{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:20:01Z","timestamp":1779340801158,"version":"3.51.4"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004702","name":"Baxter International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.wneu.2021.05.032","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:40:41Z","timestamp":1621557641000},"page":"147-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Radiotherapy and Surgical Advances in the Treatment of Metastatic Spine Tumors: A Narrative Review"],"prefix":"10.1016","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8664-7646","authenticated-orcid":false,"given":"Jose L.","family":"Porras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-860X","authenticated-orcid":false,"given":"Zach","family":"Pennington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1755-3974","authenticated-orcid":false,"given":"Andrew","family":"Hersh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Rory","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-434X","authenticated-orcid":false,"given":"Daniel M.","family":"Sciubba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2021.05.032_bib1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3171\/2018.11.SPINE18709","article-title":"Advances in the treatment of metastatic spine tumors: the future is not what it used to be","volume":"30","author":"Laufer","year":"2019","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2021.05.032_bib2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/neuros\/nyx567","article-title":"State of the art treatment of spinal metastatic disease","volume":"82","author":"Barzilai","year":"2018","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2021.05.032_bib3","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.ijrobp.2009.10.003","article-title":"Correlation of local failure with measures of dose insufficiency in the high-dose single-fraction treatment of bony metastases","volume":"77","author":"Lovelock","year":"2010","journal-title":"Int J Radiat Oncol"},{"issue":"suppl 1","key":"10.1016\/j.wneu.2021.05.032_bib4","doi-asserted-by":"crossref","first-page":"98S","DOI":"10.1177\/2192568219830323","article-title":"Essential concepts for the management of metastatic spine disease: what the surgeon should know and practice","volume":"9","author":"Barzilai","year":"2019","journal-title":"Glob Spine J"},{"key":"10.1016\/j.wneu.2021.05.032_bib5","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1227\/01.NEU.0000114263.01917.1E","article-title":"Intensity-modulated stereotactic radiotherapy of paraspinal tumors: a preliminary report","volume":"54","author":"Bilsky","year":"2004","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2021.05.032_bib6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ijrobp.2007.11.046","article-title":"High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions","volume":"71","author":"Yamada","year":"2008","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib7","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.1082504","article-title":"Tumor response to radiotherapy regulated by endothelial cell apoptosis","volume":"300","author":"Garcia-Barros","year":"2003","journal-title":"Science (80- )"},{"key":"10.1016\/j.wneu.2021.05.032_bib8","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1172\/JCI97631","article-title":"Single-dose radiotherapy disables tumor cell homologous recombination via ischemia\/reperfusion injury","volume":"129","author":"Bodo","year":"2019","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.wneu.2021.05.032_bib9","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.ijrobp.2018.01.005","article-title":"Early tissue effects of stereotactic body radiation therapy for spinal metastases","volume":"100","author":"Steverink","year":"2018","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib10","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2016.9.FOCUS16369","article-title":"The impact of histology and delivered dose on local control of spinal metastases treated with stereotactic radiosurgery","volume":"42","author":"Yamada","year":"2017","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2021.05.032_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/01.brs.0000251863.76595.a2","article-title":"Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution","volume":"32","author":"Gerszten","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2021.05.032_bib12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s13014-014-0226-2","article-title":"Safety and efficacy of stereotactic body radiotherapy as primary treatment for vertebral metastases: a multi-institutional