{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:26:51Z","timestamp":1782307611828,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860225"],"award-info":[{"award-number":["81860225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.wneu.2021.06.093","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:26:03Z","timestamp":1626222363000},"page":"e29-e38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Potential Correlation Between Depression-like Behavior and the Mitogen-Activated Protein Kinase Pathway in the Rat Hippocampus Following Spinal Cord Injury"],"prefix":"10.1016","volume":"154","author":[{"given":"Zhiping","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenke","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelong","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2021.06.093_bib1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1460-9568.1994.tb00983.x","article-title":"Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord","volume":"6","author":"Dusart","year":"1994","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.wneu.2021.06.093_bib2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3389\/fneur.2017.00662","article-title":"Factors affecting volume changes of the somatosensory cortex in patients with spinal cord injury: to be considered for future neuroprosthetic design","volume":"8","author":"Holler","year":"2017","journal-title":"Front Neurol"},{"key":"10.1016\/j.wneu.2021.06.093_bib3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainres.2012.12.034","article-title":"Functional brain reorganization after spinal cord injury: systematic review of animal and human studies","volume":"1504","author":"Nardone","year":"2013","journal-title":"Brain Res"},{"key":"10.1016\/j.wneu.2021.06.093_bib4","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/WNR.0b013e32832d0a28","article-title":"Brain protection by methylprednisolone in rats with spinal cord injury","volume":"20","author":"Chang","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.wneu.2021.06.093_bib5","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/s41393-019-0367-0","article-title":"Neurological injury as a complication of spinal surgery: incidence, risk factors, and prognosis","volume":"58","author":"Romero-Munoz","year":"2020","journal-title":"Spinal Cord"},{"key":"10.1016\/j.wneu.2021.06.093_bib6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/sj.sc.3101893","article-title":"Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey?","volume":"44","author":"Wyndaele","year":"2006","journal-title":"Spinal Cord"},{"key":"10.1016\/j.wneu.2021.06.093_bib7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/PHM.0b013e31817c16d6","article-title":"Secondary health complications in an aging Canadian spinal cord injury sample","volume":"87","author":"Hitzig","year":"2008","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.wneu.2021.06.093_bib8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3109\/09638288.2016.1152600","article-title":"Assessment of the relationship of spiritual well-being to depression and quality of life for persons with spinal cord injury","volume":"39","author":"Wilson","year":"2017","journal-title":"Disabil Rehabil"},{"key":"10.1016\/j.wneu.2021.06.093_bib9","first-page":"e118816","article-title":"Altered spontaneous brain activity in patients with acute spinal cord injury revealed by resting-state functional MRI","volume":"10","author":"Zhu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.wneu.2021.06.093_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainres.2004.05.113","article-title":"Injury in the spinal cord may produce cell death in the brain","volume":"1020","author":"Lee","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.wneu.2021.06.093_bib11","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1089\/neu.2015.4348","article-title":"Endoplasmic reticulum stress and disrupted neurogenesis in the brain are associated with cognitive impairment and depressive-like behavior after spinal cord injury","volume":"33","author":"Wu","year":"2016","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.wneu.2021.06.093_bib12","doi-asserted-by":"crossref","first-page":"10989","DOI":"10.1523\/JNEUROSCI.5110-13.2014","article-title":"Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways","volume":"34","author":"Wu","year":"2014","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.wneu.2021.06.093_bib13","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/WNR.0000000000001543","article-title":"Effects of body weight-supported treadmill training at different speeds on the motor function and depressive behaviors after spinal cord injury in rats","volume":"31","author":"Liu","year":"2020","journal-title":"Neuroreport"},{"key":"10.1016\/j.wneu.2021.06.093_bib14","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1002\/jnr.24719","article-title":"A\u00a0potential entanglement between the spinal cord and hippocampus: Theta rhythm correlates with neurogenesis deficiency following spinal cord injury in male rats","volume":"98","author":"Soltani","year":"2020","journal-title":"J\u00a0Neurosci Res"},{"key":"10.1016\/j.wneu.2021.06.093_bib15","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3390\/ijms20030600","article-title":"Astragaloside IV alleviates ammonia-induced apoptosis and oxidative stress in bovine mammary