{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:32:52Z","timestamp":1780536772217,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010041","name":"Tianjin Science and Technology Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.wneu.2021.01.024","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T01:09:53Z","timestamp":1611018593000},"page":"e565-e571","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The Prognostic Impact of Radiotherapy in Conjunction with Temozolomide in Diffuse Intrinsic Pontine Glioma: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"148","author":[{"given":"Shuai","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyue","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2021.01.024_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.semradonc.2009.09.005","article-title":"Brain tumors across the age spectrum: biology, therapy, and late effects","volume":"20","author":"Merchant","year":"2010","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s10555-019-09824-2","article-title":"Pediatric diffuse intrinsic pontine glioma: where do we stand?","volume":"38","author":"Rashed","year":"2019","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.wneu.2021.01.024_bib3","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/neuonc\/nox021","article-title":"Diffuse intrinsic pontine gliomas-current management and new biologic insights. Is there a glimmer of hope?","volume":"19","author":"Cohen","year":"2017","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2012.00205","article-title":"Diffuse intrinsic pontine glioma: poised for progress","volume":"2","author":"Warren","year":"2012","journal-title":"Front Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib5","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1097\/MPH.0b013e318279aed8","article-title":"Prolonged survival after treatment of diffuse intrinsic pontine glioma with radiation, temozolamide, and bevacizumab: report of 2 cases","volume":"35","author":"Aguilera","year":"2013","journal-title":"J\u00a0Pediatr Hematol Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijrobp.2009.04.031","article-title":"Prospective evaluation of radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma","volume":"77","author":"Jalali","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.wneu.2021.01.024_bib7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00381-012-1986-3","article-title":"Pediatric diffuse intrinsic pontine glioma patients from a single center","volume":"29","author":"Kebudi","year":"2013","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2021.01.024_bib8","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/neuonc\/noq205","article-title":"Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children\u2019s Oncology Group","volume":"13","author":"Cohen","year":"2011","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib9","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00066-013-0513-0","article-title":"Craniospinal irradiation with concurrent temozolomide for primary metastatic pediatric high-grade or diffuse intrinsic pontine gliomas. A first report from the GPOH-HIT-HGG Study Group","volume":"190","author":"Muller","year":"2014","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.wneu.2021.01.024_bib10","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00381-010-1106-1","article-title":"Role of temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: experience at a single institution","volume":"26","author":"Chiang","year":"2010","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2021.01.024_bib11","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.wneu.2021.01.024_bib12","doi-asserted-by":"crossref","first-page":"iii","DOI":"10.3310\/hta7270","article-title":"Evaluating non-randomised intervention studies","volume":"7","author":"Deeks","year":"2003","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.wneu.2021.01.024_bib13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.wneu.2021.01.024_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/cncr.20741","article-title":"Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98)","volume":"103","author":"Broniscer","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.wneu.2021.01.024_bib15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1215\/15228517-2008-025","article-title":"Concurrent radiotherapy with temozolomide followed by adjuvant temozolomide and cis-retinoic acid in children with diffuse intrinsic pontine glioma","volume":"10","author":"Sirachainan","year":"2008","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11060-010-0157-1","article-title":"A\u00a0prospective study of temozolomide plus thalidomide during and after radiation therapy for pediatric diffuse pontine gliomas: preliminary results of the Korean Society for Pediatric Neuro-Oncology study","volume":"100","author":"Kim","year":"2010","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11060-011-0681-7","article-title":"Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma","volume":"106","author":"Chassot","year":"2012","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib18","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1016\/j.ejca.2013.08.006","article-title":"Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy--results of a United Kingdom phase II trial (CNS 2007 04)","volume":"49","author":"Bailey","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.wneu.2021.01.024_bib19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/08880018.2013.829895","article-title":"Treatment of children with diffuse intrinsic pontine gliomas with chemoradiotherapy followed by a combination of temozolomide, irinotecan, and bevacizumab","volume":"30","author":"Zaky","year":"2013","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib20","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00381-014-2359-x","article-title":"Diffuse intrinsic pontine glioma in children and adolescents: a single-center experience","volume":"30","author":"Vallero","year":"2014","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2021.01.024_bib21","first-page":"106","article-title":"Temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: a broken promise?","volume":"27","author":"Rizzo","year":"2015","journal-title":"J\u00a0Chemother"},{"key":"10.1016\/j.wneu.2021.01.024_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00381-018-4001-9","article-title":"Nimotuzumab-containing regimen for pediatric diffuse intrinsic pontine gliomas: a retrospective multicenter study and review of the literature","volume":"35","author":"Kebudi","year":"2019","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.wneu.2021.01.024_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11060-011-0704-4","article-title":"Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: advancing basic and translational research and cooperation in DIPG","volume":"105","author":"Bartels","year":"2011","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fonc.2015.00147","article-title":"Pathology, molecular genetics, and epigenetics of diffuse intrinsic pontine glioma","volume":"5","author":"Buczkowicz","year":"2015","journal-title":"Front Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fonc.2017.00057","article-title":"Genomic insights into diffuse intrinsic pontine glioma","volume":"7","author":"Lapin","year":"2017","journal-title":"Front Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMoa1611977","article-title":"Short-course radiation plus temozolomide in elderly patients with glioblastoma","volume":"376","author":"Perry","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2021.01.024_bib27","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1093\/neuonc\/noy072","article-title":"Temozolomide for immunomodulation in the treatment of glioblastoma","volume":"20","author":"Karachi","year":"2018","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib28","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.adro.2019.03.009","article-title":"Role of radiation therapy in the management of diffuse intrinsic pontine glioma: a systematic review","volume":"4","author":"Gallitto","year":"2019","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11060-005-9011-2","article-title":"Phase II trial of temozolomide in children with recurrent high-grade glioma","volume":"77","author":"Ruggiero","year":"2006","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11060-019-03287-9","article-title":"Diagnostics and treatment of diffuse intrinsic pontine glioma: where do we stand?","volume":"145","author":"El-Khouly","year":"2019","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.wneu.2021.01.024_bib31","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejca.2019.03.019","article-title":"Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience","volume":"114","author":"Pfaff","year":"2019","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.wneu.2021.01.024_bib32","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00381-020-04523-8","article-title":"Biopsy in diffuse pontine gliomas: expert neurosurgeon opinion-a survey from the SIOPE brain tumor group","volume":"36","author":"Tejada","year":"2020","journal-title":"Childs Nerv Syst"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875021000450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875021000450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T08:52:54Z","timestamp":1761814374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875021000450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":32,"alternative-id":["S1878875021000450"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2021.01.024","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Prognostic Impact of Radiotherapy in Conjunction with Temozolomide in Diffuse Intrinsic Pontine Glioma: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2021.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}