{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:14:50Z","timestamp":1761815690295,"version":"build-2065373602"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.wneu.2022.07.020","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T10:35:27Z","timestamp":1657881327000},"page":"e443-e450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The Effect of Tranexamic Acid on Operative and Postoperative Blood Loss in Transforaminal Lumbar Interbody Fusions"],"prefix":"10.1016","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6932-6568","authenticated-orcid":false,"given":"Arun P.","family":"Kanhere","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9106-2228","authenticated-orcid":false,"given":"Mark J.","family":"Lambrechts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-5225","authenticated-orcid":false,"given":"Tariq Ziad","family":"Issa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0512-6019","authenticated-orcid":false,"given":"Brian A.","family":"Karamian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea J.","family":"Hendow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-863X","authenticated-orcid":false,"given":"Yashas C.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Slota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8484-0207","authenticated-orcid":false,"given":"Nicholas D.","family":"D'Antonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian David","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-5725","authenticated-orcid":false,"given":"Jose A.","family":"Canseco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barrett I.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8811-9687","authenticated-orcid":false,"given":"Alan S.","family":"Hilibrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K.","family":"Kepler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander R.","family":"Vaccaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2022.07.020_bib1","doi-asserted-by":"crossref","first-page":"e19864","DOI":"10.1097\/MD.0000000000019864","article-title":"Total and hidden blood loss between open posterior lumbar interbody fusion and transforaminal lumbar interbody fusion by Wiltse approach","volume":"99","author":"Lei","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.wneu.2022.07.020_bib2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.wneu.2017.08.113","article-title":"Comparison of the total and hidden blood loss in patients undergoing open and minimally invasive transforaminal lumbar interbody fusion","volume":"107","author":"Zhang","year":"2017","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2022.07.020_bib3","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3171\/2019.11.SPINE191174","article-title":"The effectiveness of tranexamic acid on operative and perioperative blood loss in long-segment spinal fusions: a consecutive series of 119 primary procedures","volume":"32","author":"Pernik","year":"2020","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.wneu.2022.07.020_bib4","doi-asserted-by":"crossref","first-page":"566956","DOI":"10.3389\/fphar.2020.566956","article-title":"Efficacy of intravenous tranexamic acid in reducing perioperative blood loss and blood product transfusion requirements in patients undergoing multilevel thoracic and lumbar spinal surgeries: a retrospective study","volume":"11","author":"Todeschini","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.wneu.2022.07.020_bib5","doi-asserted-by":"crossref","first-page":"888","DOI":"10.14245\/ns.2040114.057","article-title":"Postoperative low-dose tranexamic acid after major spine surgery: a matched cohort analysis","volume":"17","author":"Dunn","year":"2020","journal-title":"Neurospine"},{"key":"10.1016\/j.wneu.2022.07.020_bib6","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.2106\/JBJS.18.00314","article-title":"Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial","volume":"100","author":"Goobie","year":"2018","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.wneu.2022.07.020_bib7","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1213\/ANE.0000000000001159","article-title":"Tranexamic acid compared with placebo for reducing total blood loss in hip replacement surgery: a randomized clinical trial","volume":"122","author":"Barrachina","year":"2016","journal-title":"Anesth Analg"},{"key":"10.1016\/j.wneu.2022.07.020_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1302\/0301-620X.93B1.24984","article-title":"Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement","volume":"93","author":"Sukeik","year":"2011","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.wneu.2022.07.020_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2482-10-13","article-title":"A\u00a0prospective, randomized, double-blinded single-site control study comparing blood loss prevention of tranexamic acid (TXA) to epsilon aminocaproic acid (EACA) for corrective spinal surgery","volume":"10","author":"Verma","year":"2010","journal-title":"BMC Surg"},{"key":"10.1016\/j.wneu.2022.07.020_bib10","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/00007632-200003010-00010","article-title":"Predictors of blood transfusions in spinal instrumentation and fusion surgery","volume":"25","author":"Nuttall","year":"2000","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1 Suppl","key":"10.1016\/j.wneu.2022.07.020_bib11","doi-asserted-by":"crossref","first-page":"71S","DOI":"10.1177\/2192568219868475","article-title":"Minimizing