{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:14:32Z","timestamp":1788462872527,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.wneu.2014.06.021","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T12:01:25Z","timestamp":1403092885000},"page":"354-365","source":"Crossref","is-referenced-by-count":40,"title":["Focused Ultrasound: Relevant History and Prospects for the Addition of Mechanical Energy to the Neurosurgical Armamentarium"],"prefix":"10.1016","volume":"82","author":[{"given":"Eisha","family":"Christian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-9806","authenticated-orcid":false,"given":"Cheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.J.","family":"Apuzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2014.06.021_bib1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1552-6569.2004.tb00225.x","article-title":"CLOTBUST: Design of a randomized trial of ultrasound-enhanced thrombolysis for acute ischemic stroke","volume":"14","author":"Alexandrov","year":"2004","journal-title":"J Neuroimaging"},{"key":"10.1016\/j.wneu.2014.06.021_bib2","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1056\/NEJMoa041175","article-title":"Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke","volume":"351","author":"Alexandrov","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2014.06.021_bib3","first-page":"549","article-title":"Ultrasonic irradiation and atherosclerosis","volume":"57","author":"Anschuetz","year":"1965","journal-title":"Surgery"},{"key":"10.1016\/j.wneu.2014.06.021_bib4","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1161\/STROKEAHA.113.002713","article-title":"CLOTBUST-Hands Free: Pilot safety study of a novel operator-independent ultrasound device in patients with acute ischemic stroke","volume":"44","author":"Barreto","year":"2013","journal-title":"Stroke"},{"issue":"S1","key":"10.1016\/j.wneu.2014.06.021_bib5","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1016\/S1353-8020(13)70046-4","article-title":"Noninvasive functional neurosurgery using transcranial MR imaging-guided focused ultrasound","volume":"20","author":"Bauer","year":"2014","journal-title":"Parkinsonism and Related Disorders"},{"key":"10.1016\/j.wneu.2014.06.021_bib6","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.3171\/2011.10.FOCUS11251","article-title":"Sonothrombolysis for acute ischemic stroke: a systematic review of randomized controlled trials","volume":"32","author":"Bor-Seng-Shu","year":"2012","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2014.06.021_bib7","doi-asserted-by":"crossref","first-page":"e42311","DOI":"10.1371\/journal.pone.0042311","article-title":"High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke","volume":"7","author":"Burgess","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.wneu.2014.06.021_bib8","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1161\/01.STR.0000170707.86793.1a","article-title":"Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial","volume":"36","author":"Daffertshofer","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2014.06.021_bib9","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0140-6736(58)91905-6","article-title":"Investigation of abdominal masses by pulsed ultrasound","volume":"1","author":"Donald","year":"1958","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2014.06.021_bib10","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/bmj.2.5366.1154","article-title":"Use of ultrasonics in diagnosis of abdominal swellings","volume":"2","author":"Donald","year":"1963","journal-title":"Br Med J"},{"key":"10.1016\/j.wneu.2014.06.021_bib11","series-title":"Ultrasound in Medicine","author":"Duck","year":"1998"},{"key":"10.1016\/j.wneu.2014.06.021_bib12","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa1300962","article-title":"A\u00a0pilot study of focused ultrasound thalamotomy for essential tremor","volume":"369","author":"Elias","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2014.06.021_bib13","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/2011.10.FOCUS11252","article-title":"Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology","volume":"32","author":"Etame","year":"2012","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2014.06.021_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/1358836X0100600309","article-title":"Ultrasound and thrombolysis","volume":"6","author":"Francis","year":"2001","journal-title":"Vasc Med"},{"key":"10.1016\/j.wneu.2014.06.021_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1109\/IRET-ME.1960.5008041","article-title":"Fundamental neurological research and human neurosurgery using intense ultrasound","volume":"ME-7","author":"Fry","year":"1960","journal-title":"IRE Transac Med Electron"},{"key":"10.1016\/j.wneu.2014.06.021_bib16","first-page":"471","article-title":"Production of focal destructive lesions