{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:10:08Z","timestamp":1785510608701,"version":"3.56.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the promotion of Science","doi-asserted-by":"publisher","award":["16K10757"],"award-info":[{"award-number":["16K10757"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.wneu.2019.10.074","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T19:35:49Z","timestamp":1574105749000},"page":"e360-e371","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature"],"prefix":"10.1016","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-6501","authenticated-orcid":false,"given":"Sayuru","family":"Tsuyuguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-4946","authenticated-orcid":false,"given":"Yasuyuki","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-7258","authenticated-orcid":false,"given":"Manish","family":"Kolakshyapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Takayasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Usui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ushio","family":"Yonezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwa Jeet","family":"Amatya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Takeshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Kurisu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiyuki","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2019.10.074_bib1","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/1097-0142(19821015)50:8<1629::AID-CNCR2820500828>3.0.CO;2-1","article-title":"The growing teratoma syndrome","volume":"50","author":"Logothetis","year":"1982","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2019.10.074_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2214\/ajr.151.2.325","article-title":"The growing teratoma syndrome: an unusual manifestation of treated, nonseminomatous germ cell tumors of the testis","volume":"151","author":"Lorigan","year":"1988","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.wneu.2019.10.074_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1148\/radiology.175.2.2158120","article-title":"Nonseminomatous germ cell tumors: enlarging masses despite chemotherapy","volume":"175","author":"Panicek","year":"1990","journal-title":"Radiology"},{"key":"10.1016\/j.wneu.2019.10.074_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1378\/chest.98.1.231","article-title":"The growing teratoma syndrome. A case of primary mediastinal nonseminomatous germ cell tumor treated with chemotherapy and radiotherapy","volume":"98","author":"Chen","year":"1990","journal-title":"Chest"},{"key":"10.1016\/j.wneu.2019.10.074_bib5","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/gyno.1993.1147","article-title":"The growing teratoma syndrome: a woman with nonseminomatous germ cell tumor of the ovary","volume":"49","author":"Kattan","year":"1993","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.wneu.2019.10.074_bib6","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/(SICI)1097-0142(19970901)80:5<942::AID-CNCR16>3.0.CO;2-W","article-title":"The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland: a case report and review","volume":"80","author":"O'Callaghan","year":"1997","journal-title":"Cancer"},{"issue":"suppl","key":"10.1016\/j.wneu.2019.10.074_bib7","first-page":"i","article-title":"Report of Brain Tumor Registry of Japan (1969-1996)","volume":"43","year":"2003","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1016\/j.wneu.2019.10.074_bib8","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0360-3016(90)90396-2","article-title":"Pineal and CNS germ cell tumors: Royal Marsden Hospital experience 1962-1987","volume":"18","author":"Dearnaley","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.wneu.2019.10.074_bib9","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/00006123-200103000-00011","article-title":"Management of malignant pineal germ cell tumors with residual mature teratoma","volume":"48","author":"Friedman","year":"2001","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2019.10.074_bib10","first-page":"545","article-title":"Intracranial germ-cell tumors in children","volume":"74","author":"Hoffman","year":"1991","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2019.10.074_bib11","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.3171\/foc.1998.5.1.10","article-title":"Combined chemotherapy and radiation therapy for central nervous system germ cell tumors: preliminary results of a Phase II study of the Japanese Pediatric Brain Tumor Study Group","volume":"5","author":"Matsutani","year":"1998","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2019.10.074_bib12","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1002\/1097-0142(19860601)57:11<2108::AID-CNCR2820571103>3.0.CO;2-Z","article-title":"Successful management of metastatic and primary germ cell tumors in the brain","volume":"57","author":"Rustin","year":"1986","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2019.10.074_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/mpo.2950240112","article-title":"Paradoxical response of a pineal immature teratoma to combination chemotherapy","volume":"24","author":"Lee","year":"1995","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.wneu.2019.10.074_bib14","first-page":"568","article-title":"[Expanding mature pineal teratoma syndrome. Case report]","volume":"46","author":"Hanna","year":"2000","journal-title":"Neurochirurgie"},{"key":"10.1016\/j.wneu.2019.10.074_bib15","first-page":"359","article-title":"The growing teratoma syndrome in an intracranial germ cell tumor: a case report","volume":"28","author":"Isaka","year":"2003","journal-title":"Nervous Syst Child"},{"key":"10.1016\/j.wneu.2019.10.074_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2176\/nmc.44.33","article-title":"Growing teratoma syndrome in a patient with a non-germinomatous germ cell tumor in the neurohypophysis\u2014case report","volume":"44","author":"Yagi","year":"2004","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1016\/j.wneu.2019.10.074_bib17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1227\/01.NEU.0000144847.91050.B1","article-title":"The growing teratoma syndrome after subtotal resection of an intracranial nongerminomatous germ cell tumor in an adult: case report","volume":"56","author":"Bi","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2019.10.074_bib18","first-page":"329","article-title":"Pineal tumors showing growing teratoma syndrome after chemotherapy and irradiation: a report of 2 cases","volume":"33","author":"Hirano","year":"2008","journal-title":"Nervous Syst Child"},{"key":"10.1016\/j.wneu.2019.10.074_bib19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11060-008-9640-3","article-title":"Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report","volume":"90","author":"Peltier","year":"2008","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2019.10.074_bib20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3171\/PED.2008.2.11.331","article-title":"Intracranial