{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:51:13Z","timestamp":1779900673567,"version":"3.53.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.wneu.2016.02.042","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T23:30:18Z","timestamp":1455751818000},"page":"525-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Treatment and Outcome in 65 Children with Optic Pathway Gliomas"],"prefix":"10.1016","volume":"89","author":[{"given":"Mohamed A.","family":"El Beltagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Reda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrhman","family":"Enayet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Saad","family":"Zaghloul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeha","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Zekri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"El-Khateeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2016.02.042_bib1","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/pbc.20655","article-title":"Optic pathway gliomas","volume":"46","author":"Jahraus","year":"2006","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.wneu.2016.02.042_bib2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/1097-0142(19950215)75:4<1051::AID-CNCR2820750423>3.0.CO;2-S","article-title":"Optic pathway and hypothalamic\/chiasmatic gliomas in children younger than age 5 years with a 6-year follow-up","volume":"75","author":"Janss","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2016.02.042_bib3","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00381-014-2374-y","article-title":"Suprasellar pilocytic astrocytoma: one national Centre\u2019s experience","volume":"30","author":"Mandiwanza","year":"2014","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2016.02.042_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00401-004-0858-7","article-title":"Clinico-pathological features of pilomyxoid astrocytoma of the optic pathway","volume":"108","author":"Chikai","year":"2004","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.wneu.2016.02.042_bib5","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1227\/01.NEU.0000079330.01541.6E","article-title":"Pilocytic astrocytomas in children: prognostic factors\u2014a retrospective study of 80 cases","volume":"53","author":"Fernandez","year":"2003","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2016.02.042_bib6","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/pbc.22198","article-title":"Natural history and outcome of optic pathway gliomas in children","volume":"53","author":"Nicolin","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.wneu.2016.02.042_bib7","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.ejca.2006.02.022","article-title":"Prognostic factors for progression of childhood optic pathway glioma: a systematic review","volume":"42","author":"Opocher","year":"2006","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.wneu.2016.02.042_bib8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1001\/archopht.119.4.516","article-title":"Spontaneous regression of optic gliomas: thirteen cases documented by serial neuroimaging","volume":"119","author":"Parsa","year":"2001","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.wneu.2016.02.042_bib9","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/cncr.11119","article-title":"Survival and functional outcome of children with hypothalamic\/chiasmatic tumors","volume":"97","author":"Fouladi","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2016.02.042_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ajmg.a.20211","article-title":"Optic pathway gliomas in neurofibromatosis type 1: the effect of presenting symptoms on outcome","volume":"122","author":"King","year":"2003","journal-title":"Am J Med Genet Part A"},{"key":"10.1016\/j.wneu.2016.02.042_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-pathol-020712-164009","article-title":"Pathological and molecular advances in pediatric low grade astrocytoma","volume":"8","author":"Rodriguez","year":"2013","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.wneu.2016.02.042_bib12","first-page":"2014","article-title":"Pediatric low-grade gliomas: how modern biology reshapes the clinical field","volume":"294-307","author":"Bergthold","year":"1845","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.wneu.2016.02.042_bib13","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1200\/JCO.2011.36.6054","article-title":"Randomized study of two chemotherapy regimens for treatment of low-grade glioma in young children: a report from the Children's Oncology Group","volume":"30","author":"Ater","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.wneu.2016.02.042_bib14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1017\/S031716710012089X","article-title":"Management of optic chiasmatic\/hypothalamic astrocytomas in children","volume":"29","author":"Steinbok","year":"2002","journal-title":"Can J Neurol Sci"},{"key":"10.1016\/j.wneu.2016.02.042_bib15","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1007\/s00381-006-0086-7","article-title":"Optic pathway glioma: outcome and prognostic factors in a surgical series","volume":"22","author":"Ahn","year":"2006","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2016.02.042_bib16","first-page":"85","article-title":"Gliomas of the optic nerve or chiasm: outcome by patients' age, tumor site, and treatment","volume":"68","author":"Alvord","year":"1988","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2016.02.042_bib17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2176\/nmc.25.282","article-title":"Long-term follow up of patients with optic glioma","volume":"25","author":"Kanamori","year":"1985","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1016\/j.wneu.2016.02.042_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000028680","article-title":"Potential prognostic factors of relapse-free survival in childhood optic pathway glioma: a multivariate analysis","volume":"29","author":"Chan","year":"1998","journal-title":"Pediatr Neurosurg"},{"key":"10.1016\/j.wneu.2016.02.042_bib19","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/pbc.22748","article-title":"Optic pathway glioma: long-term visual outcome in children without neurofibromatosis type-1","volume":"55","author":"Campagna","year":"2010","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.wneu.2016.02.042_bib20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0039-6257(94)90173-2","article-title":"Gliomas of the anterior visual pathway","volume":"38","author":"Dutton","year":"1994","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.wneu.2016.02.042_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2013.8.PEDS12546","article-title":"The role of surgery in optic pathway\/hypothalamic gliomas in children: clinical article","volume":"13","author":"Goodden","year":"2014","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2016.02.042_bib22","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s004310000531","article-title":"When do children with optic pathway tumours need treatment? an oncological perspective in 106 patients treated in a single Centre","volume":"159","author":"Grill","year":"2000","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.wneu.2016.02.042_bib23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000120729","article-title":"Optic pathway\/hypothalamic gliomas: a dilemma in management","volume":"19","author":"Hoffman","year":"1993","journal-title":"Pediatr Neurosurg"},{"key":"10.1016\/j.wneu.2016.02.042_bib24","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1200\/JCO.2003.03.043","article-title":"Progression-free survival in children with optic pathway tumors: dependence on age and the quality of the response to chemotherapy\u2014results of the first French prospective study for the French Society of Pediatric Oncology","volume":"21","author":"Laithier","year":"2003","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.wneu.2016.02.042_bib25","first-page":"583","article-title":"Long-term outcome of hypothalamic\/chiasmatic astrocytomas in children treated with conservative surgery","volume":"83","author":"Sutton","year":"1995","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2016.02.042_bib26","first-page":"661","article-title":"Surgical management of exophytic chiasmatic-hypothalamic tumors of childhood","volume":"73","author":"Wisoff","year":"1990","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2016.02.042_bib27","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/neuonc\/nos330","article-title":"A\u00a0multi-disciplinary consensus statement concerning surgical approaches to low-grade, high-grade astrocytomas and diffuse intrinsic pontine gliomas in childhood (CPN Paris 2011) using the Delphi method","volume":"15","author":"Walker","year":"2013","journal-title":"Neuro Oncol"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875016002874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875016002874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T20:24:01Z","timestamp":1754684641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875016002874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":27,"alternative-id":["S1878875016002874"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2016.02.042","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment and Outcome in 65 Children with Optic Pathway Gliomas","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2016.02.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}