and magnetic resonance imaging study","volume":"11","author":"Neto","year":"2008","journal-title":"Neuromodulation"},{"key":"10.1016\/j.wneu.2012.10.007_bib29","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.biopsych.2008.09.030","article-title":"Deep brain stimulation in the nucleus accumbens for intractable Tourette\u2019s syndrome: follow-up report of 36 months","volume":"65","author":"Neuner","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.wneu.2012.10.007_bib30","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1073\/pnas.0710902105","article-title":"Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression","volume":"105","author":"Nikoshkov","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.wneu.2012.10.007_bib31","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/jnnp.2006.095315","article-title":"Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming","volume":"78","author":"Okun","year":"2007","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.wneu.2012.10.007_bib32","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1460-9568.2009.06916.x","article-title":"Neural encoding of cocaine-seeking behavior is coincident with phasic dopamine release in the accumbens core and shell","volume":"30","author":"Owesson-White","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.wneu.2012.10.007_bib33","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/S0140-6736(09)61007-2","article-title":"China clamps down on controversial therapies","volume":"373","author":"Qiu","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2012.10.007_bib34","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3109\/10826081003791932","article-title":"Effectiveness of therapies for heroin addiction in retaining patients in treatment: results from the VEdeTTE study","volume":"45","author":"Salamina","year":"2010","journal-title":"Subst Use Misuse"},{"key":"10.1016\/j.wneu.2012.10.007_bib35","series-title":"Atlas for stereotaxy of the human brain","author":"Schaltenbrand","year":"1977"},{"key":"10.1016\/j.wneu.2012.10.007_bib36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejphar.2005.09.068","article-title":"Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking","volume":"526","author":"Schmidt","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.wneu.2012.10.007_bib37","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/S0140-6736(08)60954-X","article-title":"Maintenance treatment with buprenorphine and naltrexone for heroin dependence in Malaysia: a randomised, double-blind, placebo-controlled trial","volume":"371","author":"Schottenfeld","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2012.10.007_bib38","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1001\/jama.283.10.1303","article-title":"Methadone maintenance vs 180-day psychosocially enriched detoxification for treatment of opioid dependence: a randomized controlled trial","volume":"283","author":"Sees","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.wneu.2012.10.007_bib39","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1038\/npp.2009.28","article-title":"Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior","volume":"34","author":"Simmons","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.wneu.2012.10.007_bib40","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.neuroscience.2008.04.063","article-title":"Cocaine reward and hyperactivity in the rat: sites of mu opioid receptor modulation","volume":"154","author":"Soderman","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.wneu.2012.10.007_bib41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jchemneu.2003.09.003","article-title":"The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive- and anxiety-disorders","volume":"26","author":"Sturm","year":"2003","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.wneu.2012.10.007_bib42","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00213-009-1553-0","article-title":"Control of within-binge cocaine-seeking by dopamine and glutamate in the core of nucleus accumbens","volume":"205","author":"Suto","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.wneu.2012.10.007_bib43","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1360-0443.2006.01367.x","article-title":"Opiate addiction in China: current situation and treatments","volume":"101","author":"Tang","year":"2006","journal-title":"Addiction"},{"issue":"Suppl 1","key":"10.1016\/j.wneu.2012.10.007_bib44","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1038\/sj.npp.1300144","article-title":"Obsessive-compulsive disorder: development of demand-controlled deep brain stimulation with methods from stochastic phase resetting","volume":"28","author":"Tass","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.wneu.2012.10.007_bib45","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/978-3-211-33081-4_43","article-title":"Behavioural and physiological effects of electrical stimulation in the nucleus accumbens: a review","volume":"97","author":"van Kuyck","year":"2007","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.wneu.2012.10.007_bib46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0006-8993(99)02288-X","article-title":"Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats","volume":"854","author":"Walker","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.wneu.2012.10.007_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(02)02980-3","article-title":"Effects of lesions of various brain areas on drug priming or footshock-induced reactivation of extinguished conditioned place preference","volume":"950","author":"Wang","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.wneu.2012.10.007_bib48","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/147323000803600408","article-title":"The nucleus accumbens core has a more important role in resisting reactivation of extinguished conditioned place preference in morphine-addicted rats","volume":"36","author":"Wang","year":"2008","journal-title":"J Int Med Res"},{"key":"10.1016\/j.wneu.2012.10.007_bib49","first-page":"773","article-title":"Effects of nucleus accumbens core and shell lesions on the acquisition of drug-seeking behavior under morphine reinforcement","volume":"24","author":"Wang","year":"2003","journal-title":"J Fourth Mil Med Univ"},{"key":"10.1016\/j.wneu.2012.10.007_bib50","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1111\/j.1460-9568.2006.04674.x","article-title":"Mu-opioid receptor cellular function in the nucleus accumbens is essential for hedonically driven eating","volume":"23","author":"Ward","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.wneu.2012.10.007_bib51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neulet.2010.02.019","article-title":"Preliminary findings in ablating the nucleus accumbens using stereotactic surgery for alleviating psychological dependence on alcohol","volume":"473","author":"Wu","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.wneu.2012.10.007_bib52","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neulet.2006.01.052","article-title":"Involvements of mu- and kappa-opioid receptors in morphine-induced antinociception in the nucleus accumbens of rats","volume":"399","author":"Xiong","year":"2006","journal-title":"Neurosci Lett"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875012011060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875012011060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T13:14:34Z","timestamp":1572786874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875012011060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":52,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S1878875012011060"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2012.10.007","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}