{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T22:17:21Z","timestamp":1787437041227,"version":"build-2736575974"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.wneu.2018.10.168","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T11:48:19Z","timestamp":1541159299000},"page":"409-417.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Effect of Intrawound Vancomycin on Surgical Site Infections in Nonspinal Neurosurgical Procedures: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-1830","authenticated-orcid":false,"given":"Rakan","family":"Bokhari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-3100","authenticated-orcid":false,"given":"Eunice","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A.","family":"Zeiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Bakhaidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7925-5959","authenticated-orcid":false,"given":"Khalid","family":"Bajunaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-9658","authenticated-orcid":false,"given":"Oliver","family":"Lasry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3053-7912","authenticated-orcid":false,"given":"Saleh","family":"Baeesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Marcoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2018.10.168_bib1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/02688697.2011.626878","article-title":"Oxford craniotomy infections database: a cost analysis of craniotomy infection","volume":"26","author":"O\u2019Keeffe","year":"2012","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib2","first-page":"509","article-title":"Risk factors and outcomes associated with surgical site infections after craniotomy or craniectomy","volume":"120","author":"Chiang","year":"2014","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib3","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/neuros\/nyw127","article-title":"The use of vancomycin powder for surgical prophylaxis following craniotomy","volume":"80","author":"Ravikumar","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2018.10.168_bib4","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1001\/jamasurg.2017.0904","article-title":"Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017","volume":"152","author":"Berr\u00edos-Torres","year":"2017","journal-title":"JAMA Surg"},{"key":"10.1016\/j.wneu.2018.10.168_bib5","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3171\/2015.4.PEDS14699","article-title":"Complications associated with bacitracin powder in surgical wounds","volume":"16","author":"Beckman","year":"2015","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2018.10.168_bib6","first-page":"247","article-title":"Significant reduction in stereotactic and functional neurosurgical hardware infection after local neomycin\/polymyxin application","volume":"110","author":"Miller","year":"2009","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s15010-002-2113-2","article-title":"Rifampin-impregnated silicone catheters: a potential tool for prevention and treatment of CSF shunt infections","volume":"31","author":"Hampl","year":"2003","journal-title":"Infection"},{"key":"10.1016\/j.wneu.2018.10.168_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3171\/2015.8.PEDS15253","article-title":"A\u00a0new Hydrocephalus Clinical Research Network protocol to reduce cerebrospinal fluid shunt infection","volume":"17","author":"Kestle","year":"2016","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2018.10.168_bib9","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/neuros\/nyx559","article-title":"Topical vancomycin reduces surgical-site infections after craniotomy: a prospective, controlled study","volume":"83","author":"Mallela","year":"2018","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2018.10.168_bib10","first-page":"A531","article-title":"Cost benefit estimates of the use of topical vancomycin to prevent surgical site infection after craniotomy","volume":"123","author":"Abdullah","year":"2015","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib11","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1016\/j.spinee.2014.03.011","article-title":"Cost savings analysis of intrawound vancomycin powder in posterior spinal surgery","volume":"14","author":"Emohare","year":"2014","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2018.10.168_bib12","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/BOT.0000000000000617","article-title":"Time-dependent effectiveness of locally applied vancomycin powder in a contaminated traumatic orthopaedic wound model","volume":"30","author":"Tennent","year":"2016","journal-title":"J\u00a0Orthop Trauma"},{"key":"10.1016\/j.wneu.2018.10.168_bib13","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.3171\/2015.7.FOCUS15258","article-title":"Complications from the use of intrawound vancomycin in lumbar spinal surgery: a systematic review","volume":"39","author":"Ghobrial","year":"2015","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2018.10.168_bib14","first-page":"1600","article-title":"Reducing surgical site infections following craniotomy: examination of the use of topical vancomycin","volume":"123","author":"Abdullah","year":"2015","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib15","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.wneu.2018.10.168_bib16","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.wneu.2018.10.168_bib17","author":"Wells"},{"key":"10.1016\/j.wneu.2018.10.168_bib18","series-title":"Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0 [updated March 2011]","author":"Higgins","year":"2011"},{"key":"10.1016\/j.wneu.2018.10.168_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3171\/2011.4.PEDS10551","article-title":"A\u00a0standardized protocol to reduce cerebrospinal fluid shunt infection: the Hydrocephalus Clinical Research Network Quality Improvement Initiative","volume":"8","author":"Kestle","year":"2011","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2018.10.168_bib20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/02688697.2016.1229741","article-title":"Pre-emptive