analysis","volume":"9","author":"Guckenberger","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1470-2045(11)70384-9","article-title":"Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1\u20132 trial","volume":"13","author":"Wang","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ijrobp.2018.06.047","article-title":"Imaging-based outcomes for 24 Gy in 2 daily fractions for patients with de novo spinal metastases treated with spine stereotactic body radiation therapy (SBRT)","volume":"102","author":"Tseng","year":"2018","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib15","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ijrobp.2018.02.035","article-title":"Long-term outcomes after stereotactic radiosurgery for spine metastases: radiation dose\u2013response for late toxicity","volume":"101","author":"Ling","year":"2018","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11914-013-0174-z","article-title":"Effects of radiation on bone","volume":"11","author":"Pacheco","year":"2013","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.wneu.2021.05.032_bib17","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.1016\/S1470-2045(13)70101-3","article-title":"Vertebral compression fracture after stereotactic body radiotherapy for spinal metastases","volume":"14","author":"Sahgal","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib18","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3171\/2015.10.SPINE141261","article-title":"Vertebral compression fractures after stereotactic body radiation therapy: a large, multi-institutional, multinational evaluation","volume":"24","author":"Jawad","year":"2016","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2021.05.032_bib19","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1200\/JCO.2013.50.1411","article-title":"Vertebral compression fracture after spine stereotactic body radiotherapy: a multi-institutional analysis with a focus on radiation dose and the Spinal Instability Neoplastic Score","volume":"31","author":"Sahgal","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib20","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.3171\/2016.10.FOCUS16359","article-title":"Frequency of symptomatic vertebral body compression fractures requiring intervention following single-fraction stereotactic radiosurgery for spinal metastases","volume":"42","author":"Virk","year":"2017","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2021.05.032_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.14338\/IJPT-18-00018.1","article-title":"Comparing photon and charged particle therapy using DNA damage biomarkers","volume":"5","author":"Ray","year":"2018","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.wneu.2021.05.032_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.addr.2016.11.006","article-title":"Proton therapy\u2013present and future","volume":"109","author":"Mohan","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.wneu.2021.05.032_bib23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/0284186X.2020.1834140","article-title":"High-dose proton therapy and tomotherapy for the treatment of sacral chordoma: a retrospective monocentric study","volume":"60","author":"Beddok","year":"2021","journal-title":"Acta Oncol (Madr)"},{"key":"10.1016\/j.wneu.2021.05.032_bib24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s11999.0000000000000063","article-title":"What is the effect of high-dose radiation on bone in patients with sacral chordoma? A CT study","volume":"476","author":"van Wulfften Palthe","year":"2018","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.wneu.2021.05.032_bib25","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s11999-015-4566-5","article-title":"Sacral insufficiency fractures are common after high-dose radiation for sacral chordomas treated with or without surgery","volume":"474","author":"Osler","year":"2016","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.wneu.2021.05.032_bib26","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1093\/neuros\/nyw084","article-title":"Spine oncology\u2013metastatic spine tumors","volume":"80","author":"Choi","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2021.05.032_bib27","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/j.wneu.2020.01.093","article-title":"Perioperative complications and prognosis of curative surgical resection for spinal metastases in elderly patients","volume":"137","author":"Yonezawa","year":"2020","journal-title":"World Neurosurg"},{"issue":"suppl 22","key":"10.1016\/j.wneu.2021.05.032_bib28","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1097\/BRS.0b013e3181bac4b2","article-title":"Shifting paradigms in the treatment of metastatic spine