{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:09:32Z","timestamp":1761815372703,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"am","delay-in-days":363,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.wneu.2022.03.036","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T21:46:40Z","timestamp":1647380800000},"page":"e503-e510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Reperfusion Therapy Brings Apixaban Administration Forward in Patients with Nonvalvular Arterial Fibrillation with Anterior Circulation Large Vessel Occlusion or Stenosis"],"prefix":"10.1016","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-9160","authenticated-orcid":false,"given":"Norihito","family":"Shimamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Naraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kou","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3289-1210","authenticated-orcid":false,"given":"Nobuyuki","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanta","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ezura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masunari","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihito","family":"Fukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketo","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5108-6719","authenticated-orcid":false,"given":"Takahiro","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuminori","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-739X","authenticated-orcid":false,"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2022.03.036_bib1","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2022.03.036_bib2","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1253\/circj.CJ-12-0454","article-title":"Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation\u2013the J-ROCKET AF study","volume":"76","author":"Hori","year":"2012","journal-title":"Circ J"},{"key":"10.1016\/j.wneu.2022.03.036_bib3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/2396987319841187","article-title":"Antithrombotic treatment for secondary prevention of stroke and other thromboembolic events in patients with stroke or transient ischemic attack and non-valvular atrial fibrillation: a European Stroke Organization guideline","volume":"4","author":"Klijn","year":"2019","journal-title":"Eur Stroke J"},{"key":"10.1016\/j.wneu.2022.03.036_bib4","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.wneu.2022.03.036_bib5","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STROKEAHA.118.022606","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2022.03.036_bib6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/01.STR.14.5.688","article-title":"Early recurrent embolism associated with nonvalvular atrial fibrillation: a retrospective study","volume":"14","author":"Hart","year":"1983","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2022.03.036_bib7","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1001\/jamaneurol.2017.2161","article-title":"Rivaroxaban vs warfarin sodium in the ultra-early period after atrial fibrillation-related mild ischemic stroke: a randomized clinical trial","volume":"74","author":"Hong","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.wneu.2022.03.036_bib8","doi-asserted-by":"crossref","first-page":"e007034","DOI":"10.1161\/JAHA.117.007034","article-title":"Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non-Vitamin-K Oral Anticoagulants (RAF-NOACs) study","volume":"6","author":"Paciaroni","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.wneu.2022.03.036_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12975-020-00839-4","article-title":"Safety of early administration of apixaban on clinical outcomes in patients with acute large vessel occlusion","volume":"12","author":"Yoshimura","year":"2021","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.wneu.2022.03.036_bib10","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(00)02237-6","article-title":"Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score","volume":"355","author":"Barber","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2022.03.036_bib11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.04.001","article-title":"Guidelines for the intravenous application of recombinant tissue-type plasminogen activator (alteplase), the second edition, October 2012: a guideline from the Japan Stroke Society","volume":"22","author":"Minematsu","year":"2013","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.wneu.2022.03.036_bib12","first-page":"466","article-title":"Comparative efficacy and safety of novel oral anticoagulants in patients with atrial fibrillation: a network meta-analysis with the adjustment for the possible bias from open label studies","volume":"66","author":"Morimoto","year":"2015","journal-title":"J\u00a0Cardiol"},{"key":"10.1016\/j.wneu.2022.03.036_bib13","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.STR.19.5.604","article-title":"Interobserver agreement for the assessment of handicap in stroke patients","volume":"19","author":"van Swieten","year":"1988","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2022.03.036_bib14","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1161\/01.STR.25.11.2220","article-title":"Improved reliability of the NIH Stroke Scale using video training. NINDSTPA Stroke Study Group","volume":"25","author":"Lyden","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2022.03.036_bib15","first-page":"382","article-title":"TIMI, TIBI, TICI: I came, I saw, I got confused","volume":"28","author":"Tomsick","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.wneu.2022.03.036_bib16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1474-4422(18)30356-9","article-title":"Timing of