intrathecal vancomycin therapy reduces external ventricular drain infection: a single centre retrospective case-control study","volume":"31","author":"Fu","year":"2017","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11060-016-2198-6","article-title":"Surgical resection of fourth ventricular ependymomas: case series and technical nuances","volume":"130","author":"Winkler","year":"2016","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2018.10.168_bib22","first-page":"242","article-title":"Surgical shunt infection: significant reduction when using intraventricular and systemic antibiotic agents","volume":"105","author":"Ragel","year":"2006","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3171\/2017.10.PEDS17248","article-title":"A\u00a0standardized protocol to reduce pediatric baclofen pump infections: a quality improvement initiative","volume":"21","author":"Desai","year":"2018","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2018.10.168_bib24","article-title":"Deep brain stimulation hardware\u2013related infections: 10-year experience at a single institution [e-pub ahead of print]","author":"Abode-Iyamah","year":"2018","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib25","first-page":"1241","article-title":"Risk factors for surgical site infections and assessment of vancomycin powder as a preventive measure in patients undergoing first-time cranioplasty","volume":"128","author":"Abode-Iyamah","year":"2018","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib26","first-page":"1165","article-title":"Changing of the guard: reducing infection when replacing neural pacemakers","volume":"126","author":"Pepper","year":"2017","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0190249","article-title":"Topical vancomycin reduces the cerebrospinal fluid shunt infection rate: a retrospective cohort study","volume":"13","author":"van Lindert","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.wneu.2018.10.168_bib28","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/ons\/opx293","article-title":"The utility of vancomycin powder in reducing surgical site infections in deep brain stimulation surgery","volume":"15","author":"Kochanski","year":"2018","journal-title":"Oper Neurosurg (Hagerstown)"},{"key":"10.1016\/j.wneu.2018.10.168_bib29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.clineuro.2016.02.034","article-title":"Efficacy of postoperative antibiotic injection in and around ventriculoperitoneal shunt in reduction of shunt infection: a randomized controlled trial","volume":"143","author":"Moussa","year":"2016","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.wneu.2016.07.063","article-title":"The adjunctive use of vancomycin powder appears safe and may reduce the incidence of surgical-site infections after deep brain stimulation surgery","volume":"95","author":"Rasouli","year":"2016","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3171\/2014.5.PEDS1448","article-title":"A\u00a0standardized protocol to reduce pediatric spine surgery infection: a quality improvement initiative","volume":"14","author":"Ryan","year":"2014","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2018.10.168_bib32","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJMoa1000837","article-title":"Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery","volume":"363","author":"Bennett-Guerrero","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2018.10.168_bib33","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1001\/jamainternmed.2013.9763","article-title":"Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system","volume":"173","author":"Zimlichman","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.wneu.2018.10.168_bib34","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/neuros\/nyx046","article-title":"Frontal sinus breach during routine frontal craniotomy significantly increases risk of surgical site infection: 10-year retrospective analysis","volume":"81","author":"Linzey","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2018.10.168_bib35","first-page":"1746","article-title":"Clinical significance of positive cranial bone flap cultures and associated risk of surgical site infection after craniotomies or craniectomies","volume":"114","author":"Chiang","year":"2011","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bib36","first-page":"169","article-title":"[Combined intravenous and intrathecal vancomycin in treatment of patients with intracranial infections after craniotomy]","volume":"28","author":"Bao","year":"2016","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"10.1016\/j.wneu.2018.10.168_bib37","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3171\/2016.3.SPINE151491","article-title":"The effect of vancomycin powder on human dural fibroblast culture and its implications for dural repair during spine surgery","volume":"25","author":"Goldschmidt","year":"2016","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2018.10.168_bib38","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00586-015-3943-9","article-title":"Does intrawound application of vancomycin influence bone healing in spinal surgery?","volume":"25","author":"Eder","year":"2016","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2018.10.168_bib39","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/neuros\/nyw097","article-title":"Does intrawound vancomycin application during spine surgery create vancomycin-resistant organism?","volume":"80","author":"Chotai","year":"2017","journal-title":"Neurosurgery"},{"issue":"suppl 1","key":"10.1016\/j.wneu.2018.10.168_bib40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1469-0691.2006.01344.x","article-title":"The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus","volume":"12","author":"Appelbaum","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.wneu.2018.10.168_bib41","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2307\/30148464","article-title":"Definitions of surgical wound infections definitions of nosocomial surgical site: a modification of CDC