{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:18:08Z","timestamp":1787167088661,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.wneu.2019.08.155","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T11:55:29Z","timestamp":1567166129000},"page":"e24-e32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Reduced Admission Serum Fibrinogen Levels Predict 6-Month Mortality of Poor-Grade Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.1016","volume":"136","author":[{"given":"Bingsen","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufa","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2019.08.155_bib1","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1515\/cclm-2014-1189","article-title":"Serum brain injury biomarkers as predictors of mortality after severe aneurysmal subarachnoid hemorrhage: preliminary results","volume":"53","author":"de Azua Lopez","year":"2015","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.wneu.2019.08.155_bib2","first-page":"698","article-title":"The falling rates of hospital admission, case fatality, and population-based mortality for subarachnoid hemorrhage in England, 1999-2010","volume":"125","author":"Mukhtar","year":"2016","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2019.08.155_bib3","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1136\/jnnp.2007.117655","article-title":"Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends","volume":"78","author":"de Rooij","year":"2007","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.wneu.2019.08.155_bib4","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1161\/STROKEAHA.107.484360","article-title":"Prognostic factors for outcome in patients with aneurysmal subarachnoid hemorrhage","volume":"38","author":"Rosengart","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2019.08.155_bib5","first-page":"644","article-title":"Prognostic value of premorbid hypertension and neurological status in aneurysmal subarachnoid hemorrhage: pooled analyses of individual patient data in the SAHIT repository","volume":"122","author":"Jaja","year":"2015","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2019.08.155_bib6","first-page":"1764","article-title":"Preoperative and postoperative predictors of long-term outcome after endovascular treatment of poor-grade aneurysmal subarachnoid hemorrhage","volume":"126","author":"Zhao","year":"2017","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2019.08.155_bib7","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1161\/STROKEAHA.108.519942","article-title":"Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial","volume":"39","author":"Macdonald","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2019.08.155_bib8","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s12028-010-9433-3","article-title":"Preventing vasospasm improves outcome after aneurysmal subarachnoid hemorrhage: rationale and design of CONSCIOUS-2 and CONSCIOUS-3 trials","volume":"13","author":"Macdonald","year":"2010","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.wneu.2019.08.155_bib9","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S1474-4422(11)70108-9","article-title":"Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)","volume":"10","author":"Macdonald","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.wneu.2019.08.155_bib10","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrneurol.2011.168","article-title":"Stroke: disappointing results for clazosentan in CONSCIOUS-2","volume":"7","author":"Meyers","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.wneu.2019.08.155_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-3-7091-1192-5_7","article-title":"Randomised trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2)","volume":"115","author":"Macdonald","year":"2013","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.wneu.2019.08.155_bib12","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/01.WCB.0000125886.48838.7E","article-title":"Signaling pathways for early brain injury after subarachnoid hemorrhage","volume":"24","author":"Kusaka","year":"2004","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.wneu.2019.08.155_bib13","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1038\/s41598-018-23934-x","article-title":"Higher leukocyte count predicts 3-month poor outcome of ruptured cerebral aneurysms","volume":"8","author":"Yao","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.wneu.2019.08.155_bib14","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1227\/NEU.0000000000000963","article-title":"Elevated baseline C-reactive protein as a predictor of outcome after aneurysmal subarachnoid hemorrhage: data from the Simvastatin in Aneurysmal Subarachnoid Hemorrhage (STASH) trial","volume":"77","author":"Turner","year":"2015","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2019.08.155_bib15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/1354750X.2014.881418","article-title":"Biomarkers as outcome predictors in subarachnoid hemorrhage\u2013a systematic review","volume":"19","author":"Hong","year":"2014","journal-title":"Biomarkers"},{"key":"10.1016\/j.wneu.2019.08.155_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jns.2014.04.020","article-title":"Biomarkers of vasospasm development and outcome in aneurysmal subarachnoid hemorrhage","volume":"341","author":"Rodriguez-Rodriguez","year":"2014","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.wneu.2019.08.155_bib17","article-title":"Laboratory biomarkers of delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review","volume":"17","author":"Jabbarli","year":"2018","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.wneu.2019.08.155_bib18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.4103\/1673-5374.235022","article-title":"Matricellular proteins as possible biomarkers for early brain injury after aneurysmal subarachnoid hemorrhage","volume":"13","author":"Suzuki","year":"2018","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.wneu.2019.08.155_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jns.2018.06.021","article-title":"Neurocognitive outcomes after aneurysmal subarachnoid hemorrhage: identifying inflammatory biomarkers","volume":"394","author":"Watson","year":"2018","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.wneu.2019.08.155_bib20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/neuros\/nyy045","article-title":"White blood cell count improves prediction of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage","volume":"84","author":"Al-Mufti","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2019.08.155_bib21","article-title":"Is admission lipoprotein-associated phospholipase A2 a novel predictor of vasospasm and outcome in patients with aneurysmal subarachnoid hemorrhage?","volume":"21","author":"Ding","year":"2019","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2019.08.155_bib22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1042\/bj3460603","article-title":"Hepatic