{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:20:12Z","timestamp":1793215212160,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860409"],"award-info":[{"award-number":["81860409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160437"],"award-info":[{"award-number":["82160437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["World Neurosurgery"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.wneu.2022.07.085","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T22:46:38Z","timestamp":1662158798000},"page":"e19-e27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Median Nerve Stimulation Attenuates Traumatic Brain Injury\u2013Induced Comatose State by Regulating the Orexin-A\/RasGRF1 Signaling Pathway"],"prefix":"10.1016","volume":"168","author":[{"given":"Qing","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunliang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.wneu.2022.07.085_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1227\/NEU.0000000000001432","article-title":"Guidelines for the management of severe traumatic brain injury, fourth edition","volume":"80","author":"Carney","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.wneu.2022.07.085_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12974-018-1066-z","article-title":"The role of the complement system in traumatic brain injury: a review","volume":"15","author":"Hammad","year":"2018","journal-title":"J\u00a0Neuroinflamm"},{"key":"10.1016\/j.wneu.2022.07.085_bib3","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1089\/neu.2018.5954","article-title":"Disorders of consciousness due to traumatic brain injury: functional status ten years post-injury","volume":"36","author":"Hammond","year":"2019","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.wneu.2022.07.085_bib4","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.emc.2016.06.017","article-title":"Initial diagnosis and management of coma","volume":"34","author":"Traub","year":"2016","journal-title":"Emerg Med Clin North Am"},{"key":"10.1016\/j.wneu.2022.07.085_bib5","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4103\/1673-5374.155433","article-title":"Resuscitation therapy for traumatic brain injury-induced coma in rats: mechanisms of median nerve electrical stimulation","volume":"10","author":"Feng","year":"2015","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.wneu.2022.07.085_bib6","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.1016\/j.wneu.2021.05.089","volume":"152","author":"Dong","year":"2021","journal-title":"World Neurosurg"},{"key":"10.1016\/j.wneu.2022.07.085_bib7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/09602010443000317","article-title":"Electrical treatment of reduced consciousness: experience with coma and Alzheimer's disease","volume":"15","author":"Cooper","year":"2005","journal-title":"Neuropsychol Rehabil"},{"key":"10.1016\/j.wneu.2022.07.085_bib8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4103\/1673-5374.184494","article-title":"Mechanisms responsible for the effect of median nerve electrical stimulation on traumatic brain injury-induced coma: orexin-A-mediated N-methyl-D-aspartate receptor subunit NR1 upregulation","volume":"11","author":"Feng","year":"2016","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.wneu.2022.07.085_bib9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamusspecific peptides with neuroexcitatory activity","volume":"95","author":"Lecea","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.wneu.2022.07.085_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"Sakurai","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.wneu.2022.07.085_bib11","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nature04284","article-title":"Hypothalamic regulation of sleep and circadian rhythms","volume":"437","author":"Saper","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.wneu.2022.07.085_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fendo.2013.00018","article-title":"The physiological role of orexin\/hypocretin neurons in the regulation of sleep\/wakefulness and neuroendocrine functions","volume":"4","author":"Inutsuka","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.wneu.2022.07.085_bib13","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1212\/01.WNL.0000125284.19326.80","article-title":"Undetectable CSF hypocretin-1 in \"Hashimoto's encephalopathy\" associated with coma","volume":"62","author":"Castillo","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.wneu.2022.07.085_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF03179063","article-title":"Orexin A-induced extracellular calcium influx in prefrontal cortex neurons involves L-type calcium channels","volume":"65","author":"Xia","year":"2009","journal-title":"J\u00a0Physiol Biochem"},{"key":"10.1016\/j.wneu.2022.07.085_bib15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/376524a0","article-title":"Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF","volume":"376","author":"Farnsworth","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.wneu.2022.07.085_bib16","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1046\/j.1460-9568.1999.00504.x","article-title":"Expression of Ras-GRF in the SK-N-BE neuroblastoma accelerates retinoic-acid-induced neuronal differentiation and increases the functional expression of the IRK1 potassium channel","volume":"11","author":"Tonini","year":"1999","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.wneu.2022.07.085_bib17","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/sj.emboj.7600151","article-title":"Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB","volume":"23","author":"Tian","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.wneu.2022.07.085_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/excr.1997.3660","article-title":"The Ras guanine nucleotide exchange factor CDC25Mm is present at the synaptic