disease","volume":"34","author":"Bilsky","year":"2009","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2021.05.032_bib29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0140-6736(05)66954-1","article-title":"Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial","volume":"366","author":"Patchell","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2021.05.032_bib30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.15274\/INR-2014-10019","article-title":"Intra-operative vertebroplasty combined with posterior cord decompression. A report of twelve cases","volume":"20","author":"Allegretti","year":"2014","journal-title":"Interv Neuroradiol"},{"key":"10.1016\/j.wneu.2021.05.032_bib31","doi-asserted-by":"crossref","first-page":"e889","DOI":"10.1016\/j.wneu.2018.08.182","article-title":"Minimal access surgery for spinal metastases: prospective evaluation of a treatment algorithm using patient-reported outcomes","volume":"120","author":"Barzilai","year":"2018","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib32","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1007\/s00586-009-1111-9","article-title":"Outcome of excisional surgeries for the patients with spinal metastases","volume":"18","author":"Li","year":"2009","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2021.05.032_bib33","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1097\/BRS.0b013e3181c680b9","article-title":"Efficacy evaluation of a new treatment algorithm for spinal metastases","volume":"3","author":"Gasbarrini","year":"2010","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2021.05.032_bib34","first-page":"599","article-title":"Transthoracic vertebrectomy for metastatic spinal tumors","volume":"89","author":"Gokaslan","year":"1998","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib35","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00007632-200102010-00016","article-title":"Surgical strategy for spinal metastases","volume":"26","author":"Tomita","year":"2001","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2021.05.032_bib36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.21037\/atm.2018.01.28","article-title":"Minimally invasive versus conventional spine surgery for vertebral metastases: a systematic review of the evidence","volume":"6","author":"Pennington","year":"2018","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.wneu.2021.05.032_bib37","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1302\/0301-620X.88B4.17282","article-title":"Current concepts in the management of metastatic spinal disease","volume":"88-B","author":"Singh","year":"2006","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.wneu.2021.05.032_bib38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3171\/2012.11.SPINE12111","article-title":"Local disease control for spinal metastases following \u201cseparation surgery\u201d and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients","volume":"18","author":"Laufer","year":"2013","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2021.05.032_bib39","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1097\/00007632-200009010-00016","article-title":"Single-stage posterolateral transpedicle approach for spondylectomy, epidural decompression, and circumferential fusion of spinal metastases","volume":"25","author":"Bilsky","year":"2000","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2021.05.032_bib40","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/ons\/opy137","article-title":"Hybrid therapy for metastatic epidural spinal cord compression: technique for separation surgery and spine radiosurgery","volume":"16","author":"Barzilai","year":"2019","journal-title":"Oper Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib41","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3171\/2017.4.SPINE161182","article-title":"Interbody distraction and vertebral body reconstruction with polymethylmethacrylate for the treatment of pathological fractures","volume":"27","author":"Zuckerman","year":"2017","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2021.05.032_bib42","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/neuonc\/not101","article-title":"Surgical resection of epidural disease improves local control following postoperative spine stereotactic body radiotherapy","volume":"15","author":"Al-Omair","year":"2013","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.nec.2019.11.003","article-title":"Minimally invasive surgery strategies: changing the treatment of spine tumors","volume":"31","author":"Barzilai","year":"2020","journal-title":"Neurosurg Clin North Am"},{"key":"10.1016\/j.wneu.2021.05.032_bib44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/BSD.0b013e31805fea01","article-title":"Minimally invasive transpedicular vertebrectomy for metastatic disease to the thoracic spine","volume":"21","author":"Deutsch","year":"2008","journal-title":"J\u00a0Spinal