in the central nervous system with ultrasound","volume":"11","author":"Fry","year":"1954","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2014.06.021_bib17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/mrm.20118","article-title":"500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls","volume":"52","author":"Hynynen","year":"2004","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.wneu.2014.06.021_bib18","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1148\/radiol.2202001804","article-title":"Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits","volume":"220","author":"Hynynen","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.wneu.2014.06.021_bib19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1227\/01.NEU.0000336766.18197.8E","article-title":"High-intensity focused ultrasound surgery of the brain: part 1\u2013A historical perspective with modern applications","volume":"64","author":"Jagannathan","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2014.06.021_bib20","unstructured":"Jeanmonod D, Moser D, Magara A, Kowalski M, Buler R, Pourtehrani P, Coray T, Vogel J: Study of incisionless transcranial magnetic resonance-guided focused ultrasound treatment of Parkinson's disease: safety, accuracy, and initial outcomes.\u00a0Paper presented at 3rd International Symposium on Focused Ultrasound 2012, Washington, D.C."},{"key":"10.1016\/j.wneu.2014.06.021_bib21","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.3171\/2011.10.FOCUS11248","article-title":"Transcranial magnetic resonance imaging-guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain","volume":"32","author":"Jeanmonod","year":"2012","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2014.06.021_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ncl.2013.07.008","article-title":"Magnetic resonance-guided focused ultrasound: a new technology for clinical neurosciences","volume":"32","author":"Jolesz","year":"2014","journal-title":"Neurologic Clin"},{"key":"10.1016\/j.wneu.2014.06.021_bib23","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1161\/01.CIR.86.4.1257","article-title":"Effect of ultrasound on tissue-type plasminogen activator-induced thrombolysis","volume":"86","author":"Lauer","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.wneu.2014.06.021_bib24","first-page":"E4","article-title":"Enhanced therapeutic agent delivery through magnetic resonance imaging-monitored focused ultrasound blood-brain barrier disruption for brain tumor treatment: an overview of the current preclinical status","volume":"32","author":"Liu","year":"2012","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2014.06.021_bib25","unstructured":"Looi T, Waspe A, James A, Hynynen K, Drake JM: Intraventricular hemorrhage clot lysis using MR-guided focused ultrasound in a neonatal piglet model. Paper presented at AANS\/CNS Pediatric Section 2013, Toronto, Canada."},{"key":"10.1016\/j.wneu.2014.06.021_bib26","first-page":"637","article-title":"Histology of cerebral lesions produced by focused ultrasound","volume":"20","author":"Lynn","year":"1944","journal-title":"Am J Pathol"},{"key":"10.1016\/j.wneu.2014.06.021_bib27","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.ultrasmedbio.2009.07.001","article-title":"Noninvasive thrombolysis using pulsed ultrasound cavitation therapy\u2014histotripsy","volume":"35","author":"Maxwell","year":"2009","journal-title":"Ultrasound Med & Biol"},{"key":"10.1016\/j.wneu.2014.06.021_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1227\/01.NEU.0000360379.95800.2F","article-title":"Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients","volume":"66","author":"McDannold","year":"2010","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2014.06.021_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1148\/radiol.2411051170","article-title":"Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits","volume":"241","author":"McDannold","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.wneu.2014.06.021_bib30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1227\/NEU.0b013e3182672ac9","article-title":"Magnetic resonance-guided focused ultrasound surgery: part 2. A review of current and future applications","volume":"71","author":"Medel","year":"2012","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2014.06.021_bib31","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1227\/01.NEU.0000350226.30382.98","article-title":"Sonothrombolysis: an emerging modality for the management of stroke","volume":"65","author":"Medel","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2014.06.021_bib32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(05)70233-6","article-title":"Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial","volume":"365","author":"Mendelow","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2014.06.021_bib33","first-page":"441","article-title":"The