blood loss in spine surgery","volume":"10","author":"Mikhail","year":"2020","journal-title":"Glob Spine J"},{"issue":"Suppl 5","key":"10.1016\/j.wneu.2022.07.020_bib12","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.21037\/atm.2019.05.36","article-title":"The use of tranexamic acid in spine surgery","volume":"7","author":"Yoo","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.wneu.2022.07.020_bib13","doi-asserted-by":"crossref","first-page":"593","DOI":"10.31616\/asj.2019.0134","article-title":"Use of topical tranexamic acid to reduce blood loss in single-level transforaminal lumbar interbody fusion","volume":"14","author":"Mallepally","year":"2020","journal-title":"Asian Spine J"},{"key":"10.1016\/j.wneu.2022.07.020_bib14","doi-asserted-by":"crossref","first-page":"E462","DOI":"10.1097\/BSD.0000000000000851","article-title":"Tranexamic acid in thoracic and lumbar fusions and perioperative blood loss","volume":"32","author":"Wanderman","year":"2019","journal-title":"Clin Spine Surg"},{"key":"10.1016\/j.wneu.2022.07.020_bib15","doi-asserted-by":"crossref","first-page":"E353","DOI":"10.1097\/BSD.0000000000000770","article-title":"Does prophylactic administration of TXA reduce mean operative time and postoperative blood loss in posterior approach lumbar spinal fusion surgery performed for degenerative spinal disease?","volume":"32","author":"Larson","year":"2019","journal-title":"Clin Spine Surg"},{"key":"10.1016\/j.wneu.2022.07.020_bib16","doi-asserted-by":"crossref","first-page":"E593","DOI":"10.1097\/BSD.0000000000000999","article-title":"Two doses of tranexamic acid reduce blood loss in primary posterior lumbar fusion surgery: a randomized-controlled trial","volume":"33","author":"Zhu","year":"2020","journal-title":"Clin Spine Surg"},{"key":"10.1016\/j.wneu.2022.07.020_bib17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s13018-020-01971-5","article-title":"Hidden blood loss and its possible risk factors in minimally invasive transforaminal lumbar interbody fusion","volume":"15","author":"Zhou","year":"2020","journal-title":"J\u00a0Orthop Surg"},{"key":"10.1016\/j.wneu.2022.07.020_bib18","doi-asserted-by":"crossref","first-page":"e19552","DOI":"10.1097\/MD.0000000000019552","article-title":"Tranexamic acid reduce hidden blood loss in posterior lumbar interbody fusion (PLIF) surgery","volume":"99","author":"Xu","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.wneu.2022.07.020_bib19","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler","year":"1962","journal-title":"Surgery"},{"key":"10.1016\/j.wneu.2022.07.020_bib20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/00000542-198303000-00016","article-title":"Estimating allowable blood loss: corrected for dilution","volume":"58","author":"Gross","year":"1983","journal-title":"Anesthesiology"},{"key":"10.1016\/j.wneu.2022.07.020_bib21","doi-asserted-by":"crossref","first-page":"8516504","DOI":"10.1155\/2020\/8516504","article-title":"Tranexamic acid for blood loss after transforaminal posterior lumbar interbody fusion surgery: a double-blind, placebo-controlled, randomized study","volume":"2020","author":"He","year":"2020","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.wneu.2022.07.020_bib22","doi-asserted-by":"crossref","first-page":"e1044","DOI":"10.1016\/j.wneu.2021.05.059","article-title":"Risk factors for increased surgical drain output after transforaminal lumbar interbody fusion","volume":"151","author":"Shi","year":"2021","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2022.07.020_bib23","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1097\/BRS.0b013e318188b9c5","article-title":"Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study","volume":"33","author":"Elwatidy","year":"2008","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2022.07.020_bib24","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/bja\/aew434","article-title":"Intraoperative tranexamic acid use in major spine surgery in adults: a multicentre, randomized, placebo-controlled trial","volume":"118","author":"Colomina","year":"2017","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.wneu.2022.07.020_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3171\/2020.1.SPINE191464","article-title":"Cost-benefit analysis of tranexamic acid and blood transfusion in elective lumbar spine surgery for degenerative pathologies","volume":"33","author":"Ehresman","year":"2020","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.wneu.2022.07.020_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2482-11-29","article-title":"Efficacy of tranexamic acid in reducing blood loss in posterior lumbar spine surgery for degenerative spinal stenosis with instability: a retrospective case control study","volume":"11","author":"Endres","year":"2011","journal-title":"BMC Surg"},{"key":"10.1016\/j.wneu.2022.07.020_bib27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/ANA.0b013e31822914a1","article-title":"Efficacy of prophylactic low dose of tranexamic acid in spinal fixation surgery: a randomized clinical trial","volume":"23","author":"Farrokhi","year":"2011","journal-title":"J\u00a0Neurosurg Anesthesiol"},{"key":"10.1016\/j.wneu.2022.07.020_bib28","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1007\/s00586-013-2836-z","article-title":"Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: a randomized controlled