Disord Tech"},{"key":"10.1016\/j.wneu.2021.05.032_bib45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.7785\/tcrt.2012.500230","article-title":"Minimal access spine surgery (MASS) for decompression and stabilization performed as an out-patient procedure for metastatic spinal tumours followed by spine stereotactic body radiotherapy (SBRT): first report of technique and preliminary outcomes","volume":"11","author":"Massicotte","year":"2012","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.wneu.2021.05.032_bib46","doi-asserted-by":"crossref","first-page":"E620","DOI":"10.1227\/01.NEU.0000365270.23815.B1","article-title":"Minimally invasive circumferential spinal decompression and stabilization for symptomatic metastatic spine tumor: technical case report","volume":"66","author":"Taghva","year":"2010","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2021.05.032_bib47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3171\/2012.2.SPINE11128","article-title":"Minimally invasive lateral extracavitary corpectomy: cadaveric evaluation model and report of 3 clinical cases","volume":"16","author":"Smith","year":"2012","journal-title":"J\u00a0Neurosurg Spine"},{"issue":"suppl 26","key":"10.1016\/j.wneu.2021.05.032_bib48","doi-asserted-by":"crossref","first-page":"S347","DOI":"10.1097\/BRS.0b013e3182022d0f","article-title":"Minimally invasive surgery treatment for thoracic spine tumor removal: a mini-open, lateral approach","volume":"35","author":"Uribe","year":"2010","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2021.05.032_bib49","first-page":"473","article-title":"The extreme lateral approach for treatment of thoracic and lumbar vertebral body metastases","volume":"63","author":"Serak","year":"2019","journal-title":"J\u00a0Neurosurg Sci"},{"key":"10.1016\/j.wneu.2021.05.032_bib50","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.wneu.2016.04.043","article-title":"A\u00a0modified microsurgical endoscopic-assisted transpedicular corpectomy of the thoracic spine based on virtual 3-dimensional planning","volume":"91","author":"Archavlis","year":"2016","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib51","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.spinee.2018.02.002","article-title":"\u201cMicroendoscopic\u201d versus \u201cpure endoscopic\u201d surgery for spinal intradural mass lesions: a comparative study and review","volume":"18","author":"Dhandapani","year":"2018","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2021.05.032_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clineuro.2015.03.022","article-title":"Transforaminal endoscopic surgery under local analgesia for ventral epidural thoracic spinal tumor: case report","volume":"134","author":"Telfeian","year":"2015","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib53","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.wneu.2019.09.039","article-title":"Percutaneous endoscopic excision and ablation of osteoid osteoma of the lumbar spine and sacrum: a technical note and outcomes","volume":"133","author":"Xie","year":"2020","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.nec.2019.08.014","article-title":"Robotic tissue manipulation and resection in spine surgery","volume":"31","author":"Trybula","year":"2020","journal-title":"Neurosurg Clin North Am"},{"key":"10.1016\/j.wneu.2021.05.032_bib55","first-page":"567","article-title":"Does the accuracy of pedicle screw placement differ between the attending surgeon and resident in navigated robotic-assisted minimally invasive spine surgery?","volume":"14","author":"Vardiman","year":"2020","journal-title":"J\u00a0Robot Surg"},{"key":"10.1016\/j.wneu.2021.05.032_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14444\/2001","article-title":"Robotic assisted surgeries for the treatment of spine tumors","volume":"9","author":"Hu","year":"2015","journal-title":"Int J Spine Surg"},{"key":"10.1016\/j.wneu.2021.05.032_bib57","doi-asserted-by":"crossref","first-page":"331","DOI":"10.4184\/asj.2014.8.3.331","article-title":"Accuracy of pedicle screw placement in scoliosis surgery: a comparison between conventional computed tomography-based and O-arm-based navigation techniques","volume":"8","author":"Kotani","year":"2014","journal-title":"Asian Spine J"},{"key":"10.1016\/j.wneu.2021.05.032_bib58","doi-asserted-by":"crossref","first-page":"E56","DOI":"10.1097\/01.brs.0000252094.64857.ab","article-title":"Randomized clinical study to compare the accuracy of navigated and non-navigated thoracic pedicle screws in deformity correction surgeries","volume":"32","author":"Rajasekaran","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2021.05.032_bib59","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1109\/TMI.2015.2391200","article-title":"Spinal