{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:42:24Z","timestamp":1780537344542,"version":"3.54.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.wneu.2020.06.069","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T21:55:44Z","timestamp":1592344544000},"page":"e95-e100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Low Risk of Traumatic Intracranial Hematoma Expansion with Factor Xa Inhibitors without Andexanet Reversal"],"prefix":"10.1016","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2156-7391","authenticated-orcid":false,"given":"Georgios A.","family":"Maragkos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmalin B.","family":"Nelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Stippler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2020.06.069_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.24095\/hpcdp.35.7.01","article-title":"Fall-related injuries among Canadian seniors, 2005\u20132013: an analysis of the Canadian Community Health Survey","volume":"35","author":"Do","year":"2015","journal-title":"Heal Promot Chronic Dis Prev Can"},{"key":"10.1016\/j.wneu.2020.06.069_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/TA.0000000000001414","article-title":"Novel oral anticoagulants and trauma","volume":"82","author":"Kobayashi","year":"2017","journal-title":"J\u00a0Trauma Acute Care Surg"},{"key":"10.1016\/j.wneu.2020.06.069_bib3","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1177\/000313480106701114","article-title":"Traumatic head injury in the anticoagulated elderly patient: a lethal combination","volume":"67","author":"Karni","year":"2001","journal-title":"Am Surg"},{"key":"10.1016\/j.wneu.2020.06.069_bib4","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.surg.2008.06.009","article-title":"The impact of preinjury antiplatelet and anticoagulant pharmacotherapy on outcomes in elderly patients with hemorrhagic brain injury","volume":"144","author":"Fortuna","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.wneu.2020.06.069_bib5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/jama.2017.21917","article-title":"Association of intracerebral hemorrhage among patients taking non-vitamin K antagonist vs vitamin K antagonist oral anticoagulants with in-hospital mortality","volume":"319","author":"Inohara","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.wneu.2020.06.069_bib6","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1177\/000313481508101025","article-title":"Dabigatran use does not increase intracranial hemorrhage in traumatic geriatric falls when compared with warfarin","volume":"81","author":"Pozzessere","year":"2015","journal-title":"Am Surg"},{"key":"10.1016\/j.wneu.2020.06.069_bib7","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/TA.0000000000001189","article-title":"Trauma patients on new oral anticoagulation agents have lower mortality than those on warfarin","volume":"81","author":"Maung","year":"2016","journal-title":"J\u00a0Trauma Acute Care Surg"},{"key":"10.1016\/j.wneu.2020.06.069_bib8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1097\/TA.0000000000001995","article-title":"The novel oral anticoagulants (NOACs) have worse outcomes compared with warfarin in patients with intracranial hemorrhage after TBI","volume":"85","author":"Zeeshan","year":"2018","journal-title":"J\u00a0Trauma Acute Care Surg"},{"key":"10.1016\/j.wneu.2020.06.069_bib9","author":"Scotti"},{"key":"10.1016\/j.wneu.2020.06.069_bib10","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/emermed-2011-200162","article-title":"Utility of routine follow-up head CT scanning after mild traumatic brain injury: a systematic review of the literature","volume":"29","author":"Stippler","year":"2012","journal-title":"Emerg Med J"},{"key":"10.1016\/j.wneu.2020.06.069_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.wneu.2017.05.008","article-title":"Complicated mild traumatic brain injury and the need for imaging surveillance","volume":"105","author":"Stippler","year":"2017","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2020.06.069_bib12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1182\/bloodadvances.2018024133","article-title":"Management of direct factor Xa inhibitor-related major bleeding with prothrombin complex concentrate: a meta-analysis","volume":"3","author":"Piran","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.wneu.2020.06.069_bib13","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1055\/s-0038-1636541","article-title":"Prothrombin complex concentrate for major bleeding on factor Xa inhibitors: a prospective cohort study","volume":"118","author":"Schulman","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.wneu.2020.06.069_bib14","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1182\/blood-2017-05-782060","article-title":"Management of rivaroxaban- or apixaban-associated major bleeding with prothrombin complex concentrates: a cohort study","volume":"130","author":"Majeed","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.wneu.2020.06.069_bib15","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1056\/NEJMoa1607887","article-title":"Andexanet\u00a0alfa for acute major bleeding associated with factor Xa inhibitors","volume":"375","author":"Connolly","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2020.06.069_bib16","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJMoa1814051","article-title":"Full study report of andexanet\u00a0alfa for bleeding associated with factor Xa inhibitors","volume":"380","author":"Connolly","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2020.06.069_bib17","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1161\/CIRCULATIONAHA.113.002283","article-title":"Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study","volume":"128","author":"Sarode","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.wneu.2020.06.069_bib18","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1161\/STROKEAHA.114.007343","article-title":"Accuracy of the ABC\/2 score for intracerebral hemorrhage: systematic review and analysis of MISTIE, CLEAR-IVH, and CLEAR III","volume":"46","author":"Webb","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2020.06.069_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF01808822","article-title":"Prognostic factors in severely head injured adult patients with acute subdural haematoma\u2019s","volume":"139","author":"Servadei","year":"1997","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.wneu.2020.06.069_bib20","first-page":"1139","article-title":"The natural history of brain contusion: an analysis of radiological and clinical progression","volume":"112","author":"Alahmadi","year":"2010","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2020.06.069_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/0028-3886.178030","article-title":"Post-traumatic subarachnoid hemorrhage: a review","volume":"64","author":"Modi","year":"2016","journal-title":"Neurol India"},{"key":"10.1016\/j.wneu.2020.06.069_bib22","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1056\/NEJMoa1510991","article-title":"Andexanet\u00a0alfa for the reversal of factor Xa inhibitor activity","volume":"373","author":"Siegal","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2020.06.069_bib23","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1056\/NEJMoa0707534","article-title":"Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. ONTARGET Renal Outcomes TRANSCEND","volume":"358","author":"Mayer","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2020.06.069_bib24","doi-asserted-by":"crossref","first-page":"e000134","DOI":"10.1136\/tsaco-2017-000134","article-title":"Factor VIIa administration in traumatic brain injury: an AAST-MITC propensity score analysis","volume":"3","author":"Lombardo","year":"2018","journal-title":"Trauma Surg Acute Care Open"},{"key":"10.1016\/j.wneu.2020.06.069_bib25","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1161\/STROKEAHA.112.650614","article-title":"Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial","volume":"43","author":"Hart","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2020.06.069_bib26","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/STROKEAHA.113.004506","article-title":"Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in at","volume":"45","author":"Hankey","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2020.06.069_bib27","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.3390\/ijerph14111378","article-title":"Effect of age on glasgow coma scale in patients with moderate and severe traumatic brain injury: an approach with propensity score-matched population","volume":"14","author":"Rau","year":"2017","journal-title":"Int J Environ Res Public Health"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875020313279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875020313279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T08:50:35Z","timestamp":1761814235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875020313279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":27,"alternative-id":["S1878875020313279"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2020.06.069","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low Risk of Traumatic Intracranial Hematoma Expansion with Factor Xa Inhibitors without Andexanet Reversal","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2020.06.069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}