expression, synthesis and secretion of a novel fibrinogen\/angiopoietin-related protein that prevents endothelial-cell apoptosis","volume":"346","author":"Kim","year":"2000","journal-title":"Biochem J"},{"key":"10.1016\/j.wneu.2019.08.155_bib23","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/j.1538-7836.2005.01365.x","article-title":"Fibrinogen and fibrin structure and functions","volume":"3","author":"Mosesson","year":"2005","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.wneu.2019.08.155_bib24","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1538-7836.2012.04651.x","article-title":"Early platelet activation, inflammation and acute brain injury after a subarachnoid hemorrhage: a pilot study","volume":"10","author":"Frontera","year":"2012","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.wneu.2019.08.155_bib25","first-page":"594","article-title":"Serial changes of hemostasis in aneurysmal subarachnoid hemorrhage with special reference to delayed ischemic neurological deficits","volume":"86","author":"Fujii","year":"1997","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2019.08.155_bib26","first-page":"1092","article-title":"Biological effects of acute pravastatin treatment in patients after aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled trial","volume":"107","author":"Tseng","year":"2007","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2019.08.155_bib27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/bja\/aeu086","article-title":"Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate","volume":"113","author":"Collins","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.wneu.2019.08.155_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jocn.2018.04.073","article-title":"Cerebral perfusion pressure threshold to prevent delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage","volume":"54","author":"Cai","year":"2018","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.wneu.2019.08.155_bib29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1471-2377-14-140","article-title":"Non-aneurysmal non-traumatic subarachnoid hemorrhage: patient characteristics, clinical outcome and prognostic factors based on a single-center experience in 125 patients","volume":"14","author":"Konczalla","year":"2014","journal-title":"BMC Neurol"},{"key":"10.1016\/j.wneu.2019.08.155_bib30","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1097\/ALN.0b013e318267395b","article-title":"Elderly age as a prognostic marker of 1-year poor outcome for subarachnoid hemorrhage patients through its interaction with admission hydrocephalus","volume":"117","author":"Degos","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.wneu.2019.08.155_bib31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00281-011-0290-8","article-title":"Fibrinogen as a key regulator of inflammation in disease","volume":"34","author":"Davalos","year":"2012","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.wneu.2019.08.155_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/nyas.13454","article-title":"Coagulation and fibrinolysis in gastric cancer","volume":"1404","author":"Repetto","year":"2017","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.wneu.2019.08.155_bib33","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1161\/01.STR.23.10.1404","article-title":"Hematogenous factors and prediction of delayed ischemic deficit after subarachnoid hemorrhage","volume":"23","author":"Ameriso","year":"1992","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2019.08.155_bib34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/ACO.0b013e32832678d9","article-title":"Time for changing coagulation management in trauma-related massive bleeding","volume":"22","author":"Fries","year":"2009","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.wneu.2019.08.155_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000114920","article-title":"Fibrinolytic activity in blood and cerebrospinal fluid in subarachnoid hemorrhage from ruptured intracranial saccular aneurysm before and during EACA treatment","volume":"17","author":"Filizzolo","year":"1978","journal-title":"Eur Neurol"},{"key":"10.1016\/j.wneu.2019.08.155_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1227\/00006123-198401000-00012","article-title":"Quantitative determination of plasma fibrinolytic activity in patients with ruptured intracranial aneurysms who are receiving epsilon-aminocaproic acid: relationship of possible complications of therapy to the degree of fibrinolytic inhibition","volume":"14","author":"Burchiel","year":"1984","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2019.08.155_bib37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1227\/01.NEU.0000163085.48999.D6","article-title":"D-dimer predicts outcome after aneurysmal subarachnoid hemorrhage: no effect of thromboprophylaxis on coagulation activity","volume":"57","author":"Ilveskero","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2019.08.155_bib38","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1212\/01.wnl.0000223349.97278.e0","article-title":"Plasma D-dimer predicts poor outcome after acute intracerebral hemorrhage","volume":"67","author":"Delgado","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2019.08.155_bib39","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1161\/01.STR.0000221710.55467.33","article-title":"D-dimer as an independent predictor for poor outcome after aneurysmal subarachnoid hemorrhage","volume":"37","author":"Juvela","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2019.08.155_bib40","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/jnnp.68.3.337","article-title":"Complications and outcome in patients with aneurysmal subarachnoid haemorrhage: a prospective hospital based cohort study in The Netherlands","volume":"68","author":"Roos","year":"2000","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.wneu.2019.08.155_bib41","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/jcbfm.2015.13","article-title":"Hemostasis and fibrinolysis in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a systematic review","volume":"35","author":"Boluijt","year":"2015","journal-title":"J\u00a0Cereb Blood Flow Metab"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875019323113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875019323113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T08:45:13Z","timestamp":1761813913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875019323113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":41,"alternative-id":["S1878875019323113"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2019.08.155","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced Admission Serum Fibrinogen Levels Predict 6-Month Mortality of Poor-Grade Aneurysmal Subarachnoid Hemorrhage","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2019.08.155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}