epithelial cells","volume":"20","author":"Wang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.wneu.2021.06.093_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s11010-019-03614-8","article-title":"Vaspin protects mouse mesenchymal stem cells from oxidative stress-induced apoptosis through the MAPK\/p38 pathway","volume":"462","author":"Zhu","year":"2019","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.wneu.2021.06.093_bib17","doi-asserted-by":"crossref","first-page":"5962014","DOI":"10.1155\/2019\/5962014","article-title":"MAPK pathway inhibitors attenuated hydrogen peroxide induced damage in neural cells","volume":"2019","author":"Fan","year":"2019","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.wneu.2021.06.093_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.55782\/ane-2000-1357","article-title":"MAPK regulation of gene expression in the central nervous system","volume":"60","author":"Adams","year":"2000","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"10.1016\/j.wneu.2021.06.093_bib19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/sj.mp.4001744","article-title":"ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf","volume":"11","author":"Dwivedi","year":"2006","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.wneu.2021.06.093_bib20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2009.06.036","article-title":"Differential expression of mitogen-activated protein kinase signaling pathway in the hippocampus of rats exposed to chronic unpredictable stress","volume":"205","author":"Li","year":"2009","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.wneu.2021.06.093_bib21","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/nm.2219","article-title":"A\u00a0negative regulator of MAP kinase causes depressive behavior","volume":"16","author":"Duric","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.wneu.2021.06.093_bib22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s12031-014-0328-1","article-title":"Fluoxetine signature on hippocampal MAPK signalling in sex-dependent manner","volume":"55","author":"Mitic","year":"2015","journal-title":"J\u00a0Mol Neurosci"},{"key":"10.1016\/j.wneu.2021.06.093_bib23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbi.2019.01.012","article-title":"Spinal cord injury by clip-compression induces anxiety and depression-like behaviours in female rats: the role of the inflammatory response","volume":"78","author":"do Esp\u00edrito Santo","year":"2019","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.wneu.2021.06.093_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.1995.12.1","article-title":"A\u00a0sensitive and reliable locomotor rating scale for open field testing in rats","volume":"12","author":"Basso","year":"1995","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.wneu.2021.06.093_bib25","doi-asserted-by":"crossref","first-page":"554613","DOI":"10.3389\/fncel.2020.554613","article-title":"N-acetylcysteine rescues hippocampal oxidative stress-induced neuronal injury via suppression of p38\/JNK signaling in depressed rats","volume":"14","author":"Fan","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.wneu.2021.06.093_bib26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/0269881108089814","article-title":"Anhedonia and activity deficits in rats: impact of post-stroke depression","volume":"23","author":"Wang","year":"2009","journal-title":"J\u00a0Psychopharmacol"},{"key":"10.1016\/j.wneu.2021.06.093_bib27","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1111\/ejn.13255","article-title":"Ginsenoside Rg1 reverses stress-induced depression-like behaviours and brain-derived neurotrophic factor expression within the prefrontal cortex","volume":"44","author":"Zhu","year":"2016","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.wneu.2021.06.093_bib28","first-page":"327","article-title":"Behavioural despair in mice: a primary screening test for antidepressants","volume":"2","author":"Porsolt","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1016\/j.wneu.2021.06.093_bib29","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1089\/neu.2013.3204","article-title":"Assessment of depression in a rodent model of spinal cord injury","volume":"31","author":"Luedtke","year":"2014","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.wneu.2021.06.093_bib30","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1089\/neu.2010.1424","article-title":"Characterization of a graded cervical hemicontusion spinal cord injury model in adult male rats","volume":"11","author":"Dunham","year":"2010","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.wneu.2021.06.093_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/109374001301419737","article-title":"Biomarkers of apoptosis: release of cytochrome c, activation of caspase-3, induction of 8-hydroxy-2\u2032-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene","volume":"4","author":"Abu-Qare","year":"2001","journal-title":"J\u00a0Toxicol Environ Health B Crit Rev"},{"key":"10.1016\/j.wneu.2021.06.093_bib32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbi.2015.08.009","article-title":"Inflammation is increased with anxiety- and depression-like signs in a rat model of spinal cord injury","volume":"51","author":"Maldonado-Bouchard","year":"2016","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.wneu.2021.06.093_bib33","doi-asserted-by":"crossref","first-page":"3710363","DOI":"10.1155\/2019\/3710363","article-title":"Glu-mGluR2\/3-ERK