navigation and imaging: history, trends, and future","volume":"34","author":"Helm","year":"2015","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.wneu.2021.05.032_bib60","doi-asserted-by":"crossref","unstructured":"Good CR, Orosz L, Schroerlucke SR, et al. Complications and revision rates in minimally invasive robotic-guided versus fluoroscopic-guided spinal fusions [e-pub ahead of print]. Spine (Phila Pa 1976). https:\/\/doi.org\/10.1097\/BRS.0000000000004048, accessed May 10, 2021.","DOI":"10.1097\/BRS.0000000000004048"},{"key":"10.1016\/j.wneu.2021.05.032_bib61","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1055\/s-0033-1345687","article-title":"Thorascopic resection of an apical paraspinal schwannoma using the da Vinci surgical system","volume":"75","author":"Finley","year":"2013","journal-title":"J\u00a0Neurol Surg A Cent Eur Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib62","doi-asserted-by":"crossref","first-page":"e0240","DOI":"10.2106\/JBJS.CC.18.00240","article-title":"Robotic surgery assisted staged en-bloc sacrectomy for sacral chordoma: a case report","volume":"9","author":"Chinder","year":"2019","journal-title":"JBJS Case Connect"},{"key":"10.1016\/j.wneu.2021.05.032_bib63","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12891-018-2084-9","article-title":"Robot-assisted sacral tumor resection: a preliminary study","volume":"19","author":"Yin","year":"2018","journal-title":"BMC Musculoskelet Disord"},{"issue":"suppl 1","key":"10.1016\/j.wneu.2021.05.032_bib64","doi-asserted-by":"crossref","first-page":"onsE209","DOI":"10.1227\/NEU.0b013e31826112d8","article-title":"Use of the da Vinci minimally invasive robotic system for resection of a complicated paraspinal schwannoma with thoracic extension","volume":"71","author":"Perez-Cruet","year":"2012","journal-title":"Oper Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib65","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuchi.2020.01.002","article-title":"Case report: mini-invasive surgery assisted by Da Vinci\u00ae robot for a recurrent paravertebral schwannoma","volume":"66","author":"Matveeff","year":"2020","journal-title":"Neurochirurgie"},{"issue":"2 suppl","key":"10.1016\/j.wneu.2021.05.032_bib66","doi-asserted-by":"crossref","first-page":"79S","DOI":"10.1177\/2192568219895265","article-title":"The role of minimal access surgery in the treatment of spinal metastatic tumors","volume":"10","author":"Barzilai","year":"2020","journal-title":"Glob Spine J"},{"key":"10.1016\/j.wneu.2021.05.032_bib67","first-page":"595","article-title":"Cement-augmented pedicle screw insertion assisted by spinal robotic systems for widespread spinal metastases","volume":"13","author":"Wu","year":"2019","journal-title":"J\u00a0Robot Surg"},{"key":"10.1016\/j.wneu.2021.05.032_bib68","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.3171\/2017.3.FOCUS1710","article-title":"Robotic versus fluoroscopy-guided pedicle screw insertion for metastatic spinal disease: a matched-cohort comparison","volume":"42","author":"Solomiichuk","year":"2017","journal-title":"Neurosurg Focus"},{"key":"10.1016\/j.wneu.2021.05.032_bib69","doi-asserted-by":"crossref","first-page":"e1034","DOI":"10.1016\/j.wneu.2019.05.067","article-title":"SINS score and stability: evaluating the need for stabilization within the uncertain category","volume":"128","author":"Pennington","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib70","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.spinee.2017.07.008","article-title":"Patient-reported outcomes after surgical stabilization of spinal tumors: symptom-based validation of the Spinal Instability Neoplastic Score (SINS) and surgery","volume":"18","author":"Hussain","year":"2018","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2021.05.032_bib71","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/ons\/opy186","article-title":"Utility of cement augmentation via percutaneous fenestrated pedicle screws for stabilization of cancer-related spinal instability","volume":"16","author":"Barzilai","year":"2019","journal-title":"Oper Neurosurg"},{"key":"10.1016\/j.wneu.2021.05.032_bib72","doi-asserted-by":"crossref","first-page":"S254","DOI":"10.1097\/BRS.0000000000001819","article-title":"Evidence-based review and survey of expert opinion of reconstruction of metastatic spine tumors","volume":"41","author":"Altaf","year":"2016","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2021.05.032_bib73","first-page":"323","article-title":"Composite PEEK\/carbon fiber implants can increase the effectiveness of radiotherapy in the management of spine tumors","volume":"3","author":"Tedesco","year":"2017","journal-title":"J\u00a0Spine