{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:11:33Z","timestamp":1784693493869,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004823","name":"Nagoya University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.wneu.2020.08.169","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T23:46:06Z","timestamp":1599003966000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Preoperative Intracranial Dissemination of Spinal Myxopapillary Ependymoma Attributed to Tumor Hemorrhage"],"prefix":"10.1016","volume":"145","author":[{"given":"Takayuki","family":"Awaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-1663","authenticated-orcid":false,"given":"Yoshitaka","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-319X","authenticated-orcid":false,"given":"Sho","family":"Akahori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-8537","authenticated-orcid":false,"given":"Shoichi","family":"Haimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Natsume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2020.08.169_bib1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00586-017-5413-z","article-title":"Remarkable efficacy of temozolomide for relapsed spinal myxopapillary ependymoma with multiple recurrence and cerebrospinal dissemination: a case report and literature review","volume":"27","author":"Fujiwara","year":"2018","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2020.08.169_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3171\/2017.5.SPINE161164","article-title":"Metastases of spinal myxopapillary ependymoma: unique characteristics and clinical management","volume":"28","author":"Kraetzig","year":"2018","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2020.08.169_bib3","first-page":"216","article-title":"Spinal myxopapillary ependymoma with interval drop metastasis presenting as cauda equina syndrome: case report and review of literature","volume":"2","author":"Rege","year":"2016","journal-title":"J\u00a0Spine Surg"},{"key":"10.1016\/j.wneu.2020.08.169_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF01111488","article-title":"Intracranial metastasis of a spinal myxopapillary ependymoma: a case report","volume":"21","author":"Woesler","year":"1998","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.wneu.2020.08.169_bib5","doi-asserted-by":"crossref","first-page":"e795","DOI":"10.1200\/JCO.2011.36.6625","article-title":"Cerebrospinal tumor dissemination in a patient with myxopapillary ependymoma","volume":"29","author":"Macedo","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.wneu.2020.08.169_bib6","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.wneu.2020.08.169_bib7","first-page":"925","article-title":"Malignant behavior of myxopapillary ependymoma. Report of three cases","volume":"62","author":"Davis","year":"1985","journal-title":"J\u00a0Neurosurg"},{"issue":"1 Suppl","key":"10.1016\/j.wneu.2020.08.169_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3171\/ped.2005.102.1.0059","article-title":"The high incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients. Report of five cases and review of the literature","volume":"102","author":"Fassett","year":"2005","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2020.08.169_bib9","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/1097-0142(19850815)56:4<883::AID-CNCR2820560431>3.0.CO;2-6","article-title":"Myxopapillary ependymoma. A clinicopathologic and immunocytochemical study of 77 cases","volume":"56","author":"Sonneland","year":"1985","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2020.08.169_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00701-005-0693-1","article-title":"Intracranial retrograde dissemination in filum terminale myxopapillary ependymomas","volume":"148","author":"Plans","year":"2006","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.wneu.2020.08.169_bib11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10143-009-0190-8","article-title":"Long term outcomes following surgical resection of myxopapillary ependymomas","volume":"32","author":"Bagley","year":"2009","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.wneu.2020.08.169_bib12","author":"Liu"},{"key":"10.1016\/j.wneu.2020.08.169_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2176\/nmc.53.237","article-title":"Myxopapillary ependymoma in the third ventricle area and sacral canal: dropped or retrograde metastasis?","volume":"53","author":"Wang","year":"2013","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1016\/j.wneu.2020.08.169_bib14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/02841850410004931","article-title":"Primary intracranial myxopapillary ependymomas: report of two cases and review of the literature","volume":"45","author":"Tseng","year":"2004","journal-title":"Acta Radiol"},{"key":"10.1016\/j.wneu.2020.08.169_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10014-011-0059-8","article-title":"Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature","volume":"29","author":"Chakraborti","year":"2012","journal-title":"Brain Tumor Pathol"},{"key":"10.1016\/j.wneu.2020.08.169_bib16","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fgene.2012.00268","article-title":"Gender differences in cancer susceptibility: an inadequately addressed issue","volume":"3","author":"Dorak","year":"2012","journal-title":"Front Genet"},{"key":"10.1016\/j.wneu.2020.08.169_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3109\/02688697.2010.503817","article-title":"Myxopapillary ependymoma of the cerebellopontine angle: retrograde metastasis or primary tumour?","volume":"25","author":"Shaper","year":"2011","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.wneu.2020.08.169_bib18","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.3171\/2015.5.FOCUS15164","article-title":"Outcomes following myxopapillary ependymoma resection: the importance of capsule integrity","volume":"39","author":"Abdulaziz","year":"2015","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2020.08.169_bib19","doi-asserted-by":"crossref","first-page":"E756","DOI":"10.1097\/BRS.0b013e3181b34d16","article-title":"Long-term surgical outcomes for myxopapillary ependymomas of the cauda equina","volume":"34","author":"Nakamura","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2020.08.169_bib20","first-page":"430","article-title":"Spontaneous rupture and hemorrhage of myxopapillary ependymoma of the filum terminale: a case report and literature review","volume":"61","author":"Tonogai","year":"2014","journal-title":"J\u00a0Med Invest"},{"key":"10.1016\/j.wneu.2020.08.169_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11060-006-9169-2","article-title":"Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center","volume":"80","author":"Akyurek","year":"2006","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2020.08.169_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11060-015-1955-2","article-title":"Myxopapillary ependymomas in children: imaging, treatment and outcomes","volume":"126","author":"Bandopadhayay","year":"2016","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2020.08.169_bib23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1227\/00006123-198402000-00015","article-title":"Myxopapillary ependymoma of the filum terminale and cauda equina in childhood: report of seven cases and review of the literature","volume":"14","author":"Chan","year":"1984","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2020.08.169_bib24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF00301925","article-title":"Ependymomas of the filum terminale in childhood: report of four cases and review of the literature","volume":"9","author":"Gagliardi","year":"1993","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2020.08.169_bib25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1227\/00006123-199202000-00009","article-title":"Ependymoma of the cauda equina region: diagnosis, treatment, and outcome in 15 patients","volume":"30","author":"Schweitzer","year":"1992","journal-title":"Neurosurgery"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875020319380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875020319380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T08:51:35Z","timestamp":1761814295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875020319380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":25,"alternative-id":["S1878875020319380"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2020.08.169","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preoperative Intracranial Dissemination of Spinal Myxopapillary Ependymoma Attributed to Tumor Hemorrhage","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2020.08.169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}