signaling regulates apoptosis of hippocampal neurons in diabetic-depression model rats","volume":"2019","author":"Liu","year":"2019","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.wneu.2021.06.093_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2020.01.026","article-title":"Tanshinone IIA improves depression-like behavior in mice by activating the ERK-CREB-BDNF signaling pathway","volume":"430","author":"Lu","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.wneu.2021.06.093_bib35","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1017\/S1461145709990575","article-title":"Aberrant extracellular signal-regulated kinase (ERK)1\/2 signalling in suicide brain: role of ERK kinase 1 (MEK1)","volume":"12","author":"Dwivedi","year":"2009","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.wneu.2021.06.093_bib36","first-page":"7241","article-title":"p38 predicts depression and poor outcome in esophageal cancer","volume":"14","author":"Cheng","year":"2017","journal-title":"Oncol Lett"},{"key":"10.1016\/j.wneu.2021.06.093_bib37","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1167\/iovs.18-24394","article-title":"Effect of a p38 mitogen-activated protein kinase inhibitor on corneal endothelial cell proliferation","volume":"59","author":"Nakahara","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.wneu.2021.06.093_bib38","doi-asserted-by":"crossref","first-page":"e671","DOI":"10.1038\/tp.2015.168","article-title":"A\u00a0requirement of serotonergic p38alpha mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors","volume":"5","author":"Baganz","year":"2015","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.wneu.2021.06.093_bib39","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.bbi.2011.02.015","article-title":"Early activation of p38 mitogen activated protein kinase is associated with interferon-alpha-induced depression and fatigue","volume":"25","author":"Felger","year":"2011","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.wneu.2021.06.093_bib40","doi-asserted-by":"crossref","first-page":"12286","DOI":"10.1074\/jbc.M312868200","article-title":"Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression","volume":"279","author":"Huang","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.wneu.2021.06.093_bib41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/15216540500097111","article-title":"From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance","volume":"57","author":"Karin","year":"2005","journal-title":"IUBMB Life"},{"key":"10.1016\/j.wneu.2021.06.093_bib42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ceb.2007.02.001","article-title":"The JNK signal transduction pathway","volume":"19","author":"Weston","year":"2007","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.wneu.2021.06.093_bib43","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00702-012-0776-0","article-title":"Chronic isolation stress compromises JNK\/c-Jun signaling in rat brain","volume":"119","author":"Filipovic","year":"2012","journal-title":"J\u00a0Neural Transm (Vienna)"},{"key":"10.1016\/j.wneu.2021.06.093_bib44","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1017\/S1461145711000897","article-title":"Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation","volume":"15","author":"Galeotti","year":"2012","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.wneu.2021.06.093_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3233\/BPL-170062","article-title":"JNK Regulation of depression and anxiety","volume":"3","author":"Hollos","year":"2018","journal-title":"Brain Plast"},{"key":"10.1016\/j.wneu.2021.06.093_bib46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.brainres.2008.08.057","article-title":"Acute cold exposure and rewarming enhanced spatial memory and activated the MAPK cascades in the rat brain","volume":"1239","author":"Zheng","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.wneu.2021.06.093_bib47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1677\/JOE-08-0509","article-title":"Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain","volume":"202","author":"Adzic","year":"2009","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.wneu.2021.06.093_bib48","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1089\/neu.2012.2689","article-title":"Involvement of extracellular signal regulated kinases in traumatic brain injury-induced depression in rodents","volume":"30","author":"Kuo","year":"2013","journal-title":"J\u00a0Neurotrauma"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875021009347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875021009347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:03:18Z","timestamp":1761814998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875021009347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":48,"alternative-id":["S1878875021009347"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2021.06.093","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential Correlation Between Depression-like Behavior and the Mitogen-Activated Protein Kinase Pathway in the Rat Hippocampus Following Spinal Cord Injury","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2021.06.093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}