{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:10:27Z","timestamp":1782141027029,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2018HXBH031"],"award-info":[{"award-number":["2018HXBH031"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2016102"],"award-info":[{"award-number":["2016102"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2015SZ0051"],"award-info":[{"award-number":["2015SZ0051"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M633373"],"award-info":[{"award-number":["2018M633373"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2017SCU12048"],"award-info":[{"award-number":["2017SCU12048"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010032","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["18PJ425"],"award-info":[{"award-number":["18PJ425"]}],"id":[{"id":"10.13039\/501100010032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.wneu.2019.01.143","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T12:16:23Z","timestamp":1549023383000},"page":"e651-e657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Predictive Accuracy of Neutrophil-to-Lymphocyte Ratio on Long-Term Outcome in Patients with Spontaneous Intracerebral Hemorrhage"],"prefix":"10.1016","volume":"125","author":[{"given":"Fan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingke","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyuan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2019.01.143_bib1","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJM200105103441907","article-title":"Spontaneous intracerebral hemorrhage","volume":"344","author":"Qureshi","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2019.01.143_bib2","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.116.013176","article-title":"Leukocyte count and intracerebral hemorrhage expansion","volume":"47","author":"Morotti","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2019.01.143_bib3","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1161\/STROKEAHA.114.005801","article-title":"Veltkamp R Leukocyte invasion of the brain after experimental intracerebral hemorrhage in mice","volume":"45","author":"Mracsko","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2019.01.143_bib4","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/S0140-6736(09)60371-8","article-title":"Intracerebral haemorrhage","volume":"373","author":"Qureshi","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2019.01.143_bib5","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/sj.jcbfm.9600403","article-title":"Inflammation after intracerebral hemorrhage","volume":"27","author":"Wang","year":"2007","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.wneu.2019.01.143_bib6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/neurintsurg-2013-010780","article-title":"Admission neutrophil-lymphocyte ratio predicts 90 day outcome after endovascular stroke therapy","volume":"6","author":"Brooks","year":"2014","journal-title":"J\u00a0Neurointerv Surg"},{"key":"10.1016\/j.wneu.2019.01.143_bib7","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.01.011","article-title":"Neutrophil lymphocyte ratio as a predictor of stroke","volume":"22","author":"Tokgoz","year":"2013","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.wneu.2019.01.143_bib8","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.04.007","article-title":"Is neutrophil\/lymphocyte ratio predict to short-term mortality in acute cerebral infarct independently from infarct volume?","volume":"23","author":"Tokgoz","year":"2014","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.wneu.2019.01.143_bib9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000468996","article-title":"Neutrophil-to-lymphocyte ratio is an independent predictor for in-hospital mortality in spontaneous intracerebral hemorrhage","volume":"44","author":"Giede-Jeppe","year":"2017","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.wneu.2019.01.143_bib10","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1161\/STROKEAHA.116.013627","article-title":"Neutrophil-to-lymphocyte ratio predicts the outcome of acute intracerebral hemorrhage","volume":"47","author":"Lattanzi","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2019.01.143_bib11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.09.013","article-title":"Neutrophil-to-lymphocyte ratio and 30-day mortality in patients with acute intracerebral hemorrhage","volume":"25","author":"Wang","year":"2016","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.wneu.2019.01.143_bib12","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/01.STR.27.8.1304","article-title":"The ABCs of measuring intracerebral hemorrhage volumes","volume":"27","author":"Kothari","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2019.01.143_bib13","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1471-4159.2007.04643.x","article-title":"Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha","volume":"102","author":"Nguyen","year":"2007","journal-title":"J\u00a0Neurochem"},{"key":"10.1016\/j.wneu.2019.01.143_bib14","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.09.006","article-title":"Peripheral monocyte count is associated with case fatality after intracerebral hemorrhage","volume":"23","author":"Adeoye","year":"2014","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.wneu.2019.01.143_bib15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/NEN.0b013e31820d94a5","article-title":"Neutrophil depletion reduces blood-brain barrier breakdown, axon injury, and inflammation after intracerebral hemorrhage","volume":"70","author":"Moxon-Emre","year":"2011","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.wneu.2019.01.143_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ajem.2016.11.037","article-title":"Neutrophil to lymphocyte ratio and the hematoma volume and stroke severity in acute intracerebral hemorrhage patients","volume":"35","author":"Sun","year":"2017","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.wneu.2019.01.143_bib17","doi-asserted-by":"crossref","first-page":"e74839","DOI":"10.1371\/journal.pone.0074839","article-title":"Stress mediators and immune dysfunction in patients with acute cerebrovascular diseases","volume":"8","author":"Liesz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.wneu.2019.01.143_bib18","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrn1765","article-title":"Central nervous system injury-induced immune deficiency syndrome","volume":"6","author":"Meisel","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.wneu.2019.01.143_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0006-8993(97)00251-5","article-title":"New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats","volume":"759","author":"Yamasaki","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.wneu.2019.01.143_bib20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s12028-016-0332-0","article-title":"Clinical value of neutrophil to lymphocyte and platelet to lymphocyte ratio after aneurysmal subarachnoid hemorrhage","volume":"26","author":"Tao","year":"2017","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.wneu.2019.01.143_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2217\/bmm-2016-0187","article-title":"Admission neutrophil count and neutrophil to lymphocyte ratio predict 90-day outcome in intracerebral hemorrhage","volume":"11","author":"Tao","year":"2017","journal-title":"Biomark Med"},{"key":"10.1016\/j.wneu.2019.01.143_bib22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12028-016-0255-9","article-title":"Systemic inflammatory response syndrome and outcomes in intracerebral hemorrhage","volume":"25","author":"Boehme","year":"2016","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.wneu.2019.01.143_bib23","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1161\/01.STR.0000251441.89665.bc","article-title":"Stroke-induced immunodepression: experimental evidence and clinical relevance","volume":"38","author":"Dirnagl","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2019.01.143_bib24","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/neurintsurg-2017-013197","article-title":"Neuroprotective strategies following intraparenchymal hemorrhage","volume":"9","author":"Babadjouni","year":"2017","journal-title":"J\u00a0Neurointerv Surg"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875019302438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875019302438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T08:19:11Z","timestamp":1761812351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875019302438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":24,"alternative-id":["S1878875019302438"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2019.01.143","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictive Accuracy of Neutrophil-to-Lymphocyte Ratio on Long-Term Outcome in Patients with Spontaneous Intracerebral Hemorrhage","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2019.01.143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}