International Surgical Trial in Intracerebral Haemorrhage (ISTICH)","volume":"86","author":"Mendelow","year":"2003","journal-title":"Acta Neurochirugica Supplement"},{"key":"10.1016\/j.wneu.2014.06.021_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/MCC.0b013e3280a9e5c2","article-title":"Surgical treatment of intracerebral haemorrhage","volume":"13","author":"Mendelow","year":"2007","journal-title":"Cur Opin Crit Care"},{"key":"10.1016\/j.wneu.2014.06.021_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2202-12-23","article-title":"Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity","volume":"12","author":"Min","year":"2011","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.wneu.2014.06.021_bib36","first-page":"319","article-title":"Transcranial magnetic resonance-guided focused ultrasound surgery for trigeminal neuralgia: a cadaveric and laboratory feasibility study","volume":"118","author":"Monteith","year":"2013","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2014.06.021_bib37","first-page":"1035","article-title":"Minimally invasive treatment of intracerebral hemorrhage with magnetic resonance-guided focused ultrasound","volume":"118","author":"Monteith","year":"2013","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2014.06.021_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0039-6109(05)70308-X","article-title":"The history of ultrasound","volume":"78","author":"Newman","year":"1998","journal-title":"Surg Clin N Am"},{"key":"10.1016\/j.wneu.2014.06.021_bib39","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1227\/01.NEU.0000254439.02736.D8","article-title":"Magnetic resonance imaging-guided, high-intensity focused ultrasound for brain tumor therapy","volume":"59","author":"Ram","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2014.06.021_bib40","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0735-1097(90)90651-5","article-title":"Experimental ultrasonic angioplasty: disruption of atherosclerotic plaques and thrombi in vitro and arterial recanalization in vivo","volume":"15","author":"Rosenschein","year":"1990","journal-title":"J\u00a0Am Col Cardiol"},{"key":"10.1016\/j.wneu.2014.06.021_bib41","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/01.CIR.102.2.238","article-title":"Ultrasound imaging-guided noninvasive ultrasound thrombolysis: preclinical results","volume":"102","author":"Rosenschein","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.wneu.2014.06.021_bib42","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1038\/sj.gt.3302323","article-title":"Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound","volume":"11","author":"Shimamura","year":"2004","journal-title":"Gene Therapy"},{"key":"10.1016\/j.wneu.2014.06.021_bib43","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0140-6736(89)90832-5","article-title":"Percutaneous ultrasonic angioplasty:initial clinical experience","volume":"2","author":"Siegel","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2014.06.021_bib44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1148\/radiol.11100155","article-title":"Focused ultrasound surgery in oncology: overview and principles","volume":"259","author":"Tempany","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.wneu.2014.06.021_bib45","first-page":"901","article-title":"Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. International journal of cancer","volume":"121","author":"Treat","year":"2007","journal-title":"J\u00a0Intern Cancer"},{"key":"10.1016\/j.wneu.2014.06.021_bib46","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0301-5629(95)00038-S","article-title":"Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo","volume":"21","author":"Vykhodtseva","year":"1995","journal-title":"Ultrasound Med & Biol"},{"key":"10.1016\/j.wneu.2014.06.021_bib47","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.ultrasmedbio.2006.06.026","article-title":"Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison","volume":"32","author":"Vykhodtseva","year":"2006","journal-title":"Ultrasound Med & Biol"},{"key":"10.1016\/j.wneu.2014.06.021_bib48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/RLI.0b013e31823cc75c","article-title":"In vitro and in vivo high-intensity focused ultrasound thrombolysis","volume":"47","author":"Wright","year":"2012","journal-title":"Invest Radiol"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875014005671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875014005671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T10:34:47Z","timestamp":1689330887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875014005671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":48,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S1878875014005671"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2014.06.021","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]}}}