anticoagulation after recent ischaemic stroke in patients with atrial fibrillation","volume":"18","author":"Seiffge","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.wneu.2022.03.036_bib17","doi-asserted-by":"crossref","first-page":"e0212354","DOI":"10.1371\/journal.pone.0212354","article-title":"Rivaroxaban administration after acute ischemic stroke: the RELAXED study","volume":"14","author":"Yasaka","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.wneu.2022.03.036_bib18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1161\/01.STR.0000254600.92975.1f","article-title":"Efficacy and safety of anticoagulant treatment in acute cardioembolic stroke: a meta-analysis of randomized controlled trials","volume":"38","author":"Paciaroni","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2022.03.036_bib19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1474-4422(13)70079-6","article-title":"Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials","volume":"12","author":"Whiteley","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.wneu.2022.03.036_bib20","first-page":"1164","article-title":"Early apixaban therapy after ischemic stroke in patients with atrial fibrillation","volume":"52","author":"Alrohimi","year":"2021","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.wneu.2022.03.036_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/brainsci11010030","article-title":"Prospective observational study of Safety of Early Treatment with Edoxaban in Patients with Ischemic Stroke and Atrial Fibrillation (SATES Study)","volume":"11","author":"Frisullo","year":"2020","journal-title":"Brain Sci"},{"key":"10.1016\/j.wneu.2022.03.036_bib22","first-page":"1026","article-title":"Long-term outcome changes after mechanical thrombectomy for anterior circulation acute ischemic stroke","volume":"267","author":"Fuhrer","year":"2020","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.wneu.2022.03.036_bib23","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.wneu.2022.03.036_bib24","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1161\/STROKEAHA.114.005603","article-title":"Predictors of functional dependence despite successful revascularization in large-vessel occlusion strokes","volume":"45","author":"Shi","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2022.03.036_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12883-018-1033-4","article-title":"Clinical and radiological factors associated with unfavorable outcome after intravenous thrombolysis in patients with mild ischemic stroke","volume":"18","author":"Kim","year":"2018","journal-title":"BMC Neurol"},{"key":"10.1016\/j.wneu.2022.03.036_bib26","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3389\/fneur.2020.00907","article-title":"Predictors of poor outcome despite successful mechanical thrombectomy of anterior circulation large vessel occlusions within 6 h of symptom onset","volume":"11","author":"Mohammaden","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.wneu.2022.03.036_bib27","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3390\/brainsci10120911","article-title":"Predicting factors of functional outcome in patients with acute ischemic stroke admitted to neuro-intensive care unit\u2013a prospective cohort study","volume":"10","author":"Pilato","year":"2020","journal-title":"Brain Sci"},{"key":"10.1016\/j.wneu.2022.03.036_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12975-021-00905-5","article-title":"Prediction of outcome after endovascular embolectomy in anterior circulation stroke using biomarkers","volume":"13","author":"Pujol-Calderon","year":"2022","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.wneu.2022.03.036_bib29","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.04.015","article-title":"Admission leukocytosis in acute cerebral ischemia: influence on early outcome","volume":"21","author":"Nardi","year":"2012","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.wneu.2022.03.036_bib30","doi-asserted-by":"crossref","first-page":"e0238312","DOI":"10.1371\/journal.pone.0238312","article-title":"The correlation between novel peripheral blood cell ratios and 90-day mortality in patients with acute ischemic stroke","volume":"15","author":"Cao","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.wneu.2022.03.036_bib31","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/STROKEAHA.120.032130","article-title":"Neutrophil-to-lymphocyte ratio predicts cerebral edema and clinical worsening early after reperfusion therapy in stroke","volume":"52","author":"Ferro","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.wneu.2022.03.036_bib32","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jocn.2019.01.028","article-title":"Platelet-to-neutrophil ratio is a prognostic marker for 90-days outcome in acute ischemic stroke","volume":"63","author":"Jin","year":"2019","journal-title":"J\u00a0Clin Neurosci"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022003278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022003278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:07:12Z","timestamp":1761815232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875022003278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":32,"alternative-id":["S1878875022003278"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2022.03.036","relation":{},"ISSN":["1878-8750"],"issn-type":[{"type":"print","value":"1878-8750"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reperfusion Therapy Brings Apixaban Administration Forward in Patients with Nonvalvular Arterial Fibrillation with Anterior Circulation Large Vessel Occlusion or Stenosis","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2022.03.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}