teratomas in children: the role and timing of surgical removal","volume":"2","author":"Noudel","year":"2008","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2019.10.074_bib21","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3171\/2009.1.PEDS0857","article-title":"Intracranial growing teratoma syndrome mimicking tumor relapse: a diagnostic dilemma","volume":"3","author":"Kong","year":"2009","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.wneu.2019.10.074_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00701-009-0332-3","article-title":"Intracranial growing teratoma syndrome following radiotherapy\u2014an unusually fulminant course","volume":"152","author":"Moiyadi","year":"2010","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.wneu.2019.10.074_bib23","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1007\/s00701-010-0807-2","article-title":"What's growing on? The growing teratoma syndrome","volume":"152","author":"Denaro","year":"2010","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.wneu.2019.10.074_bib24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11060-010-0238-1","article-title":"Intracranial growing teratoma syndrome: clinical characteristics and treatment strategy","volume":"101","author":"Kim","year":"2011","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2019.10.074_bib25","first-page":"75","article-title":"Growing teratoma syndrome of the pineal gland recognized very early during chemotherapy in a child with a non-germinomatous germ-cell tumor","volume":"20","author":"Zhang","year":"2013","journal-title":"Clin Pediatr Hematology-Oncology"},{"key":"10.1016\/j.wneu.2019.10.074_bib26","first-page":"859","article-title":"[A mixed germ cell tumor that underwent dramatic size changes]","volume":"42","author":"Kuwayama","year":"2014","journal-title":"No Shinkei Geka"},{"key":"10.1016\/j.wneu.2019.10.074_bib27","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s00381-014-2396-5","article-title":"The pathogenesis of intracranial growing teratoma syndrome: proliferation of tumor cells or formation of multiple expanding cysts? Two case reports and review of the literature","volume":"30","author":"Oya","year":"2014","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2019.10.074_bib28","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00381-013-2295-1","article-title":"Growing teratoma syndrome in intracranial non-germinomatous germ cell tumors (iNGGCTs): a risk for secondary malignant transformation\u2014a report of two cases","volume":"30","author":"Glass","year":"2014","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2019.10.074_bib29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.17116\/neiro201579369-74","article-title":"[Growing teratoma syndrome in a patient with intracranial germ cell tumor]","volume":"79","author":"Zheludkova","year":"2015","journal-title":"Zh Vopr Neirokhir Im N N Burdenko"},{"key":"10.1016\/j.wneu.2019.10.074_bib30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1620\/tjem.238.273","article-title":"Neoadjuvant chemotherapy for facilitating surgical resection of infantile massive intracranial immature teratoma","volume":"238","author":"Kitahara","year":"2016","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.wneu.2019.10.074_bib31","first-page":"18","article-title":"A\u00a0case report of growing teratoma syndrome in a patient with intracranial mixed germ cell tumor","volume":"24","author":"Li","year":"2017","journal-title":"Prog Neuro-Oncology"},{"key":"10.1016\/j.wneu.2019.10.074_bib32","first-page":"rjx038","article-title":"Intracranial monodermal teratoma presenting with growing teratoma syndrome","volume":"2017","author":"Khoo","year":"2017","journal-title":"J\u00a0Surg Case Rep"},{"key":"10.1016\/j.wneu.2019.10.074_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1464-410X.1991.tb15109.x","article-title":"The growing teratoma syndrome","volume":"67","author":"Jeffery","year":"1991","journal-title":"Br J Urol"},{"key":"10.1016\/j.wneu.2019.10.074_bib34","first-page":"346","article-title":"Chemotherapeutic retroconversion of immature teratoma of the ovary","volume":"49","author":"DiSaia","year":"1977","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.wneu.2019.10.074_bib35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ygyno.2003.10.024","article-title":"Growing teratoma syndrome vs chemotherapeutic retroconversion: case report and review of the literature","volume":"92","author":"Amsalem","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.wneu.2019.10.074_bib36","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/PGP.0b013e3181cef16b","article-title":"Immature teratoma of the ovary with distant metastases: favorable prognosis and insights into chemotherapeutic retroconversion","volume":"29","author":"Kurata","year":"2010","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.wneu.2019.10.074_bib37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0090-8258(92)90145-9","article-title":"Synchronous mature teratomas of the ovary and liver: a case presenting 11 years following chemotherapy for immature teratoma","volume":"47","author":"Caldas","year":"1992","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.wneu.2019.10.074_bib38","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1200\/JCO.2014.59.5132","article-title":"Phase II Trial assessing the ability of neoadjuvant chemotherapy with or without second-look surgery to eliminate measurable disease for nongerminomatous germ cell tumors: a children's oncology group study","volume":"33","author":"Goldman","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.wneu.2019.10.074_bib39","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11060-018-2827-3","article-title":"Indications for salvage surgery during treatment for intracranial germ cell tumors","volume":"138","author":"Kanamori","year":"2018","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2019.10.074_bib40","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1227\/NEU.0000000000000697","article-title":"Second-look surgery for intracranial germ cell tumors","volume":"76","author":"Ogiwara","year":"2015","journal-title":"Neurosurgery"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875019326920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875019326920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T08:44:55Z","timestamp":1761813895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875019326920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":40,"alternative-id":["S1878875019326920"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2019.10.074","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2019.10.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}