trial","volume":"22","author":"Wang","year":"2013","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2022.07.020_bib29","article-title":"Combined use of tranexamic acid and rivaroxaban in posterior\/transforaminal lumbar interbody fusion surgeries safely reduces blood loss and incidence of thrombosis: evidence from a prospective, randomized, double-blind, placebo-controlled study","author":"Li","year":"2021","journal-title":"Glob Spine J"},{"key":"10.1016\/j.wneu.2022.07.020_bib30","doi-asserted-by":"crossref","first-page":"e55436","DOI":"10.1371\/journal.pone.0055436","article-title":"Systematic review and meta-analysis of perioperative intravenous tranexamic acid use in spinal surgery","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.wneu.2022.07.020_bib31","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/CM9.0000000000000108","article-title":"Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis","volume":"132","author":"Yuan","year":"2019","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.wneu.2022.07.020_bib32","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1007\/s00586-017-5230-4","article-title":"The effectiveness of low-dose and high-dose tranexamic acid in posterior lumbar interbody fusion: a double-blinded, placebo-controlled randomized study","volume":"26","author":"Kim","year":"2017","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2022.07.020_bib33","doi-asserted-by":"crossref","first-page":"e572","DOI":"10.1016\/j.wneu.2017.11.070","article-title":"A\u00a0randomized controlled trial of low-dose tranexamic acid versus placebo to reduce red blood cell transfusion during complex multilevel spine fusion surgery","volume":"110","author":"Carabini","year":"2018","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2022.07.020_bib34","doi-asserted-by":"crossref","first-page":"e5718","DOI":"10.1097\/MD.0000000000005718","article-title":"Tranexamic acid reduces perioperative blood loss of posterior lumbar surgery for stenosis or spondylolisthesis: a randomized trial","volume":"96","author":"Shi","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.wneu.2022.07.020_bib35","doi-asserted-by":"crossref","DOI":"10.1007\/s43390-022-00539-z","article-title":"Randomized, controlled trial of two tranexamic acid dosing protocols in adult spinal deformity surgery","author":"Clohisy","year":"2022","journal-title":"Spine Deform"},{"key":"10.1016\/j.wneu.2022.07.020_bib36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4103\/ija.IJA_495_16","article-title":"The effect of different dose regimens of tranexamic acid in reducing blood loss during hip surgery","volume":"61","author":"Thipparampall","year":"2017","journal-title":"Indian J Anaesth"},{"key":"10.1016\/j.wneu.2022.07.020_bib37","first-page":"100086","article-title":"Tranexamic acid dosing strategies and blood loss reduction in multilevel spine surgery: a systematic review and network meta-analysis: tranexamic acid for multilevel spine surgery","volume":"8","author":"Rahmani","year":"2021","journal-title":"North Am Spine Soc J"},{"key":"10.1016\/j.wneu.2022.07.020_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/BRS.0000000000004157","article-title":"Oral is as effective as intravenous tranexamic acid at reducing blood loss in thoracolumbar spinal fusions: a prospective randomized trial","volume":"47","author":"Yu","year":"2022","journal-title":"Spine"},{"key":"10.1016\/j.wneu.2022.07.020_bib39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13018-017-0672-2","article-title":"A\u00a0randomized controlled trial on the effects of collagen sponge and topical tranexamic acid in posterior spinal fusion surgeries","volume":"12","author":"Xu","year":"2017","journal-title":"J\u00a0Orthop Surg"},{"key":"10.1016\/j.wneu.2022.07.020_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4038\/slja.v25i1.8182","article-title":"A\u00a0randomized prospective study of efficacy of tranexamic acid on perioperative blood loss in thoracic spine fixation","volume":"25","author":"Basavaraj","year":"2017","journal-title":"Sri Lankan J Anaesthesiol"},{"key":"10.1016\/j.wneu.2022.07.020_bib41","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1302\/0301-620X.99B11.BJJ-2017-0488.R1","article-title":"Multiple boluses of intravenous tranexamic acid to reduce hidden blood loss and the inflammatory response following enhanced-recovery primary total hip arthroplasty","volume":"99-B","author":"Xie","year":"2017","journal-title":"Bone Joint J"},{"key":"10.1016\/j.wneu.2022.07.020_bib42","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1016\/j.arth.2016.04.034","article-title":"Multiple boluses of intravenous tranexamic acid to reduce hidden blood loss after primary total knee arthroplasty without tourniquet: a randomized clinical trial","volume":"31","author":"Xie","year":"2016","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.wneu.2022.07.020_bib43","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.spinee.2013.02.008","article-title":"Hidden blood loss during posterior spine fusion surgery","volume":"13","author":"Smorgick","year":"2013","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2022.07.020_bib44","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/j.1537-2995.2008.01670.x","article-title":"A\u00a0comparison of hemolysis and red cell mechanical fragility in blood collected with different cell salvage suction