Surg"},{"key":"10.1016\/j.wneu.2021.05.032_bib74","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13014-016-0649-z","article-title":"The dosimetric impact of implants on the spinal cord dose during stereotactic body radiotherapy","volume":"11","author":"Yazici","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib75","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1088\/0031-9155\/58\/19\/6733","article-title":"Effect of spine hardware on small spinal stereotactic radiosurgery dosimetry","volume":"58","author":"Wang","year":"2013","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.wneu.2021.05.032_bib76","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s00586-017-5258-5","article-title":"Carbon-fiber-reinforced PEEK fixation system in the treatment of spine tumors: a preliminary report","volume":"27","author":"Boriani","year":"2018","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2021.05.032_bib77","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12957-018-1545-9","article-title":"Carbon fibre\/polyether ether ketone (CF\/PEEK) implants in orthopaedic oncology","volume":"16","author":"Laux","year":"2018","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib78","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3171\/2015.2.SPINE141185","article-title":"Utilization of laser interstitial thermotherapy guided by real-time thermal MRI as an alternative to separation surgery in the management of spinal metastasis","volume":"23","author":"Tatsui","year":"2015","journal-title":"J\u00a0Neurosurg Spine"},{"key":"10.1016\/j.wneu.2021.05.032_bib79","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/j.prro.2015.09.014","article-title":"The use of image guided laser interstitial thermotherapy to supplement spine stereotactic radiosurgery to manage metastatic epidural spinal cord compression: proof of concept and dosimetric analysis","volume":"6","author":"Ghia","year":"2016","journal-title":"Pract Radiat Oncol"},{"issue":"suppl 1","key":"10.1016\/j.wneu.2021.05.032_bib80","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1227\/NEU.0000000000001444","article-title":"Spinal laser interstitial thermal therapy: a novel alternative to surgery for metastatic epidural spinal cord compression","volume":"79","author":"Tatsui","year":"2016","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2021.05.032_bib81","first-page":"317","article-title":"Treatment of metastatic spinal lesions with a navigational bipolar radiofrequency ablation device: a multicenter retrospective study","volume":"17","author":"Anchala","year":"2014","journal-title":"Pain Physician"},{"key":"10.1016\/j.wneu.2021.05.032_bib82","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/neurintsurg-2016-012908","article-title":"Multicenter clinical and imaging evaluation of targeted radiofrequency ablation (t-RFA) and cement augmentation of neoplastic vertebral lesions","volume":"10","author":"Reyes","year":"2018","journal-title":"J\u00a0Neurointerv Surg"},{"key":"10.1016\/j.wneu.2021.05.032_bib83","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3174\/ajnr.A4595","article-title":"Radiographic local control of spinal metastases with percutaneous radiofrequency ablation and vertebral augmentation","volume":"37","author":"Wallace","year":"2016","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.wneu.2021.05.032_bib84","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3174\/ajnr.A4521","article-title":"Spine cryoablation: pain palliation and local tumor control for vertebral metastases","volume":"37","author":"Tomasian","year":"2016","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.wneu.2021.05.032_bib85","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.nec.2019.08.017","article-title":"Emerging percutaneous ablative and radiosurgical techniques for treatment of spinal metastases","volume":"31","author":"Hadzipasic","year":"2020","journal-title":"Neurosurg Clin North Am"},{"key":"10.1016\/j.wneu.2021.05.032_bib86","doi-asserted-by":"crossref","first-page":"142","DOI":"10.2214\/AJR.17.18205","article-title":"Percutaneous thermal ablation of spinal metastases: recent advances and review","volume":"210","author":"Tomasian","year":"2018","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.wneu.2021.05.032_bib87","doi-asserted-by":"crossref","unstructured":"Sciubba DM, Pennington Z, Colman MW, et al. Spinal Metastases 2021: a review of the current state of the art and future directions [e-pub ahead of print]. Spine J. https:\/\/doi.org\/10.1016\/j.spinee.2021.04.012, accessed May 10, 2021.","DOI":"10.1016\/j.spinee.2021.04.012"},{"key":"10.1016\/j.wneu.2021.05.032_bib88","doi-asserted-by":"crossref","first-page":"E720","DOI":"10.1016\/S1470-2045(17)30612-5","article-title":"An