definitions","volume":"13","author":"Horan","year":"1992","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.wneu.2018.10.168_bibE1","first-page":"509","article-title":"Risk factors and outcomes associated with surgical site infections after craniotomy or craniectomy","volume":"120","author":"Chiang","year":"2014","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bibE2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3171\/2017.10.PEDS17248","article-title":"A\u00a0standardized protocol to reduce pediatric baclofen pump infections: a quality improvement initiative","volume":"21","author":"Desai","year":"2018","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2018.10.168_bibE3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/02688697.2016.1229741","article-title":"Pre-emptive intrathecal vancomycin therapy reduces external ventricular drain infection: a single centre retrospective case-control study","volume":"31","author":"Fu","year":"2017","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bibE4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cct.2017.10.004","article-title":"Topical vancomycin to reduce surgical-site infections in neurosurgery: study protocol for a multi-center, randomized controlled trial","volume":"64","author":"Jonokuchi","year":"2018","journal-title":"Contemp Clin Trials"},{"key":"10.1016\/j.wneu.2018.10.168_bibE5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3171\/2011.4.PEDS10551","article-title":"A\u00a0standardized protocol to reduce cerebrospinal fluid shunt infection: the Hydrocephalus Clinical Research Network Quality Improvement Initiative","volume":"8","author":"Kestle","year":"2011","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2018.10.168_bibE6","first-page":"242","article-title":"Surgical shunt infection: significant reduction when using intraventricular and systemic antibiotic agents","volume":"105","author":"Ragel","year":"2006","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bibE7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11060-016-2198-6","article-title":"Surgical resection of fourth ventricular ependymomas: case series and technical nuances","volume":"130","author":"Winkler","year":"2016","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2018.10.168_bibE8","first-page":"1600","article-title":"Reducing surgical site infections following craniotomy: examination of the use of topical vancomycin","volume":"123","author":"Abdullah","year":"2015","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bibE9","first-page":"1241","article-title":"Risk factors for surgical site infections and assessment of vancomycin powder as a preventive measure in patients undergoing first-time cranioplasty","volume":"128","author":"Abode-Iyamah","year":"2018","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bibE10","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2307\/30148464","article-title":"Definitions of surgical wound infections definitions of nosocomial surgical site: a modification of CDC definitions","volume":"13","author":"Horan","year":"1992","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.wneu.2018.10.168_bibE11","article-title":"Deep brain stimulation hardware\u2013related infections: 10-year experience at a single institution [e-pub ahead of print]","author":"Abode-Iyamah","year":"2018","journal-title":"J Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bibE12","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/ons\/opx293","article-title":"The utility of vancomycin powder in reducing surgical site infections in deep brain stimulation surgery","volume":"15","author":"Kochanski","year":"2018","journal-title":"Oper Neurosurg (Hagerstown)"},{"key":"10.1016\/j.wneu.2018.10.168_bibE13","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/neuros\/nyx559","article-title":"Topical vancomycin reduces surgical-site infections after craniotomy: a prospective, controlled study","volume":"83","author":"Mallela","year":"2018","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2018.10.168_bibE14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.clineuro.2016.02.034","article-title":"Efficacy of postoperative antibiotic injection in and around ventriculoperitoneal shunt in reduction of shunt infection: a randomized controlled trial","volume":"143","author":"Moussa","year":"2016","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bibE15","first-page":"1165","article-title":"Changing of the guard: reducing infection when replacing neural pacemakers","volume":"126","author":"Pepper","year":"2017","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bibE16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.wneu.2016.07.063","article-title":"The adjunctive use of vancomycin powder appears safe and may reduce the incidence of surgical-site infections after deep brain stimulation surgery","volume":"95","author":"Rasouli","year":"2016","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2018.10.168_bibE17","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/neuros\/nyw127","article-title":"The use of vancomycin powder for surgical prophylaxis following craniotomy","volume":"80","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2018.10.168_bibE18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0190249","article-title":"Topical vancomycin reduces the cerebrospinal fluid shunt infection rate: a retrospective cohort study","volume":"13","author":"van Lindert","year":"2018","journal-title":"PLoS One"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875018324665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875018324665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T23:17:34Z","timestamp":1571959054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875018324665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":59,"alternative-id":["S1878875018324665"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2018.10.168","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Intrawound Vancomycin on Surgical Site Infections in Nonspinal Neurosurgical Procedures: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2018.10.168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}