{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T08:28:49Z","timestamp":1761812929888,"version":"build-2065373602"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.wneu.2019.04.081","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T22:27:08Z","timestamp":1555453628000},"page":"e1172-e1175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Intracerebral Delivery in Complex 3D Arrays: The Intracerebral Microinjection Instrument"],"prefix":"10.1016","volume":"127","author":[{"given":"Miles","family":"Cunningham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Azimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GuangZhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2019.04.081_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000268743","article-title":"Safety and function of a new clinical intracerebral microinjection instrument for stem cells and therapeutics examined in the Gottingen minipig","volume":"88","author":"Bjarkam","year":"2010","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1016\/j.wneu.2019.04.081_bib2","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1227\/01.NEU.0000125007.03145.00","article-title":"Preclinical evaluation of a novel intracerebral microinjection instrument permitting electrophysiologically guided delivery of therapeutics","volume":"54","author":"Cunningham","year":"2004","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2019.04.081_bib3","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/ner.12484","article-title":"Feasibility of three-dimensional placement of human therapeutic stem cells using the intracerebral microinjection instrument","volume":"19","author":"Glud","year":"2016","journal-title":"Neuromodulation"},{"key":"10.1016\/j.wneu.2019.04.081_bib4","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3727\/000000004783983350","article-title":"Evaluation of surgical techniques for neuronal cell transplantation used in patients with stroke","volume":"13","author":"Kondziolka","year":"2004","journal-title":"Cell Transpl"},{"key":"10.1016\/j.wneu.2019.04.081_bib5","first-page":"38","article-title":"Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial","volume":"103","author":"Kondziolka","year":"2005","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2019.04.081_bib6","first-page":"493","article-title":"Neural transplantation cannula and microinjector system: experimental and clinical experience. Technical note","volume":"92","author":"Mendez","year":"2000","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2019.04.081_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0165-0270(01)00332-6","article-title":"A\u00a0simple method to microinject solid neural tracers into deep structures of the brain","volume":"106","author":"Marin","year":"2001","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.wneu.2019.04.081_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/mt.2014.155","article-title":"Interventional magnetic resonance imaging-guided cell transplantation into the brain with radially branched deployment","volume":"23","author":"Silvestrini","year":"2015","journal-title":"Mol Ther"},{"key":"10.1016\/j.wneu.2019.04.081_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0079-6123(08)62597-2","article-title":"Immune reactions against intracerebral murine xenografts of fetal hippocampal tissue and cultured cortical astrocytes in the adult rat","volume":"82","author":"Finsen","year":"1990","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.wneu.2019.04.081_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0165-5728(91)90008-U","article-title":"Leukocyte infiltration and glial reactions in xenografts of mouse brain tissue undergoing rejection in the adult rat brain: a light and electron microscopical immunocytochemical study","volume":"32","author":"Finsen","year":"1991","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.wneu.2019.04.081_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-8993(94)91532-6","article-title":"Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model","volume":"633","author":"Nikkhah","year":"1994","journal-title":"Brain Res"},{"key":"10.1016\/j.wneu.2019.04.081_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0306-4522(94)90007-8","article-title":"A\u00a0microtransplantation approach for cell suspension grafting in the rat Parkinson model: a detailed account of the methodology","volume":"63","author":"Nikkhah","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.wneu.2019.04.081_bib13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.nbd.2015.03.023","article-title":"Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with alpha-synucleinopathies","volume":"78","author":"Bartus","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.wneu.2019.04.081_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/mt.2013.281","article-title":"Parkinson's disease gene therapy: success by design meets failure by efficacy","volume":"22","author":"Bartus","year":"2014","journal-title":"Mol Ther"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875019310733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875019310733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T08:24:25Z","timestamp":1761812665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875019310733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":14,"alternative-id":["S1878875019310733"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2019.04.081","relation":{},"ISSN":["1878-8750"],"issn-type":[{"type":"print","value":"1878-8750"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracerebral Delivery in Complex 3D Arrays: The Intracerebral Microinjection Instrument","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2019.04.081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}