integrated multidisciplinary algorithm for the management of spinal metastases: an International Spine Oncology Consortium report","volume":"18","author":"Spratt","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.wneu.2021.05.032_bib89","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.3346\/jkms.2021.36.e52","article-title":"Surgical impacts of metastatic non-small cell lung cancer to the thoracic and lumbar spine","volume":"36","author":"Jung","year":"2021","journal-title":"J\u00a0Korean Med Sci"},{"key":"10.1016\/j.wneu.2021.05.032_bib90","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/neuros\/nyaa380","article-title":"Survival trends after surgery for spinal metastatic tumors: 20-year cancer center experience","volume":"88","author":"Rothrock","year":"2020","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2021.05.032_bib91","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s13277-012-0584-z","article-title":"The effects of Hsp90 expression alteration on spinal metastases of breast carcinoma","volume":"34","author":"Yan","year":"2013","journal-title":"Tumor Biol"},{"key":"10.1016\/j.wneu.2021.05.032_bib92","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41393-019-0352-7","article-title":"Functional outcomes and survival after surgical stabilization for inoperable non-small-cell lung cancer with spinal metastasis of the thoracic and lumbar spines: a retrospective comparison between epidermal growth factor receptor-tyrosine kinase inhibitor","volume":"58","author":"Lin","year":"2020","journal-title":"Spinal Cord"},{"key":"10.1016\/j.wneu.2021.05.032_bib93","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00586-019-05879-5","article-title":"Development of a novel model for predicting survival of patients with spine metastasis from colorectal cancer","volume":"28","author":"Liu","year":"2019","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2021.05.032_bib94","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.spinee.2016.12.003","article-title":"Prognostic factors in patients with spinal metastasis: a systematic review and meta-analysis","volume":"17","author":"Luksanapruksa","year":"2017","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2021.05.032_bib95","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.2147\/CMAR.S258429","article-title":"Role of multimodal treatment in urothelial carcinoma spinal metastasis: 15 patients\u2019 experiences in a single center","volume":"12","author":"Wang","year":"2020","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.wneu.2021.05.032_bib96","first-page":"552","article-title":"The effect of chemotherapy with 5-fluorouracil, bleomycin and cisplatin in the healing of colonic anastomoses in rats","volume":"91","author":"Lambrou","year":"2020","journal-title":"Ann Ital Chir"},{"key":"10.1016\/j.wneu.2021.05.032_bib97","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/IGC.0000000000001258","article-title":"Angiogenesis inhibitors for the treatment of ovarian cancer: an updated systematic review and meta-analysis of randomized controlled trials","volume":"28","author":"Wang","year":"2018","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.wneu.2021.05.032_bib98","doi-asserted-by":"crossref","first-page":"82473","DOI":"10.18632\/oncotarget.12666","article-title":"Bevacizumab and wound-healing complications: a systematic review and meta-analysis of randomized controlled trials","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.wneu.2021.05.032_bib99","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jocn.2014.05.054","article-title":"Timing of surgery and bevacizumab therapy in neurosurgical patients with recurrent high grade glioma","volume":"22","author":"Abrams","year":"2015","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.wneu.2021.05.032_bib100","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/SAP.0b013e3181828141","article-title":"A\u00a0review on bevacizumab and surgical wound healing","volume":"62","author":"Gordon","year":"2009","journal-title":"Ann Plast Surg"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875021007270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875021007270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T08:56:28Z","timestamp":1761814588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875021007270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":100,"alternative-id":["S1878875021007270"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2021.05.032","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiotherapy and Surgical Advances in the Treatment of Metastatic Spine Tumors: A Narrative Review","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2021.05.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}