junction","volume":"235","author":"Sturani","year":"1997","journal-title":"Exper Cel Res"},{"key":"10.1016\/j.wneu.2022.07.085_bib19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/382268a0","article-title":"Phosphorylation-dependent activation of the Ras-GRF\/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits","volume":"382","author":"Mattingly","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.wneu.2022.07.085_bib20","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.3892\/mmr.2015.3898","article-title":"Wake-promoting actions of median nerve stimulation in TBI-induced coma: an investigation of orexin-A and orexin receptor 1 in the hypothalamic region","volume":"12","author":"Zhong","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.wneu.2022.07.085_bib21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1528-1157.1994.tb02928.x","article-title":"Effects of valproate and citrulline on ammonium-induced encephalopathy","volume":"35","author":"Stephens","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.wneu.2022.07.085_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neures.2008.01.016","article-title":"Parameters of optic nerve electrical stimulation affecting neuroprotection of axotomized retinal ganglion cells in adult rats","volume":"61","author":"Okazaki","year":"2008","journal-title":"Neurosci Res"},{"key":"10.1016\/j.wneu.2022.07.085_bib23","first-page":"7","article-title":"Electrical treatment of coma via the median nerve","volume":"87","author":"Cooper","year":"2003","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.wneu.2022.07.085_bib24","first-page":"11","article-title":"Regaining consciousness for prolonged comatose patients with right median nerve stimulation","volume":"87","author":"Liu","year":"2003","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.wneu.2022.07.085_bib25","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/02699052.2021.1887522","article-title":"The effectiveness of median nerve electrical stimulation in patients with disorders of consciousness: a systematic review","volume":"35","author":"Feller","year":"2021","journal-title":"Brain Inj"},{"key":"10.1016\/j.wneu.2022.07.085_bib26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neulet.2012.05.038","article-title":"Orexin-A excites pyramidal neurons in layer 2\/3 of the rat prefrontal cortex","volume":"520","author":"Yan","year":"2012","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.wneu.2022.07.085_bib27","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.neuropharm.2011.08.047","article-title":"Arousal effects of orexin A on acute alcohol intoxication-induced coma in rats","volume":"62","author":"Jia","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.wneu.2022.07.085_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s12031-010-9438-6","article-title":"Expression and localization of the orexin-1 receptor (OX1R) after traumatic brain injury in mice","volume":"43","author":"Mihara","year":"2011","journal-title":"J\u00a0Mol Neurosci"},{"key":"10.1016\/j.wneu.2022.07.085_bib29","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0306-4522(03)00554-2","article-title":"Orexinergic neurons and barbiturate anesthesia","volume":"121","author":"Kushikata","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.wneu.2022.07.085_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-62703-791-4_9","article-title":"Behavioral methods for the study of the Ras-ERK pathway in memory formation and consolidation: passive avoidance and novel object recognition tests","volume":"1120","author":"d'Isa","year":"2014","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.wneu.2022.07.085_bib31","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.biopsych.2009.03.014","article-title":"Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine","volume":"66","author":"Fasano","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.wneu.2022.07.085_bib32","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brainresbull.2018.04.008","article-title":"Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-\u03baB and MAPK signaling pathway","volume":"140","author":"Tao","year":"2018","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.wneu.2022.07.085_bib33","doi-asserted-by":"crossref","first-page":"e95259","DOI":"10.1371\/journal.pone.0095259","article-title":"Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCalpha and ERK1\/2 signals","volume":"9","author":"Shu","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.wneu.2022.07.085_bib34","first-page":"170","article-title":"The RasGrf family of mammalian guanine nucleotide exchange factors","volume":"1815","author":"Fernandez-Medarde","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.wneu.2022.07.085_bib35","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/00001756-200505120-00025","article-title":"Mechanisms of orexin A-evoked changes of intracellular calcium in primary cultured cortical neurons","volume":"16","author":"Xia","year":"2005","journal-title":"Neuroreport"}],"container-title":["World Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022010336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878875022010336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:19:48Z","timestamp":1761815988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878875022010336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":35,"alternative-id":["S1878875022010336"],"URL":"https:\/\/doi.org\/10.1016\/j.wneu.2022.07.085","relation":{},"ISSN":["1878-8750"],"issn-type":[{"value":"1878-8750","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Median Nerve Stimulation Attenuates Traumatic Brain Injury\u2013Induced Comatose State by Regulating the Orexin-A\/RasGRF1 Signaling Pathway","name":"articletitle","label":"Article Title"},{"value":"World Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.wneu.2022.07.085","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}