devices","volume":"48","author":"Yazer","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.wneu.2022.07.020_bib45","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1007\/s00586-020-06572-8","article-title":"Efficacy of topical versus intravenous tranexamic acid in spinal deformity","volume":"29","author":"Weissmann","year":"2020","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2022.07.020_bib46","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s00586-021-07079-6","article-title":"Closed-suction drainage in thoracolumbar spinal surgery\u2013clinical routine without evidence? A systematic review","volume":"31","author":"Schnake","year":"2022","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2022.07.020_bib47","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1007\/s00586-020-06540-2","article-title":"Risk\u2013benefit analysis of wound drain usage in spine surgery: a systematic review and meta-analysis with evidence summary","volume":"29","author":"Muthu","year":"2020","journal-title":"Eur Spine J"},{"key":"10.1016\/j.wneu.2022.07.020_bib48","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.spinee.2021.01.001","article-title":"Consensus statement for perioperative care in lumbar spinal fusion: Enhanced Recovery After Surgery (ERAS\u00ae) Society recommendations","volume":"21","author":"Debono","year":"2021","journal-title":"Spine J"},{"key":"10.1016\/j.wneu.2022.07.020_bib49","doi-asserted-by":"crossref","first-page":"e846","DOI":"10.1016\/j.wneu.2019.07.013","article-title":"Prolonged post-surgical drain retention increases risk for deep wound infection after spine surgery","volume":"130","author":"Pennington","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2022.07.020_bib50","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.thromres.2008.09.015","article-title":"Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials","volume":"123","author":"Kagoma","year":"2009","journal-title":"Thromb Res"},{"key":"10.1016\/j.wneu.2022.07.020_bib51","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/TA.0000000000002061","article-title":"Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism","volume":"86","author":"Myers","year":"2019","journal-title":"J\u00a0Trauma Acute Care Surg"},{"key":"10.1016\/j.wneu.2022.07.020_bib52","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3171\/2021.7.SPINE202217","article-title":"Association of tranexamic acid with decreased blood loss in patients undergoing laminectomy and fusion with posterior instrumentation: a systematic review and meta-analysis","volume":"36","author":"Brown","year":"2021","journal-title":"J\u00a0Neurosurg Spine"},{"issue":"Suppl 1","key":"10.1016\/j.wneu.2022.07.020_bib53","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2106\/JBJS.21.01518","article-title":"Recommendations from the ICM-VTE: spine","volume":"104","year":"2022","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.wneu.2022.07.020_bib54","doi-asserted-by":"crossref","first-page":"E949","DOI":"10.1097\/BRS.0000000000002580","article-title":"The perioperative efficacy and safety of antifibrinolytics in adult spinal fusion surgery: a systematic review and meta-analysis","volume":"43","author":"Lu","year":"2018","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2022.07.020_bib55","doi-asserted-by":"crossref","first-page":"E71","DOI":"10.1097\/BSD.0000000000000860","article-title":"Does tranexamic acid increase the incidence of thromboembolism after spinal fusion surgery?","volume":"33","author":"Ko","year":"2020","journal-title":"Clin Spine Surg"},{"key":"10.1016\/j.wneu.2022.07.020_bib56","doi-asserted-by":"crossref","first-page":"E734","DOI":"10.1097\/BRS.0000000000002491","article-title":"Tranexamic acid decreases visible and hidden blood loss without affecting prethrombotic state molecular markers in transforaminal thoracic interbody fusion for treatment of thoracolumbar fracture-dislocation","volume":"43","author":"Wang","year":"2018","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.wneu.2022.07.020_bib57","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4236\/ojo.2013.36046","article-title":"Does pre-operative tranexamic acid increase the incidence of thromboembolism in primary lower limb arthroplasty?","volume":"3","author":"Selvaratnam","year":"2013","journal-title":"Open J Orthop"},{"key":"10.1016\/j.wneu.2022.07.020_bib58","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3171\/2021.1.SPINE201935","article-title":"Influence of tranexamic acid use on venous thromboembolism risk in patients undergoing surgery for spine tumors","volume":"35","author":"Pennington","year":"2021","journal-title":"J\u00a0Neurosurg Spine"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022009573?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022009573?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:12:26Z","timestamp":1761815546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875022009573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":58,"alternative-id":["S1878875022009573"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2022.07.020","relation":{},"ISSN":["1878-8750"],"issn-type":[{"type":"print","value":"1878-8750"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effect of Tranexamic Acid on Operative and Postoperative Blood Loss in Transforaminal Lumbar Interbody Fusions","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2022.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}